Aliases for XCR1 Gene
External Ids for XCR1 Gene
Previous HGNC Symbols for XCR1 Gene
Previous GeneCards Identifiers for XCR1 Gene
The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2020]
GeneCards Summary for XCR1 Gene
XCR1 (X-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with XCR1 include Leber Plus Disease. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR4.
UniProtKB/Swiss-Prot Summary for XCR1 Gene
Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.