Free for academic non-profit institutions. Other users need a Commercial license
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1... See more...
Aliases for XPO1 Gene
Aliases for XPO1 Gene
External Ids for XPO1 Gene
- HGNC: 12825
- NCBI Entrez Gene: 7514
- Ensembl: ENSG00000082898
- OMIM®: 602559
- UniProtKB/Swiss-Prot: O14980
Previous GeneCards Identifiers for XPO1 Gene
- GC02M061833
- GC02M061662
- GC02M061679
- GC02M061616
- GC02M061704
Summaries for XPO1 Gene
-
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]
GeneCards Summary for XPO1 Gene
XPO1 (Exportin 1) is a Protein Coding gene. Diseases associated with XPO1 include Primary Mediastinal Large B-Cell Lymphoma and Influenza. Among its related pathways are Signaling by GPCR and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include RNA binding and transporter activity. An important paralog of this gene is XPO5.
UniProtKB/Swiss-Prot Summary for XPO1 Gene
-
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap.
-
(Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
Additional gene information for XPO1 Gene
- HGNC (12825)
- NCBI Entrez Gene (7514)
- Ensembl (ENSG00000082898)
- OMIM® (602559)
- UniProtKB/Swiss-Prot (O14980)
- Open Targets Platform(ENSG00000082898)
- Monarch Initiative
- Search for XPO1 at DataMed
- Search for XPO1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for XPO1 Gene
Genomics for XPO1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for XPO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around XPO1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for XPO1
- Top Transcription factor binding sites by QIAGEN in the XPO1 gene promoter:
-
- c-Myb
- CUTL1
- GATA-3
- Pax-2
- Pax-2a
- Pax-2b
- PPAR-gamma1
- PPAR-gamma2
- Sp1
- XBP-1
Genomic Locations for XPO1 Gene
Latest Assembly
- chr2:61,476,032-61,538,741
- (GRCh38/hg38)
- Size:
- 62,710 bases
- Orientation:
- Minus strand
Previous Assembly
- chr2:61,704,984-61,765,491
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 60,508 bases
- Orientation:
- Minus strand
- chr2:61,704,984-61,765,761
- (GRCh37/hg19 by Ensembl)
- Size:
- 60,778 bases
- Orientation:
- Minus strand
Genomic View for XPO1 Gene
Genes around XPO1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p15 by HGNC
- 2p15 by Entrez Gene
- 2p15 by Ensembl
XPO1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for XPO1 Gene
Proteins for XPO1 Gene
-
Protein details for XPO1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14980-XPO1_HUMAN
- Recommended name:
- Exportin-1
- Protein Accession:
- O14980
- A6NL14
- A8K1K5
- D6W5E2
- Q63HP8
- Q68CP3
- Q99433
Protein attributes for XPO1 Gene
- Size:
- 1071 amino acids
- Molecular mass:
- 123386 Da
- Quaternary structure:
-
- Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA (By similarity). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUP42, NUP88, NUP214, RANBP3 and TERT. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at 'Lys-129'. Interacts with DTNBP1 and SERTAD2; the interactions translocate DTNBP1 and SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with CPEB3 (PubMed:22730302). Interacts with HAX1 (PubMed:23164465). Interacts with BOK; translocates to the cytoplasm (PubMed:16302269). Interacts with HSP90AB1 (PubMed:22022502).
- (Microbial infection) Interacts with HIV-1 Rev.
- (Microbial infection) Interacts with HTLV-1 Rex.
- (Microbial infection) Interacts with influenza A nucleoprotein.
- (Microbial infection) Interacts with Epstein-Barr virus protein BMLF1.
- (Microbial infection) Part of a tetrameric complex composed of CRM1, importin alpha/beta dimer and the Venezuelan equine encephalitis virus (VEEV) capsid; this complex blocks the receptor-mediated transport through the nuclear pore.
- (Microbial infection) Interacts with SARS-CoV virus protein ORF9b; this interaction mediates protein ORF9b export out of the nucleus.
- Miscellaneous:
-
- Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor.
