Aliases for XPR1 Gene
External Ids for XPR1 Gene
Previous GeneCards Identifiers for XPR1 Gene
The protein encoded by this gene is a receptor for the xenotropic and polytropic classes of murine leukemia viruses. The encoded protein is involved in phosphate homeostasis by mediating phosphate export from the cell. Defects in this gene have been associated with idiopathic basal ganglia calcification-6. [provided by RefSeq, Jun 2016]
GeneCards Summary for XPR1 Gene
XPR1 (Xenotropic And Polytropic Retrovirus Receptor 1) is a Protein Coding gene. Diseases associated with XPR1 include Basal Ganglia Calcification, Idiopathic, 6 and Primary Familial Brain Calcification. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity.
UniProtKB/Swiss-Prot Summary for XPR1 Gene
Plays a role in phosphate homeostasis. Mediates phosphate export from the cell (PubMed:23791524, PubMed:25938945). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106).