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Aliases for XKRX Gene

Aliases for XKRX Gene

  • XK Related, X-Linked 2 3 5
  • XK, Kell Blood Group Complex Subunit-Related, X-Linked 2 3
  • X Kell Blood Group Precursor-Related, X-Linked 2 3
  • Membrane Protein XPLAC 3 4
  • XPLAC 3 4
  • XKR2 3 4
  • XRG2 3 4
  • X-Linked Kx Blood Group Related, X-Linked 3
  • X Kell Blood Group-Related, X-Linked 4
  • XK-Related Protein 2 3

External Ids for XKRX Gene

Previous GeneCards Identifiers for XKRX Gene

  • GC0XM098942
  • GC0XM099974
  • GC0XM100055
  • GC0XM100168
  • GC0XM089966
  • GC0XM100913
  • GC0XM100890
  • GC0XM100892
  • GC0XM100894
  • GC0XM100895
  • GC0XM100896
  • GC0XM100897

Summaries for XKRX Gene

Entrez Gene Summary for XKRX Gene

  • This gene encodes a protein that is related to a component of the XK/Kell complex of the Kell blood group system. The encoded protein includes several transmembrane domains, is known to be exposed to the cell surface, and may function as a membrane transporter. [provided by RefSeq, May 2010]

GeneCards Summary for XKRX Gene

XKRX (XK Related, X-Linked) is a Protein Coding gene. An important paralog of this gene is XKR3.

Additional gene information for XKRX Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKRX Gene

Genomics for XKRX Gene

GeneHancer (GH) Regulatory Elements for XKRX Gene

Promoters and enhancers for XKRX Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI100927 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.3 +28.6 28598 2 NFIB ZFP64 MAX ZNF335 ZFHX2 EGR1 PATZ1 ZNF143 PRDM10 RUNX3 XKRX PIR43386 LOC286453
GH0XI100993 Enhancer 1.1 Ensembl ENCODE 6.8 -37.8 -37815 4.2 HDAC1 PKNOX1 BATF RAD21 BRCA1 RFX5 TCF12 EGR1 RCOR1 FOS TRMT2B XKRX ARL13A
GH0XI100895 Enhancer 0.5 ENCODE 12.4 +61.4 61429 0.4 SOX5 SOX13 CTCF FOXA2 SCRT2 XKRX GC0XP100905 GC0XM100886
GH0XI100931 Enhancer 0.6 ENCODE 0.3 +25.5 25517 0.9 PKNOX1 BCL11A IKZF1 CREB1 BATF ATF2 RUNX3 SPI1 PIR43386 LOC286453 XKRX
GH0XI100939 Enhancer 0.3 ENCODE 0.4 +17.8 17838 0.5 USF1 LOC100132658 PIR43386 XKRX LOC286453
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around XKRX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the XKRX gene promoter:

Genomic Locations for XKRX Gene

Genomic Locations for XKRX Gene
70,478 bases
Minus strand

Genomic View for XKRX Gene

Genes around XKRX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XKRX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XKRX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKRX Gene

Proteins for XKRX Gene

  • Protein details for XKRX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    XK-related protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RNN6
    • B4DKU2
    • Q5H9J6

    Protein attributes for XKRX Gene

    449 amino acids
    Molecular mass:
    52052 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI37011.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI37012.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAT00456.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAT07088.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for XKRX Gene


neXtProt entry for XKRX Gene

Post-translational modifications for XKRX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XKRX Gene

No data available for DME Specific Peptides for XKRX Gene

Domains & Families for XKRX Gene

Gene Families for XKRX Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for XKRX Gene


Suggested Antigen Peptide Sequences for XKRX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the XK family.
  • Belongs to the XK family.
genes like me logo Genes that share domains with XKRX: view

Function for XKRX Gene

genes like me logo Genes that share phenotypes with XKRX: view

Animal Models for XKRX Gene

MGI Knock Outs for XKRX:
  • Xkrx tm1b(EUCOMM)Wtsi

Animal Model Products

CRISPR Products

miRNA for XKRX Gene

miRTarBase miRNAs that target XKRX

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XKRX Gene

Localization for XKRX Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKRX Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XKRX gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for XKRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XKRX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for XKRX Gene

Pathways & Interactions for XKRX Gene

No Data Available

Interacting Proteins for XKRX Gene

Selected Interacting proteins: Q6PP77-XKR2_HUMAN for XKRX Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for XKRX Gene


No data available for Pathways by source and SIGNOR curated interactions for XKRX Gene

Drugs & Compounds for XKRX Gene

No Compound Related Data Available

Transcripts for XKRX Gene

mRNA/cDNA for XKRX Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XKRX Gene

XK, Kell blood group complex subunit-related, X-linked:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for XKRX Gene

No ASD Table

Relevant External Links for XKRX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XKRX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XKRX Gene

mRNA differential expression in normal tissues according to GTEx for XKRX Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.4) and Skin - Not Sun Exposed (Suprapubic) (x11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for XKRX Gene

NURSA nuclear receptor signaling pathways regulating expression of XKRX Gene:


SOURCE GeneReport for Unigene cluster for XKRX Gene:


mRNA Expression by UniProt/SwissProt for XKRX Gene:

Tissue specificity: Expressed predominantly in the placenta, in syncytiotrophoblasts. Moderate levels in the adrenal gland, low levels in the trachea and very low levels in the bone marrow.

Evidence on tissue expression from TISSUES for XKRX Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with XKRX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for XKRX Gene

Orthologs for XKRX Gene

This gene was present in the common ancestor of chordates.

Orthologs for XKRX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia XKRX 33 34
  • 100 (n)
(Canis familiaris)
Mammalia XKRX 33 34
  • 93.24 (n)
(Bos Taurus)
Mammalia XKRX 33 34
  • 91.54 (n)
(Mus musculus)
Mammalia Xkrx 33 16 34
  • 90.57 (n)
(Rattus norvegicus)
Mammalia Xkrx 33
  • 90.48 (n)
(Monodelphis domestica)
Mammalia XKRX 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
(Gallus gallus)
Aves XKRX 33
  • 59.63 (n)
-- 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia xkrx 33
  • 58.33 (n)
(Danio rerio)
Actinopterygii xkrx 33 34
  • 55.25 (n)
Species where no ortholog for XKRX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XKRX Gene

Gene Tree for XKRX (if available)
Gene Tree for XKRX (if available)

Paralogs for XKRX Gene

Paralogs for XKRX Gene

(4) SIMAP similar genes for XKRX Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with XKRX: view

Variants for XKRX Gene

Sequence variations from dbSNP and Humsavar for XKRX Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000071282 -- 100,907,201(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000125753 -- 100,908,765(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000130675 -- 100,892,826(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000136736 -- 100,897,303(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000243631 -- 100,917,690(-) G/A/T intron_variant

Variation tolerance for XKRX Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XKRX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for XKRX Gene

Disorders for XKRX Gene

Additional Disease Information for XKRX

No disorders were found for XKRX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XKRX Gene

Publications for XKRX Gene

  1. Identification of two new members, XPLAC and XTES, of the XK family. (PMID: 16431037) Calenda G … Lee S (Gene 2006) 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for XKRX Gene

Sources for XKRX Gene

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