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Aliases for XAGE5 Gene

Aliases for XAGE5 Gene

  • X Antigen Family Member 5 2 3 5
  • Cancer/Testis Antigen Family 12, Member 5 2 3
  • G Antigen Family D Member 5 3 4
  • Cancer/Testis Antigen 12.5 3 4
  • G Antigen, Family D, 5 2 3
  • GAGED5 3 4
  • CT12.5 3 4
  • XAGE-5 3 4
  • X Antigen Family, Member 5 2
  • Protein XAGE-5 3

External Ids for XAGE5 Gene

Previous HGNC Symbols for XAGE5 Gene

  • GAGED5

Previous GeneCards Identifiers for XAGE5 Gene

  • GC0XP052726
  • GC0XP049907

Summaries for XAGE5 Gene

Entrez Gene Summary for XAGE5 Gene

  • This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]

GeneCards Summary for XAGE5 Gene

XAGE5 (X Antigen Family Member 5) is a Protein Coding gene. An important paralog of this gene is XAGE3.

Additional gene information for XAGE5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE5 Gene

Genomics for XAGE5 Gene

GeneHancer (GH) Regulatory Elements for XAGE5 Gene

Promoters and enhancers for XAGE5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI052992 Enhancer 0.2 FANTOM5 5.6 +181.3 181320 0 XAGE5 GPR173 FAM156A GC0XP052962
GH0XI053126 Enhancer 0.5 FANTOM5 1.4 +315.0 315022 0.4 ZNF316 NFE2 FAM156A GPR173 IQSEC2 XAGE5 FAM156B TSPYL2 RNU7-37P ENSG00000235224 KANTR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around XAGE5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the XAGE5 gene promoter:

Genomic Locations for XAGE5 Gene

Genomic Locations for XAGE5 Gene
7,008 bases
Plus strand

Genomic View for XAGE5 Gene

Genes around XAGE5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XAGE5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XAGE5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XAGE5 Gene

Proteins for XAGE5 Gene

  • Protein details for XAGE5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    X antigen family member 5
    Protein Accession:
    Secondary Accessions:
    • Q5JS81

    Protein attributes for XAGE5 Gene

    108 amino acids
    Molecular mass:
    12077 Da
    Quaternary structure:
    No Data Available

neXtProt entry for XAGE5 Gene

Post-translational modifications for XAGE5 Gene

No Post-translational modifications

Other Protein References for XAGE5 Gene

No data available for DME Specific Peptides for XAGE5 Gene

Domains & Families for XAGE5 Gene

Gene Families for XAGE5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for XAGE5 Gene


Suggested Antigen Peptide Sequences for XAGE5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with XAGE5: view

Function for XAGE5 Gene

genes like me logo Genes that share phenotypes with XAGE5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE5 Gene

Localization for XAGE5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XAGE5 gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for XAGE5 Gene

Pathways & Interactions for XAGE5 Gene

SuperPathways for XAGE5 Gene

No Data Available

Interacting Proteins for XAGE5 Gene

Gene Ontology (GO) - Biological Process for XAGE5 Gene


No data available for Pathways by source and SIGNOR curated interactions for XAGE5 Gene

Drugs & Compounds for XAGE5 Gene

No Compound Related Data Available

Transcripts for XAGE5 Gene

mRNA/cDNA for XAGE5 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XAGE5 Gene

X antigen family, member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for XAGE5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for XAGE5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XAGE5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XAGE5 Gene

mRNA differential expression in normal tissues according to GTEx for XAGE5 Gene

This gene is overexpressed in Testis (x47.3) and Brain - Spinal cord (cervical c-1) (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of XAGE5 Gene:


SOURCE GeneReport for Unigene cluster for XAGE5 Gene:

genes like me logo Genes that share expression patterns with XAGE5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XAGE5 Gene

Orthologs for XAGE5 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC743413 33
  • 99.07 (n)
XAGE5 34
  • 98 (a)
Species where no ortholog for XAGE5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for XAGE5 Gene

Gene Tree for XAGE5 (if available)
Gene Tree for XAGE5 (if available)

Paralogs for XAGE5 Gene

Paralogs for XAGE5 Gene

genes like me logo Genes that share paralogs with XAGE5: view

Variants for XAGE5 Gene

Sequence variations from dbSNP and Humsavar for XAGE5 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1003005575 -- 52,809,551(+) T/C upstream_transcript_variant
rs1003358942 -- 52,810,080(+) C/T upstream_transcript_variant
rs1006755160 -- 52,809,428(+) A/G upstream_transcript_variant
rs1008271768 -- 52,811,037(+) G/C upstream_transcript_variant
rs1013066009 -- 52,810,665(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for XAGE5 Gene

Variant ID Type Subtype PubMed ID
esv2740170 CNV deletion 23290073
esv3576877 CNV gain 25503493
nsv7446 OTHER inversion 18451855

Variation tolerance for XAGE5 Gene

Residual Variation Intolerance Score: 62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XAGE5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XAGE5 Gene

Disorders for XAGE5 Gene

Additional Disease Information for XAGE5

No disorders were found for XAGE5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XAGE5 Gene

Publications for XAGE5 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman AJ … Van Muijen GN (International journal of cancer 2002) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for XAGE5 Gene

Sources for XAGE5 Gene

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