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This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009] See more...
Aliases for XPNPEP1 Gene
Aliases for XPNPEP1 Gene
External Ids for XPNPEP1 Gene
- HGNC: 12822
- NCBI Entrez Gene: 7511
- Ensembl: ENSG00000108039
- OMIM®: 602443
- UniProtKB/Swiss-Prot: Q9NQW7
Previous HGNC Symbols for XPNPEP1 Gene
- XPNPEP
- XPNPEPL1
- XPNPEPL
Previous GeneCards Identifiers for XPNPEP1 Gene
- GC10M110517
- GC10M110858
- GC10M111755
- GC10M111289
- GC10M111614
- GC10M105255
Summaries for XPNPEP1 Gene
-
This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
GeneCards Summary for XPNPEP1 Gene
XPNPEP1 (X-Prolyl Aminopeptidase 1) is a Protein Coding gene. Diseases associated with XPNPEP1 include Chicken Egg Allergy and Biliary Atresia. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and manganese ion binding. An important paralog of this gene is XPNPEP2.
UniProtKB/Swiss-Prot Summary for XPNPEP1 Gene
-
Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.
Additional gene information for XPNPEP1 Gene
- HGNC (12822)
- NCBI Entrez Gene (7511)
- Ensembl (ENSG00000108039)
- OMIM® (602443)
- UniProtKB/Swiss-Prot (Q9NQW7)
- Open Targets Platform(ENSG00000108039)
- Monarch Initiative
- Search for XPNPEP1 at DataMed
- Search for XPNPEP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for XPNPEP1 Gene
Genomics for XPNPEP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for XPNPEP1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10J109921 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 250.7 | +0.8 | 845 | 3.1 | TBP NR2C1 SMAD5 POLR2A BRCA1 ELF1 NONO ZNF610 THAP11 SIN3A | XPNPEP1 ADD3-AS1 ADD3 RNU4-5P lnc-SMNDC1-10 | |
| GH10J109925 | Enhancer | 0.3 | ENCODE | 250.7 | -1.6 | -1638 | 0.7 | SCRT1 ZBTB20 | XPNPEP1 ADD3-AS1 RNU4-5P piR-45035-031 ADD3 | |
| GH10J109924 | Enhancer | 0.3 | ENCODE dbSUPER | 250.7 | -1.0 | -1020 | 0 | XPNPEP1 ADD3-AS1 RNU4-5P piR-45035-031 ADD3 | ||
| GH10J109953 | Promoter | 0.3 | EPDnew | 250.3 | -30.4 | -30374 | 0.1 | XPNPEP1 piR-45035-031 ADD3 ADD3-AS1 | ||
| GH10J110644 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE dbSUPER | 31.8 | -722.5 | -722548 | 6.6 | ZSCAN16 TBP MNT IKZF1 ZEB1 CTCF ZIC2 ZNF623 REST VEZF1 | RBM20 SMC3 XPNPEP1 SMNDC1 ENSG00000270589 ADRA2A BBIP1 ADD3-AS1 ENSG00000223302 piR-38736-003 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around XPNPEP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for XPNPEP1
- Top Transcription factor binding sites by QIAGEN in the XPNPEP1 gene promoter:
-
- AP-4
- ATF-2
- CRE-BP1
- E47
- Evi-1
- Hlf
- HNF-4alpha1
- RP58
- Sox5
- Tal-1beta
Genomic Locations for XPNPEP1 Gene
Latest Assembly
- chr10:109,864,766-109,923,553
- (GRCh38/hg38)
- Size:
- 58,788 bases
- Orientation:
- Minus strand
Previous Assembly
- chr10:111,624,524-111,683,269
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 58,746 bases
- Orientation:
- Minus strand
- chr10:111,624,524-111,683,311
- (GRCh37/hg19 by Ensembl)
- Size:
- 58,788 bases
- Orientation:
- Minus strand
Genomic View for XPNPEP1 Gene
Genes around XPNPEP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q25.1 by HGNC
- 10q25.1 by Entrez Gene
- 10q25.1 by Ensembl
XPNPEP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for XPNPEP1 Gene
Proteins for XPNPEP1 Gene
-
Protein details for XPNPEP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NQW7-XPP1_HUMAN
- Recommended name:
- Xaa-Pro aminopeptidase 1
- Protein Accession:
- Q9NQW7
- A8K071
- G5E9Y2
- G8JLB2
- O15250
- Q53EX6
- Q8N3Q0
- Q96D23
Protein attributes for XPNPEP1 Gene
- Size:
- 623 amino acids
- Molecular mass:
- 69918 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Homodimer.
