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Aliases for XKR6 Gene

Aliases for XKR6 Gene

  • XK Related 6 2 3 5
  • XK, Kell Blood Group Complex Subunit-Related Family, Member 6 2 3
  • X Kell Blood Group Precursor-Related Family, Member 6 2 3
  • C8orf21 3 4
  • C8orf5 3 4
  • C8orf7 3 4
  • XRG6 3 4
  • Chromosome 8 Open Reading Frame 21 2
  • Chromosome 8 Open Reading Frame 7 2
  • Chromosome 8 Open Reading Frame 5 2
  • X-Linked Kx Blood Group Related 6 3
  • Transmembrane Protein C8orf5 3
  • XK-Related Protein 6 3

External Ids for XKR6 Gene

Previous HGNC Symbols for XKR6 Gene

  • C8orf7
  • C8orf21
  • C8orf5

Previous GeneCards Identifiers for XKR6 Gene

  • GC08M010794
  • GC08M009683

Summaries for XKR6 Gene

GeneCards Summary for XKR6 Gene

XKR6 (XK Related 6) is a Protein Coding gene. Diseases associated with XKR6 include Keratolytic Winter Erythema. An important paralog of this gene is XKR4.

Additional gene information for XKR6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKR6 Gene

Genomics for XKR6 Gene

GeneHancer (GH) Regulatory Elements for XKR6 Gene

Promoters and enhancers for XKR6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I011199 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 617 3.4 HDGF PKNOX1 GLI4 ZNF2 YY1 GLIS2 ZNF213 ELK1 ZNF143 ZNF207 GC08P011201 XKR6 PINX1 LOC101929290 ENSG00000254936 ENSG00000269918 GC08M011176
GH08I011092 Enhancer 0.8 Ensembl 11.1 +108.8 108780 0.4 FOXA2 BACH1 SIN3A KMT2B THRB ZSCAN9 RARA ZNF766 GATAD1 ZNF143 LOC101929269 XKR6 ENSG00000254936 ENSG00000269918
GH08I011455 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.3 -256.1 -256056 3.1 HDGF PKNOX1 FOXA2 SMAD1 SIN3A ZNF2 IRF4 GLIS2 ZNF143 ATF7 FAM167A BLK LOC105379241 ENSG00000255354 ENSG00000255518 ENSG00000255310 XKR6 MTMR9 PIR35143
GH08I011178 Enhancer 0.3 FANTOM5 14.3 +22.4 22432 0.2 ZNF600 XKR6 ENSG00000254936 MTMR9 RPL17P29 GC08M011176
GH08I011138 Enhancer 0.4 ENCODE 10.3 +62.0 62004 1.1 CTCF POLR2A RCOR1 ENSG00000254556 LOC105379241 XKR6 ENSG00000255518 RPL17P29
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around XKR6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the XKR6 gene promoter:

Genomic Locations for XKR6 Gene

Genomic Locations for XKR6 Gene
305,337 bases
Minus strand

Genomic View for XKR6 Gene

Genes around XKR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XKR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XKR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKR6 Gene

Proteins for XKR6 Gene

  • Protein details for XKR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    XK-related protein 6
    Protein Accession:
    Secondary Accessions:
    • Q8TBA0

    Protein attributes for XKR6 Gene

    641 amino acids
    Molecular mass:
    71638 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for XKR6 Gene


neXtProt entry for XKR6 Gene

Post-translational modifications for XKR6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XKR6 Gene

No data available for DME Specific Peptides for XKR6 Gene

Domains & Families for XKR6 Gene

Gene Families for XKR6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for XKR6 Gene


Suggested Antigen Peptide Sequences for XKR6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the XK family.
  • Belongs to the XK family.
genes like me logo Genes that share domains with XKR6: view

Function for XKR6 Gene

Phenotypes From GWAS Catalog for XKR6 Gene

genes like me logo Genes that share phenotypes with XKR6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XKR6 Gene

Localization for XKR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKR6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XKR6 gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for XKR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XKR6: view

Pathways & Interactions for XKR6 Gene

No Data Available

Interacting Proteins for XKR6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q5GH73-XKR6_HUMAN ENSP00000416707 for XKR6 Gene via IID STRING

Gene Ontology (GO) - Biological Process for XKR6 Gene


No data available for Pathways by source and SIGNOR curated interactions for XKR6 Gene

Drugs & Compounds for XKR6 Gene

No Compound Related Data Available

Transcripts for XKR6 Gene

mRNA/cDNA for XKR6 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XKR6 Gene

XK, Kell blood group complex subunit-related family, member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for XKR6 Gene

No ASD Table

Relevant External Links for XKR6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XKR6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XKR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XKR6 Gene

This gene is overexpressed in Testis (x4.3).