Protein Expression for XPO1 Gene
Post-translational modifications for XPO1 Gene
Other Protein References for XPO1 Gene
- ENSEMBL proteins:
-
- ENSP00000503789
- ENSP00000504286
- ENSP00000505574
- ENSP00000503482
- ENSP00000504172
- ENSP00000502889
- ENSP00000503809
- ENSP00000502940
- ENSP00000504543
- ENSP00000503572
- ENSP00000503474
- ENSP00000502854
- ENSP00000503342
- ENSP00000503554
- ENSP00000503638
- ENSP00000503194
- ENSP00000503075
- ENSP00000503167
- ENSP00000504594
- ENSP00000504198
- ENSP00000503419
- ENSP00000503702
- ENSP00000504087
- ENSP00000503808
- ENSP00000504848
- ENSP00000504749
- ENSP00000504247
- ENSP00000384863
- ENSP00000407170
- ENSP00000504771
- ENSP00000413853
- ENSP00000504617
- ENSP00000503395
- ENSP00000385942
- ENSP00000385559
- ENSP00000406428
- ENSP00000406819
- O14980.201
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences XPO1 / CRM1 Antibody (LS-B1776) and XPO1 / CRM1 Antibody (LS-B11039)
- NSJ Bioreagents CRM1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for XPO1
- Novus Biologicals Antibodies for XPO1
-
Abcam antibodies for XPO1
- Invitrogen Antibodies for XPO1 (AFLGC-XPO1)
- antibodies-online: Show 28 available XPO1 Antibodies ranked by validation data
- Compare Top XPO1 Antibodies
-
Recommended
- 88 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 52 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 26 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
-
Biorbyt antibodies for XPO1
-
Boster Bio Antibodies for XPO1
-
Custom Antibody ServicesProSci Antibodies for XPO1
-
Santa Cruz Biotechnology (SCBT) Antibodies for XPO1
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for XPO1
- Origene Custom Protein Services for XPO1
- Novus Biologicals proteins for XPO1
-
Abcam proteins for XPO1
Assay products for research
No data available for DME Specific Peptides for XPO1 Gene
Domains & Families for XPO1 Gene
Gene Families for XPO1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transporters
Protein Domains for XPO1 Gene
- InterPro:
- Blocks:
-
- Importin-beta, N-terminal
- Exportin 1-like
- ProtoNet:
Suggested Antigen Peptide Sequences for XPO1 Gene
- GenScript: Design optimal peptide antigens:
-
- Chromosome region maintenance 1 protein homolog (XPO1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O14980- Family:
-
- Belongs to the exportin family.
Function for XPO1 Gene
Molecular function for XPO1 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
- GENATLAS Biochemistry:
- exportin 1,CAN/NUP214 and NUP88 interacting protein CRM1,112kDa,cell-cycle regulated gene,expressed in nuclear pore complex and nucleoplasmin and essential mediator of the leucine-rich NES-dependent nuclear export of proteins,maybe involved in the leukemogenic effect of DEK-CAN and SET-CAN fusion chimeric proteins (forming a complex with EIF5A)
Phenotypes From GWAS Catalog for XPO1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005049 | nuclear export signal receptor activity | IDA,IMP | 12724356 |
| GO:0005515 | protein binding | IPI | 10358091 |
| GO:0008536 | Ran GTPase binding | IEA | -- |
| GO:0019904 | protein domain specific binding | IPI | -- |
Phenotypes for XPO1 Gene
- MGI mutant phenotypes for XPO1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for XPO1:
-
- no effect
- Decreased viability
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Synthetic lethal with Ras
- Decreased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Reduced mammosphere formation
- FOXO1 nuclear localization
- Decreased IL-8 secretion
- Nuclear 60S biogenesis defects
- Decreased HIV-LTR-beta-galactosidase protein expression
- Nucleolar pre-40S maturation defects
- Inconclusive
- Decreased shRNA abundance
- Increased cell death HMECs cells
- Decreased influenza A/WSN/33 replication
- Increased cell death in HCT116 cells
- Increased cell death in DLD-1 cells
- Decreased cell number
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased interferon-beta reporter expression
- Increased cell death in HCC-1954 cells
- Decreased homologous recombination repair frequency
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
- Downregulation of RLR pathway after Sendai virus (SeV) infection
- Decreased viability with SS1P at EC30
- HIV Rev nuclear localization
- Nuclear 40S maturation defects
- Decreased cell number, increased S DNA content
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for XPO1 - Starting at $85 >
