Aliases for XPNPEP1 Gene
External Ids for XPNPEP1 Gene
Previous HGNC Symbols for XPNPEP1 Gene
Previous GeneCards Identifiers for XPNPEP1 Gene
This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
GeneCards Summary for XPNPEP1 Gene
XPNPEP1 (X-Prolyl Aminopeptidase 1) is a Protein Coding gene. Diseases associated with XPNPEP1 include Biliary Atresia and Parkinson Disease 4, Autosomal Dominant. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and manganese ion binding. An important paralog of this gene is XPNPEP2.
UniProtKB/Swiss-Prot Summary for XPNPEP1 Gene
Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.