Aliases for XPO7 Gene
External Ids for XPO7 Gene
Previous HGNC Symbols for XPO7 Gene
Previous GeneCards Identifiers for XPO7 Gene
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
GeneCards Summary for XPO7 Gene
XPO7 (Exportin 7) is a Protein Coding gene. Diseases associated with XPO7 include Hemolytic Anemia and Arts Syndrome. Gene Ontology (GO) annotations related to this gene include binding and nuclear export signal receptor activity. An important paralog of this gene is RANBP17.
UniProtKB/Swiss-Prot Summary for XPO7 Gene
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.