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XPO7 Gene(Protein Coding)

Exportin 7

GCID:
GC08P021833
GIFtS:
45
Genes Participants
UDN Logo

Aliases for XPO7 Gene

Aliases for XPO7 Gene

  • Exportin 7 2 3 5
  • RAN Binding Protein 16 2 3
  • RANBP16 3 4
  • EXP7 3 4
  • Ran-Binding Protein 16 4
  • Exportin-7 3
  • KIAA0745 4

External Ids for XPO7 Gene

Previous HGNC Symbols for XPO7 Gene

  • RANBP16

Previous GeneCards Identifiers for XPO7 Gene

  • GC08P022130
  • GC08P021597
  • GC08P021799
  • GC08P020319
  • GC08P021779

Summaries for XPO7 Gene

Entrez Gene Summary for XPO7 Gene

  • The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]

GeneCards Summary for XPO7 Gene

XPO7 (Exportin 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and nuclear export signal receptor activity. An important paralog of this gene is RANBP17.

UniProtKB/Swiss-Prot for XPO7 Gene

  • Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Additional gene information for XPO7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPO7 Gene

Genomics for XPO7 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for XPO7 Gene

Promoters and enhancers for XPO7 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08I021917 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 550.8 +0.4 446 4.3 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A YY1 ZNF766 ZNF207 XPO7 ENSG00000253200 BIN3 FGF17 FAM160B2 NPM2 C8orf58 POLR3D GFRA2 DMTN
GH08I022692 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 30.3 +774.9 774914 3.6 HDGF ARID4B SIN3A YBX1 ZNF2 ZBTB7B POLR2B ZNF213 E2F8 ZNF416 EGR3 LOC105379321 LOC105379322 FAM160B2 ENSG00000253200 BMP1 LOC107986927 LOXL2 XPO7 C8orf58
GH08I022439 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 +525.0 524996 10.2 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A ZNF2 IRF4 YY1 PPP3CC ENSG00000253200 CCAR2 C8orf58 SORBS3 ENSG00000251034 FAM160B2 POLR3D BIN3 XPO7
GH08I022558 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.3 +643.5 643527 8.9 HDGF FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 ZNF213 SORBS3 CCAR2 ENSG00000253200 XPO7 C8orf58 BIN3 PDLIM2 ENSG00000254230 GC08M022549
GH08I022700 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.4 +783.6 783604 6 HDGF PKNOX1 SMAD1 ARID4B YBX1 IRF4 ZNF48 YY1 ZNF207 ZNF143 XPO7 BIN3 CCAR2 ENSG00000253200 NPM2 TNFRSF10C PDLIM2 TNFRSF10B PPP3CC EGR3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around XPO7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the XPO7 gene promoter:

Genomic Locations for XPO7 Gene

Genomic Locations for XPO7 Gene
chr8:21,919,669-22,006,585
(GRCh38/hg38)
Size:
86,917 bases
Orientation:
Plus strand
chr8:21,777,180-21,864,096
(GRCh37/hg19)

Genomic View for XPO7 Gene

Genes around XPO7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPO7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPO7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for XPO7 Gene

Proteins for XPO7 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for XPO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIA9-XPO7_HUMAN
    Recommended name:
    Exportin-7
    Protein Accession:
    Q9UIA9
    Secondary Accessions:
    • O94846
    • Q6PJK9
    • Q8NEK7

    Protein attributes for XPO7 Gene

    Size:
    1087 amino acids
    Molecular mass:
    123907 Da
    Quaternary structure:
    • Binds to nucleoporins. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ARHGAP1 and SFN. Interacts with Ran and cargo proteins in a GTP-dependent manner.
    SequenceCaution:
    • Sequence=BAA34465.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for XPO7 Gene

Protein Expression for XPO7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for XPO7 Gene

Other Protein References for XPO7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XPO7 Gene

Domains & Families for XPO7 Gene

Gene Families for XPO7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for XPO7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for XPO7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIA9

UniProtKB/Swiss-Prot:

XPO7_HUMAN :
  • Belongs to the exportin family.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPO7: view

Function for XPO7 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for XPO7 Gene

UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Phenotypes From GWAS Catalog for XPO7 Gene

Gene Ontology (GO) - Molecular Function for XPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005049 nuclear export signal receptor activity IDA 11024021
GO:0005515 protein binding IPI 25416956
GO:0008536 Ran GTPase binding IEA,IBA --
genes like me logo Genes that share ontologies with XPO7: view
genes like me logo Genes that share phenotypes with XPO7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XPO7 Gene

Localization for XPO7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO7 Gene

Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XPO7 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for XPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 11071879
GO:0005643 nuclear pore IDA,IEA 11024021
GO:0005737 cytoplasm IEA,IDA 11071879
genes like me logo Genes that share ontologies with XPO7: view

