Free for academic non-profit institutions. Other users need a Commercial license

Aliases for XPO6 Gene

Aliases for XPO6 Gene

  • Exportin 6 2 3 5
  • Ran-Binding Protein 20 3 4
  • RANBP20 3 4
  • EXP6 3 4
  • RAN Binding Protein 20 2
  • Exportin-6 3
  • KIAA0370 4

External Ids for XPO6 Gene

Previous HGNC Symbols for XPO6 Gene

  • RANBP20

Previous GeneCards Identifiers for XPO6 Gene

  • GC16M028207
  • GC16M028031
  • GC16M028075
  • GC16M028016
  • GC16M026200

Summaries for XPO6 Gene

Entrez Gene Summary for XPO6 Gene

  • The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GeneCards Summary for XPO6 Gene

XPO6 (Exportin 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and Ran GTPase binding.

UniProtKB/Swiss-Prot for XPO6 Gene

  • Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.

Gene Wiki entry for XPO6 Gene

Additional gene information for XPO6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPO6 Gene

Genomics for XPO6 Gene

GeneHancer (GH) Regulatory Elements for XPO6 Gene

Promoters and enhancers for XPO6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I028209 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 559.9 +0.4 358 3.5 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 XPO6 SH2B1 ENSG00000261766 RPS15AP33 NPIPB9 ENSG00000260853 SPNS1 NFATC2IP ENSG00000260367 RNY1P10
GH16I028185 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 559.5 +23.9 23868 5 HDGF PKNOX1 ZBTB6 INSM2 BACH1 EBF1 BATF IRF4 NCOA2 RELA XPO6 RNY1P10 GC16M028181
GH16I028138 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 71.4 +70.7 70680 5.6 HDGF PKNOX1 ATF1 SMAD1 BMI1 IRF4 RAD21 ZBTB40 YY1 ZNF121 XPO6 APOBR ATXN2L NFATC2IP SPNS1 ENSG00000260853 ENSG00000260367 ENSG00000200652 RNY1P10 SGF29
GH16I028165 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 57.6 +45.4 45390 2.3 CTCF RFX1 INSM2 JUNB EBF1 BATF JUND PRDM10 ZNF600 FOS XPO6 APOBR SULT1A1 GC16P028181 TPRKBP2
GH16I028157 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 44.5 +53.7 53659 1.8 ZNF362 ZFP64 ZNF223 MAX ZNF184 SCRT2 ZBTB33 ZNF600 ZBTB17 ZBTB20 XPO6 APOBR SULT1A1 GC16P028181 TPRKBP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around XPO6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the XPO6 gene promoter:

Genomic Locations for XPO6 Gene

Genomic Locations for XPO6 Gene
chr16:28,097,976-28,211,960
(GRCh38/hg38)
Size:
113,985 bases
Orientation:
Minus strand
chr16:28,109,300-28,223,241
(GRCh37/hg19)

Genomic View for XPO6 Gene

Genes around XPO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO6 Gene

Proteins for XPO6 Gene

  • Protein details for XPO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QU8-XPO6_HUMAN
    Recommended name:
    Exportin-6
    Protein Accession:
    Q96QU8
    Secondary Accessions:
    • A1L3W4
    • D3DWF9
    • Q2YDX3
    • Q53G88
    • Q68G50
    • Q76N88
    • Q96CP8
    • Q9BT21

    Protein attributes for XPO6 Gene

    Size:
    1125 amino acids
    Molecular mass:
    128883 Da
    Quaternary structure:
    • Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner.
    SequenceCaution:
    • Sequence=BAA20825.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for XPO6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XPO6 Gene

Post-translational modifications for XPO6 Gene

No data available for DME Specific Peptides for XPO6 Gene

Domains & Families for XPO6 Gene

Gene Families for XPO6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for XPO6 Gene

Suggested Antigen Peptide Sequences for XPO6 Gene

Graphical View of Domain Structure for InterPro Entry

Q96QU8

UniProtKB/Swiss-Prot:

XPO6_HUMAN :
  • Belongs to the exportin family.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPO6: view

Function for XPO6 Gene

Molecular function for XPO6 Gene

UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.

