Aliases for XPNPEP1 Gene
Aliases for XPNPEP1 Gene
External Ids for XPNPEP1 Gene
- HGNC: 12822
- Entrez Gene: 7511
- Ensembl: ENSG00000108039
- OMIM: 602443
- UniProtKB: Q9NQW7
Previous HGNC Symbols for XPNPEP1 Gene
- XPNPEP
- XPNPEPL1
- XPNPEPL
Previous GeneCards Identifiers for XPNPEP1 Gene
- GC10M110517
- GC10M110858
- GC10M111755
- GC10M111289
- GC10M111614
- GC10M105255
Summaries for XPNPEP1 Gene
-
This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
GeneCards Summary for XPNPEP1 Gene
XPNPEP1 (X-Prolyl Aminopeptidase 1) is a Protein Coding gene. Diseases associated with XPNPEP1 include Mature Cataract and Biliary Atresia. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and manganese ion binding. An important paralog of this gene is XPNPEP2.
UniProtKB/Swiss-Prot for XPNPEP1 Gene
-
Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.
Additional gene information for XPNPEP1 Gene
- Monarch Initiative
- Search for XPNPEP1 at DataMed
- Search for XPNPEP1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XPNPEP1 Gene
Genomics for XPNPEP1 Gene
GeneHancer (GH) Regulatory Elements for XPNPEP1 Gene
Promoters and enhancers for XPNPEP1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10I109921 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE dbSUPER | 550.8 | +0.8 | 845 | 3.1 | ATF1 ARID4B SIN3A BRCA1 YY1 POLR2B ZNF207 ZNF143 ATF7 RUNX3 | XPNPEP1 ADD3-AS1 ADD3 RNU4-5P | |
| GH10I109924 | Enhancer | 0.4 | ENCODE dbSUPER | 550.8 | -1.0 | -1020 | 0 | XPNPEP1 ADD3-AS1 RNU4-5P ADD3 | ||
| GH10I109925 | Enhancer | 0.4 | ENCODE | 550.8 | -1.6 | -1638 | 0.7 | SCRT1 SCRT2 ZBTB20 | XPNPEP1 ADD3-AS1 RNU4-5P ADD3 | |
| GH10I110915 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE | 19.2 | -995.3 | -995251 | 5.9 | CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 | BBIP1 SHOC2 SMC3 SMNDC1 XPNPEP1 ENSG00000270589 ADRA2A PDCD4 | |
| GH10I110566 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 20.1 | -644.7 | -644711 | 4.5 | PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 | SMC3 LOC105378483 SMNDC1 XPNPEP1 ENSG00000270589 RBM20 GC10M110607 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around XPNPEP1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for XPNPEP1 Gene
Genomic Locations for XPNPEP1 Gene
- chr10:109,864,766-109,923,553
- (GRCh38/hg38)
- Size:
- 58,788 bases
- Orientation:
- Minus strand
- chr10:111,624,524-111,683,311
- (GRCh37/hg19)
Genomic View for XPNPEP1 Gene
Genes around XPNPEP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q25.1 by Ensembl
- 10q25.1 by Entrez Gene
- 10q25.1 by HGNC
XPNPEP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for XPNPEP1 Gene
Proteins for XPNPEP1 Gene
-
Protein details for XPNPEP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NQW7-XPP1_HUMAN
- Recommended name:
- Xaa-Pro aminopeptidase 1
- Protein Accession:
- Q9NQW7
- A8K071
- G5E9Y2
- G8JLB2
- O15250
- Q53EX6
- Q8N3Q0
- Q96D23
Protein attributes for XPNPEP1 Gene
- Size:
- 623 amino acids
- Molecular mass:
- 69918 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Homodimer.
