Free for academic non-profit institutions. Other users need a Commercial license

Aliases for XCR1 Gene

Aliases for XCR1 Gene

  • X-C Motif Chemokine Receptor 1 2 3 5
  • Chemokine (C Motif) XC Receptor 1 2 3
  • Chemokine (C Motif) Receptor 1 2 3
  • XC Chemokine Receptor 1 3 4
  • Lymphotactin Receptor 3 4
  • CCXCR1 3 4
  • GPR5 3 4
  • G Protein-Coupled Receptor 5 3
  • G-Protein Coupled Receptor 5 4
  • Chemokine XC Receptor 1 3

External Ids for XCR1 Gene

Previous HGNC Symbols for XCR1 Gene

  • GPR5
  • CCXCR1

Previous GeneCards Identifiers for XCR1 Gene

  • GC03M045303
  • GC03M045881
  • GC03M046023

Summaries for XCR1 Gene

Entrez Gene Summary for XCR1 Gene

  • The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for XCR1 Gene

XCR1 (X-C Motif Chemokine Receptor 1) is a Protein Coding gene. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is ACKR2.

UniProtKB/Swiss-Prot for XCR1 Gene

  • Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.

Gene Wiki entry for XCR1 Gene

Additional gene information for XCR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XCR1 Gene

Genomics for XCR1 Gene

GeneHancer (GH) Regulatory Elements for XCR1 Gene

Promoters and enhancers for XCR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I046027 Promoter 0.5 EPDnew 550.8 0.0 -20 0.1 XCR1 LOC105377066
GH03I046028 Promoter 0.5 EPDnew 550.8 +0.1 92 0.1 XCR1 NRBF2P2
GH03I046973 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 -950.7 -950683 9.7 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B NBEAL2 CCDC12 FYCO1 SCAP XCR1 PTH1R BOLA2P2 GC03P046964
GH03I045387 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.3 +638.9 638852 2.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 LARS2 LIMD1 FYCO1 XCR1 LARS2-AS1
GH03I045117 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +904.8 904753 10.7 HDGF PKNOX1 ARNT SIN3A ATF7 FOS ZNF623 ZNF592 ATF4 GMEB1 RN7SL145P ZNF852 LIMD1 ZNF502 ZNF445 TMEM158 ZNF197 FYCO1 CDCP1 RNU5B-3P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around XCR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the XCR1 gene promoter:

Genomic Locations for XCR1 Gene

Genomic Locations for XCR1 Gene
10,719 bases
Minus strand

Genomic View for XCR1 Gene

Genes around XCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XCR1 Gene

Proteins for XCR1 Gene

  • Protein details for XCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chemokine XC receptor 1
    Protein Accession:

    Protein attributes for XCR1 Gene

    333 amino acids
    Molecular mass:
    38508 Da
    Quaternary structure:
    No Data Available

neXtProt entry for XCR1 Gene

Post-translational modifications for XCR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for XCR1 Gene

Domains & Families for XCR1 Gene

Gene Families for XCR1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for XCR1 Gene

Suggested Antigen Peptide Sequences for XCR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with XCR1: view

Function for XCR1 Gene

Molecular function for XCR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.

Phenotypes From GWAS Catalog for XCR1 Gene

Gene Ontology (GO) - Molecular Function for XCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004950 chemokine receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with XCR1: view
genes like me logo Genes that share phenotypes with XCR1: view

Animal Models for XCR1 Gene

MGI Knock Outs for XCR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for XCR1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for XCR1 Gene

Localization for XCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for XCR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XCR1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for XCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9632725
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with XCR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for XCR1 Gene

Pathways & Interactions for XCR1 Gene

genes like me logo Genes that share pathways with XCR1: view

SIGNOR curated interactions for XCR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for XCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA,TAS --
GO:0006954 inflammatory response TAS 9632725
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 9632725
genes like me logo Genes that share ontologies with XCR1: view

