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Aliases for XPO1 Gene

Aliases for XPO1 Gene

  • Exportin 1 2 3 5
  • Chromosome Region Maintenance 1 Protein Homolog 3 4
  • Exportin 1 (CRM1 Homolog, Yeast) 2 3
  • Exp1 3 4
  • CRM1 3 4
  • Exportin-1 (Required For Chromosome Region Maintenance) 3
  • Chromosome Region Maintenance 1 Homolog (Yeast) 2
  • Chromosome Region Maintenance 1 Homolog 3
  • Exportin 1 (CRM1, Yeast, Homolog) 2
  • Exportin-1 3
  • Emb 3

External Ids for XPO1 Gene

Previous GeneCards Identifiers for XPO1 Gene

  • GC02M061833
  • GC02M061662
  • GC02M061679
  • GC02M061616
  • GC02M061704

Summaries for XPO1 Gene

Entrez Gene Summary for XPO1 Gene

  • This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

GeneCards Summary for XPO1 Gene

XPO1 (Exportin 1) is a Protein Coding gene. Diseases associated with XPO1 include Influenza and Mixed Malaria. Among its related pathways are Influenza Viral RNA Transcription and Replication and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include RNA binding and transporter activity.

UniProtKB/Swiss-Prot for XPO1 Gene

  • Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Gene Wiki entry for XPO1 Gene

Additional gene information for XPO1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPO1 Gene

Genomics for XPO1 Gene

GeneHancer (GH) Regulatory Elements for XPO1 Gene

Promoters and enhancers for XPO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I061534 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 582.1 +1.2 1236 5.2 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 XPO1 CCT4 USP34 AHSA2P ENSG00000232713 REL LOC339803 PAPOLG NONOP2 ENSG00000236498
GH02I061015 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.2 +520.7 520728 4.4 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PUS10 PEX13 AHSA2P USP34 CCT4 PAPOLG ENSG00000232713 ENSG00000236498 NONOP2 XPO1
GH02I062194 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.4 -659.1 -659061 7.1 HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 B3GNT2 XPO1 USP34 LOC105377633 MIR5192 GC02P062192 GC02M062151
GH02I062504 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.4 -967.5 -967458 2.3 HDGF PKNOX1 SMAD1 SIN3A YY1 POLR2B ZNF766 CBX5 ZNF263 SP3 TMEM17 RPL37P13 XPO1 ENSG00000226622 CCT4 ENSG00000236498 EHBP1 LOC100132215 OTX1 RN7SL18P
GH02I062320 Enhancer 0.9 ENCODE dbSUPER 37.5 -782.7 -782699 1.8 ZFP64 ZNF140 BATF ZNF697 ZNF664 RUNX3 ZBTB11 NR2F1 ZC3H11A REST XPO1 USP34 ENSG00000236498 B3GNT2 CCT4 GC02M062151 LOC105374761
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around XPO1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the XPO1 gene promoter:

Genomic Locations for XPO1 Gene

Genomic Locations for XPO1 Gene
chr2:61,477,849-61,538,626
(GRCh38/hg38)
Size:
60,778 bases
Orientation:
Minus strand
chr2:61,704,984-61,765,761
(GRCh37/hg19)

Genomic View for XPO1 Gene

Genes around XPO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XPO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XPO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XPO1 Gene

Proteins for XPO1 Gene

  • Protein details for XPO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14980-XPO1_HUMAN
    Recommended name:
    Exportin-1
    Protein Accession:
    O14980
    Secondary Accessions:
    • A6NL14
    • A8K1K5
    • D6W5E2
    • Q63HP8
    • Q68CP3
    • Q99433

    Protein attributes for XPO1 Gene

    Size:
    1071 amino acids
    Molecular mass:
    123386 Da
    Quaternary structure:
    • Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA (By similarity). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214, RANBP3 and TERT. Also found in complex with several viral proteins involved in RNAs nuclear export like HIV-1 Rev and HTLV-1 Rex. Interacts presumably with influenza A nucleoprotein. Interacts with Epstein-Barr virus BMLF1. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at Lys-129. Interacts with DTNBP1 and SERTAD2; the interactions translocate DTNBP1 and SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with CPEB3 (PubMed:22730302). Interacts with HAX1 (PubMed:23164465). Interacts with BOK; translocates to the cytoplasm (PubMed:16302269). Interacts with HSP90AB1 (PubMed:22022502).
    Miscellaneous:
    • Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor.