Protein differential expression in normal tissues from HIPED for XKR6 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for XKR6 Gene

Protein tissue co-expression partners for XKR6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XKR6 Gene:


SOURCE GeneReport for Unigene cluster for XKR6 Gene:

genes like me logo Genes that share expression patterns with XKR6: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XKR6 Gene

Orthologs for XKR6 Gene

This gene was present in the common ancestor of animals.

Orthologs for XKR6 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia XKR6 34
  • 96 (a)
(Bos Taurus)
Mammalia XKR6 33 34
  • 95.66 (n)
(Canis familiaris)
Mammalia XKR6 33 34
  • 95.46 (n)
(Pan troglodytes)
Mammalia XKR6 33
  • 93.22 (n)
XKR5 34
  • 18 (a)
(Mus musculus)
Mammalia Xkr6 33 16 34
  • 92.62 (n)
(Rattus norvegicus)
Mammalia Xkr6 33
  • 92.52 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 12 (a)
(Gallus gallus)
Aves XKR6 33 34
  • 87.06 (n)
(Anolis carolinensis)
Reptilia XKR6 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia xkr6 33
  • 80.19 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17018 33
(Danio rerio)
Actinopterygii XKR6 (1 of 2) 34
  • 78 (a)
xkr6 33 34
  • 71.99 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000599 33
  • 46.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32579 33 34
  • 38.1 (n)
(Caenorhabditis elegans)
Secernentea ced-8 33 34
  • 42 (n)
Species where no ortholog for XKR6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XKR6 Gene

Gene Tree for XKR6 (if available)
Gene Tree for XKR6 (if available)

Paralogs for XKR6 Gene

Paralogs for XKR6 Gene

(3) SIMAP similar genes for XKR6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with XKR6: view

Variants for XKR6 Gene

Sequence variations from dbSNP and Humsavar for XKR6 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000005280 -- 11,021,239(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000009708 -- 10,964,509(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000019071 -- 11,108,952(-) C/T genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000020513 -- 10,975,197(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000024177 -- 11,112,665(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for XKR6 Gene

Variant ID Type Subtype PubMed ID
dgv448n21 CNV loss 19592680
dgv7011n100 CNV gain 25217958
dgv7013n100 CNV loss 25217958
esv1006630 CNV insertion 20482838
esv1732990 CNV insertion 17803354
esv1926132 CNV deletion 18987734
esv2147573 CNV deletion 18987734
esv25007 CNV gain 19812545
esv2506669 CNV insertion 19546169
esv2667237 CNV deletion 23128226
esv275517 CNV gain+loss 21479260
esv3447417 CNV duplication 20981092
esv3572511 CNV loss 25503493
esv3616235 CNV loss 21293372
esv3616237 CNV loss 21293372
esv3616238 CNV loss 21293372
esv3616240 CNV loss 21293372
nsv1019796 CNV gain 25217958
nsv1022434 CNV gain 25217958
nsv1027845 CNV gain 25217958
nsv1077515 CNV duplication 25765185
nsv1119167 CNV deletion 24896259
nsv1137609 CNV deletion 24896259
nsv397981 CNV deletion 16902084
nsv516033 CNV loss 19592680
nsv519941 CNV loss 19592680
nsv521721 CNV loss 19592680
nsv522127 CNV loss 19592680
nsv831232 CNV loss 17160897
nsv831233 CNV gain 17160897

Variation tolerance for XKR6 Gene

Residual Variation Intolerance Score: 8.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XKR6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XKR6 Gene

Disorders for XKR6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for XKR6 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
keratolytic winter erythema
  • kwe
- elite association - COSMIC cancer census association via MalaCards
Search XKR6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for XKR6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with XKR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XKR6 Gene

Publications for XKR6 Gene

  1. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PMID: 20962850) Budarf ML … Rioux JD (Genes and immunity 2011) 3 44 58
  2. Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. (PMID: 20160193) Weissglas-Volkov D … Pajukanta P (Circulation. Cardiovascular genetics 2010) 3 44 58
  3. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S … Cupples LA (Nature genetics 2009) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. (PMID: 24388013) Ferreira MA … Australian Asthma Genetics Consortium Collaborators (The Journal of allergy and clinical immunology 2014) 3 58

Products for XKR6 Gene

Sources for XKR6 Gene

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