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Aliases for XKR4 Gene

Aliases for XKR4 Gene

  • XK Related 4 2 3 5
  • XK, Kell Blood Group Complex Subunit-Related Family, Member 4 2 3
  • X Kell Blood Group Precursor-Related Family, Member 4 2 3
  • XRG4 3 4
  • X-Linked Kx Blood Group Related 4 3
  • XK-Related Protein 4 3
  • KIAA1889 4

External Ids for XKR4 Gene

Previous GeneCards Identifiers for XKR4 Gene

  • GC08P056178
  • GC08P056015
  • GC08P051483

Summaries for XKR4 Gene

GeneCards Summary for XKR4 Gene

XKR4 (XK Related 4) is a Protein Coding gene. An important paralog of this gene is XKR6.

Additional gene information for XKR4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XKR4 Gene

Genomics for XKR4 Gene

GeneHancer (GH) Regulatory Elements for XKR4 Gene

Promoters and enhancers for XKR4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I055100 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 -0.2 -165 2.5 ELF3 ARID4B SIN3A DNMT3B ZNF48 ZSCAN9 RARA ETS1 SLC30A9 ZNF335 XKR4 GC08P055061
GH08I055441 Enhancer 0.2 FANTOM5 6 +339.2 339225 0.3 XKR4 SBF1P1 GC08M055302
GH08I055369 Enhancer 0.3 FANTOM5 3 +267.2 267150 0.1 XKR4 GC08M055302 GC08P055254
GH08I055156 Enhancer 0.2 FANTOM5 3.5 +54.1 54096 0.3 XKR4 LOC105375844 ENSG00000253976
GH08I055439 Enhancer 0.2 FANTOM5 2.7 +337.6 337567 0 XKR4 SBF1P1 GC08M055302
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around XKR4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the XKR4 gene promoter:

Genomic Locations for XKR4 Gene

Genomic Locations for XKR4 Gene
439,666 bases
Plus strand

Genomic View for XKR4 Gene

Genes around XKR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XKR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XKR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XKR4 Gene

Proteins for XKR4 Gene

  • Protein details for XKR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    XK-related protein 4
    Protein Accession:
    Secondary Accessions:
    • Q96PZ8

    Protein attributes for XKR4 Gene

    650 amino acids
    Molecular mass:
    71501 Da
    Quaternary structure:
    No Data Available

neXtProt entry for XKR4 Gene

Post-translational modifications for XKR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for XKR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XKR4 Gene

Domains & Families for XKR4 Gene

Gene Families for XKR4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for XKR4 Gene


Suggested Antigen Peptide Sequences for XKR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the XK family.
  • Belongs to the XK family.
genes like me logo Genes that share domains with XKR4: view

Function for XKR4 Gene

Phenotypes From GWAS Catalog for XKR4 Gene

genes like me logo Genes that share phenotypes with XKR4: view

Animal Model Products

miRNA for XKR4 Gene

miRTarBase miRNAs that target XKR4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XKR4 Gene

Localization for XKR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XKR4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XKR4 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for XKR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XKR4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for XKR4 Gene

Pathways & Interactions for XKR4 Gene

No Data Available

Interacting Proteins for XKR4 Gene

Selected Interacting proteins: Q5GH76-XKR4_HUMAN for XKR4 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for XKR4 Gene


No data available for Pathways by source and SIGNOR curated interactions for XKR4 Gene

Drugs & Compounds for XKR4 Gene

No Compound Related Data Available

Transcripts for XKR4 Gene

mRNA/cDNA for XKR4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XKR4 Gene

XK, Kell blood group complex subunit-related family, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for XKR4 Gene

No ASD Table

Relevant External Links for XKR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XKR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XKR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XKR4 Gene

This gene is overexpressed in Nerve - Tibial (x5.5).

