The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multip... See more...

Aliases for XPO6 Gene

Aliases for XPO6 Gene

  • Exportin 6 2 3 5
  • Ran-Binding Protein 20 3 4
  • Exportin-6 3 4
  • RANBP20 3 4
  • RAN Binding Protein 20 2
  • KIAA0370 4
  • EXP6 3
  • Exp6 4

External Ids for XPO6 Gene

Previous HGNC Symbols for XPO6 Gene

  • RANBP20

Previous GeneCards Identifiers for XPO6 Gene

  • GC16M028207
  • GC16M028031
  • GC16M028075
  • GC16M028016
  • GC16M026200
  • GC16M028109

Summaries for XPO6 Gene

Entrez Gene Summary for XPO6 Gene

  • The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GeneCards Summary for XPO6 Gene

XPO6 (Exportin 6) is a Protein Coding gene. Diseases associated with XPO6 include Arts Syndrome. Gene Ontology (GO) annotations related to this gene include binding and Ran GTPase binding.

UniProtKB/Swiss-Prot Summary for XPO6 Gene

  • Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.

Gene Wiki entry for XPO6 Gene

Additional gene information for XPO6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for XPO6 Gene

Genomics for XPO6 Gene

GeneHancer (GH) Regulatory Elements for XPO6 Gene

Promoters and enhancers for XPO6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J028210 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 509.8 +0.7 678 4.2 HNRNPK FOXK2 ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A MYC NRF1 POLR2G XPO6 piR-35674-184 SH2B1 ENSG00000261766 ENSG00000240634 NPIPB9 SPNS1 ENSG00000260853 RRN3P2 RNY1P10
GH16J028425 Promoter 0.3 EPDnew 500.1 -214.5 -214476 0.1 piR-55926-001 XPO6 piR-47374-001
GH16J028138 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 71.4 +70.7 70680 5.6 ZBTB40 EP300 CTCF RCOR1 RAD21 TRIM22 NFYB BCL11A TCF12 CBFB XPO6 APOBR ENSG00000200652 RNY1P10 SULT1A1 HSALNG0110474 lnc-GSG1L-5
GH16J028165 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 57.6 +45.4 45381 2.3 JUND FOS RFX1 ZBTB17 POLR2A CTCF FOSL2 BATF EBF1 PRDM1 XPO6 APOBR SULT1A1 lnc-GSG1L-6 HSALNG0110474
GH16J028157 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 44.5 +53.7 53653 0.2 ZBTB17 ZBTB33 MAX CEBPB SCRT2 XPO6 APOBR SULT1A1 HSALNG0110474 lnc-GSG1L-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around XPO6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for XPO6

Top Transcription factor binding sites by QIAGEN in the XPO6 gene promoter:
  • CBF(2)
  • COMP1
  • ER-alpha
  • LCR-F1
  • NF-Y
  • Roaz
  • STAT1
  • STAT1alpha
  • STAT1beta
  • ZID

Genomic Locations for XPO6 Gene

Genomic Locations for XPO6 Gene
chr16:28,097,976-28,211,960
(GRCh38/hg38)
Size:
113,985 bases
Orientation:
Minus strand
chr16:28,109,300-28,223,241
(GRCh37/hg19)
Size:
113,942 bases
Orientation:
Minus strand

Genomic View for XPO6 Gene

Genes around XPO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO6 Gene

Proteins for XPO6 Gene

  • Protein details for XPO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QU8-XPO6_HUMAN
    Recommended name:
    Exportin-6
    Protein Accession:
    Q96QU8
    Secondary Accessions:
    • A1L3W4
    • D3DWF9
    • Q2YDX3
    • Q53G88
    • Q68G50
    • Q76N88
    • Q96CP8
    • Q9BT21

    Protein attributes for XPO6 Gene

    Size:
    1125 amino acids
    Molecular mass:
    128883 Da
    Quaternary structure:
    • Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB (PubMed:14592989). Interacts with ACTB in a RanGTP-dependent manner (PubMed:14592989).
    SequenceCaution:
    • Sequence=BAA20825.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for XPO6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XPO6 Gene

Post-translational modifications for XPO6 Gene

  • Ubiquitination at Lys288
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for XPO6 Gene

Domains & Families for XPO6 Gene

Gene Families for XPO6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for XPO6 Gene

Blocks:
  • Exportin 1-like
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for XPO6 Gene

GenScript: Design optimal peptide antigens:
  • XPO6 protein (B7ZM10_HUMAN)
  • Exportin 6, isoform CRA_a (D3DWF9_HUMAN)
  • Ran-binding protein 20 (XPO6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96QU8

UniProtKB/Swiss-Prot:

XPO6_HUMAN :
  • Belongs to the exportin family.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPO6: view

Function for XPO6 Gene

Molecular function for XPO6 Gene

UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.