- SequenceCaution:
-
- Sequence=CAD38640.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for XPNPEP1 Gene
Selected DME Specific Peptides for XPNPEP1 Gene
- Q9NQW7:
-
- DGTTDVTRT
- QGRQEALEWL
- TSELLRQLRQAMRN
- SGFDGSAG
- NLVDKIWTDRPERPCKPL
- NGAIIHY
- ALDEIAWL
- FGIRIENV
- DAHQSEYI
Post-translational modifications for XPNPEP1 Gene
Other Protein References for XPNPEP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences XPNPEP1 / Aminopeptidase P Antibody
- Novus Biologicals Antibodies for XPNPEP1
- Invitrogen Antibodies for XPNPEP1 (AFLGC-Xpnpep1)
-
Boster Bio Antibodies for XPNPEP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for XPNPEP1
- Sino Biological Antibodies for XPNPEP1
Protein products for research
- G Biosciences Human Aminopeptidase P1/XPNPEP1, Liquid
- Search Origene for MassSpec and Protein Over-expression Lysates for XPNPEP1
- Origene Custom Protein Services for XPNPEP1
- ProSpec Recombinant Proteins for XPNPEP1
-
ProSci Proteins for XPNPEP1
-
Abcam proteins for XPNPEP1
Assay products for research
- RayBiotech Human Aminopeptidase P1 ELISA
Domains & Families for XPNPEP1 Gene
Gene Families for XPNPEP1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for XPNPEP1 Gene
Suggested Antigen Peptide Sequences for XPNPEP1 Gene
- GenScript: Design optimal peptide antigens:
-
- X-prolyl aminopeptidase (Aminopeptidase P) 1, soluble (Q5T6G8_HUMAN)
- X-prolyl aminopeptidase (Aminopeptidase P) 1, soluble (Q5T6H1_HUMAN)
- X-prolyl aminopeptidase (Aminopeptidase P) 1, soluble (Q5T6H2_HUMAN)
- X-prolyl aminopeptidase (Aminopeptidase P) 1, soluble (Q5T6H3_HUMAN)
- X-prolyl aminopeptidase (Aminopeptidase P) 1, soluble (Q5T6H5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NQW7- Family:
-
- Belongs to the peptidase M24B family.
Function for XPNPEP1 Gene
Molecular function for XPNPEP1 Gene
- UniProtKB/Swiss-Prot Function:
- Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.; EC=3.4.11.9; Evidence={ECO:0000269|PubMed:11106490, ECO:0000269|PubMed:18515364};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=100.6 uM for bradykinin {ECO:0000269|PubMed:11106490, ECO:0000269|PubMed:18515364}; KM=308 uM for the tripeptide Arg-Pro-Pro {ECO:0000269|PubMed:11106490, ECO:0000269|PubMed:18515364}; pH dependence: Optimum pH is 8.2. {ECO:0000269|PubMed:11106490, ECO:0000269|PubMed:18515364};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by apstatin and the metal ion chelators EDTA and 1,10-phenanthroline. Partially inhibited by dithiothreitol. Not inhibited by enalaprilat or amastatin.