Protein differential expression in normal tissues from HIPED for XKR4 Gene

This gene is overexpressed in Brain (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for XKR4 Gene

Protein tissue co-expression partners for XKR4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XKR4 Gene:


SOURCE GeneReport for Unigene cluster for XKR4 Gene:


Evidence on tissue expression from TISSUES for XKR4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with XKR4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for XKR4 Gene

Orthologs for XKR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for XKR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia XKR4 33 34
  • 99.54 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 96 (a)
-- 34
  • 85 (a)
(Canis familiaris)
Mammalia XKR4 33 34
  • 93.75 (n)
(Mus musculus)
Mammalia Xkr4 33 16 34
  • 90.93 (n)
(Rattus norvegicus)
Mammalia Xkr4 33
  • 90.67 (n)
(Bos Taurus)
Mammalia XKR4 33 34
  • 88.91 (n)
(Ornithorhynchus anatinus)
Mammalia XKR4 34
  • 61 (a)
(Gallus gallus)
Aves LOC100858171 33
  • 84.18 (n)
-- 34
  • 26 (a)
(Anolis carolinensis)
Reptilia XKR4 34
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia xkr4 33
  • 77.78 (n)
(Danio rerio)
Actinopterygii zgc:123035 33 34
  • 73.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32579 34
  • 20 (a)
(Caenorhabditis elegans)
Secernentea ced-8 34
  • 22 (a)
Species where no ortholog for XKR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for XKR4 Gene

Gene Tree for XKR4 (if available)
Gene Tree for XKR4 (if available)

Paralogs for XKR4 Gene

Paralogs for XKR4 Gene

(2) SIMAP similar genes for XKR4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XKR4: view

Variants for XKR4 Gene

Sequence variations from dbSNP and Humsavar for XKR4 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000003736 -- 55,145,258(+) A/G intron_variant
rs1000011549 -- 55,501,325(+) C/T intron_variant
rs1000025709 -- 55,500,482(+) A/G intron_variant
rs1000027054 -- 55,345,658(+) C/T intron_variant
rs1000039210 -- 55,352,433(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for XKR4 Gene

Variant ID Type Subtype PubMed ID
dgv1287e199 CNV deletion 23128226
dgv3826n106 CNV deletion 24896259
dgv7227n100 CNV gain 25217958
esv1014449 CNV deletion 17803354
esv1133504 CNV deletion 17803354
esv2060022 CNV deletion 18987734
esv2575236 CNV deletion 19546169
esv2663524 CNV deletion 23128226
esv2668736 CNV deletion 23128226
esv2677140 CNV deletion 23128226
esv2737012 CNV deletion 23290073
esv2737013 CNV deletion 23290073
esv2737014 CNV deletion 23290073
esv2761178 CNV loss 21179565
esv2761201 CNV gain 21179565
esv3272274 CNV deletion 24192839
esv3303645 CNV mobile element insertion 20981092
esv3543517 CNV deletion 23714750
esv3543518 CNV deletion 23714750
esv3543523 CNV deletion 23714750
esv3572771 CNV loss 25503493
esv3572772 CNV loss 25503493
esv3617273 CNV loss 21293372
esv3617274 CNV loss 21293372
esv3617275 CNV loss 21293372
esv3617276 CNV loss 21293372
esv3617277 CNV loss 21293372
esv3617279 CNV loss 21293372
esv3617280 CNV loss 21293372
esv4576 CNV loss 18987735
esv5044 CNV loss 18987735
esv7601 CNV loss 19470904
nsv1074256 CNV deletion 25765185
nsv1077046 CNV deletion 25765185
nsv1119179 CNV deletion 24896259
nsv1147626 CNV deletion 26484159
nsv398441 CNV deletion 16902084
nsv516136 CNV gain+loss 19592680
nsv525982 CNV loss 19592680
nsv611390 CNV loss 21841781
nsv611391 CNV loss 21841781
nsv6198 CNV deletion 18451855
nsv8348 CNV loss 18304495
nsv951431 CNV deletion 24416366
nsv957683 CNV deletion 24416366

Variation tolerance for XKR4 Gene

Residual Variation Intolerance Score: 5.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XKR4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XKR4 Gene

Disorders for XKR4 Gene

Additional Disease Information for XKR4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for XKR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XKR4 Gene

Publications for XKR4 Gene

  1. Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. (PMID: 18521090) Lavedan C … Polymeropoulos MH (Molecular psychiatry 2009) 3 22 44 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia. (PMID: 19573479) Volpi S … Lavedan C (The Journal of clinical psychiatry 2009) 3 44 58
  4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58

Products for XKR4 Gene

Sources for XKR4 Gene

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