- * XPO1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for XPO1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for XPO1
-
Santa Cruz Biotechnology (SCBT) CRISPR for XPO1
miRNA for XPO1 Gene
- miRTarBase miRNAs that target XPO1
-
- hsa-miR-193b-3p (MIRT016294)
- hsa-miR-155-5p (MIRT020549)
- hsa-miR-192-5p (MIRT026224)
- hsa-miR-30a-5p (MIRT028476)
- hsa-miR-16-5p (MIRT031490)
- hsa-miR-1236-3p (MIRT036257)
- hsa-miR-125a-5p (MIRT045717)
- hsa-miR-23b-3p (MIRT046310)
- hsa-miR-92a-3p (MIRT049604)
- hsa-miR-17-3p (MIRT050787)
- hsa-miR-30c-5p (MIRT206887)
- hsa-miR-30d-5p (MIRT206888)
- hsa-miR-30b-5p (MIRT206889)
- hsa-miR-30e-5p (MIRT206890)
- hsa-miR-382-5p (MIRT439276)
- hsa-miR-485-5p (MIRT439277)
- hsa-miR-4495 (MIRT545978)
- hsa-miR-4538 (MIRT545979)
- hsa-miR-4453 (MIRT545980)
- hsa-miR-224-5p (MIRT545981)
- mmu-miR-1199-5p (MIRT588458)
- mmu-miR-3089-5p (MIRT588459)
- mmu-miR-1195 (MIRT588460)
- mmu-miR-5135 (MIRT588461)
- mmu-miR-376c-3p (MIRT588462)
- mmu-miR-3060-3p (MIRT588463)
- mmu-miR-706 (MIRT600170)
- mmu-miR-760-5p (MIRT600171)
- mmu-miR-665-3p (MIRT600172)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for XPO1
- Browse OriGene Inhibitory RNA Products For XPO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPO1
Clone products for research
- Applied Biological Materials (abm): Clones for XPO1 - Starting at $45 >
- * XPO1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for XPO1
- Addgene plasmids for XPO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for XPO1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XPO1 Gene
Localization for XPO1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for XPO1 Gene
- Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Cytosol (4)
- Nuclear membrane (4)
- Nucleoplasm (4)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | kinetochore | IDA | 17363900 |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005635 | nuclear envelope | TAS | 9368044 |
| GO:0005642 | annulate lamellae | IDA | 12210765 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for XPO1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.91
.64
|
.45
|
| 2 | Transport of the SLBP independent Mature mRNA | ||
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 5 | Mitotic Metaphase and Anaphase |
.94
|
|
Pathways by source for XPO1 Gene
9 BioSystems pathways for XPO1 Gene
38 Reactome pathways for XPO1 Gene
4 KEGG pathways for XPO1 Gene
2 GeneGo (Thomson Reuters) pathways for XPO1 Gene
- Cell cycle ESR1 regulation of G1/S transition
- Immune response MIF-JAB1 signaling
1 R&D Systems pathway for XPO1 Gene
3 Qiagen pathways for XPO1 Gene
- NFAT in Immune Response
- Ran Pathway
- SMAD Signaling Network
1 Cell Signaling Technology pathway for XPO1 Gene
Interacting Proteins for XPO1 Gene
Selected Interacting proteins:
O14980-XPO1_HUMAN
ENSP00000384863
for XPO1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for XPO1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000054 | ribosomal subunit export from nucleus | IMP | 12724356 |
| GO:0000055 | ribosomal large subunit export from nucleus | IBA,IMP | 12773398 |
| GO:0000056 | ribosomal small subunit export from nucleus | IBA,IMP | 12773398 |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | -- |
| GO:0006611 | protein export from nucleus | IPI | 29666234 |
Drugs & Compounds for XPO1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Selinexor | Approved, Investigational | Pharma | Target, inhibitor | 0 | ||
| Isoniazid | Approved, Investigational | Pharma | 234 | |||
| Guanosine triphosphate | Experimental | Pharma | 0 | |||
| Drugs For Treatment Of Tuberculosis | Pharma | 0 | ||||
| KPT-185 | Pharma | CRM1 inhibitor,selective and irrversible | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(4) ApexBio Compounds for XPO1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| KPT-185 | CRM1 inhibitor,selective and irrversible | 1333151-73-7 |
| KPT-276 | 1421919-75-6 | |
| KPT-330 | 1393477-72-9 | |
| Verdinexor (KPT-335) | 1392136-43-4 |
Transcripts for XPO1 Gene
mRNA/cDNA for XPO1 Gene
- 1 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 55 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000401558 4988 nts (view in UCSC)
- ENST00000404992 4105 nts (view in UCSC)
- ENST00000406957 3479 nts (view in UCSC)
- ENST00000420673 3297 nts (view in UCSC)
- ENST00000428210 6776 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for XPO1 - Starting at $85 >
- * XPO1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for XPO1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for XPO1