Enzyme Numbers (IUBMB) for XPNPEP1 Gene
Phenotypes From GWAS Catalog for XPNPEP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004177 | aminopeptidase activity | TAS,IDA | 11106490 |
| GO:0005515 | protein binding | IPI | -- |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008237 | metallopeptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for XPNPEP1 Gene
- MGI mutant phenotypes for XPNPEP1:
-
inferred from 2 alleles
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cardiovascular system phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- renal/urinary system phenotype
- liver/biliary system phenotype
- hematopoietic system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- skeleton phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for XPNPEP1:
-
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- no effect
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased influenza A/WSN/33 replication
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Increased replication of vaccinia virus (VACV)
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
Animal Models for XPNPEP1 Gene
- MGI Knock Outs for XPNPEP1:
-
- Xpnpep1 Xpnpep1<tm1a(KOMP)Wtsi>
Animal Models for research
-
Taconic Biosciences Mouse Models for XPNPEP1
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for XPNPEP1 - Starting at $85 >
- * XPNPEP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for XPNPEP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for XPNPEP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for XPNPEP1
miRNA for XPNPEP1 Gene
- miRTarBase miRNAs that target XPNPEP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for XPNPEP1
- Browse OriGene Inhibitory RNA Products For XPNPEP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPNPEP1
Clone products for research
- Applied Biological Materials (abm): Clones for XPNPEP1 - Starting at $45 >
- * XPNPEP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for XPNPEP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for XPNPEP1
Cell Lines for research
-
Horizon Cell Lines for XPNPEP1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XPNPEP1 Gene
Localization for XPNPEP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for XPNPEP1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| lysosome | 1 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
Pathways & Interactions for XPNPEP1 Gene
Interacting Proteins for XPNPEP1 Gene
Selected Interacting proteins:
Q9NQW7-XPP1_HUMAN
ENSP00000421566
for XPNPEP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for XPNPEP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA,IDA | 11106490 |
| GO:0010815 | bradykinin catabolic process | IDA | 18515364 |
No data available for Pathways by source and SIGNOR curated interactions for XPNPEP1 Gene
Drugs & Compounds for XPNPEP1 Gene
Drug products for research
- G Biosciences Human Aminopeptidase P1/XPNPEP1, Liquid
Transcripts for XPNPEP1 Gene
mRNA/cDNA for XPNPEP1 Gene
- 9 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 29 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000322238 2467 nts (view in UCSC)
- ENST00000369658 881 nts (view in UCSC)
- ENST00000369683 2344 nts (view in UCSC)
- ENST00000403138 1006 nts (view in UCSC)
- ENST00000423625 712 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for XPNPEP1 - Starting at $85 >
- * XPNPEP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for XPNPEP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for XPNPEP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for XPNPEP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for XPNPEP1
- Browse OriGene Inhibitory RNA Products For XPNPEP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPNPEP1
Clone products for research
- Applied Biological Materials (abm): Clones for XPNPEP1 - Starting at $45 >
- * XPNPEP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for XPNPEP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for XPNPEP1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | · | 18c | · | 18d | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||
| SP4: | |||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||
| SP7: | |||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||
| SP12: | - | - | |||||||||||||||||||||
| SP13: | - |
Relevant External Links for XPNPEP1 Gene
- GeneLoc Exon Structure for
- XPNPEP1
Expression for XPNPEP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
-
Hair
- Basal Keratinocytes Embryonic Epidermis
- Intestine (Gastrointestinal Tract)
This gene is overexpressed in Peripheral blood mononuclear cells (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for XPNPEP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for XPNPEP1
SOURCE GeneReport for Unigene cluster for XPNPEP1 Gene:
Hs.390623mRNA Expression by UniProt/SwissProt for XPNPEP1 Gene:
Q9NQW7-XPP1_HUMAN
Tissue specificity:
Expressed in all tissues tested, including pancreas, heart, muscle, kidney, liver, lung and brain. Highest levels in pancreas.
