Aliases for XRN2 Gene
External Ids for XRN2 Gene
Previous GeneCards Identifiers for XRN2 Gene
This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
GeneCards Summary for XRN2 Gene
XRN2 (5'-3' Exoribonuclease 2) is a Protein Coding gene. Diseases associated with XRN2 include X-Linked Nephrolithiasis Type I and Amyotrophic Lateral Sclerosis 4, Juvenile. Among its related pathways are Deadenylation-dependent mRNA decay and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nuclease activity. An important paralog of this gene is XRN1.
UniProtKB/Swiss-Prot Summary for XRN2 Gene
Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).