Gene Ontology (GO) - Molecular Function for XPO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14592989
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity IDA 14592989
genes like me logo Genes that share ontologies with XPO6: view
genes like me logo Genes that share phenotypes with XPO6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XPO6 Gene

Localization for XPO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO6 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XPO6 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for XPO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IC 14592989
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with XPO6: view

Pathways & Interactions for XPO6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for XPO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus IDA 14592989
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with XPO6: view

No data available for Pathways by source and SIGNOR curated interactions for XPO6 Gene

Drugs & Compounds for XPO6 Gene

No Compound Related Data Available

Transcripts for XPO6 Gene

Unigene Clusters for XPO6 Gene

Exportin 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for XPO6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11: -
SP12:
SP13:

ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28a · 28b · 28c · 28d · 28e
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:

Relevant External Links for XPO6 Gene

GeneLoc Exon Structure for
XPO6
ECgene alternative splicing isoforms for
XPO6

Expression for XPO6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XPO6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XPO6 Gene

This gene is overexpressed in Whole Blood (x20.7).

Protein differential expression in normal tissues from HIPED for XPO6 Gene

This gene is overexpressed in Bone (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for XPO6 Gene



NURSA nuclear receptor signaling pathways regulating expression of XPO6 Gene:

XPO6

SOURCE GeneReport for Unigene cluster for XPO6 Gene:

Hs.460468

Evidence on tissue expression from TISSUES for XPO6 Gene

  • Nervous system(4.9)
  • Skin(4.4)
  • Thyroid gland(4.3)
  • Lung(3)
genes like me logo Genes that share expression patterns with XPO6: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for XPO6 Gene

Orthologs for XPO6 Gene

This gene was present in the common ancestor of animals.

Orthologs for XPO6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPO6 33 34
  • 99.7 (n)
oppossum
(Monodelphis domestica)
Mammalia XPO6 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPO6 33 34
  • 94.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 94 (a)
OneToMany
-- 34
  • 93 (a)
OneToMany
-- 34
  • 92 (a)
OneToMany
-- 34
  • 88 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
cow
(Bos Taurus)
Mammalia XPO6 34 33
  • 93.36 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Xpo6 33 16 34
  • 91.01 (n)
rat
(Rattus norvegicus)
Mammalia Xpo6 33
  • 90.93 (n)
chicken
(Gallus gallus)
Aves XPO6 33 34
  • 84 (n)
lizard
(Anolis carolinensis)
Reptilia XPO6 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491765 33
  • 73.73 (n)
Str.7195 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7298 33
zebrafish
(Danio rerio)
Actinopterygii xpo6 33 34
  • 69.41 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5198 33
fruit fly
(Drosophila melanogaster)
Insecta Exp6 34
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13929 33
Species where no ortholog for XPO6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XPO6 Gene

ENSEMBL:
Gene Tree for XPO6 (if available)
TreeFam:
Gene Tree for XPO6 (if available)

Paralogs for XPO6 Gene

Pseudogenes.org Pseudogenes for XPO6 Gene

genes like me logo Genes that share paralogs with XPO6: view

No data available for Paralogs for XPO6 Gene

Variants for XPO6 Gene

Sequence variations from dbSNP and Humsavar for XPO6 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000020262 -- 28,136,887(-) A/G intron_variant
rs1000045684 -- 28,103,281(-) ATGCATGTGAAACTCAT/AT genic_downstream_transcript_variant, intron_variant
rs1000054161 -- 28,181,253(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000057066 -- 28,151,423(-) C/T intron_variant
rs1000124293 -- 28,161,293(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for XPO6 Gene

Variant ID Type Subtype PubMed ID
nsv9410 CNV gain 18304495
nsv9409 CNV gain 18304495
nsv9408 CNV gain 18304495
nsv525423 CNV gain 19592680
nsv507812 OTHER sequence alteration 20534489
nsv469663 CNV loss 16826518
nsv1136212 CNV deletion 24896259
nsv1070342 CNV deletion 25765185
nsv1060105 CNV gain 25217958
nsv103104 CNV deletion 16902084
esv3638331 CNV loss 21293372
esv2758640 CNV gain+loss 17122850
esv2656622 CNV deletion 23128226

Variation tolerance for XPO6 Gene

Residual Variation Intolerance Score: 7.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XPO6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
XPO6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO6 Gene

Disorders for XPO6 Gene

Additional Disease Information for XPO6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for XPO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XPO6 Gene

Publications for XPO6 Gene

  1. Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes. (PMID: 14592989) Stüven T … Görlich D (The EMBO journal 2003) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Differentiation-associated alteration in gene expression of importins and exportins in human leukemia HL-60 cells. (PMID: 18614847) Suzuki T … Isemura M (Biomedical research (Tokyo, Japan) 2008) 3 22 58
  4. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. (PMID: 18676839) Ambs S … Croce CM (Cancer research 2008) 3 22 58
  5. DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. (PMID: 16847355) Suzuki T … Isemura M (Biomedical research (Tokyo, Japan) 2006) 3 22 58

Products for XPO6 Gene

Sources for XPO6 Gene

Content
Loading form....