Aliases for XPNPEP2 Gene
External Ids for XPNPEP2 Gene
Previous GeneCards Identifiers for XPNPEP2 Gene
Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for XPNPEP2 Gene
XPNPEP2 (X-Prolyl Aminopeptidase 2) is a Protein Coding gene. Diseases associated with XPNPEP2 include Angioedema Induced By Ace Inhibitors and Angioedema. Among its related pathways are Metabolism of proteins and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include hydrolase activity and aminopeptidase activity. An important paralog of this gene is XPNPEP1.
UniProtKB/Swiss-Prot Summary for XPNPEP2 Gene
Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.