This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity wit... See more...

Aliases for XAGE1B Gene

Aliases for XAGE1B Gene

  • X Antigen Family Member 1B 2 3 5
  • Cancer/Testis Antigen Family 12, Member 1b 2 3
  • X Antigen Family, Member 1C 2 3
  • X Antigen Family, Member 1D 2 3
  • G Antigen Family D Member 2 3 4
  • X Antigen Family Member 1E 2 3
  • Cancer/Testis Antigen 12.1 3 4
  • X Antigen Family Member 1 3 4
  • CT12.1b 2 3
  • CT12.1 3 4
  • GAGED2 3 4
  • XAGE-1 3 4
  • XAGE1 3 4
  • Cancer/Testis Antigen Family 12, Member 1c 3
  • Cancer/Testis Antigen Family 12, Member 1d 3
  • Cancer/Testis Antigen Family 12, Member 1e 3
  • Cancer/Testis Associated Protein 3
  • X Antigen Family, Member 1B 2
  • X Antigen Family, Member 1E 2
  • X Antigen Family Member 1C 2
  • X Antigen Family Member 1D 2
  • Protein XAGE-1 3
  • CT12.1C 3
  • CT12.1D 3
  • CT12.1E 3
  • CT12.1c 2
  • CT12.1d 2
  • XAGE1C 3
  • XAGE1D 3
  • XAGE1E 3
  • XAGE1B 5
  • CTP9 3

External Ids for XAGE1B Gene

Previous HGNC Symbols for XAGE1B Gene

  • XAGE1C
  • XAGE1D
  • XAGE1E

Previous GeneCards Identifiers for XAGE1B Gene

  • GC0XU900702
  • GC0XM052272
  • GC0XP052530
  • GC0XM052561
  • GC0XP052239
  • GC0XP052495

Summaries for XAGE1B Gene

Entrez Gene Summary for XAGE1B Gene

  • This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010]

GeneCards Summary for XAGE1B Gene

XAGE1B (X Antigen Family Member 1B) is a Protein Coding gene. Diseases associated with XAGE1B include Ewing Sarcoma and Sarcoma. An important paralog of this gene is XAGE1A.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for XAGE1B Gene

Genomics for XAGE1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for XAGE1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ052517 Promoter 0.3 EPDnew 600.7 +3.7 3720 0.1 XAGE1B lnc-XAGE1B-6 RBM22P7 lnc-XAGE1A-2 XAGE1A
GH0XJ052515 Promoter 0.3 EPDnew 600.4 +5.7 5746 0.1 XAGE1B lnc-XAGE1B-6 RBM22P7 lnc-XAGE1A-2 XAGE1A
GH0XJ052574 Enhancer 0.5 Ensembl 0.2 -54.1 -54063 0.5 CTCF RAD21 ZSCAN5C CUX1 SMC3 ZNF654 ZNF660 ZNF143 ENSG00000228771 LOC107985659 lnc-XAGE1A-8 ENSG00000231593 XAGE1B SSX7
GH0XJ052497 Promoter 0.3 EPDnew 0.4 +23.0 22970 0.1 XAGE1A RBM22P7 lnc-XAGE1A-2 XAGE1B
GH0XJ052496 Promoter 0.3 Ensembl 0.4 +24.4 24403 0.4 XAGE1A RBM22P7 lnc-XAGE1A-2 XAGE1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around XAGE1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for XAGE1B

Top Transcription factor binding sites by QIAGEN in the XAGE1B gene promoter:
  • AML1a
  • FOXD1
  • p53
  • POU3F2

Genomic Locations for XAGE1B Gene

Genomic Locations for XAGE1B Gene
chrX:52,512,074-52,520,803
(GRCh38/hg38)
Size:
8,730 bases
Orientation:
Minus strand
chrX:52,235,228-52,243,954
(GRCh37/hg19)
Size:
8,727 bases
Orientation:
Plus strand

Genomic View for XAGE1B Gene

Genes around XAGE1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XAGE1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XAGE1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XAGE1B Gene

Proteins for XAGE1B Gene

  • Protein details for XAGE1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD64-XAGE1_HUMAN
    Recommended name:
    X antigen family member 1
    Protein Accession:
    Q9HD64
    Secondary Accessions:
    • A6NJ94
    • Q5JPN8
    • Q5JPP0
    • Q5JPP3
    • Q8WWG5
    • Q8WWG6
    • Q969J6

    Protein attributes for XAGE1B Gene

    Size:
    81 amino acids
    Molecular mass:
    9078 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG01401.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH09538.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAC82986.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAI41526.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41534.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    Miscellaneous:
    • According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified.
    • [Isoform B]: XAGE-1a and XAGE-1b mRNAs are produced by alternative promoter usage. However, for both isoforms, the translation initiator codon remains the same, generating an identical protein. XAGE-1b is the predominant transcript, compared to XAGE-1a.

    Alternative splice isoforms for XAGE1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XAGE1B Gene

Post-translational modifications for XAGE1B Gene

  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

Other Protein References for XAGE1B Gene

No data available for DME Specific Peptides for XAGE1B Gene

Domains & Families for XAGE1B Gene

Gene Families for XAGE1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for XAGE1B Gene

InterPro:
Blocks:
  • GAGE
ProtoNet:

Suggested Antigen Peptide Sequences for XAGE1B Gene

GenScript: Design optimal peptide antigens:
  • Protein XAGE-1 (GAGD2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HD64

UniProtKB/Swiss-Prot:

XAGE1_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with XAGE1B: view

Function for XAGE1B Gene

Gene Ontology (GO) - Molecular Function for XAGE1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with XAGE1B: view
genes like me logo Genes that share phenotypes with XAGE1B: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE1B Gene

Localization for XAGE1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XAGE1B gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for XAGE1B Gene

Pathways & Interactions for XAGE1B Gene

PathCards logo

SuperPathways for XAGE1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for XAGE1B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for XAGE1B Gene

Drugs & Compounds for XAGE1B Gene

No Compound Related Data Available

Transcripts for XAGE1B Gene

mRNA/cDNA for XAGE1B Gene

9 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for XAGE1B Gene

No ASD Table

Relevant External Links for XAGE1B Gene

GeneLoc Exon Structure for
XAGE1B

Expression for XAGE1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for XAGE1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for XAGE1B Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (32.2), Colon muscle (27.6), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for XAGE1B Gene



Protein tissue co-expression partners for XAGE1B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for XAGE1B

mRNA Expression by UniProt/SwissProt for XAGE1B Gene:

Q9HD64-XAGE1_HUMAN
Tissue specificity: In normal tissues, highly expressed in testis. Expressed also in many different types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewing's cell lines, in some Ewing's sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample.
genes like me logo Genes that share expression patterns with XAGE1B: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XAGE1B Gene

Orthologs for XAGE1B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 53 (a)
OneToMany
Species where no ortholog for XAGE1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for XAGE1B Gene

ENSEMBL:
Gene Tree for XAGE1B (if available)
TreeFam:
Gene Tree for XAGE1B (if available)

Paralogs for XAGE1B Gene

(1) SIMAP similar genes for XAGE1B Gene using alignment to 1 proteins:

  • XAGE1_HUMAN
genes like me logo Genes that share paralogs with XAGE1B: view

Variants for XAGE1B Gene

Additional dbSNP identifiers (rs#s) for XAGE1B Gene

Structural Variations from Database of Genomic Variants (DGV) for XAGE1B Gene

Variant ID Type Subtype PubMed ID
esv1003754 CNV loss 20482838
esv1003754 CNV loss 20482838
esv991419 CNV loss 20482838
esv991419 CNV loss 20482838
esv994563 CNV loss 20482838
esv994563 CNV loss 20482838

Additional Variant Information for XAGE1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
XAGE1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for XAGE1B Gene

Disorders for XAGE1B Gene

MalaCards: The human disease database

(4) MalaCards diseases for XAGE1B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ewing sarcoma
  • es
sarcoma
  • connective and soft tissue neoplasm
rhabdomyosarcoma
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with XAGE1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XAGE1B Gene

Publications for XAGE1B Gene

  1. Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors. (PMID: 17335148) Sato S … Nakayama E (Cancer immunity 2007) 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman AJ … Van Muijen GN (International journal of cancer 2002) 3 4
  5. Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers. (PMID: 12479262) Egland KA … Pastan I (Molecular cancer therapeutics 2002) 3 4

Products for XAGE1B Gene

Sources for XAGE1B Gene