This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008] See more...

Aliases for XPOT Gene

Aliases for XPOT Gene

  • Exportin For TRNA 2 3 5
  • Exportin, TRNA (Nuclear Export Receptor For TRNAs) 2 3
  • Exportin(TRNA) 3 4
  • TRNA Exportin 3 4
  • Exportin-T 3 4
  • Exportin, TRNA 2
  • XPO3 3

External Ids for XPOT Gene

Previous GeneCards Identifiers for XPOT Gene

  • GC12U990131
  • GC07P055820
  • GC12P064514
  • GC12P063090
  • GC12P063084
  • GC12P064798
  • GC12P061850

Summaries for XPOT Gene

Entrez Gene Summary for XPOT Gene

  • This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]

GeneCards Summary for XPOT Gene

XPOT (Exportin For TRNA) is a Protein Coding gene. Diseases associated with XPOT include 12Q14 Microdeletion Syndrome and Osteopoikilosis. Among its related pathways are tRNA processing and Gene Expression. Gene Ontology (GO) annotations related to this gene include binding and Ran GTPase binding.

UniProtKB/Swiss-Prot Summary for XPOT Gene

  • Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Wiki entry for XPOT Gene

Additional gene information for XPOT Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for XPOT Gene

Genomics for XPOT Gene

GeneHancer (GH) Regulatory Elements for XPOT Gene

Promoters and enhancers for XPOT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J064403 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 500.7 +0.5 491 3.1 RXRA ZBTB40 ZNF217 EP300 NRF1 TCF12 MYC USF1 POLR2G SP1 XPOT LEMD3 TBK1 SRGAP1 PABPC1P4 ENSG00000255566 C12orf56 LOC100420899
GH12J064450 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 +48.1 48051 4 ZNF217 SIN3A TCF12 NRF1 POLR2G USF1 PHF8 FOS ZFX POLR2A TBK1 ENSG00000277895 XPOT ENSG00000243024
GH12J063821 Promoter/Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 9.8 -581.9 -581915 2.1 POLR2A FOXA2 RAD21 TEAD3 ZNF202 RBM39 YY1 PABPC1P4 MIR10527-001 RXYLT1-AS1 ENSG00000243024 XPOT RNU6-1009P
GH12J063419 Enhancer 0.9 Ensembl 12.1 -985.0 -984994 0.6 ZNF217 RBAK ZNF639 ZNF10 KLF7 CUX1 ATF2 GATAD2B CTBP1 ZNF148 MON2 ENSG00000257354 PABPC1P4 SRGAP1 XPOT ENSG00000258117 piR-32023-060
GH12J064458 Promoter/Enhancer 0.9 Ensembl ENCODE 10.3 +55.1 55101 1.7 SIN3A IRF1 ZNF592 CHD1 NBN IRF2 ELF1 CHD2 MXI1 MTA2 XPOT ENSG00000243024 RASSF3 ENSG00000256670 TBK1 ENSG00000277895 L13715-008
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around XPOT on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for XPOT

Top Transcription factor binding sites by QIAGEN in the XPOT gene promoter:
  • ATF6
  • CUTL1
  • E47
  • Hlf
  • MyoD
  • N-Myc
  • Pax-2
  • Pax-2a
  • Pbx1a
  • Sox5

Genomic Locations for XPOT Gene

Genomic Locations for XPOT Gene
chr12:64,404,350-64,451,125
(GRCh38/hg38)
Size:
46,776 bases
Orientation:
Plus strand
chr12:64,798,130-64,844,907
(GRCh37/hg19)
Size:
46,778 bases
Orientation:
Plus strand

Genomic View for XPOT Gene

Genes around XPOT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPOT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPOT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPOT Gene

Proteins for XPOT Gene

  • Protein details for XPOT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43592-XPOT_HUMAN
    Recommended name:
    Exportin-T
    Protein Accession:
    O43592
    Secondary Accessions:
    • A6NLH1
    • O43784
    • Q8WUG2
    • Q9BVS7

    Protein attributes for XPOT Gene

    Size:
    962 amino acids
    Molecular mass:
    109964 Da
    Quaternary structure:
    • Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins. Interacts with Ran and tRNA in a GTP-dependent manner.

neXtProt entry for XPOT Gene

Post-translational modifications for XPOT Gene

  • Ubiquitination at Lys557 and Lys634
  • Modification sites at PhosphoSitePlus

Other Protein References for XPOT Gene

No data available for DME Specific Peptides for XPOT Gene

Domains & Families for XPOT Gene

Gene Families for XPOT Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for XPOT Gene

Blocks:
  • Exportin 1-like
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XPOT Gene

GenScript: Design optimal peptide antigens:
  • tRNA exportin (XPOT_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43592

UniProtKB/Swiss-Prot:

XPOT_HUMAN :
  • Belongs to the exportin family.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPOT: view

