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This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
XPNPEP1 (X-Prolyl Aminopeptidase 1) is a Protein Coding gene. Diseases associated with XPNPEP1 include Chicken Egg Allergy and Biliary Atresia. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and manganese ion binding. An important paralog of this gene is XPNPEP2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10J109921 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 250.7 | +0.8 | 845 | 3.1 | TBP NR2C1 SMAD5 POLR2A BRCA1 ELF1 NONO ZNF610 THAP11 SIN3A | XPNPEP1 ADD3-AS1 ADD3 RNU4-5P lnc-SMNDC1-10 | |
GH10J109925 | Enhancer | 0.3 | ENCODE | 250.7 | -1.6 | -1638 | 0.7 | SCRT1 ZBTB20 | XPNPEP1 ADD3-AS1 RNU4-5P piR-45035-031 ADD3 | |
GH10J109924 | Enhancer | 0.3 | ENCODE dbSUPER | 250.7 | -1.0 | -1020 | 0 | XPNPEP1 ADD3-AS1 RNU4-5P piR-45035-031 ADD3 | ||
GH10J109953 | Promoter | 0.3 | EPDnew | 250.3 | -30.4 | -30374 | 0.1 | XPNPEP1 piR-45035-031 ADD3 ADD3-AS1 | ||
GH10J110644 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE dbSUPER | 31.8 | -722.5 | -722548 | 6.6 | ZSCAN16 TBP MNT IKZF1 ZEB1 CTCF ZIC2 ZNF623 REST VEZF1 | RBM20 SMC3 XPNPEP1 SMNDC1 ENSG00000270589 ADRA2A BBIP1 ADD3-AS1 ENSG00000223302 piR-38736-003 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004177 | aminopeptidase activity | TAS,IDA | 11106490 |
GO:0005515 | protein binding | IPI | -- |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008237 | metallopeptidase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | ISS | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0070062 | extracellular exosome | HDA | 23533145 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA,IDA | 11106490 |
GO:0010815 | bradykinin catabolic process | IDA | 18515364 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | · | 18c | · | 18d | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||
SP4: | |||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||
SP7: | |||||||||||||||||||||||
SP8: | |||||||||||||||||||||||
SP9: | |||||||||||||||||||||||
SP10: | |||||||||||||||||||||||
SP11: | |||||||||||||||||||||||
SP12: | - | - | |||||||||||||||||||||
SP13: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | XPNPEP1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | XPNPEP1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | XPNPEP1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | XPNPEP1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Xpnpep1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Xpnpep1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | XPNPEP1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | XPNPEP1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | XPNPEP1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | xpnpep1 30 31 |
|
OneToOne | |
zgc56366 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9323 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001037 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | ApepP 30 31 32 |
|
OneToMany | |
CG6225 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | app-1 30 31 |
|
ManyToMany | |
W03G9.4 32 |
|
|
|||
Y45G5AM.2 32 |
|
|
|||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGL032C 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FRA1 30 31 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F18128g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | APP1 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3027 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.16537 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os11g0540100 30 |
|
||
Barley (Hordeum vulgare) |
Liliopsida | Hv.3717 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.23391 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.8053 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4225 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU00112 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC22G7.01c 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
chicken egg allergy |
|
|
biliary atresia |
|
|
gastrointestinal adenoma |
|
|
mature cataract |
|
|
jejunoileitis |
|
|