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Aliases for XAGE2 Gene

Aliases for XAGE2 Gene

  • X Antigen Family Member 2 2 3 5
  • Cancer/Testis Antigen Family 12, Member 2 2 3
  • X Antigen Family, Member 2B 2 3
  • G Antigen Family D Member 3 3 4
  • Cancer/Testis Antigen 12.2 3 4
  • GAGED3 3 4
  • XAGE2B 3 4
  • CT12.2 3 4
  • XAGE-2 3 4
  • X Antigen Family, Member 2 2
  • G Antigen, Family D, 3 2

External Ids for XAGE2 Gene

Previous HGNC Symbols for XAGE2 Gene

  • GAGED3
  • XAGE2B

Previous GeneCards Identifiers for XAGE2 Gene

  • GC0XP051946
  • GC0XM052397
  • GC0XP049516

Summaries for XAGE2 Gene

Entrez Gene Summary for XAGE2 Gene

  • This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in normal testis, and in Ewing's sarcoma, rhabdomyosarcoma, a breast cancer and a germ cell tumor. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]

GeneCards Summary for XAGE2 Gene

XAGE2 (X Antigen Family Member 2) is a Protein Coding gene. Diseases associated with XAGE2 include Ewing Sarcoma. An important paralog of this gene is XAGE3.

Additional gene information for XAGE2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE2 Gene

Genomics for XAGE2 Gene

GeneHancer (GH) Regulatory Elements for XAGE2 Gene

Promoters and enhancers for XAGE2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI052368 Promoter 0.5 EPDnew 550.8 +0.2 191 0.1 GC0XM052364 XAGE2 ENSG00000225957
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around XAGE2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for XAGE2 Gene

Genomic Locations for XAGE2 Gene
6,873 bases
Plus strand

Genomic View for XAGE2 Gene

Genes around XAGE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XAGE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XAGE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XAGE2 Gene

Proteins for XAGE2 Gene

  • Protein details for XAGE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    X antigen family member 2
    Protein Accession:
    Secondary Accessions:
    • Q5HYR4

    Protein attributes for XAGE2 Gene

    111 amino acids
    Molecular mass:
    12354 Da
    Quaternary structure:
    No Data Available

neXtProt entry for XAGE2 Gene

Post-translational modifications for XAGE2 Gene

No Post-translational modifications

Other Protein References for XAGE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for XAGE2 Gene

Domains & Families for XAGE2 Gene

Gene Families for XAGE2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for XAGE2 Gene


Suggested Antigen Peptide Sequences for XAGE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with XAGE2: view

Function for XAGE2 Gene

Gene Ontology (GO) - Molecular Function for XAGE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with XAGE2: view
genes like me logo Genes that share phenotypes with XAGE2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE2 Gene

Localization for XAGE2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for XAGE2 Gene

Pathways & Interactions for XAGE2 Gene

SuperPathways for XAGE2 Gene

No Data Available

Interacting Proteins for XAGE2 Gene

Gene Ontology (GO) - Biological Process for XAGE2 Gene


No data available for Pathways by source and SIGNOR curated interactions for XAGE2 Gene

Drugs & Compounds for XAGE2 Gene

No Compound Related Data Available

Transcripts for XAGE2 Gene

mRNA/cDNA for XAGE2 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for XAGE2 Gene

X antigen family, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for XAGE2 Gene

No ASD Table

Relevant External Links for XAGE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XAGE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XAGE2 Gene

Protein differential expression in normal tissues from HIPED for XAGE2 Gene

This gene is overexpressed in Placenta (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for XAGE2 Gene

Protein tissue co-expression partners for XAGE2 Gene

NURSA nuclear receptor signaling pathways regulating expression of XAGE2 Gene:


SOURCE GeneReport for Unigene cluster for XAGE2 Gene:

genes like me logo Genes that share expression patterns with XAGE2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XAGE2 Gene

Orthologs for XAGE2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia XAGE2 33 34
  • 99.4 (n)
Species where no ortholog for XAGE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for XAGE2 Gene

Gene Tree for XAGE2 (if available)
Gene Tree for XAGE2 (if available)

Paralogs for XAGE2 Gene

Paralogs for XAGE2 Gene

genes like me logo Genes that share paralogs with XAGE2: view

Variants for XAGE2 Gene

Sequence variations from dbSNP and Humsavar for XAGE2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1001102424 -- 52,371,842(+) C/T intron_variant
rs1001161064 -- 52,371,361(+) C/T intron_variant
rs1001557594 -- 52,367,622(+) A/G upstream_transcript_variant
rs1001610082 -- 52,367,246(+) G/A upstream_transcript_variant
rs1001817154 -- 52,375,477(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for XAGE2 Gene

Variant ID Type Subtype PubMed ID
nsv1133764 CNV deletion 24896259

Additional Variant Information for XAGE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for XAGE2 Gene

Disorders for XAGE2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for XAGE2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
ewing sarcoma
  • es
- elite association - COSMIC cancer census association via MalaCards
Search XAGE2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for XAGE2

genes like me logo Genes that share disorders with XAGE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XAGE2 Gene

Publications for XAGE2 Gene

  1. Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database. (PMID: 10197611) Brinkmann U … Pastan I (Cancer research 1999) 2 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman AJ … Van Muijen GN (International journal of cancer 2002) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for XAGE2 Gene

Sources for XAGE2 Gene

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