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This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing result... See more...
Aliases for YAP1 Gene
Aliases for YAP1 Gene
External Ids for YAP1 Gene
- HGNC: 16262
- Entrez Gene: 10413
- Ensembl: ENSG00000137693
- OMIM: 606608
- UniProtKB: P46937
Previous GeneCards Identifiers for YAP1 Gene
- GC11P104175
- GC11P103338
- GC11P102015
- GC11P101519
- GC11P101486
- GC11P097907
Summaries for YAP1 Gene
-
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
GeneCards Summary for YAP1 Gene
YAP1 (Yes Associated Protein 1) is a Protein Coding gene. Diseases associated with YAP1 include Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/Palate, And/Or Mental Retardation and Coloboma Of Macula. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Hippo signaling pathway. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription regulatory region DNA binding. An important paralog of this gene is WWTR1.
UniProtKB/Swiss-Prot Summary for YAP1 Gene
-
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).
-
[Isoform 2]: Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).
Additional gene information for YAP1 Gene
- Monarch Initiative
- Search for YAP1 at DataMed
- Search for YAP1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for YAP1 Gene
Genomics for YAP1 Gene
GeneHancer (GH) Regulatory Elements for YAP1 Gene
Promoters and enhancers for YAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around YAP1 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for YAP1
- Top Transcription factor binding sites by QIAGEN in the YAP1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- JunD
- p300
- p53
- TBP
- TFIID
Genomic Locations for YAP1 Gene
Genomic Locations for YAP1 Gene
- chr11:102,110,254-102,233,424
- (GRCh38/hg38)
- Size:
- 123,171 bases
- Orientation:
- Plus strand
- chr11:101,981,192-102,104,154
- (GRCh37/hg19)
- Size:
- 122,963 bases
- Orientation:
- Plus strand
Genomic View for YAP1 Gene
Genes around YAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q22.1 by HGNC
- 11q22.1 by Entrez Gene
- 11q22.1 by Ensembl
YAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for YAP1 Gene
Proteins for YAP1 Gene
-
Protein details for YAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46937-YAP1_HUMAN
- Recommended name:
- Transcriptional coactivator YAP1
- Protein Accession:
- P46937
- B4DTY1
- B7ZA01
- E3WEB5
- E3WEB6
- E9PRV2
- F5H202
- K0KQ18
- K0KYZ8
- K0L195
- K0L1G3
- Q7Z574
- Q8IUY9
Protein attributes for YAP1 Gene
- Size:
- 504 amino acids
- Molecular mass:
- 54462 Da
- Quaternary structure:
-
- Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2 (PubMed:9202023). Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB (PubMed:17974916). Interacts (via WW domains) with LATS1 (via PPxY motif 2) (PubMed:18158288). Interacts with LATS2 (PubMed:18158288). Isoform 2 and isoform 3 interact (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2) (PubMed:12807903). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (PubMed:18579750, PubMed:20123905, PubMed:20123908). Interacts with TP73 (PubMed:18280240). Interacts with RUNX1 (PubMed:18280240). Interacts with HCK (PubMed:17535448). Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity (PubMed:22525271).
- Miscellaneous:
-
- [Isoform 9]: Highest expression in ovary and placenta, lowest in skeletal muscle and brain.
Three dimensional structures from OCA and Proteopedia for YAP1 Gene
Protein Expression for YAP1 Gene
Post-translational modifications for YAP1 Gene
- Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation (PubMed:18158288, PubMed:20048001). Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage (PubMed:18280240). Phosphorylation at Ser-400 and Ser-403 by CK1 is triggered by previous phosphorylation at Ser-397 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation (PubMed:20048001). Phosphorylated at Thr-119, Ser-138, Thr-154, Ser-367 and Thr-412 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regulation of apoptosis by YAP1 (PubMed:21364637).
- Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for YAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences YAP / YAP1 Monoclonal Antibody (LS-B4494) and YAP / YAP1 Monoclonal Antibody (LS-B4495)
- NSJ Bioreagents YAP1 Antibody
- Creative Diagnostics Anti-YAP1 monoclonal antibody, clone 2B23
- GeneTex Anti-YAP1 antibody [GT256] and Anti-YAP1 antibody
- Novus Biologicals Antibodies for YAP1
-
Abcam antibodies for YAP1
- Invitrogen Antibodies for YAP1 (AFLGC-YAP1)
- antibodies-online: Show 58 available YAP1 Antibodies ranked by validation data
- Compare Top YAP1 Antibodies
-
Recommended
- 214 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 3 DB Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 94 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 72 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for YAP1
- Sino Biological Antibodies for YAP1
Protein Products
-
OriGene Purified Proteins for YAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for YAP1
- Origene Custom Protein Services for YAP1
-
Abcam proteins for YAP1
No data available for DME Specific Peptides for YAP1 Gene
Domains & Families for YAP1 Gene
Gene Families for YAP1 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for YAP1 Gene
Suggested Antigen Peptide Sequences for YAP1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ51091, highly similar to 65 kDa Yes-associated protein (B4DTY1_HUMAN)
- Yes-associated protein beta (E3WEB5_HUMAN)
- Yes-associated protein delta (E3WEB6_HUMAN)
- 65 kDa Yes-associated protein (YAP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P46937UniProtKB/Swiss-Prot:
YAP1_HUMAN :- The first coiled-coil region mediates most of the interaction with TEAD transcription factors.
- Belongs to the YAP1 family.
- Domain:
-
- The first coiled-coil region mediates most of the interaction with TEAD transcription factors.
- Family:
-
- Belongs to the YAP1 family.
Function for YAP1 Gene
Molecular function for YAP1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).
- UniProtKB/Swiss-Prot Function:
- [Isoform 2]: Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).
Phenotypes From GWAS Catalog for YAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003713 | transcription coactivator activity | IEA,IMP | 20123905 |
| GO:0003714 | transcription corepressor activity | IDA | 18158288 |
| GO:0005515 | protein binding | IPI,IEA | 7644498 |
Phenotypes for YAP1 Gene
- MGI mutant phenotypes for YAP1:
-
inferred from 10 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- liver/biliary system phenotype
- embryo phenotype
- renal/urinary system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for YAP1:
-
- Decreased NANOG protein expression
- Decreased POU5F1-GFP protein expression
- Decreased OCT4 protein expression
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased ionizing radiation sensitivity
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Increased viability with SS1P at EC90
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for YAP1 - Select products 50% OFF >
- * YAP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for YAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YAP1
- genomics-online: gRNA clones - Search for available YAP1 gRNA products
- Overview of 134 available YAP1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for YAP1
miRNA for YAP1 Gene
- miRTarBase miRNAs that target YAP1
-
- hsa-let-7b-5p (MIRT005047)
- hsa-mir-630 (MIRT005580)
- hsa-mir-375 (MIRT006154)
- hsa-mir-200a-3p (MIRT007299)
- hsa-mir-26b-5p (MIRT030244)
- hsa-mir-141-3p (MIRT052906)
- gga-mir-375 (MIRT053170)
- hsa-mir-15a-5p (MIRT054283)
- hsa-mir-16-5p (MIRT054284)
- hsa-mir-559 (MIRT264357)
- hsa-mir-548b-5p (MIRT264358)
- hsa-mir-548a-5p (MIRT264359)
- hsa-mir-548c-5p (MIRT264360)
- hsa-mir-548d-5p (MIRT264361)
- hsa-mir-1468-3p (MIRT264362)
- hsa-mir-877-5p (MIRT264364)
- hsa-mir-548j-5p (MIRT264365)
- hsa-mir-548k (MIRT264366)
- hsa-mir-548l (MIRT264367)
- hsa-mir-548h-5p (MIRT264370)
- hsa-mir-548p (MIRT264371)
