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Aliases for YAE1D1 Gene

Aliases for YAE1D1 Gene

  • Yae1 Domain Containing 1 2 3 5
  • C7orf36 3 4
  • Chromosome 7 Open Reading Frame 36 2
  • Yae1 Domain-Containing Protein 1 3
  • GK003 3

External Ids for YAE1D1 Gene

Previous HGNC Symbols for YAE1D1 Gene

  • C7orf36

Previous GeneCards Identifiers for YAE1D1 Gene

  • GC07P039605

Summaries for YAE1D1 Gene

GeneCards Summary for YAE1D1 Gene

YAE1D1 (Yae1 Domain Containing 1) is a Protein Coding gene.

Additional gene information for YAE1D1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YAE1D1 Gene

Genomics for YAE1D1 Gene

GeneHancer (GH) Regulatory Elements for YAE1D1 Gene

Promoters and enhancers for YAE1D1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I039565 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 86 1.9 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B LOC105375240 YAE1D1 CDK13 MPLKIP RALA LINC00265 GC07M039569
GH07I040132 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 +568.0 568018 2.8 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 IRF4 MPLKIP GC07P040132 SUGCT CDK13 CICP22 ENSG00000228554 ENSG00000259826 LINC00265 LOC100101126 YAE1D1
GH07I039732 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE 11.3 +167.8 167820 3.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT SIN3A FEZF1 IRF4 E2F8 ZNF207 LINC00265 CDK13 CICP22 ENSG00000228554 RALA LOC105375240 YAE1D1 MPLKIP RNU6-719P
GH07I039588 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +23.4 23424 3.3 PKNOX1 SMAD1 ARNT FEZF1 IRF4 ZNF766 ZNF207 FOS JUNB REST RALA LOC105375240 YAE1D1 LINC00265 GC07P039582 GC07P039609
GH07I039607 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 10.9 +43.0 42988 4.5 HDAC1 CTCF JUN ETV1 TAL1 ZBTB40 GATA3 POLR2A RCOR1 EZH2 ENSG00000106540 GC07P039609 LOC646999 ENSG00000231951 LOC105375240 YAE1D1 RALA GC07P039582
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around YAE1D1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for YAE1D1 Gene

Genomic Locations for YAE1D1 Gene
chr7:39,566,376-39,612,089
(GRCh38/hg38)
Size:
45,714 bases
Orientation:
Plus strand
chr7:39,605,975-39,649,919
(GRCh37/hg19)

Genomic View for YAE1D1 Gene

Genes around YAE1D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YAE1D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YAE1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YAE1D1 Gene

Proteins for YAE1D1 Gene

  • Protein details for YAE1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRH1-YAED1_HUMAN
    Recommended name:
    Yae1 domain-containing protein 1
    Protein Accession:
    Q9NRH1
    Secondary Accessions:
    • A4D1W4
    • B4DE83
    • Q6IAF7
    • Q8WVZ5

    Protein attributes for YAE1D1 Gene

    Size:
    226 amino acids
    Molecular mass:
    25299 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for YAE1D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YAE1D1 Gene

Post-translational modifications for YAE1D1 Gene

No Post-translational modifications

Other Protein References for YAE1D1 Gene

No data available for DME Specific Peptides for YAE1D1 Gene

Domains & Families for YAE1D1 Gene

Gene Families for YAE1D1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for YAE1D1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for YAE1D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with YAE1D1: view

No data available for UniProtKB/Swiss-Prot for YAE1D1 Gene

Function for YAE1D1 Gene

Phenotypes for YAE1D1 Gene

GenomeRNAi human phenotypes for YAE1D1:
genes like me logo Genes that share phenotypes with YAE1D1: view

Animal Model Products

miRNA for YAE1D1 Gene

miRTarBase miRNAs that target YAE1D1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YAE1D1 Gene

Localization for YAE1D1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YAE1D1 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for YAE1D1 Gene

Pathways & Interactions for YAE1D1 Gene

SuperPathways for YAE1D1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YAE1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IBA --
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with YAE1D1: view

No data available for Pathways by source and SIGNOR curated interactions for YAE1D1 Gene

Drugs & Compounds for YAE1D1 Gene

No Compound Related Data Available

Transcripts for YAE1D1 Gene

Unigene Clusters for YAE1D1 Gene

Yae1 domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for YAE1D1 Gene

No ASD Table

Relevant External Links for YAE1D1 Gene

GeneLoc Exon Structure for
YAE1D1
ECgene alternative splicing isoforms for
YAE1D1

Expression for YAE1D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YAE1D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YAE1D1 Gene

This gene is overexpressed in Bone (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YAE1D1 Gene



Protein tissue co-expression partners for YAE1D1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of YAE1D1 Gene:

YAE1D1

SOURCE GeneReport for Unigene cluster for YAE1D1 Gene:

Hs.83313

Evidence on tissue expression from TISSUES for YAE1D1 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with YAE1D1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YAE1D1 Gene

Orthologs for YAE1D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for YAE1D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YAE1D1 33
  • 99.56 (n)
C7H7ORF36 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YAE1D1 33 34
  • 89.38 (n)
dog
(Canis familiaris)
Mammalia YAE1D1 33 34
  • 89.23 (n)
mouse
(Mus musculus)
Mammalia Yae1d1 33 16 34
  • 79.48 (n)
Gm6505 34
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia YAE1D1 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YAE1D1 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H7ORF36 33
  • 60.61 (n)
YAE1D1 34
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YAE1D1 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia yae1d1 33
  • 53.27 (n)
zebrafish
(Danio rerio)
Actinopterygii fam105ba 34 33
  • 48.64 (n)
OneToOne
Species where no ortholog for YAE1D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YAE1D1 Gene

ENSEMBL:
Gene Tree for YAE1D1 (if available)
TreeFam:
Gene Tree for YAE1D1 (if available)

Paralogs for YAE1D1 Gene

No data available for Paralogs for YAE1D1 Gene

Variants for YAE1D1 Gene

Sequence variations from dbSNP and Humsavar for YAE1D1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000106247 -- 39,574,600(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000171925 -- 39,571,468(+) G/ intron_variant
rs1000204464 -- 39,571,202(+) C/G intron_variant
rs1000313582 -- 39,577,507(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000356529 -- 39,589,825(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for YAE1D1 Gene

Variant ID Type Subtype PubMed ID
dgv6337n100 CNV gain 25217958

Variation tolerance for YAE1D1 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YAE1D1 Gene

Human Gene Mutation Database (HGMD)
YAE1D1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
YAE1D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YAE1D1 Gene

Disorders for YAE1D1 Gene

Additional Disease Information for YAE1D1

No disorders were found for YAE1D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YAE1D1 Gene

Publications for YAE1D1 Gene

  1. The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion. (PMID: 26182403) Paul VD … Lill R (eLife 2015) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for YAE1D1 Gene

Sources for YAE1D1 Gene

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