Drugs & Compounds for XCR1 Gene

(4) Drugs for XCR1 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
XCL1 Pharma Full agonist, Agonist 0
XCL2 Pharma Agonist 0
[<SUP>125</SUP>I]XCL1 (HUMAN) Pharma 0

(2) Additional Compounds for XCR1 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist
Full agonist, Agonist
genes like me logo Genes that share compounds with XCR1: view

Transcripts for XCR1 Gene

mRNA/cDNA for XCR1 Gene

(8) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XCR1 Gene

Chemokine (C motif) receptor 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for XCR1 Gene

No ASD Table

Relevant External Links for XCR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XCR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XCR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for XCR1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x10.7), Skin - Not Sun Exposed (Suprapubic) (x9.4), Spleen (x7.1), and Whole Blood (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of XCR1 Gene:


SOURCE GeneReport for Unigene cluster for XCR1 Gene:


Evidence on tissue expression from TISSUES for XCR1 Gene

  • Lymph node(2.5)
  • Spleen(2.4)
genes like me logo Genes that share expression patterns with XCR1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for XCR1 Gene

Orthologs for XCR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for XCR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia XCR1 33 34
  • 99.5 (n)
(Bos Taurus)
Mammalia XCR1 33 34
  • 83.98 (n)
(Canis familiaris)
Mammalia XCR1 33 34
  • 83.54 (n)
(Rattus norvegicus)
Mammalia Xcr1 33
  • 77.6 (n)
(Mus musculus)
Mammalia Xcr1 33 16 34
  • 76.07 (n)
(Ornithorhynchus anatinus)
Mammalia XCR1 34
  • 62 (a)
(Monodelphis domestica)
Mammalia XCR1 34
  • 60 (a)
(Gallus gallus)
Aves XCR1 33
  • 57.56 (n)
  • 51 (a)
(Anolis carolinensis)
Reptilia XCR1 34
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia xcr1 33
  • 52.94 (n)
(Danio rerio)
Actinopterygii LOC100329796 33
  • 55.13 (n)
xcr1a 34
  • 39 (a)
XCR1 (1 of 4) 34
  • 38 (a)
XCR1 (4 of 4) 34
  • 37 (a)
XCR1 (2 of 4) 34
  • 35 (a)
Species where no ortholog for XCR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for XCR1 Gene

Gene Tree for XCR1 (if available)
Gene Tree for XCR1 (if available)

Paralogs for XCR1 Gene

Variants for XCR1 Gene

Sequence variations from dbSNP and Humsavar for XCR1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000017008 -- 46,067,345(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000040252 -- 46,070,133(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000118251 -- 46,017,731(-) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000140690 -- 46,033,127(-) G/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000165046 -- 46,044,478(-) G/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for XCR1 Gene

Variant ID Type Subtype PubMed ID
esv2759145 CNV loss 17122850
esv3596057 CNV loss 21293372
nsv965163 CNV duplication 23825009

Variation tolerance for XCR1 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XCR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XCR1 Gene

Disorders for XCR1 Gene

Additional Disease Information for XCR1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for XCR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XCR1 Gene

Publications for XCR1 Gene

  1. Isolation of three novel human genes encoding G protein-coupled receptors. (PMID: 7832990) Heiber M … George SR (DNA and cell biology 1995) 2 3 4 22 58
  2. Identification of single C motif-1/lymphotactin receptor XCR1. (PMID: 9632725) Yoshida T … Yoshie O (The Journal of biological chemistry 1998) 3 4 22 58
  3. The herpesvirus 8 encoded chemokines vCCL2 (vMIP-II) and vCCL3 (vMIP-III) target the human but not the murine lymphotactin receptor. (PMID: 18426556) Lüttichau HR (Virology journal 2008) 3 22 58
  4. Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3. (PMID: 17403668) Lüttichau HR … Schwartz TW (The Journal of biological chemistry 2007) 3 22 58
  5. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. (PMID: 17135764) Nakamura H … Eboshida A (International archives of allergy and immunology 2007) 3 44 58

Products for XCR1 Gene

Sources for XCR1 Gene

Loading form....