- hsa-mir-548i (MIRT264372)
- hsa-mir-3121-3p (MIRT264373)
- hsa-mir-3125 (MIRT264374)
- hsa-mir-3159 (MIRT264375)
- hsa-mir-548w (MIRT264376)
- hsa-mir-3916 (MIRT264380)
- hsa-mir-548y (MIRT264381)
- hsa-mir-548o-5p (MIRT264382)
- hsa-mir-548ab (MIRT264383)
- hsa-mir-548ad-5p (MIRT264384)
- hsa-mir-548ae-5p (MIRT264385)
- hsa-mir-548ak (MIRT264387)
- hsa-mir-548am-5p (MIRT264388)
- hsa-mir-548ap-5p (MIRT264389)
- hsa-mir-548aq-5p (MIRT264390)
- hsa-mir-548ar-5p (MIRT264391)
- hsa-mir-548as-5p (MIRT264392)
- hsa-mir-548au-5p (MIRT264393)
- hsa-mir-548av-5p (MIRT264394)
- hsa-mir-548ay-5p (MIRT264396)
- hsa-mir-6859-5p (MIRT264398)
- hsa-mir-8054 (MIRT264399)
- hsa-mir-548bb-5p (MIRT264400)
- hsa-mir-506-3p (MIRT438349)
- hsa-mir-4639-5p (MIRT697598)
- hsa-mir-6844 (MIRT697599)
- hsa-mir-138-2-3p (MIRT697600)
- hsa-mir-4272 (MIRT697601)
- hsa-mir-4729 (MIRT697602)
- hsa-mir-10a-3p (MIRT697603)
- hsa-mir-509-3p (MIRT731507)
- hsa-mir-27a-3p (MIRT732285)
- hsa-mir-195-5p (MIRT734329)
- hsa-mir-424-3p (MIRT734416)
- hsa-mir-199a-3p (MIRT734710)
- hsa-mir-138-5p (MIRT734731)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for YAP1
- Browse OriGene Inhibitory RNA Products For YAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YAP1
- genomics-online: shRNA clones - Search for available YAP1 shRNA products
- Overview of 134 available YAP1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for YAP1 - Select products 50% OFF >
- * YAP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226049
- MR212130
- MR212130L3
- MR212130L4
- MR226049
- MR226049L3
- MR226049L4
- RC214393
- RC214393L1
- RC214393L2
- RC214393L3
- RC214393L4
- RC225864
- RC225864L1
- RC225864L2
- RC225864L3
- RC225864L4
- RC230803
- RC230803L3
- RC230803L4
- RC231269
- RC231269L1
- RC231269L2
- RC231269L3
- RC231269L4
- RC238320
- RC238394
- RC238419
- RC238545
- RC238628
- RG214393
- RG225864
- RG230803
- RG231269
- RR205630
- RR205630L1
- RR205630L2
- RR205630L3
- RR205630L4
- MR212130L3V
- MR212130L4V
- MR226049L3V
- MR226049L4V
- RC214393L1V
- RC214393L2V
- RC214393L3V
- RC214393L4V
- RC225864L1V
- RC225864L2V
- RC225864L3V
- RC225864L4V
- RC230803L3V
- RC230803L4V
- RC231269L1V
- RC231269L2V
- RC231269L3V
- RC231269L4V
- RR205630L1V
- RR205630L2V
- RR205630L3V
- RR205630L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for YAP1
- Addgene plasmids for YAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for YAP1
- genomics-online: cdna clones - Search for available YAP1 CDNA products
- Overview of 134 available YAP1 gene related products
- orf clones - Search for available YAP1 ORF products
- Overview of 134 available YAP1 gene related products
Cell Line Products
-
Horizon Cell Lines for YAP1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for YAP1 Gene
Localization for YAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for YAP1 Gene
- Cytoplasm. Nucleus. Note=Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). {ECO:0000269 PubMed:18158288, ECO:0000269 PubMed:20048001, ECO:0000269 PubMed:22525271}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoli (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IBA | 17974916 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IEA | -- |
| GO:0005737 | cytoplasm | IBA,IDA | 17974916 |
| GO:0005829 | cytosol | TAS,IEA | -- |
Pathways & Interactions for YAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | Signaling by ERBB4 | ||
| 3 | Gene Expression |
.48
|
|
| 4 | Metabolism |
.40
|
|
| 5 | Glucose / Energy Metabolism | ||
Pathways by source for YAP1 Gene
5 BioSystems pathways for YAP1 Gene
12 Reactome pathways for YAP1 Gene
2 KEGG pathways for YAP1 Gene
1 GeneGo (Thomson Reuters) pathway for YAP1 Gene
- CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
3 Qiagen pathways for YAP1 Gene
- 14-3-3 and Regulation of BAD Activity
- 14-3-3 Induced Intracellular Signaling
- Akt Signaling
4 Cell Signaling Technology pathways for YAP1 Gene
Interacting Proteins for YAP1 Gene
