XRCC3 Gene (Protein Coding)

X-Ray Repair Cross Complementing 3

GC14M103697
GIFtS:
42
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatell... See more...

Aliases for XRCC3 Gene

Aliases for XRCC3 Gene

  • X-Ray Repair Cross Complementing 3 2 3 5
  • X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 3 2 3
  • X-Ray Repair Cross-Complementing Protein 3 3 4
  • DNA Repair Protein XRCC3 3 4
  • RAD51-Like 2
  • CMM6 3

External Ids for XRCC3 Gene

Previous GeneCards Identifiers for XRCC3 Gene

  • GC14M101555
  • GC14M097979
  • GC14M102153
  • GC14M103233
  • GC14M104163
  • GC14M084342

Summaries for XRCC3 Gene

Entrez Gene Summary for XRCC3 Gene

  • This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for XRCC3 Gene

XRCC3 (X-Ray Repair Cross Complementing 3) is a Protein Coding gene. Diseases associated with XRCC3 include Melanoma, Cutaneous Malignant 6 and Breast Cancer. Among its related pathways are Homologous DNA Pairing and Strand Exchange and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include DNA-dependent ATPase activity and crossover junction endodeoxyribonuclease activity. An important paralog of this gene is RAD51B.

UniProtKB/Swiss-Prot Summary for XRCC3 Gene

  • Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.

Gene Wiki entry for XRCC3 Gene

Additional gene information for XRCC3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for XRCC3 Gene

Genomics for XRCC3 Gene

GeneHancer (GH) Regulatory Elements for XRCC3 Gene

Promoters and enhancers for XRCC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around XRCC3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for XRCC3

Top Transcription factor binding sites by QIAGEN in the XRCC3 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • GR
  • GR-alpha
  • GR-beta
  • p53
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for XRCC3 Gene

Genomic Locations for XRCC3 Gene
chr14:103,697,608-103,715,504
(GRCh38/hg38)
Size:
17,897 bases
Orientation:
Minus strand
chr14:104,163,946-104,181,841
(GRCh37/hg19)
Size:
17,896 bases
Orientation:
Minus strand

Genomic View for XRCC3 Gene

Genes around XRCC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XRCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XRCC3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for XRCC3 Gene

Proteins for XRCC3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for XRCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43542-XRCC3_HUMAN
    Recommended name:
    DNA repair protein XRCC3
    Protein Accession:
    O43542
    Secondary Accessions:
    • O43568
    • Q9BU18

    Protein attributes for XRCC3 Gene

    Size:
    346 amino acids
    Molecular mass:
    37850 Da
    Quaternary structure:
    • Interacts with RAD51C and RAD51. Part of the CX3 complex consisting of RAD51C and XRCC3; the complex has a ring-like structure arranged into a flat disc around a central channel; CX3 can interact with RAD51 in vitro. Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.

neXtProt entry for XRCC3 Gene

Protein Expression for XRCC3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for XRCC3 Gene

  • Ubiquitination at Lys172
  • Modification sites at PhosphoSitePlus

Other Protein References for XRCC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XRCC3 Gene

Domains & Families for XRCC3 Gene

Gene Families for XRCC3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for XRCC3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XRCC3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ42507 fis, clone BRACE2040514, highly similar to DNA-repair protein XRCC3 (Q53XC8_HUMAN)
  • X-ray repair cross-complementing protein 3 (XRCC3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43542

UniProtKB/Swiss-Prot:

XRCC3_HUMAN :
  • Belongs to the RecA family. RAD51 subfamily.
Family:
  • Belongs to the RecA family. RAD51 subfamily.
genes like me logo Genes that share domains with XRCC3: view

Function for XRCC3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for XRCC3 Gene

UniProtKB/Swiss-Prot Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
UniProtKB/Swiss-Prot Induction:
Stress-induced increase in the mitochondrial levels is seen.
GENATLAS Biochemistry:
repair X-ray defect,complementing defect in CHO cells,3,involved in recombinational repair,interacting with RAD51 for maintenance of genomic integrity

Phenotypes From GWAS Catalog for XRCC3 Gene

Gene Ontology (GO) - Molecular Function for XRCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000400 contributes_to four-way junction DNA binding IBA,IDA 20207730
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 9469824
GO:0005524 ATP binding IEA --
GO:0008094 DNA-dependent ATPase activity IEA --
genes like me logo Genes that share ontologies with XRCC3: view
genes like me logo Genes that share phenotypes with XRCC3: view

Human Phenotype Ontology for XRCC3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for XRCC3 Gene

MGI Knock Outs for XRCC3:
  • Xrcc3 Xrcc3<tm1b(KOMP)Mbp>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for XRCC3 Gene

Localization for XRCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XRCC3 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XRCC3 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for XRCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IC 15507207
GO:0005634 nucleus IDA 16215984
GO:0005654 nucleoplasm TAS --
GO:0005657 replication fork IBA,IDA 20207730
GO:0005737 cytoplasm IDA,IEA 16215984
genes like me logo Genes that share ontologies with XRCC3: view

Pathways & Interactions for XRCC3 Gene

genes like me logo Genes that share pathways with XRCC3: view

Gene Ontology (GO) - Biological Process for XRCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000722 telomere maintenance via recombination IBA,IMP 15507207
GO:0000724 double-strand break repair via homologous recombination IMP 23149936
GO:0006281 DNA repair IGI,IEA 10422536
GO:0006310 DNA recombination TAS 9660962
GO:0006974 cellular response to DNA damage stimulus TAS 7603995
genes like me logo Genes that share ontologies with XRCC3: view

No data available for SIGNOR curated interactions for XRCC3 Gene

Drugs & Compounds for XRCC3 Gene

Products:

  1. Drug

(11) Drugs for XRCC3 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 2258
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1353
leucovorin Approved Pharma 3891,1378
Platinum compounds Pharma 0

(4) Additional Compounds for XRCC3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with XRCC3: view

Transcripts for XRCC3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for XRCC3 Gene

6 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for XRCC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - -
SP10: - -
SP11: - - - -
SP12: - - - -
SP13:

Relevant External Links for XRCC3 Gene

GeneLoc Exon Structure for
XRCC3

Expression for XRCC3 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for XRCC3 Gene

mRNA expression in normal human tissues for XRCC3 Gene
mRNA expression by BioGPS for XRCC3 GenemRNA expression by GTEx for XRCC3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for XRCC3 Gene



Protein tissue co-expression partners for XRCC3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for XRCC3

SOURCE GeneReport for Unigene cluster for XRCC3 Gene:

Hs.592325

Evidence on tissue expression from TISSUES for XRCC3 Gene

  • Muscle(4.1)
  • Blood(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with XRCC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for XRCC3 Gene

Orthologs for XRCC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XRCC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia XRCC3 31 30
  • 99.33 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia XRCC3 31 30
  • 82.61 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia XRCC3 31 30
  • 79.09 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia LOC102551085 30
  • 77.52 (n)
mouse
(Mus musculus)
 Mammalia Xrcc3 17 31 30
  • 76.97 (n)
oppossum
(Monodelphis domestica)
 Mammalia XRCC3 31
  • 63 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia XRCC3 31
  • 58 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves XRCC3 31 30
  • 62.34 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia XRCC3 31
  • 52 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia xrcc3 30
  • 58.41 (n)
zebrafish
(Danio rerio)
 Actinopterygii xrcc3 31 30
  • 57.97 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta spn-B 31 30
  • 47.06 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP013180 30
  • 45.18 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes RAD57 31
  • 15 (a)
 OneToOne
thale cress
(Arabidopsis thaliana)
 eudicotyledons XRCC3 30
  • 43.7 (n)
rice
(Oryza sativa)
 Liliopsida Os02g0562100 30
  • 49.44 (n)
bread mold
(Neurospora crassa)
 Ascomycetes NCU01771 30
  • 48.35 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes rhp57 30
  • 38.51 (n)
Species where no ortholog for XRCC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XRCC3 Gene

ENSEMBL:
Gene Tree for XRCC3 (if available)
TreeFam:
Gene Tree for XRCC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for XRCC3: view image

Paralogs for XRCC3 Gene

Paralogs for XRCC3 Gene

genes like me logo Genes that share paralogs with XRCC3: view

Variants for XRCC3 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for XRCC3 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
695535 Benign: not provided 103,699,410(-) C/T MISSENSE_VARIANT,INTRON_VARIANT
695578 Benign: not provided 103,703,179(-) G/A SYNONYMOUS_VARIANT
8945 Risk Factor: Breast cancer, susceptibility to 103,699,590(-) T/C INTRON_VARIANT
rs861539 Risk Factor: Cutaneous malignant melanoma 6. Melanoma, cutaneous malignant 6 (CMM6) [MIM:613972] 103,699,416(-) G/Ap.Thr241Met MISSENSE_VARIANT,INTRON_VARIANT
rs28903080 - p.Gly271Arg

Additional dbSNP identifiers (rs#s) for XRCC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for XRCC3 Gene

Variant ID Type Subtype PubMed ID
esv2749175 CNV deletion 23290073
esv2760013 CNV loss 17122850
esv3635603 CNV gain 21293372
nsv1054574 CNV loss 25217958
nsv470673 CNV loss 18288195
nsv527425 CNV loss 19592680
nsv566023 CNV loss 21841781
nsv827071 CNV gain 20364138
nsv9171 CNV gain 18304495
nsv952260 CNV deletion 24416366

Variation tolerance for XRCC3 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.18; 75.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XRCC3 Gene

Human Gene Mutation Database (HGMD)
XRCC3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
XRCC3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XRCC3 Gene

Disorders for XRCC3 Gene

MalaCards: The human disease database

(17) MalaCards diseases for XRCC3 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma, cutaneous malignant 6
  • melanoma, cutaneous malignant, susceptibility to, 6
breast cancer
  • breast cancer, familial
cardiomyopathy, familial hypertrophic, 15
  • cmh15
xeroderma pigmentosum, variant type
  • xpv
xeroderma pigmentosum, complementation group d
  • xpd
- elite association - COSMIC cancer census association via MalaCards
Search XRCC3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

XRCC3_HUMAN
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. {ECO:0000269 PubMed:12023982}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Melanoma, cutaneous malignant 6 (CMM6) [MIM:613972]: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. {ECO:0000269 PubMed:11059748}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for XRCC3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with XRCC3: view

No data available for Genatlas for XRCC3 Gene

Publications for XRCC3 Gene

  1. Variants in DNA double-strand break repair genes and breast cancer susceptibility. (PMID: 12023982) Kuschel B … Dunning A (Human molecular genetics 2002) 3 4 23 41 54
  2. A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk. (PMID: 19915856) Jiang Z … Cai S (International journal of colorectal disease 2010) 3 23 41 54
  3. Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1). (PMID: 19414392) Narter KF … Isbir T (Anticancer research 2009) 3 23 41 54
  4. Chromosomal aberrations in railroad transit workers: effect of genetic polymorphisms. (PMID: 19177501) Catalán J … Norppa H (Environmental and molecular mutagenesis 2009) 3 23 41 54
  5. Do DNA repair genes OGG1, XRCC3 and XRCC7 have an impact on susceptibility to bladder cancer in the North Indian population? (PMID: 19815090) Gangwar R … Mittal RD (Mutation research 2009) 3 23 41 54

ExternalLinks

View latest publications for XRCC3 gene in Mastermind

Products for XRCC3 Gene