This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011] See more...

Aliases for XPO5 Gene

Aliases for XPO5 Gene

  • Exportin 5 2 3 5
  • Ran-Binding Protein 21 3 4
  • Exportin-5 3 4
  • Exp5 3 4
  • KIAA1291 4
  • RANBP21 4

External Ids for XPO5 Gene

Previous GeneCards Identifiers for XPO5 Gene

  • GC06M043492
  • GC06M043536
  • GC06M043598
  • GC06M043490
  • GC06M043209

Summaries for XPO5 Gene

Entrez Gene Summary for XPO5 Gene

  • This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]

GeneCards Summary for XPO5 Gene

XPO5 (Exportin 5) is a Protein Coding gene. Diseases associated with XPO5 include Brain Cancer and Cutaneous Diphtheria. Among its related pathways are Gene Expression and Formation of HIV-1 elongation complex containing HIV-1 Tat. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is XPO1.

UniProtKB/Swiss-Prot Summary for XPO5 Gene

  • Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.
  • Mediates the nuclear export of micro-RNA precursors, which form short hairpins (PubMed:14681208, PubMed:14631048, PubMed:15613540). Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs (PubMed:19965479). Binding is dependent on Ran-GTP (PubMed:19965479).
  • (Microbial infection) Mediates the nuclear export of adenovirus VA1 dsRNA.

Gene Wiki entry for XPO5 Gene

Additional gene information for XPO5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for XPO5 Gene

Genomics for XPO5 Gene

GeneHancer (GH) Regulatory Elements for XPO5 Gene

Promoters and enhancers for XPO5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around XPO5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for XPO5

Top Transcription factor binding sites by QIAGEN in the XPO5 gene promoter:
  • Bach2
  • c-Myb
  • CUTL1
  • Elk-1
  • Nkx2-5
  • POU3F2
  • PPAR-gamma1
  • PPAR-gamma2
  • RP58
  • Zic3

Genomic Locations for XPO5 Gene

Genomic Locations for XPO5 Gene
chr6:43,522,330-43,576,075
(GRCh38/hg38)
Size:
53,746 bases
Orientation:
Minus strand
chr6:43,490,068-43,543,812
(GRCh37/hg19)
Size:
53,745 bases
Orientation:
Minus strand

Genomic View for XPO5 Gene

Genes around XPO5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPO5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO5 Gene

Proteins for XPO5 Gene

  • Protein details for XPO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAV4-XPO5_HUMAN
    Recommended name:
    Exportin-5
    Protein Accession:
    Q9HAV4
    Secondary Accessions:
    • Q5JTE6
    • Q96G48
    • Q96HN3
    • Q9BWM6
    • Q9BZV5
    • Q9H9M4
    • Q9NT89
    • Q9NW39
    • Q9ULC9

    Protein attributes for XPO5 Gene

    Size:
    1204 amino acids
    Molecular mass:
    136311 Da
    Quaternary structure:
    • Component of a nuclear export receptor complex composed of XPO5, RAN, dsRNA-binding proteins and dsRNA. Found in a nuclear export complex with XPO5, RAN, EEF1A1, and aminoacylated tRNA. Found in a nuclear export complex with XPO5, RAN, ILF3 and dsRNA. Found in a nuclear export complex with XPO5, RAN and pre-miRNA (PubMed:19965479). Found in a nuclear export complex with XPO5, RAN, ILF3 and minihelix VA1 dsRNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and dsRNA. Interacts with EEF1A1, ILF3, NUP153, NUP214 and ZNF346. Interacts with RAN and cargo proteins in a GTP-dependent manner. Interacts with isoform 5 of ADAR/ADAR1 (via DRBM domains). Interacts with SMAD4; mediates nuclear export of SMAD4 (PubMed:26878725). Interacts with RAN (GTP-bound form) (PubMed:19965479).
    SequenceCaution:
    • Sequence=AAH00129.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA86605.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91547.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for XPO5 Gene

neXtProt entry for XPO5 Gene

Post-translational modifications for XPO5 Gene

  • Ubiquitination at Lys216, Lys396, Lys930, Lys1140, Lys1173, and Lys1180
  • Modification sites at PhosphoSitePlus

Other Protein References for XPO5 Gene

No data available for DME Specific Peptides for XPO5 Gene

Domains & Families for XPO5 Gene

Gene Families for XPO5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for XPO5 Gene

Suggested Antigen Peptide Sequences for XPO5 Gene

GenScript: Design optimal peptide antigens:
  • Exportin 5 (Q5JTE7_HUMAN)
  • Exportin 5 (Q5JTE8_HUMAN)
  • Exportin 5 (Q5JTE9_HUMAN)
  • Exportin 5 (Q5JTF0_HUMAN)
  • Exportin 5 (Q5JTF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HAV4

UniProtKB/Swiss-Prot:

XPO5_HUMAN :
  • Belongs to the exportin family.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPO5: view

Function for XPO5 Gene

Molecular function for XPO5 Gene

UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.
UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of micro-RNA precursors, which form short hairpins (PubMed:14681208, PubMed:14631048, PubMed:15613540). Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs (PubMed:19965479). Binding is dependent on Ran-GTP (PubMed:19965479).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Mediates the nuclear export of adenovirus VA1 dsRNA.