Pathways & Interactions for XPO7 Gene

SuperPathways for XPO7 Gene

PathCards logo More details on SuperPathways for XPO7
No Data Available

Gene Ontology (GO) - Biological Process for XPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus IDA 11024021
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with XPO7: view

No data available for Pathways by source and SIGNOR curated interactions for XPO7 Gene

Drugs & Compounds for XPO7 Gene

Products:

  1. Drug

(1) Drugs for XPO7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with XPO7: view

Transcripts for XPO7 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for XPO7 Gene

(7) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(405) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XPO7 Gene

Exportin 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for XPO7 Gene

No ASD Table

Relevant External Links for XPO7 Gene

GeneLoc Exon Structure for
XPO7
ECgene alternative splicing isoforms for
XPO7

Expression for XPO7 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XPO7 Gene

mRNA expression in normal human tissues for XPO7 Gene
mRNA expression by GTEx for XPO7 GenemRNA expression by BioGPS for XPO7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for XPO7 Gene

This gene is overexpressed in Bone (44.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for XPO7 Gene



Protein tissue co-expression partners for XPO7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XPO7 Gene:

XPO7

SOURCE GeneReport for Unigene cluster for XPO7 Gene:

Hs.172685

mRNA Expression by UniProt/SwissProt for XPO7 Gene:

Q9UIA9-XPO7_HUMAN
Tissue specificity: Strong expression in testis, thyroid and bone marrow, low expression in lung, liver and small intestine, no expression in thymus, and remaining tissues studied have moderate expression. Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.

Evidence on tissue expression from TISSUES for XPO7 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Lung(4.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with XPO7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for XPO7 Gene

Orthologs for XPO7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPO7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia XPO7 33 34
  • 99.82 (n)
oppossum
(Monodelphis domestica)
 Mammalia XPO7 34
  • 99 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia XPO7 33 34
  • 95.01 (n)
cow
(Bos Taurus)
 Mammalia XPO7 33 34
  • 93.56 (n)
rat
(Rattus norvegicus)
 Mammalia Xpo7 33
  • 92.12 (n)
mouse
(Mus musculus)
 Mammalia Xpo7 33 16 34
  • 91.78 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia XPO7 34
  • 85 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves XPO7 33 34
  • 84.76 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia xpo7 33
  • 77.37 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.2294 33
zebrafish
(Danio rerio)
 Actinopterygii xpo7 33 34
  • 80.13 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP004535 33
  • 60.46 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Ranbp16 33 34
  • 58.91 (n)
worm
(Caenorhabditis elegans)
 Secernentea C35A5.8 33 34
  • 49.16 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT5G06120 33
  • 51.84 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 58 (a)
 OneToMany
Species where no ortholog for XPO7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XPO7 Gene

ENSEMBL:
Gene Tree for XPO7 (if available)
TreeFam:
Gene Tree for XPO7 (if available)

Paralogs for XPO7 Gene

Paralogs for XPO7 Gene

(2) SIMAP similar genes for XPO7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with XPO7: view

Variants for XPO7 Gene

Sequence variations from dbSNP and Humsavar for XPO7 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000007426 -- 21,919,730(+) G/A/C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant
rs1000049065 -- 21,955,769(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000059439 -- 21,988,954(+) C/G/T intron_variant
rs1000143429 -- 22,002,518(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000235806 -- 21,918,374(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for XPO7 Gene

Variant ID Type Subtype PubMed ID
nsv8319 CNV gain 18304495
nsv1032771 CNV loss 25217958
nsv1023009 CNV gain 25217958
nsv1019785 CNV gain+loss 25217958
esv3383227 CNV duplication 20981092
esv2759604 CNV loss 17122850
esv2736744 CNV deletion 23290073
dgv7135n100 CNV loss 25217958
dgv7134n100 CNV gain 25217958
dgv7133n100 CNV gain 25217958
dgv7132n100 CNV gain 25217958
dgv7131n100 CNV gain 25217958

Variation tolerance for XPO7 Gene

Residual Variation Intolerance Score: 2.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XPO7 Gene

Human Gene Mutation Database (HGMD)
XPO7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
XPO7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO7 Gene

Disorders for XPO7 Gene

Additional Disease Information for XPO7

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for XPO7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XPO7 Gene

Publications for XPO7 Gene

  1. Exportin 7 defines a novel general nuclear export pathway. (PMID: 15282546) Mingot JM … Görlich D (The EMBO journal 2004) 3 4 22 58
  2. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. (PMID: 11024021) Kutay U … Bischoff FR (The Journal of biological chemistry 2000) 2 3 4 58
  3. Identification of a novel putative Ran-binding protein and its close homologue. (PMID: 11071879) Koch P … Janssen JW (Biochemical and biophysical research communications 2000) 3 4 22 58
  4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  5. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y … Kamatani N (Nature genetics 2010) 3 44 58

Products for XPO7 Gene

Sources for XPO7 Gene

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