Selected Interacting proteins:
P46937-YAP1_HUMAN
ENSP00000478927
for YAP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for YAP1
SIGNOR curated interactions for YAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0001570 | vasculogenesis | IEA | -- |
| GO:0001894 | tissue homeostasis | IEA | -- |
| GO:0003015 | heart process | IEA | -- |
| GO:0003143 | embryonic heart tube morphogenesis | IEA | -- |
Transcripts for YAP1 Gene
mRNA/cDNA for YAP1 Gene
- 9 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000282441 5401 bps (ENST00000282441.10)
- ENST00000345877 5284 bps (ENST00000345877.6)
- ENST00000524575 1638 bps (ENST00000524575.5)
- ENST00000526343 2393 bps (ENST00000526343.5)
- ENST00000526594 785 bps (ENST00000526594.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for YAP1 - Select products 50% OFF >
- * YAP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for YAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YAP1
- genomics-online: gRNA clones - Search for available YAP1 gRNA products
- Overview of 134 available YAP1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for YAP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for YAP1
- Browse OriGene Inhibitory RNA Products For YAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YAP1
- genomics-online: shRNA clones - Search for available YAP1 shRNA products
- Overview of 134 available YAP1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for YAP1 - Select products 50% OFF >
- * YAP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226049
- MR212130
- MR212130L3
- MR212130L4
- MR226049
- MR226049L3
- MR226049L4
- RC214393
- RC214393L1
- RC214393L2
- RC214393L3
- RC214393L4
- RC225864
- RC225864L1
- RC225864L2
- RC225864L3
- RC225864L4
- RC230803
- RC230803L3
- RC230803L4
- RC231269
- RC231269L1
- RC231269L2
- RC231269L3
- RC231269L4
- RC238320
- RC238394
- RC238419
- RC238545
- RC238628
- RG214393
- RG225864
- RG230803
- RG231269
- RR205630
- RR205630L1
- RR205630L2
- RR205630L3
- RR205630L4
- MR212130L3V
- MR212130L4V
- MR226049L3V
- MR226049L4V
- RC214393L1V
- RC214393L2V
- RC214393L3V
- RC214393L4V
- RC225864L1V
- RC225864L2V
- RC225864L3V
- RC225864L4V
- RC230803L3V
- RC230803L4V
- RC231269L1V
- RC231269L2V
- RC231269L3V
- RC231269L4V
- RR205630L1V
- RR205630L2V
- RR205630L3V
- RR205630L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for YAP1
- Addgene plasmids for YAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for YAP1
- genomics-online: cdna clones - Search for available YAP1 CDNA products
- Overview of 134 available YAP1 gene related products
- orf clones - Search for available YAP1 ORF products
- Overview of 134 available YAP1 gene related products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e | · | 12f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||
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Relevant External Links for YAP1 Gene
- GeneLoc Exon Structure for
- YAP1
Expression for YAP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Cap Mesenchyme Cells Cap Mesenchyme
- Cortical Stroma Cells Interstitial Stroma
- S-shaped Body Distal Cells S-shaped Body Distal Segment
- S-shaped Body Proximal Cells S-shaped Body Proximal Segment
- Proximal Renal Vesicle Cells Renal Vesicle
- Endothelium (Cardiovascular System)
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Trophoblast (Extraembryonic Tissues)
- Trophoblast Cells Trophoblast
- NULL (Uncategorized)
- Smooth Muscle (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Esophagus (Gastrointestinal Tract)
-
Ovary (Reproductive System)
This gene is overexpressed in Bone marrow stromal cell (9.3), Uterus (9.2), and Cerebral cortex (8.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for YAP1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for YAP1
SOURCE GeneReport for Unigene cluster for YAP1 Gene:
Hs.503692mRNA Expression by UniProt/SwissProt for YAP1 Gene:
P46937-YAP1_HUMAN
Tissue specificity:
Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).