-
Santa Cruz Biotechnology (SCBT) CRISPR for XPO1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for XPO1
- Browse OriGene Inhibitory RNA Products For XPO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPO1
Clone products for research
- Applied Biological Materials (abm): Clones for XPO1 - Starting at $45 >
- * XPO1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for XPO1
- Addgene plasmids for XPO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for XPO1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16a | · | 16b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - |
| ExUns: | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||
| SP11: |
Relevant External Links for XPO1 Gene
- GeneLoc Exon Structure for
- XPO1
Expression for XPO1 Gene
This gene is overexpressed in Bone (48.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for XPO1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for XPO1
SOURCE GeneReport for Unigene cluster for XPO1 Gene:
Hs.370770mRNA Expression by UniProt/SwissProt for XPO1 Gene:
O14980-XPO1_HUMAN
Tissue specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.
Evidence on tissue expression from TISSUES for XPO1 Gene
- Nervous system(4.9)
- Liver(4.7)
- Lung(3.4)
- Kidney(3.2)
- Intestine(3.1)
- Skin(3.1)
- Muscle(3.1)
- Heart(2.8)
- Spleen(2.8)
- Lymph node(2.8)
- Bone marrow(2.7)
- Blood(2.6)
- Eye(2.6)
- Thyroid gland(2.4)
- Stomach(2.3)
- Adrenal gland(2.2)
- Pancreas(2.1)
Primer products for research
-
OriGene qPCR primer pairs for XPO1
-
OriGene qPCR primer pairs and template standards for XPO1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for XPO1 Gene
Orthologs for XPO1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | XPO1 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | XPO1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | XPO1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | XPO1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | XPO1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Xpo1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Xpo1 30 |
|
||
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| XPO1 30 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | XPO1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | xpo1 30 |
|
||
| Str.2050 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xpo1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | xpo1a 31 |
|
OneToMany | |
| xpo1b 30 31 |
|
OneToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6091 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009929 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | emb 30 31 32 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | xpo-1 30 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CRM1 30 31 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E16061g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADL128C 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | XPO1A 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os03g0858100 30 |
|
||
| Os.9258 30 |
|
||||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.1208 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2375 31 |
|
OneToOne | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | crm1 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU01820 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5454 30 |
|
- Species where no ortholog for XPO1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for XPO1 Gene
- ENSEMBL:
- Gene Tree for XPO1 (if available)
- TreeFam:
- Gene Tree for XPO1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for XPO1: view image
Paralogs for XPO1 Gene
Variants for XPO1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for XPO1 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057520009 | Likely Pathogenic: Chronic lymphocytic leukemia; Breast neoplasm; Neoplasm of the large intestine; Adenocarcinoma of prostate; Malignant neoplasm of body of uterus | 61,492,337(-) |
C/T NM_003400.4(XPO1):c.1711G>A (p.Glu571Lys) |
MISSENSE | |
| rs1057520010 | Likely Pathogenic: Chronic lymphocytic leukemia; Breast neoplasm; Neoplasm of the large intestine; Adenocarcinoma of prostate; Malignant neoplasm of body of uterus. Likely Pathogenic: Chronic lymphocytic leukemia; Breast neoplasm; Neoplasm of the large intestine; Adenocarcinoma of prostate; Malignant neoplasm of body of uterus | 61,492,336(-) |
T/AT/G NM_003400.4(XPO1):c.1712A>T (p.Glu571Val) |
MISSENSE | |