Phenotypes From GWAS Catalog for XPO5 Gene

Gene Ontology (GO) - Molecular Function for XPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003723 RNA binding TAS --
GO:0003729 mRNA binding IDA 21297638
GO:0005049 nuclear export signal receptor activity IEA,IMP 14681208
GO:0005515 protein binding IPI 11777942
genes like me logo Genes that share ontologies with XPO5: view
genes like me logo Genes that share phenotypes with XPO5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPO5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XPO5 Gene

Localization for XPO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO5 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XPO5 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for XPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IDA,IBA 11777942
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IBA,IDA 11777942
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with XPO5: view

Pathways & Interactions for XPO5 Gene

genes like me logo Genes that share pathways with XPO5: view

Pathways by source for XPO5 Gene

2 BioSystems pathways for XPO5 Gene
1 KEGG pathway for XPO5 Gene
1 Cell Signaling Technology pathway for XPO5 Gene

Gene Ontology (GO) - Biological Process for XPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus IDA,IEA 11777942
GO:0006886 intracellular protein transport IEA --
GO:0010586 miRNA metabolic process TAS --
GO:0015031 protein transport IEA --
GO:0031047 gene silencing by RNA IEA --
genes like me logo Genes that share ontologies with XPO5: view

No data available for SIGNOR curated interactions for XPO5 Gene

Drugs & Compounds for XPO5 Gene

(1) Drugs for XPO5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for XPO5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with XPO5: view

Transcripts for XPO5 Gene

mRNA/cDNA for XPO5 Gene

1 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPO5

Alternative Splicing Database (ASD) splice patterns (SP) for XPO5 Gene

No ASD Table

Relevant External Links for XPO5 Gene

GeneLoc Exon Structure for
XPO5

Expression for XPO5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for XPO5 Gene

Protein differential expression in normal tissues from HIPED for XPO5 Gene

This gene is overexpressed in Bone (60.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for XPO5 Gene



Protein tissue co-expression partners for XPO5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for XPO5

SOURCE GeneReport for Unigene cluster for XPO5 Gene:

Hs.203206

mRNA Expression by UniProt/SwissProt for XPO5 Gene:

Q9HAV4-XPO5_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for XPO5 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with XPO5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for XPO5 Gene

Orthologs for XPO5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPO5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPO5 31 30
  • 99.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia XPO5 31 30
  • 92.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia XPO5 31 30
  • 91.32 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xpo5 30
  • 87.15 (n)
oppossum
(Monodelphis domestica)
Mammalia XPO5 31
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xpo5 17 31 30
  • 86.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 85 (a)
OneToMany
-- 31
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves XPO5 31 30
  • 76.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XPO5 31
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xpo5 30 30
  • 63.34 (n)
zebrafish
(Danio rerio)
Actinopterygii xpo5 30
  • 63.74 (n)
XPO5 31
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011888 30
  • 48.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ranbp21 31 32 30
  • 47.21 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSN5 33 31
  • 18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HST 30
  • 39.99 (n)
rice
(Oryza sativa)
Liliopsida Os01g0363900 30
  • 38.62 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 26 (a)
OneToOne
Species where no ortholog for XPO5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XPO5 Gene

ENSEMBL:
Gene Tree for XPO5 (if available)
TreeFam:
Gene Tree for XPO5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for XPO5: view image

Paralogs for XPO5 Gene

Paralogs for XPO5 Gene

genes like me logo Genes that share paralogs with XPO5: view

Variants for XPO5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for XPO5 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
714314 Benign: not provided 43,534,016(-) A/C INTRON_VARIANT
769314 Benign: not provided 43,533,926(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
787830 Benign: not provided 43,572,565(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs11544379 Uncertain Significance: not provided. - 43,551,372(-) C/Tp.Val552Ile MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
rs12173786 - p.Lys610Asn

Additional dbSNP identifiers (rs#s) for XPO5 Gene

Structural Variations from Database of Genomic Variants (DGV) for XPO5 Gene

Variant ID Type Subtype PubMed ID
nsv478539 CNV novel sequence insertion 20440878
nsv603000 CNV loss 21841781
nsv818414 CNV gain 17921354
nsv981139 CNV duplication 23825009

Variation tolerance for XPO5 Gene

Residual Variation Intolerance Score: 9.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XPO5 Gene

Human Gene Mutation Database (HGMD)
XPO5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
XPO5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO5 Gene

Disorders for XPO5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for XPO5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
brain cancer
  • adult brain tumor
cutaneous diphtheria
digeorge syndrome
  • cayler cardiofacial syndrome
leukemia, chronic lymphocytic
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search XPO5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for XPO5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with XPO5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XPO5 Gene

Publications for XPO5 Gene

  1. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. (PMID: 12426392) Bohnsack MT … Görlich D (The EMBO journal 2002) 2 3 4 23 54
  2. Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins. (PMID: 11777942) Brownawell AM … Macara IG (The Journal of cell biology 2002) 2 3 4 23 54
  3. RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1. (PMID: 19124606) Fritz J … Jantsch MF (Molecular and cellular biology 2009) 3 4 23 54
  4. A high-resolution structure of the pre-microRNA nuclear export machinery. (PMID: 19965479) Okada C … Tsukihara T (Science (New York, N.Y.) 2009) 3 4 23 54
  5. Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. (PMID: 15613540) Yi R … Cullen BR (RNA (New York, N.Y.) 2005) 3 4 23 54

Products for XPO5 Gene

Sources for XPO5 Gene