Evidence on tissue expression from TISSUES for YAP1 Gene
- Liver(4.5)
- Lung(4.5)
- Nervous system(4.4)
- Pancreas(4.3)
- Skin(2.9)
- Muscle(2.3)
- Heart(2.2)
- Thyroid gland(2.2)
- Intestine(2.1)
- Kidney(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for YAP1 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- integumentary
- nervous
- urinary
Regions:
Head and neck:
- brain
- eye
- face
- head
- lip
- mouth
Abdomen:
- kidney
General:
- blood
- red blood cell
- skin
Primer Products
-
OriGene qPCR primer pairs for YAP1
-
OriGene qPCR primer pairs and template standards for YAP1
- genomics-online: primer clones - Search for available YAP1 Primer products
- Overview of 134 available YAP1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for YAP1 Gene
Orthologs for YAP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | YAP1 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| YAP1 30 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | YAP1 31 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | YAP1 31 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Yap1 17 31 30 |
|
||
| dog (Canis familiaris) |
Mammalia | YAP1 31 30 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | YAP1 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | YAP1 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | yap1 30 |
|
||
| Str.16747 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7656 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | yap1 31 30 |
|
OneToOne | |
| Dr.12698 30 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | yki 31 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7043 31 |
|
OneToMany |
- Species where no ortholog for YAP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for YAP1 Gene
- ENSEMBL:
- Gene Tree for YAP1 (if available)
- TreeFam:
- Gene Tree for YAP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for YAP1: view image
Paralogs for YAP1 Gene
(3) SIMAP similar genes for YAP1 Gene using alignment to 3 proteins:
- YAP1_HUMAN
- H0YCI3_HUMAN
- K0KVU2_HUMAN
Pseudogenes.org Pseudogenes for YAP1 Gene
Variants for YAP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for YAP1 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 711380 | Benign: not provided | 102,110,869(+) | G/A | SYNONYMOUS_VARIANT | |
| 717444 | Likely Benign: not provided | 102,209,523(+) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
| 722492 | Likely Benign: not provided | 102,229,779(+) | A/G | MISSENSE_VARIANT | |
| 725467 | Likely Benign: not provided | 102,111,052(+) | C/G | SYNONYMOUS_VARIANT | |
| 726526 | Likely Benign: not provided | 102,111,164(+) | C/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1269n100 | CNV | gain | 25217958 |
| esv2524266 | CNV | deletion | 19546169 |
| esv3580072 | CNV | gain | 25503493 |
| esv3627522 | CNV | loss | 21293372 |
| nsv1043388 | CNV | gain | 25217958 |
| nsv1069618 | CNV | deletion | 25765185 |
| nsv556141 | CNV | gain | 21841781 |
| nsv832251 | CNV | loss | 17160897 |
| nsv972064 | CNV | duplication | 23825009 |
| nsv975221 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.46;
28.52% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for YAP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YAP1 Gene
Disorders for YAP1 Gene
(33) MalaCards diseases for YAP1 Gene - From: LncRNADisease, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation |
|
|
| coloboma of macula |
|
|
| epithelioid hemangioendothelioma |
|
|
| coloboma, ocular, autosomal dominant |
|
|
| gastric cancer |
|
Search YAP1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
YAP1_HUMAN- Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation (COB1) [MIM:120433]: An autosomal dominant disease characterized by uveal colobomata, microphthalmia, cataract and cleft lip/palate. Considerable variability is observed among patients, uveal colobomata being the most constant feature. Some patients manifest mental retardation of varying degree and/or sensorineural, mid-frequency hearing loss. {ECO:0000269 PubMed:24462371}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for YAP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for YAP1 Gene
Publications for YAP1 Gene
- Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. (PMID: 7782338) Sudol M … Lehman D (The Journal of biological chemistry 1995) 2 3 4 23 54
