External Ids for YAF2 Gene
Previous GeneCards Identifiers for YAF2 Gene
This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016]
GeneCards Summary for YAF2 Gene
YAF2 (YY1 Associated Factor 2) is a Protein Coding gene. Diseases associated with YAF2 include Progressive Myoclonus Epilepsy 1B and Tukel Syndrome. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and transcription corepressor activity. An important paralog of this gene is RYBP.
UniProtKB/Swiss-Prot Summary for YAF2 Gene
Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.