- SequenceCaution:
-
- Sequence=CAD38640.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for XPNPEP1 Gene
Selected DME Specific Peptides for XPNPEP1 Gene
- Q9NQW7:
-
- DGTTDVTRT
- QGRQEALEWL
- TSELLRQLRQAMRN
- SGFDGSAG
- NLVDKIWTDRPERPCKPL
- NGAIIHY
- ALDEIAWL
- FGIRIENV
- DAHQSEYI
Post-translational modifications for XPNPEP1 Gene
- Ubiquitination at isoforms=2, 3, 4276
Other Protein References for XPNPEP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for XPNPEP1 (Aminopeptidase P1/XPNPEP1)
- Novus Biologicals Antibodies for XPNPEP1
- Invitrogen Antibodies for XPNPEP1
- Search GeneTex for Antibodies for XPNPEP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for XPNPEP1
Protein Products
- R&D Systems Proteins and Enzymes for XPNPEP1 (Aminopeptidase P1/XPNPEP1)
-
OriGene Purified Proteins for XPNPEP1
- Search Origene for MassSpec and Protein Over-expression Lysates for XPNPEP1
- Origene Custom Protein Services for XPNPEP1
- ProSpec Recombinant Proteins for XPNPEP1
- Search GeneTex for Proteins for XPNPEP1
-
ProSci Proteins for XPNPEP1
-
Abcam proteins for XPNPEP1
Assay Products
Domains & Families for XPNPEP1 Gene
Gene Families for XPNPEP1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for XPNPEP1 Gene
Suggested Antigen Peptide Sequences for XPNPEP1 Gene
- GenScript: Design optimal peptide antigens:
-
- X-prolyl aminopeptidase (Aminopeptidase P) 1, soluble (Q5T6G8_HUMAN)
- X-prolyl aminopeptidase (Aminopeptidase P) 1, soluble (Q5T6H1_HUMAN)
- X-prolyl aminopeptidase (Aminopeptidase P) 1, soluble (Q5T6H2_HUMAN)
- X-prolyl aminopeptidase (Aminopeptidase P) 1, soluble (Q5T6H3_HUMAN)
- X-prolyl aminopeptidase (Aminopeptidase P) 1, soluble (Q5T6H5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NQW7- Family:
-
- Belongs to the peptidase M24B family.
Function for XPNPEP1 Gene
Molecular function for XPNPEP1 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=100.6 uM for bradykinin {ECO:0000269 PubMed:11106490, ECO:0000269 PubMed:18515364}; KM=308 uM for the tripeptide Arg-Pro-Pro {ECO:0000269 PubMed:11106490, ECO:0000269 PubMed:18515364}; pH dependence: Optimum pH is 8.2. {ECO:0000269 PubMed:11106490, ECO:0000269 PubMed:18515364};
- UniProtKB/Swiss-Prot CatalyticActivity:
- Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by apstatin and the metal ion chelators EDTA and 1,10-phenanthroline. Partially inhibited by dithiothreitol. Not inhibited by enalaprilat or amastatin.
- UniProtKB/Swiss-Prot Function:
- Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.
Enzyme Numbers (IUBMB) for XPNPEP1 Gene
Phenotypes From GWAS Catalog for XPNPEP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004177 | aminopeptidase activity | IDA | 11106490 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008237 | metallopeptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0030145 | manganese ion binding | IDA | 18515364 |
Phenotypes for XPNPEP1 Gene
- MGI mutant phenotypes for XPNPEP1:
-
inferred from 2 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for XPNPEP1:
-
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased influenza A/WSN/33 replication
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
Animal Models for XPNPEP1 Gene
- MGI Knock Outs for XPNPEP1:
-
- Xpnpep1 tm1a(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for XPNPEP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for XPNPEP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XPNPEP1 gene
- Search ViGene Biosciences for XPNPEP1
CRISPR Products
-
OriGene CRISPR knockouts for XPNPEP1
- genomics-online: gRNA clones - Search results for available XPNPEP1 gene related products
- Applied Biological Materials CRISPR for XPNPEP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for XPNPEP1
- GenScript: Design CRISPR guide RNA sequences for XPNPEP1
miRNA for XPNPEP1 Gene
- miRTarBase miRNAs that target XPNPEP1
miRNA Products
- Search ViGene Biosciences for XPNPEP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for XPNPEP1
- Browse OriGene Inhibitory RNA Products For XPNPEP1
- genomics-online: shRNA clones - Search results for available XPNPEP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for XPNPEP1 gene
Clone Products
- Sino Biological Human cDNA Clone for XPNPEP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XPNPEP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XPNPEP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available XPNPEP1 gene related products
- orf clones - Search results for available XPNPEP1 gene related products
- Applied Biological Materials Clones for XPNPEP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for XPNPEP1
-
ViGene Biosciences adenoviral particle packaged cDNA for XPNPEP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for XPNPEP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XPNPEP1 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XPNPEP1 Gene
Localization for XPNPEP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for XPNPEP1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0070062 | extracellular exosome | IDA,HDA | 23376485 |
Pathways & Interactions for XPNPEP1 Gene
No Data Available
Interacting Proteins for XPNPEP1 Gene
Selected Interacting proteins:
ENSP00000421566
Q9NQW7-XPP1_HUMAN
for XPNPEP1 Gene via
STRING
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA,IDA | 11106490 |
| GO:0010815 | bradykinin catabolic process | IDA | 18515364 |
No data available for Pathways by source and SIGNOR curated interactions for XPNPEP1 Gene
Transcripts for XPNPEP1 Gene
mRNA/cDNA for XPNPEP1 Gene
- (13) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (425) Selected AceView cDNA sequences:
- (29) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for XPNPEP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for XPNPEP1
- genomics-online: gRNA clones - Search results for available XPNPEP1 gene related products
- Applied Biological Materials CRISPR for XPNPEP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for XPNPEP1
