This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1... See more...

Aliases for XPO1 Gene

Aliases for XPO1 Gene

  • Exportin 1 2 3 5
  • Chromosome Region Maintenance 1 Protein Homolog 3 4
  • Exportin 1 (CRM1 Homolog, Yeast) 2 3
  • Exportin-1 3 4
  • Exp1 3 4
  • CRM1 3 4
  • Exportin-1 (Required For Chromosome Region Maintenance) 3
  • Chromosome Region Maintenance 1 Homolog (Yeast) 2
  • Chromosome Region Maintenance 1 Homolog 3
  • Exportin 1 (CRM1, Yeast, Homolog) 2
  • CRM-1 3
  • Emb 3

External Ids for XPO1 Gene

Previous GeneCards Identifiers for XPO1 Gene

  • GC02M061833
  • GC02M061662
  • GC02M061679
  • GC02M061616
  • GC02M061704

Summaries for XPO1 Gene

Entrez Gene Summary for XPO1 Gene

  • This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

GeneCards Summary for XPO1 Gene

XPO1 (Exportin 1) is a Protein Coding gene. Diseases associated with XPO1 include Influenza and Primary Mediastinal Large B-Cell Lymphoma. Among its related pathways are Role of Calcineurin-dependent NFAT signaling in lymphocytes and RET signaling. Gene Ontology (GO) annotations related to this gene include RNA binding and transporter activity. An important paralog of this gene is XPO5.

UniProtKB/Swiss-Prot Summary for XPO1 Gene

  • Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap.
  • (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Gene Wiki entry for XPO1 Gene

Additional gene information for XPO1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for XPO1 Gene

Genomics for XPO1 Gene

GeneHancer (GH) Regulatory Elements for XPO1 Gene

Promoters and enhancers for XPO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around XPO1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the XPO1 gene promoter:
  • c-Myb
  • CUTL1
  • GATA-3
  • Pax-2
  • Pax-2a
  • Pax-2b
  • PPAR-gamma1
  • PPAR-gamma2
  • Sp1
  • XBP-1

Genomic Locations for XPO1 Gene

Genomic Locations for XPO1 Gene
chr2:61,477,849-61,538,626
(GRCh38/hg38)
Size:
60,778 bases
Orientation:
Minus strand
chr2:61,704,984-61,765,761
(GRCh37/hg19)
Size:
60,778 bases
Orientation:
Minus strand

Genomic View for XPO1 Gene

Genes around XPO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO1 Gene

Proteins for XPO1 Gene

  • Protein details for XPO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14980-XPO1_HUMAN
    Recommended name:
    Exportin-1
    Protein Accession:
    O14980
    Secondary Accessions:
    • A6NL14
    • A8K1K5
    • D6W5E2
    • Q63HP8
    • Q68CP3
    • Q99433

    Protein attributes for XPO1 Gene

    Size:
    1071 amino acids
    Molecular mass:
    123386 Da
    Quaternary structure:
    • Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA (By similarity). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUP42, NUP88, NUP214, RANBP3 and TERT. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at 'Lys-129'. Interacts with DTNBP1 and SERTAD2; the interactions translocate DTNBP1 and SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with CPEB3 (PubMed:22730302). Interacts with HAX1 (PubMed:23164465). Interacts with BOK; translocates to the cytoplasm (PubMed:16302269). Interacts with HSP90AB1 (PubMed:22022502).
    • (Microbial infection) Interacts with HIV-1 Rev.
    • (Microbial infection) Interacts with HTLV-1 Rex.
    • (Microbial infection) Interacts with influenza A nucleoprotein.
    • (Microbial infection) Interacts with Epstein-Barr virus protein BMLF1.
    • (Microbial infection) Part of a tetrameric complex composed of CRM1, importin alpha/beta dimer and the Venezuelan equine encephalitis virus (VEEV) capsid; this complex blocks the receptor-mediated transport through the nuclear pore.
    Miscellaneous:
    • Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor.

