Aliases for XPOT Gene
External Ids for XPOT Gene
Previous GeneCards Identifiers for XPOT Gene
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]
GeneCards Summary for XPOT Gene
XPOT (Exportin For TRNA) is a Protein Coding gene. Diseases associated with XPOT include 12Q14 Microdeletion Syndrome and Glaucoma, Normal Tension. Among its related pathways are tRNA processing and RNA transport. Gene Ontology (GO) annotations related to this gene include binding and Ran GTPase binding.
UniProtKB/Swiss-Prot Summary for XPOT Gene
Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.