This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity wit... See more...

Aliases for XAGE1A Gene

Aliases for XAGE1A Gene

  • X Antigen Family Member 1A 2 3 5
  • Cancer/Testis Antigen Family 12, Member 1a 2 3
  • G Antigen Family D Member 2 3 4
  • Cancer/Testis Antigen 12.1 3 4
  • X Antigen Family Member 1 3 4
  • G Antigen, Family D, 2 2 3
  • GAGED2 3 4
  • CT12.1 3 4
  • XAGE-1 3 4
  • XAGE1 3 4
  • Cancer/Testis Antigen Family 12, Member 1b 3
  • Cancer/Testis Associated Protein 3
  • X Antigen Family, Member 1A 2
  • X Antigen Family Member 1B 3
  • X Antigen Family, Member 1 2
  • Protein XAGE-1 3
  • CT12.1A 3
  • CT12.1B 3
  • XAGE1B 3
  • CTP9 3

External Ids for XAGE1A Gene

Previous HGNC Symbols for XAGE1A Gene

  • GAGED2
  • XAGE1

Previous GeneCards Identifiers for XAGE1A Gene

  • GC0XM052546
  • GC0XP052532
  • GC0XP052258
  • GC0XP052238
  • GC0XM052255

Summaries for XAGE1A Gene

Entrez Gene Summary for XAGE1A Gene

  • This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010]

GeneCards Summary for XAGE1A Gene

XAGE1A (X Antigen Family Member 1A) is a Protein Coding gene. Diseases associated with XAGE1A include Ewing Sarcoma and Sarcoma. An important paralog of this gene is XAGE1B.

Additional gene information for XAGE1A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for XAGE1A Gene

Genomics for XAGE1A Gene

GeneHancer (GH) Regulatory Elements for XAGE1A Gene

Promoters and enhancers for XAGE1A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ052496 Promoter 0.3 Ensembl 500.7 +0.7 732 0.4 XAGE1A lnc-XAGE1A-2 RBM22P7
GH0XJ052497 Promoter 0.3 EPDnew 500.7 +2.2 2165 0.1 XAGE1A lnc-XAGE1A-2 RBM22P7
GH0XJ052495 Promoter 0.3 EPDnew 500.7 +0.1 139 0.1 XAGE1A lnc-XAGE1A-2 RBM22P7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around XAGE1A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for XAGE1A

Top Transcription factor binding sites by QIAGEN in the XAGE1A gene promoter:
  • AML1a
  • FOXC1
  • p53
  • POU3F2

Genomic Locations for XAGE1A Gene

Genomic Locations for XAGE1A Gene
chrX:52,495,668-52,500,812
(GRCh38/hg38)
Size:
5,145 bases
Orientation:
Plus strand
chrX:52,255,219-52,260,363
(GRCh37/hg19)
Size:
5,145 bases
Orientation:
Minus strand

Genomic View for XAGE1A Gene

Genes around XAGE1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XAGE1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XAGE1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XAGE1A Gene

Proteins for XAGE1A Gene

  • Protein details for XAGE1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD64-XAGE1_HUMAN
    Recommended name:
    X antigen family member 1
    Protein Accession:
    Q9HD64
    Secondary Accessions:
    • A6NJ94
    • Q5JPN8
    • Q5JPP0
    • Q5JPP3
    • Q8WWG5
    • Q8WWG6
    • Q969J6

    Protein attributes for XAGE1A Gene

    Size:
    81 amino acids
    Molecular mass:
    9078 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified.
    • [Isoform B]: XAGE-1a and XAGE-1b mRNAs are produced by alternative promoter usage. However, for both isoforms, the translation initiator codon remains the same, generating an identical protein. XAGE-1b is the predominant transcript, compared to XAGE-1a.
    SequenceCaution:
    • Sequence=AAG01401.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH09538.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAC82986.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAI41526.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41534.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for XAGE1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XAGE1A Gene

Post-translational modifications for XAGE1A Gene

  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

Other Protein References for XAGE1A Gene

No data available for DME Specific Peptides for XAGE1A Gene

Domains & Families for XAGE1A Gene

Gene Families for XAGE1A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for XAGE1A Gene

Blocks:
  • GAGE
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9HD64

UniProtKB/Swiss-Prot:

XAGE1_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with XAGE1A: view

No data available for Suggested Antigen Peptide Sequences for XAGE1A Gene

Function for XAGE1A Gene

Gene Ontology (GO) - Molecular Function for XAGE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with XAGE1A: view
genes like me logo Genes that share phenotypes with XAGE1A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XAGE1A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE1A Gene

Localization for XAGE1A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XAGE1A gene
Compartment Confidence
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for XAGE1A Gene

Pathways & Interactions for XAGE1A Gene

PathCards logo

SuperPathways for XAGE1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for XAGE1A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for XAGE1A Gene

Drugs & Compounds for XAGE1A Gene

No Compound Related Data Available

Transcripts for XAGE1A Gene

mRNA/cDNA for XAGE1A Gene

6 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for XAGE1A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for XAGE1A Gene

No ASD Table

Relevant External Links for XAGE1A Gene

GeneLoc Exon Structure for
XAGE1A

Expression for XAGE1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for XAGE1A Gene

Protein differential expression in normal tissues from HIPED for XAGE1A Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (32.2), Colon muscle (27.6), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for XAGE1A Gene



Protein tissue co-expression partners for XAGE1A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for XAGE1A

mRNA Expression by UniProt/SwissProt for XAGE1A Gene:

Q9HD64-XAGE1_HUMAN
Tissue specificity: In normal tissues, highly expressed in testis. Expressed also in many different types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewing's cell lines, in some Ewing's sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample.
genes like me logo Genes that share expression patterns with XAGE1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XAGE1A Gene

Orthologs for XAGE1A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 53 (a)
OneToMany
Species where no ortholog for XAGE1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for XAGE1A Gene

ENSEMBL:
Gene Tree for XAGE1A (if available)
TreeFam:
Gene Tree for XAGE1A (if available)

Paralogs for XAGE1A Gene

(1) SIMAP similar genes for XAGE1A Gene using alignment to 1 proteins:

  • XAGE1_HUMAN
genes like me logo Genes that share paralogs with XAGE1A: view

Variants for XAGE1A Gene

Additional dbSNP identifiers (rs#s) for XAGE1A Gene

Additional Variant Information for XAGE1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
XAGE1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for XAGE1A Gene

Disorders for XAGE1A Gene

MalaCards: The human disease database

(4) MalaCards diseases for XAGE1A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ewing sarcoma
  • es
sarcoma
  • connective and soft tissue neoplasm
rhabdomyosarcoma
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for XAGE1A

genes like me logo Genes that share disorders with XAGE1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XAGE1A Gene

Publications for XAGE1A Gene

  1. Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors. (PMID: 17335148) Sato S … Nakayama E (Cancer immunity 2007) 3 4 54
  2. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman AJ … Van Muijen GN (International journal of cancer 2002) 3 4 54
  3. Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers. (PMID: 12479262) Egland KA … Pastan I (Molecular cancer therapeutics 2002) 3 4 54
  4. XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. (PMID: 10987281) Liu XF … Pastan I (Cancer research 2000) 3 4 54
  5. Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database. (PMID: 10197611) Brinkmann U … Pastan I (Cancer research 1999) 2 3 54

Products for XAGE1A Gene

Sources for XAGE1A Gene