Phenotypes From GWAS Catalog for XPO6 Gene

Gene Ontology (GO) - Molecular Function for XPO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005049 nuclear export signal receptor activity IDA 14592989
GO:0005515 protein binding IPI 14592989
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with XPO6: view
genes like me logo Genes that share phenotypes with XPO6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPO6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XPO6 Gene

Localization for XPO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO6 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269 PubMed:14592989}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XPO6 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
cytoskeleton 2
extracellular 1
mitochondrion 0
peroxisome 0
endoplasmic reticulum 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for XPO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IEA,IC 14592989
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IC 14592989
genes like me logo Genes that share ontologies with XPO6: view

Pathways & Interactions for XPO6 Gene

PathCards logo

SuperPathways for XPO6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for XPO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus IEA,IDA 14592989
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with XPO6: view

No data available for Pathways by source and SIGNOR curated interactions for XPO6 Gene

Drugs & Compounds for XPO6 Gene

No Compound Related Data Available

Transcripts for XPO6 Gene

mRNA/cDNA for XPO6 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPO6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for XPO6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11: -
SP12:
SP13:

ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28a · 28b · 28c · 28d · 28e
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:

Relevant External Links for XPO6 Gene

GeneLoc Exon Structure for
XPO6

Expression for XPO6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for XPO6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XPO6 Gene

This gene is overexpressed in Whole Blood (x20.7).

Protein differential expression in normal tissues from HIPED for XPO6 Gene

This gene is overexpressed in Bone (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for XPO6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for XPO6

SOURCE GeneReport for Unigene cluster for XPO6 Gene:

Hs.460468

Evidence on tissue expression from TISSUES for XPO6 Gene

  • Nervous system(4.9)
  • Skin(4.4)
  • Thyroid gland(4.3)
  • Lung(3)
genes like me logo Genes that share expression patterns with XPO6: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for XPO6 Gene

Orthologs for XPO6 Gene

This gene was present in the common ancestor of animals.

Orthologs for XPO6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPO6 31 30
  • 99.7 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XPO6 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPO6 31 30
  • 94.01 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 94 (a)
OneToMany
-- 31
  • 93 (a)
OneToMany
-- 31
  • 92 (a)
OneToMany
-- 31
  • 88 (a)
OneToMany
-- 31
  • 65 (a)
OneToMany
cow
(Bos Taurus)
Mammalia XPO6 31 30
  • 93.36 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Xpo6 17 31 30
  • 91.01 (n)
rat
(Rattus norvegicus)
Mammalia Xpo6 30
  • 90.93 (n)
chicken
(Gallus gallus)
Aves XPO6 31 30
  • 84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XPO6 31
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491765 30
  • 73.73 (n)
Str.7195 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7298 30
zebrafish
(Danio rerio)
Actinopterygii xpo6 31 30 30
  • 69.41 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5198 30
fruit fly
(Drosophila melanogaster)
Insecta Exp6 31
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
OneToOne
Cin.13929 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13929 30
Species where no ortholog for XPO6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XPO6 Gene

ENSEMBL:
Gene Tree for XPO6 (if available)
TreeFam:
Gene Tree for XPO6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for XPO6: view image

Paralogs for XPO6 Gene

Pseudogenes.org Pseudogenes for XPO6 Gene

genes like me logo Genes that share paralogs with XPO6: view

No data available for Paralogs for XPO6 Gene

Variants for XPO6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for XPO6 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs14672 - p.Val1029Leu

Additional dbSNP identifiers (rs#s) for XPO6 Gene

Structural Variations from Database of Genomic Variants (DGV) for XPO6 Gene

Variant ID Type Subtype PubMed ID
esv2656622 CNV deletion 23128226
esv2758640 CNV gain+loss 17122850
esv3638331 CNV loss 21293372
nsv103104 CNV deletion 16902084
nsv1060105 CNV gain 25217958
nsv1070342 CNV deletion 25765185
nsv1136212 CNV deletion 24896259
nsv469663 CNV loss 16826518
nsv507812 OTHER sequence alteration 20534489
nsv525423 CNV gain 19592680
nsv9408 CNV gain 18304495
nsv9409 CNV gain 18304495
nsv9410 CNV gain 18304495

Variation tolerance for XPO6 Gene

Residual Variation Intolerance Score: 7.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XPO6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
XPO6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO6 Gene

Disorders for XPO6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for XPO6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
arts syndrome
  • arts
- elite association - COSMIC cancer census association via MalaCards
Search XPO6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for XPO6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with XPO6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XPO6 Gene

Publications for XPO6 Gene

  1. Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes. (PMID: 14592989) Stüven T … Görlich D (The EMBO journal 2003) 2 3 4 23 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Differentiation-associated alteration in gene expression of importins and exportins in human leukemia HL-60 cells. (PMID: 18614847) Suzuki T … Isemura M (Biomedical research (Tokyo, Japan) 2008) 3 23 54
  4. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. (PMID: 18676839) Ambs S … Croce CM (Cancer research 2008) 3 23 54
  5. DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. (PMID: 16847355) Suzuki T … Isemura M (Biomedical research (Tokyo, Japan) 2006) 3 23 54

Products for XPO6 Gene

Sources for XPO6 Gene