    Three dimensional structures from OCA and Proteopedia for XPO1 Gene

neXtProt entry for XPO1 Gene

Post-translational modifications for XPO1 Gene

  • Ubiquitination at posLast=5454, posLast=144144, isoforms=415, isoforms=455, posLast=479479, posLast=686686, and isoforms=693

No data available for DME Specific Peptides for XPO1 Gene

Domains & Families for XPO1 Gene

Gene Families for XPO1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for XPO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14980

UniProtKB/Swiss-Prot:

XPO1_HUMAN :
  • Belongs to the exportin family.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with XPO1: view

Function for XPO1 Gene

Molecular function for XPO1 Gene

GENATLAS Biochemistry:
exportin 1,CAN/NUP214 and NUP88 interacting protein CRM1,112kDa,cell-cycle regulated gene,expressed in nuclear pore complex and nucleoplasmin and essential mediator of the leucine-rich NES-dependent nuclear export of proteins,maybe involved in the leukemogenic effect of DEK-CAN and SET-CAN fusion chimeric proteins (forming a complex with EIF5A)
UniProtKB/Swiss-Prot Function:
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Phenotypes From GWAS Catalog for XPO1 Gene

Gene Ontology (GO) - Molecular Function for XPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005049 nuclear export signal receptor activity IMP 12724356
GO:0005215 transporter activity TAS --
GO:0005487 nuclear pore activity IMP 12773398
GO:0005515 protein binding IPI 10358091
genes like me logo Genes that share ontologies with XPO1: view
genes like me logo Genes that share phenotypes with XPO1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XPO1 Gene

Localization for XPO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XPO1 Gene

Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XPO1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nuclear membrane (4)
  • Nucleoplasm (4)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for XPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 17363900
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA --
GO:0005635 nuclear envelope TAS 9368044
GO:0005642 annulate lamellae IDA 12210765
genes like me logo Genes that share ontologies with XPO1: view

Pathways & Interactions for XPO1 Gene

genes like me logo Genes that share pathways with XPO1: view

SIGNOR curated interactions for XPO1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for XPO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000054 ribosomal subunit export from nucleus IMP 12724356
GO:0000055 ribosomal large subunit export from nucleus IMP 12773398
GO:0000056 ribosomal small subunit export from nucleus IMP 12773398
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006611 protein export from nucleus IMP,IDA 12773398
genes like me logo Genes that share ontologies with XPO1: view

Drugs & Compounds for XPO1 Gene

(13) Drugs for XPO1 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
KPT-185 Pharma CRM1 inhibitor,selective and irrversible 0
KPT-276 Pharma 0
KPT-330 Pharma 0
Verdinexor (KPT-335) Pharma 0

(4) Additional Compounds for XPO1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) ApexBio Compounds for XPO1 Gene

Compound Action Cas Number
KPT-185 CRM1 inhibitor,selective and irrversible 1333151-73-7
KPT-276 1421919-75-6
KPT-330 1393477-72-9
Verdinexor (KPT-335) 1392136-43-4
genes like me logo Genes that share compounds with XPO1: view

Drug Products

Transcripts for XPO1 Gene

Unigene Clusters for XPO1 Gene

Exportin 1 (CRM1 homolog, yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for XPO1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
SP1: - - - - - -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: - -
SP8: -
SP9:
SP10: - -
SP11: -

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for XPO1 Gene

GeneLoc Exon Structure for
XPO1
ECgene alternative splicing isoforms for
XPO1

Expression for XPO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XPO1 Gene

Protein differential expression in normal tissues from HIPED for XPO1 Gene

This gene is overexpressed in Bone (48.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for XPO1 Gene



Protein tissue co-expression partners for XPO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XPO1 Gene:

XPO1

SOURCE GeneReport for Unigene cluster for XPO1 Gene:

Hs.370770

mRNA Expression by UniProt/SwissProt for XPO1 Gene:

O14980-XPO1_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.