- A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). (PMID: 20048001) Zhao B … Guan KL (Genes & development 2010) 3 4 23 54
- Structural insights into the YAP and TEAD complex. (PMID: 20123905) Li Z … Xu Y (Genes & development 2010) 3 4 23 54
- Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. (PMID: 18280240) Levy D … Shaul Y (Molecular cell 2008) 2 3 4 54
- Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (PMID: 17974916) Zhao B … Guan KL (Genes & development 2007) 3 4 23 54
ExternalLinks
Products for YAP1 Gene
- Custom Antibody ServicesOriGene Antibodies for YAP1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for YAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for YAP1
- Origene Custom Protein Services for YAP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for YAP1
- Browse OriGene Inhibitory RNA Products For YAP1
- OriGene qPCR primer pairs for YAP1
- OriGene qPCR primer pairs and template standards for YAP1
- OriGene CRISPR knockouts for YAP1
- MG226049
- MR212130
- MR212130L3
- MR212130L4
- MR226049
- MR226049L3
- MR226049L4
- RC214393
- RC214393L1
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- RC231269L1
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- RC238320
- RC238394
- RC238419
- RC238545
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- RG214393
- RG225864
- RG230803
- RG231269
- RR205630
- RR205630L1
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- RR205630L3
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- MR212130L3V
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- MR226049L3V
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- RC214393L1V
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- RC214393L4V
- RC225864L1V
- RC225864L2V
- RC225864L3V
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- RC230803L3V
- RC230803L4V
- RC231269L1V
- RC231269L2V
- RC231269L3V
- RC231269L4V
- RR205630L1V
- RR205630L2V
- RR205630L3V
- RR205630L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For YAP1
- Sino Biological Human cDNA Clone for YAP1
- Browse Sino Biological Recombinant Proteins
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- Sino Biological Antibodies for YAP1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for YAP1
- Novus Biologicals proteins and lysates for YAP1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for YAP1
- Abcam proteins for YAP1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for YAP1 (AFLGC-YAP1)
- VectorBuilder Custom and pre-made DNA vectors for YAP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for YAP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for YAP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for YAP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for YAP1
- Addgene plasmids for YAP1
- antibodies-online: Show 58 available YAP1 Antibodies ranked by validation data
- Compare Top YAP1 Antibodies
- Recommended
- 214 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 3 DB Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 94 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 72 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- antibodies-online: Show 26 available YAP1 Elisa Kits ranked by validation data
- Compare Top YAP1 Elisa Kits
- antibodies-online: Show 9 available YAP1 Proteins ranked by validation data
- Compare Top YAP1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for YAP1
- Search Santa Cruz Biotechnology (SCBT) for YAP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for YAP1
- Horizon Cell Lines for YAP1
- genomics-online: cdna clones - Search for available YAP1 CDNA products
- Overview of 134 available YAP1 gene related products
- orf clones - Search for available YAP1 ORF products
- Overview of 134 available YAP1 gene related products
- genomics-online: gRNA clones - Search for available YAP1 gRNA products
- Overview of 134 available YAP1 gene related products
- genomics-online: primer clones - Search for available YAP1 Primer products
- Overview of 134 available YAP1 gene related products
- genomics-online: shRNA clones - Search for available YAP1 shRNA products
- Overview of 134 available YAP1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for YAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for YAP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for YAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for YAP1
Sources for YAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody