Aliases for XRCC2 Gene
External Ids for XRCC2 Gene
Previous GeneCards Identifiers for XRCC2 Gene
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]
GeneCards Summary for XRCC2 Gene
XRCC2 (X-Ray Repair Cross Complementing 2) is a Protein Coding gene. Diseases associated with XRCC2 include Fanconi Anemia, Complementation Group U and Hereditary Breast Ovarian Cancer Syndrome. Among its related pathways are Homologous DNA Pairing and Strand Exchange and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include DNA-dependent ATPase activity and four-way junction DNA binding. An important paralog of this gene is RAD51C.
UniProtKB/Swiss-Prot Summary for XRCC2 Gene
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.