Evidence on tissue expression from TISSUES for XPNPEP1 Gene
- Nervous system(4.6)
- Blood(4.5)
- Liver(4.4)
- Intestine(3)
- Stomach(2.8)
- Muscle(2.6)
- Skin(2.3)
- Bone marrow(2.3)
- Eye(2.2)
- Spleen(2.2)
- Lymph node(2.2)
- Kidney(2.1)
- Heart(2.1)
- Lung(2)
Primer products for research
-
OriGene qPCR primer pairs for XPNPEP1
-
OriGene qPCR primer pairs and template standards for XPNPEP1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for XPNPEP1 Gene
Orthologs for XPNPEP1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | XPNPEP1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | XPNPEP1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | XPNPEP1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | XPNPEP1 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Xpnpep1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Xpnpep1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | XPNPEP1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | XPNPEP1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | XPNPEP1 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | xpnpep1 30 31 |
|
OneToOne | |
| zgc56366 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9323 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001037 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | ApepP 30 31 32 |
|
OneToMany | |
| CG6225 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | app-1 30 31 |
|
ManyToMany | |
| W03G9.4 32 |
|
|
|||
| Y45G5AM.2 32 |
|
|
|||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGL032C 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FRA1 30 31 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F18128g 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | APP1 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3027 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.16537 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os11g0540100 30 |
|
||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.3717 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.23391 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.8053 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4225 31 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU00112 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC22G7.01c 30 |
|
- Species where no ortholog for XPNPEP1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
Evolution for XPNPEP1 Gene
- ENSEMBL:
- Gene Tree for XPNPEP1 (if available)
- TreeFam:
- Gene Tree for XPNPEP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for XPNPEP1: view image
Paralogs for XPNPEP1 Gene
Paralogs for XPNPEP1 Gene
(2) SIMAP similar genes for XPNPEP1 Gene using alignment to 5 proteins:
- XPP1_HUMAN
- G8JLB2_HUMAN
- Q5T6H2_HUMAN
- Q5T6H3_HUMAN
- Q5T6H7_HUMAN
Variants for XPNPEP1 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
7.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.73;
32.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for XPNPEP1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for XPNPEP1 Gene
Disorders for XPNPEP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chicken egg allergy |
|
|
| biliary atresia |
|
|
| gastrointestinal adenoma |
|
|
| mature cataract |
|
|
| jejunoileitis |
|
|
Search XPNPEP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for XPNPEP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for XPNPEP1 Gene
Publications for XPNPEP1 Gene
- Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit. (PMID: 18515364) Li X … Rao Z (The Journal of biological chemistry 2008) 2 3 4 23
- Cloning, chromosomal sublocalization of the human soluble aminopeptidase P gene (XPNPEP1) to 10q25.3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2. (PMID: 10871044) Sprinkle TJ … Ryan JW (Archives of biochemistry and biophysics 2000) 2 3 4 23
- Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme. (PMID: 11106490) Cottrell GS … Turner AJ (Biochemistry 2000) 3 4 23
- Isolation and sequence analysis of a human cDNA clone (XPNPEPL) homologous to X-prolyl aminopeptidase (aminopeptidase P). (PMID: 9465902) Vanhoof G … Scharpé S (Cytogenetics and cell genetics 1997) 3 4 23
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
ExternalLinks
Products for XPNPEP1 Gene
- View all 3 R&D Systems XPNPEP1 (Aminopeptidase P1/XPNPEP1) Products
- View all R&D Systems XPNPEP1 (Aminopeptidase P1/XPNPEP1) Proteins and Enzymes
- View all 2 R&D Systems XPNPEP1 (Aminopeptidase P1/XPNPEP1) Primary Antibodies
- Learn more about R&D Systems custom XPNPEP1 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for XPNPEP1
- Browse OriGene ELISA Kits
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- OriGene qPCR primer pairs and template standards for XPNPEP1
- OriGene CRISPR knockouts for XPNPEP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for XPNPEP1
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins and lysates for XPNPEP1
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- Taconic Biosciences Mouse Models for XPNPEP1
- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Invitrogen Antibodies for XPNPEP1 (AFLGC-Xpnpep1)
- VectorBuilder Custom and pre-made DNA vectors for XPNPEP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for XPNPEP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for XPNPEP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
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- VectorBuilder Stable cell line generation for XPNPEP1
- antibodies-online: Show 8 available XPNPEP1 Antibodies ranked by validation data
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- antibodies-online: Search results for available XPNPEP1 related products ranked by validation data
- antibodies-online: Show 9 available XPNPEP1 Proteins ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for XPNPEP1
- Search Santa Cruz Biotechnology (SCBT) for XPNPEP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for XPNPEP1
- Custom Antibody ServicesProSci Antibodies for XPNPEP1
- ProSci Proteins for XPNPEP1
- Horizon Cell Lines for XPNPEP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for XPNPEP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for XPNPEP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for XPNPEP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XPNPEP1
- Boster Bio Antibodies for XPNPEP1
- Browse Boster Bio ELISA Kits
Sources for XPNPEP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB