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This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010]
XAGE1B (X Antigen Family Member 1B) is a Protein Coding gene. Diseases associated with XAGE1B include Ewing Sarcoma and Sarcoma. An important paralog of this gene is XAGE1A.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ052517 | Promoter | 0.3 | EPDnew | 600.7 | +3.7 | 3720 | 0.1 | XAGE1B lnc-XAGE1B-6 RBM22P7 lnc-XAGE1A-2 XAGE1A | ||
GH0XJ052515 | Promoter | 0.3 | EPDnew | 600.4 | +5.7 | 5746 | 0.1 | XAGE1B lnc-XAGE1B-6 RBM22P7 lnc-XAGE1A-2 XAGE1A | ||
GH0XJ052574 | Enhancer | 0.5 | Ensembl | 0.2 | -54.1 | -54063 | 0.5 | CTCF RAD21 ZSCAN5C CUX1 SMC3 ZNF654 ZNF660 ZNF143 | ENSG00000228771 LOC107985659 lnc-XAGE1A-8 ENSG00000231593 XAGE1B SSX7 | |
GH0XJ052497 | Promoter | 0.3 | EPDnew | 0.4 | +23.0 | 22970 | 0.1 | XAGE1A RBM22P7 lnc-XAGE1A-2 XAGE1B | ||
GH0XJ052496 | Promoter | 0.3 | Ensembl | 0.4 | +24.4 | 24403 | 0.4 | XAGE1A RBM22P7 lnc-XAGE1A-2 XAGE1B |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25416956 |
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
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OneToMany |
Disorder | Aliases | PubMed IDs |
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ewing sarcoma |
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sarcoma |
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rhabdomyosarcoma |
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prostate cancer |
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