    Three dimensional structures from OCA and Proteopedia for XPO1 Gene

neXtProt entry for XPO1 Gene

Post-translational modifications for XPO1 Gene

  • Ubiquitination at Lys54, Lys144, Lys415, Lys446, Lys455, Lys479, Lys686, and Lys693
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for XPO1 Gene

Domains & Families for XPO1 Gene

Gene Families for XPO1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for XPO1 Gene

GenScript: Design optimal peptide antigens:
  • Chromosome region maintenance 1 protein homolog (XPO1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14980

UniProtKB/Swiss-Prot:

XPO1_HUMAN :
  • Belongs to the exportin family.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPO1: view

Function for XPO1 Gene

Molecular function for XPO1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
GENATLAS Biochemistry:
exportin 1,CAN/NUP214 and NUP88 interacting protein CRM1,112kDa,cell-cycle regulated gene,expressed in nuclear pore complex and nucleoplasmin and essential mediator of the leucine-rich NES-dependent nuclear export of proteins,maybe involved in the leukemogenic effect of DEK-CAN and SET-CAN fusion chimeric proteins (forming a complex with EIF5A)

Phenotypes From GWAS Catalog for XPO1 Gene

Gene Ontology (GO) - Molecular Function for XPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005049 nuclear export signal receptor activity IMP,IBA 12724356
GO:0005515 protein binding IPI 10358091
GO:0008536 Ran GTPase binding IEA --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with XPO1: view
genes like me logo Genes that share phenotypes with XPO1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPO1

Clone Products

  • Addgene plasmids for XPO1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XPO1 Gene

Localization for XPO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO1 Gene

Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XPO1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nuclear membrane (4)
  • Nucleoplasm (4)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for XPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 17363900
GO:0005623 cell IEA --
GO:0005634 nucleus IDA,IEA --
GO:0005635 nuclear envelope TAS 9368044
GO:0005642 annulate lamellae IDA 12210765
genes like me logo Genes that share ontologies with XPO1: view

Pathways & Interactions for XPO1 Gene

genes like me logo Genes that share pathways with XPO1: view

SIGNOR curated interactions for XPO1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for XPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000054 ribosomal subunit export from nucleus IMP 12724356
GO:0000055 ribosomal large subunit export from nucleus IMP 12773398
GO:0000056 ribosomal small subunit export from nucleus IMP 12773398
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006611 protein export from nucleus IDA,IMP 12773398
genes like me logo Genes that share ontologies with XPO1: view

Drugs & Compounds for XPO1 Gene

(13) Drugs for XPO1 Gene - From: PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isoniazid Approved, Investigational Pharma 202
Guanosine triphosphate Experimental Pharma 0
KPT-185 Pharma CRM1 inhibitor,selective and irrversible 0
KPT-276 Pharma 0
KPT-330 Pharma 0

(5) Additional Compounds for XPO1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) ApexBio Compounds for XPO1 Gene

Compound Action Cas Number
KPT-185 CRM1 inhibitor,selective and irrversible 1333151-73-7
KPT-276 1421919-75-6
KPT-330 1393477-72-9
Verdinexor (KPT-335) 1392136-43-4
genes like me logo Genes that share compounds with XPO1: view

Transcripts for XPO1 Gene

mRNA/cDNA for XPO1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPO1

Clone Products

  • Addgene plasmids for XPO1

Alternative Splicing Database (ASD) splice patterns (SP) for XPO1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
SP1: - - - - - -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: - -
SP8: -
SP9:
SP10: - -
SP11: -

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for XPO1 Gene

GeneLoc Exon Structure for
XPO1
ECgene alternative splicing isoforms for
XPO1

Expression for XPO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XPO1 Gene

Protein differential expression in normal tissues from HIPED for XPO1 Gene

This gene is overexpressed in Bone (48.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for XPO1 Gene



Protein tissue co-expression partners for XPO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XPO1 Gene:

XPO1

SOURCE GeneReport for Unigene cluster for XPO1 Gene:

Hs.370770

mRNA Expression by UniProt/SwissProt for XPO1 Gene:

O14980-XPO1_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.

Evidence on tissue expression from TISSUES for XPO1 Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Lung(2.9)
  • Intestine(2.8)
  • Muscle(2.7)
  • Kidney(2.6)
  • Heart(2.4)
  • Blood(2.3)
  • Skin(2.3)
  • Bone marrow(2.1)
  • Lymph node(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with XPO1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for XPO1 Gene