Evidence on tissue expression from TISSUES for XPO1 Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Lung(2.9)
  • Intestine(2.8)
  • Muscle(2.7)
  • Kidney(2.6)
  • Heart(2.4)
  • Blood(2.3)
  • Skin(2.3)
  • Bone marrow(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with XPO1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for XPO1 Gene

Orthologs for XPO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for XPO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia XPO1 33 34
  • 99.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia XPO1 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia XPO1 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XPO1 33 34
  • 94.37 (n)
cow
(Bos Taurus)
Mammalia XPO1 33 34
  • 93.65 (n)
mouse
(Mus musculus)
Mammalia Xpo1 33 16 34
  • 91.53 (n)
rat
(Rattus norvegicus)
Mammalia Xpo1 33
  • 89.57 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 91 (a)
OneToMany
XPO1 33 34
  • 86.9 (n)
lizard
(Anolis carolinensis)
Reptilia XPO1 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia xpo1 33
  • 81.89 (n)
Str.2050 33
African clawed frog
(Xenopus laevis)
Amphibia Xpo1 33
zebrafish
(Danio rerio)
Actinopterygii xpo1a 34
  • 88 (a)
OneToMany
xpo1b 33 34
  • 77.68 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6091 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009929 33
  • 63.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta emb 35 33 34
  • 63.02 (n)
worm
(Caenorhabditis elegans)
Secernentea xpo-1 33 34
  • 55.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRM1 33 34
  • 55.07 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16061g 33
  • 54.42 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL128C 33
  • 53.54 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons XPO1A 33
  • 56.44 (n)
rice
(Oryza sativa)
Liliopsida Os03g0858100 33
  • 56.65 (n)
Os.9258 33
barley
(Hordeum vulgare)
Liliopsida Hv.1208 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2375 34
  • 73 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes crm1 33
  • 59.23 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01820 33
  • 53.82 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5454 33
Species where no ortholog for XPO1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XPO1 Gene

ENSEMBL:
Gene Tree for XPO1 (if available)
TreeFam:
Gene Tree for XPO1 (if available)

Paralogs for XPO1 Gene

No data available for Paralogs for XPO1 Gene

Variants for XPO1 Gene

Sequence variations from dbSNP and Humsavar for XPO1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1057520009 likely-pathogenic, Colorectal Neoplasms, Adenocarcinoma of prostate, Malignant neoplasm of body of uterus, Neoplasm of the breast, Chronic lymphocytic leukemia 61,492,337(-) C/T coding_sequence_variant, missense_variant
rs1057520010 likely-pathogenic, Adenocarcinoma of prostate, Neoplasm of the breast, Chronic lymphocytic leukemia, Malignant neoplasm of body of uterus, Colorectal Neoplasms 61,492,336(-) T/A/G coding_sequence_variant, missense_variant
rs587778011 not-provided, not specified 61,492,797(-) T/C intron_variant
rs587778764 not-provided, not specified 61,493,980(-) A/G coding_sequence_variant, missense_variant
rs1000045662 -- 61,510,488(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for XPO1 Gene

Variant ID Type Subtype PubMed ID
esv2463303 CNV deletion 19546169
nsv1012689 CNV gain 25217958
nsv1014905 CNV gain 25217958
nsv1133471 CNV deletion 24896259
nsv582118 CNV gain 21841781
nsv582119 CNV loss 21841781
nsv582120 CNV loss 21841781
nsv7313 OTHER inversion 18451855
nsv953132 CNV deletion 24416366
nsv954194 CNV deletion 24416366
nsv9935 CNV loss 18304495
nsv9946 CNV gain+loss 18304495

Variation tolerance for XPO1 Gene

Residual Variation Intolerance Score: 3.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XPO1 Gene

Human Gene Mutation Database (HGMD)
XPO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
XPO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPO1 Gene

Disorders for XPO1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for XPO1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
mixed malaria
  • malaria by more than one parasite
tooth ankylosis
  • ankylosis of teeth
chromosome 2p16.1-p15 deletion syndrome
  • 2p15-p16.1 microdeletion syndrome
breast abscess
  • abscess of breast
- elite association - COSMIC cancer census association via MalaCards
Search XPO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for XPO1

genes like me logo Genes that share disorders with XPO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XPO1 Gene

Publications for XPO1 Gene

  1. Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. (PMID: 9368044) Kudo N … Horinouchi S (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. (PMID: 18316374) Cheong JK … Hsu SI (The Journal of biological chemistry 2008) 3 4 22 58
  3. Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo. (PMID: 15632073) Daelemans D … Pavlakis GN (Molecular and cellular biology 2005) 3 4 22 58
  4. A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. (PMID: 14612415) Hakata Y … Shida H (Molecular and cellular biology 2003) 3 4 22 58
  5. Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. (PMID: 12724356) Thomas F … Kutay U (Journal of cell science 2003) 3 4 22 58

Products for XPO1 Gene

Sources for XPO1 Gene

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