Aliases for XRCC1 Gene
External Ids for XRCC1 Gene
Previous HGNC Symbols for XRCC1 Gene
Previous GeneCards Identifiers for XRCC1 Gene
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
GeneCards Summary for XRCC1 Gene
XRCC1 (X-Ray Repair Cross Complementing 1) is a Protein Coding gene. Diseases associated with XRCC1 include Spinocerebellar Ataxia, Autosomal Recessive 26 and Gastric Cardia Carcinoma. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include enzyme binding and damaged DNA binding. An important paralog of this gene is ENSG00000268361.
UniProtKB/Swiss-Prot Summary for XRCC1 Gene
Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.