Orthologs for XPO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPO1 33 32
  • 99.75 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XPO1 33
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XPO1 33
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPO1 33 32
  • 94.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia XPO1 33 32
  • 93.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Xpo1 17 33 32
  • 91.53 (n)
rat
(Rattus norvegicus)
Mammalia Xpo1 32
  • 89.57 (n)
chicken
(Gallus gallus)
Aves -- 33
  • 91 (a)
OneToMany
XPO1 33 32
  • 86.9 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia XPO1 33
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xpo1 32
  • 81.89 (n)
Str.2050 32
African clawed frog
(Xenopus laevis)
Amphibia Xpo1 32
zebrafish
(Danio rerio)
Actinopterygii xpo1a 33
  • 88 (a)
OneToMany
xpo1b 33 32
  • 77.68 (n)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6091 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009929 32
  • 63.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta emb 33 34 32
  • 63.02 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea xpo-1 33 32
  • 55.82 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRM1 33 32
  • 55.07 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16061g 32
  • 54.42 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL128C 32
  • 53.54 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons XPO1A 32
  • 56.44 (n)
rice
(Oryza sativa)
Liliopsida Os03g0858100 32
  • 56.65 (n)
Os.9258 32
barley
(Hordeum vulgare)
Liliopsida Hv.1208 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2375 33
  • 73 (a)
OneToOne
Cin.5454 32
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes crm1 32
  • 59.23 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01820 32
  • 53.82 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5454 32
Species where no ortholog for XPO1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XPO1 Gene

ENSEMBL:
Gene Tree for XPO1 (if available)
TreeFam:
Gene Tree for XPO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for XPO1: view image

Paralogs for XPO1 Gene

Paralogs for XPO1 Gene

genes like me logo Genes that share paralogs with XPO1: view

Variants for XPO1 Gene

Sequence variations from dbSNP and Humsavar for XPO1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1057520009 likely-pathogenic, Neoplasm of the large intestine, Adenocarcinoma of prostate, Malignant neoplasm of body of uterus, Neoplasm of the breast, Chronic lymphocytic leukemia 61,492,337(-) C/T coding_sequence_variant, missense_variant
rs1057520010 likely-pathogenic, Adenocarcinoma of prostate, Neoplasm of the breast, Chronic lymphocytic leukemia, Malignant neoplasm of body of uterus, Neoplasm of the large intestine 61,492,336(-) T/A/G coding_sequence_variant, missense_variant
rs587778011 not-provided, not specified 61,492,797(-) T/C intron_variant
rs587778764 not-provided, not specified 61,493,980(-) A/G coding_sequence_variant, missense_variant
rs1000045662 -- 61,510,488(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for XPO1 Gene

Variant ID Type Subtype PubMed ID
esv2463303 CNV deletion 19546169
nsv1012689 CNV gain 25217958
nsv1014905 CNV gain 25217958
nsv1133471 CNV deletion 24896259
nsv582118 CNV gain 21841781
nsv582119 CNV loss 21841781
nsv582120 CNV loss 21841781
nsv7313 OTHER inversion 18451855
nsv953132 CNV deletion 24416366
nsv954194 CNV deletion 24416366
nsv9935 CNV loss 18304495
nsv9946 CNV gain+loss 18304495

Variation tolerance for XPO1 Gene

Residual Variation Intolerance Score: 3.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XPO1 Gene

Human Gene Mutation Database (HGMD)
XPO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
XPO1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO1 Gene

Disorders for XPO1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for XPO1 Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
primary mediastinal large b-cell lymphoma
  • large cell lymphoma of the mediastinum
venezuelan equine encephalitis
  • venezuelan equine fever
hemorrhoid
  • hemorrhoidal disease
primary mediastinal b-cell lymphoma
  • large cell lymphoma of the mediastinum
- elite association - COSMIC cancer census association via MalaCards
Search XPO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for XPO1

genes like me logo Genes that share disorders with XPO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XPO1 Gene

Publications for XPO1 Gene

  1. Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. (PMID: 9368044) Kudo N … Horinouchi S (The Journal of biological chemistry 1997) 2 3 4 23 56
  2. CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. (PMID: 18316374) Cheong JK … Hsu SI (The Journal of biological chemistry 2008) 3 4 23 56
  3. Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo. (PMID: 15632073) Daelemans D … Pavlakis GN (Molecular and cellular biology 2005) 3 4 23 56
  4. Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. (PMID: 12724356) Thomas F … Kutay U (Journal of cell science 2003) 3 4 23 56
  5. A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. (PMID: 14612415) Hakata Y … Shida H (Molecular and cellular biology 2003) 3 4 23 56

Products for XPO1 Gene

Sources for XPO1 Gene