| rs1281320213 | Likely Benign: not provided | 61,492,425(-) |
T/C NM_003400.4(XPO1):c.1623A>G (p.Ala541=) |
SYNONYMOUS | |
| rs13385575 | Benign: not provided | 61,484,076(-) |
C/T NM_003400.4(XPO1):c.2538G>A (p.Thr846=) |
SYNONYMOUS | |
| rs140857799 | Benign: not provided | 61,496,870(-) |
T/C NM_003400.4(XPO1):c.888+9A>G |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2463303 | CNV | deletion | 19546169 |
| nsv1012689 | CNV | gain | 25217958 |
| nsv1014905 | CNV | gain | 25217958 |
| nsv1133471 | CNV | deletion | 24896259 |
| nsv582118 | CNV | gain | 21841781 |
| nsv582119 | CNV | loss | 21841781 |
| nsv582120 | CNV | loss | 21841781 |
| nsv7313 | OTHER | inversion | 18451855 |
| nsv953132 | CNV | deletion | 24416366 |
| nsv954194 | CNV | deletion | 24416366 |
| nsv9935 | CNV | loss | 18304495 |
| nsv9946 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
3.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.39;
8.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for XPO1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO1 Gene
Disorders for XPO1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| primary mediastinal large b-cell lymphoma |
|
|
| influenza |
|
|
| suppression of tumorigenicity 12 |
|
|
| primary mediastinal b-cell lymphoma |
|
|
| hemorrhoid |
|
|
Search XPO1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for XPO1
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for XPO1 Gene
Publications for XPO1 Gene
- Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. (PMID: 9368044) Kudo N ā¦ Horinouchi S (The Journal of biological chemistry 1997) 2 3 4 23
- CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. (PMID: 18316374) Cheong JK ā¦ Hsu SI (The Journal of biological chemistry 2008) 3 4 23
- Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo. (PMID: 15632073) Daelemans D ā¦ Pavlakis GN (Molecular and cellular biology 2005) 3 4 23
- A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. (PMID: 14612415) Hakata Y ā¦ Shida H (Molecular and cellular biology 2003) 3 4 23
- Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. (PMID: 12724356) Thomas F ā¦ Kutay U (Journal of cell science 2003) 3 4 23
ExternalLinks
Products for XPO1 Gene
- Custom Antibody ServicesOriGene Antibodies for XPO1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for XPO1
- Origene Custom Protein Services for XPO1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for XPO1
- Browse OriGene Inhibitory RNA Products For XPO1
- OriGene qPCR primer pairs for XPO1
- OriGene qPCR primer pairs and template standards for XPO1
- OriGene CRISPR knockouts for XPO1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For XPO1
- Sino Biological Human cDNA Clone for XPO1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for XPO1
- Novus Biologicals proteins for XPO1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for XPO1
- Abcam proteins for XPO1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for XPO1 (AFLGC-XPO1)
- ApexBio compounds for XPO1
- VectorBuilder Custom and pre-made DNA vectors for XPO1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for XPO1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for XPO1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for XPO1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for XPO1
- Addgene plasmids for XPO1
- antibodies-online: Show 28 available XPO1 Antibodies ranked by validation data
- Compare Top XPO1 Antibodies
- Recommended
- 88 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 52 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 26 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Show 11 available XPO1 Elisa Kits ranked by validation data
- Compare Top XPO1 Elisa Kits
- antibodies-online: Show 4 available XPO1 Proteins ranked by validation data
- Compare Top XPO1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for XPO1
- Search Santa Cruz Biotechnology (SCBT) for XPO1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for XPO1
- Custom Antibody ServicesProSci Antibodies for XPO1
- Search for XPO1 Proteins at ProSci
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for XPO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for XPO1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for XPO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPO1
- Boster Bio Antibodies for XPO1
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for XPO1
Sources for XPO1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21)