External Ids for XPO4 Gene
Previous GeneCards Identifiers for XPO4 Gene
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]
GeneCards Summary for XPO4 Gene
XPO4 (Exportin 4) is a Protein Coding gene. Diseases associated with XPO4 include Conjunctival Degeneration and Pinguecula. Among its related pathways are Ran Pathway and eIF5A regulation in response to inhibition of the nuclear export system. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is XPO7.
UniProtKB/Swiss-Prot Summary for XPO4 Gene
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.