- GenScript: Design CRISPR guide RNA sequences for XPNPEP1
miRNA Products
- Search ViGene Biosciences for XPNPEP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for XPNPEP1
- Browse OriGene Inhibitory RNA Products For XPNPEP1
- genomics-online: shRNA clones - Search results for available XPNPEP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for XPNPEP1 gene
Clone Products
- Sino Biological Human cDNA Clone for XPNPEP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XPNPEP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XPNPEP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available XPNPEP1 gene related products
- orf clones - Search results for available XPNPEP1 gene related products
- Applied Biological Materials Clones for XPNPEP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | · | 18c | · | 18d | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||
| SP4: | |||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||
| SP7: | |||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||
| SP12: | - | - | |||||||||||||||||||||
| SP13: | - |
Expression for XPNPEP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
-
Hair
- Basal Keratinocytes Embryonic Epidermis
- Intestine (Gastrointestinal Tract)
This gene is overexpressed in Peripheral blood mononuclear cells (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for XPNPEP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of XPNPEP1 Gene:
XPNPEP1SOURCE GeneReport for Unigene cluster for XPNPEP1 Gene:
Hs.390623mRNA Expression by UniProt/SwissProt for XPNPEP1 Gene:
Q9NQW7-XPP1_HUMAN
Tissue specificity:
Expressed in all tissues tested, including pancreas, heart, muscle, kidney, liver, lung and brain. Highest levels in pancreas.
Evidence on tissue expression from TISSUES for XPNPEP1 Gene
- Nervous system(4.6)
- Blood(4.4)
- Liver(4.4)
- Intestine(2.7)
- Stomach(2.4)
- Bone marrow(2)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for XPNPEP1
-
OriGene qPCR primer pairs and template standards for XPNPEP1
- genomics-online: primer clones - Search results for available XPNPEP1 gene related products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for XPNPEP1 Gene
Orthologs for XPNPEP1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | XPNPEP1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | XPNPEP1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | XPNPEP1 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | XPNPEP1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Xpnpep1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Xpnpep1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | XPNPEP1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | XPNPEP1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | XPNPEP1 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | xpnpep1 33 34 |
|
||
| zgc56366 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9323 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001037 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | ApepP 35 33 34 |
|
||
| CG6225 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | app-1 33 34 |
|
||
| W03G9.4 35 |
|
|
|||
| Y45G5AM.2 35 |
|
|
|||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGL032C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FRA1 33 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F18128g 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | APP1 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.16537 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3027 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os11g0540100 33 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.3717 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.23391 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.8053 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4225 34 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU00112 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC22G7.01c 33 |
|
- Species where no ortholog for XPNPEP1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
Paralogs for XPNPEP1 Gene
(2) SIMAP similar genes for XPNPEP1 Gene using alignment to 5 proteins:
Variants for XPNPEP1 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000025674 | -- | 109,868,326(-) | G/C | intron_variant | |
| rs1000046369 | -- | 109,905,093(-) | A/C | intron_variant | |
| rs1000063193 | -- | 109,868,021(-) | C/T | intron_variant | |
| rs1000121621 | -- | 109,917,762(-) | G/T | intron_variant | |
| rs1000125487 | -- | 109,874,270(-) | A/G | intron_variant |
Residual Variation Intolerance Score:
7.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.73;
32.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for XPNPEP1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XPNPEP1 Gene
Disorders for XPNPEP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mature cataract |
|
|
| biliary atresia |
|
|
Search XPNPEP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for XPNPEP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for XPNPEP1 Gene
Publications for XPNPEP1 Gene
- Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit. (PMID: 18515364) Li X … Rao Z (The Journal of biological chemistry 2008) 2 3 4 22 58
- Cloning, chromosomal sublocalization of the human soluble aminopeptidase P gene (XPNPEP1) to 10q25.3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2. (PMID: 10871044) Sprinkle TJ … Ryan JW (Archives of biochemistry and biophysics 2000) 2 3 4 22 58
- Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme. (PMID: 11106490) Cottrell GS … Turner AJ (Biochemistry 2000) 3 4 22 58
- Isolation and sequence analysis of a human cDNA clone (XPNPEPL) homologous to X-prolyl aminopeptidase (aminopeptidase P). (PMID: 9465902) Vanhoof G … Scharpé S (Cytogenetics and cell genetics 1997) 3 4 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
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Sources for XPNPEP1 Gene
- (1) GeneCards
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