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This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]
XAGE3 (X Antigen Family Member 3) is a Protein Coding gene. Diseases associated with XAGE3 include Diffuse Pulmonary Fibrosis and White-Sutton Syndrome. An important paralog of this gene is XAGE2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ052868 | Promoter | 0.4 | EPDnew | 600.7 | +0.0 | 37 | 0.1 | NRF1 | XAGE3 HSALNG0137966 MN297907-035 XAGE5 | |
GH0XJ052864 | Enhancer | 0.3 | ENCODE | 0.7 | +2.6 | 2648 | 1.8 | SP1 HNF4A | HSALNG0137966 XAGE3 MN297907-035 XAGE5 | |
GH0XJ052851 | Enhancer | 0.3 | ENCODE | 0.4 | +15.4 | 15382 | 2.7 | SPI1 | FAM156A HSALNG0137966 MN297907-035 XAGE3 XAGE5 | |
GH0XJ052829 | Enhancer | 0.2 | Ensembl | 0.3 | +37.1 | 37140 | 2 | ENSG00000196395 LOC107985641 lnc-SPANXN5-2 lnc-XAGE3-2 FAM156B XAGE5 XAGE3 | ||
GH0XJ052830 | Enhancer | 0.2 | Ensembl | 0.3 | +38.6 | 38639 | 0.6 | ENSG00000196395 LOC107985641 piR-36393-549 lnc-SPANXN5-2 piR-52438-123 piR-50308-685 lnc-XAGE3-2 XAGE5 XAGE3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 23275563 |
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | XAGE3 30 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2740170 | CNV | deletion | 23290073 |
esv2740175 | CNV | deletion | 23290073 |
esv3576877 | CNV | gain | 25503493 |
nsv435891 | CNV | deletion | 17901297 |
Disorder | Aliases | PubMed IDs |
---|---|---|
diffuse pulmonary fibrosis |
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white-sutton syndrome |
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