Function for XPOT Gene

Molecular function for XPOT Gene

UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
GENATLAS Biochemistry:
exportin (tRNA),RanGTP-binding,importin beta-related factor with predominantly nuclear localization,specific mediator of tRNA export,shuttling between nucleus and cytoplasm and interacting with nuclear pore complexes (NPC)

Gene Ontology (GO) - Molecular Function for XPOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 9660920
GO:0003723 RNA binding IEA --
GO:0008536 Ran GTPase binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with XPOT: view
genes like me logo Genes that share phenotypes with XPOT: view

Animal Models for XPOT Gene

MGI Knock Outs for XPOT:
  • Xpot Xpot<tm3b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for XPOT Gene

miRTarBase miRNAs that target XPOT

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPOT

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XPOT Gene

Localization for XPOT Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPOT Gene

Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XPOT gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for XPOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 colocalizes_with nuclear pore IDA,IBA 9660920
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm IDA,IEA 9660920
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with XPOT: view

Pathways & Interactions for XPOT Gene

PathCards logo

SuperPathways for XPOT Gene

genes like me logo Genes that share pathways with XPOT: view

Pathways by source for XPOT Gene

1 KEGG pathway for XPOT Gene
1 Qiagen pathway for XPOT Gene
  • Ran Pathway

Gene Ontology (GO) - Biological Process for XPOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006409 tRNA export from nucleus IEA,TAS --
GO:0006886 intracellular protein transport IEA --
GO:0071528 tRNA re-export from nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with XPOT: view

No data available for SIGNOR curated interactions for XPOT Gene

Drugs & Compounds for XPOT Gene

(2) Drugs for XPOT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for XPOT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with XPOT: view

Transcripts for XPOT Gene

mRNA/cDNA for XPOT Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPOT

Alternative Splicing Database (ASD) splice patterns (SP) for XPOT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^
SP1: - -
SP2:
SP3: - -
SP4: - - -
SP5: - -
SP6: -
SP7:
SP8:
SP9: -

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for XPOT Gene

GeneLoc Exon Structure for
XPOT

Expression for XPOT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for XPOT Gene

Protein differential expression in normal tissues from HIPED for XPOT Gene

This gene is overexpressed in Bone (57.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for XPOT Gene



Protein tissue co-expression partners for XPOT Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for XPOT

SOURCE GeneReport for Unigene cluster for XPOT Gene:

Hs.85951

Evidence on tissue expression from TISSUES for XPOT Gene

  • Nervous system(3)
  • Eye(2)
genes like me logo Genes that share expression patterns with XPOT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for XPOT Gene

Orthologs for XPOT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPOT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPOT 31 30
  • 99.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia XPOT 31 30
  • 95.11 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XPOT 31
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia XPOT 31 30
  • 94.28 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XPOT 31
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xpot 17 31 30
  • 87.01 (n)
chicken
(Gallus gallus)
Aves XPOT 31 30
  • 83.44 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XPOT 31
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xpot 30
  • 78.76 (n)
Str.5914 30
zebrafish
(Danio rerio)
Actinopterygii xpot 31 30
  • 70.24 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13873 30
worm
(Caenorhabditis elegans)
Secernentea xpo-3 31 30
  • 43.33 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B14036g 30
  • 43.39 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LOS1 33 31 30
  • 41.82 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR424C 30
  • 40.36 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PSD 30
  • 43.15 (n)
rice
(Oryza sativa)
Liliopsida Os07g0613300 30
  • 42.5 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes los1 30
  • 44.19 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11169 30
  • 41.52 (n)
Species where no ortholog for XPOT was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XPOT Gene

ENSEMBL:
Gene Tree for XPOT (if available)
TreeFam:
Gene Tree for XPOT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for XPOT: view image

Paralogs for XPOT Gene

Pseudogenes.org Pseudogenes for XPOT Gene

genes like me logo Genes that share paralogs with XPOT: view

No data available for Paralogs for XPOT Gene

Variants for XPOT Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for XPOT Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs1051396 - p.Glu716Asp
rs17851795 - p.Ala526Val

Additional dbSNP identifiers (rs#s) for XPOT Gene

Structural Variations from Database of Genomic Variants (DGV) for XPOT Gene

Variant ID Type Subtype PubMed ID
esv2745988 CNV deletion 23290073
esv3629773 CNV loss 21293372
nsv472434 CNV novel sequence insertion 20440878

Variation tolerance for XPOT Gene

Residual Variation Intolerance Score: 7.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XPOT Gene

Human Gene Mutation Database (HGMD)
XPOT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
XPOT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPOT Gene

Disorders for XPOT Gene

MalaCards: The human disease database

(3) MalaCards diseases for XPOT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
12q14 microdeletion syndrome
  • del(12)(q14)
osteopoikilosis
  • osteopathia condensans disseminata
glaucoma, normal tension
  • glaucoma, normal tension, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search XPOT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for XPOT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with XPOT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XPOT Gene

Publications for XPOT Gene

No publications were found for XPOT Gene.

Products for XPOT Gene

Sources for XPOT Gene