This gene produces a spliced long non-coding RNA that is thought to play a role in the control of X-chromosome inactivation (XCI). This transcript has been shown to specifically coat the active X chromosome in human pluripotent cells. [provided by RefSeq, Mar 2015] See more...

Aliases for XACT Gene

Subcategory (RNA class) for XACT Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for XACT Gene

  • X Active Specific Transcript 2 3 5
  • X Active Specific Transcript (Non-Protein Coding) 2 3
  • X Active Coating Transcript 2 3
  • XACT 2 168
  • HSALNG0141630 167
  • NONHSAG055124 92

External Ids for XACT Gene

Previous GeneCards Identifiers for XACT Gene

  • GC00U934172
  • GC0XU902142

Summaries for XACT Gene

Entrez Gene Summary for XACT Gene

  • This gene produces a spliced long non-coding RNA that is thought to play a role in the control of X-chromosome inactivation (XCI). This transcript has been shown to specifically coat the active X chromosome in human pluripotent cells. [provided by RefSeq, Mar 2015]

GeneCards Summary for XACT Gene

XACT (X Active Specific Transcript) is an RNA Gene, and is affiliated with the lncRNA class.

Additional gene information for XACT Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for XACT Gene

Genomics for XACT Gene

GeneHancer (GH) Regulatory Elements for XACT Gene

Promoters and enhancers for XACT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ114058 Promoter/Enhancer 1.2 Ensembl ENCODE 500.7 +0.3 261 1.7 PHB2 AFF1 TARDBP HES1 CTBP1 HDAC3 NCOR1 MBD2 TRIM25 ZNF282 XACT piR-56133-245 piR-30444-351 lnc-HTR2C-4
GH0XJ114036 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.4 +21.5 21452 2.9 TEAD4 CTBP1 NCOR1 NANOG ZBTB11 ZNF426 ZNF213 TAL1 HDAC2 TCF12 NONHSAG055125.2 ENSG00000212611 XACT
GH0XJ114047 Enhancer 0.7 Ensembl ENCODE 0.4 +11.5 11479 0.6 USF1 POLR2A NR2F1 MITF USF2 RAD51 MNT MGA RNU1-57P piR-30444-351 lnc-HTR2C-4 XACT
GH0XJ114041 Enhancer 0.7 ENCODE 0.4 +17.6 17605 0.2 NCOR1 NR2F1 TAL1 HDAC2 HLTF TCF12 DPF2 SMARCA4 SMARCE1 E4F1 NONHSAG055125.2 lnc-HTR2C-4 piR-37432-137 piR-48950-224 XACT
GH0XJ114051 Enhancer 0.5 Ensembl ENCODE 0.4 +7.6 7589 0.6 POLR2A ZNF592 lnc-HTR2C-4 XACT piR-30444-351
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around XACT on UCSC Golden Path with GeneCards custom track

Genomic Locations for XACT Gene

Genomic Locations for XACT Gene
chrX:113,616,299-114,059,289
(GRCh38/hg38)
Size:
442,991 bases
Orientation:
Minus strand

Genomic View for XACT Gene

Genes around XACT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XACT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XACT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XACT Gene

Proteins for XACT Gene

Post-translational modifications for XACT Gene

No Post-translational modifications

No data available for DME Specific Peptides for XACT Gene

Domains & Families for XACT Gene

Gene Families for XACT Gene

genes like me logo Genes that share domains with XACT: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for XACT Gene

Function for XACT Gene

Phenotypes From GWAS Catalog for XACT Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XACT Gene

Localization for XACT Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for XACT Gene

Pathways & Interactions for XACT Gene

PathCards logo

SuperPathways for XACT Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for XACT Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for XACT Gene

Drugs & Compounds for XACT Gene

No Compound Related Data Available

Transcripts for XACT Gene

mRNA/cDNA for XACT Gene

6 RNACentral transcripts :
1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
1 NONCODE transcripts :
1 LncBook transcripts :
2 LNCipedia transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for XACT Gene

No ASD Table

Relevant External Links for XACT Gene

GeneLoc Exon Structure for
XACT

Expression for XACT Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XACT Gene

Orthologs for XACT Gene

Evolution for XACT Gene

ENSEMBL:
Gene Tree for XACT (if available)
TreeFam:
Gene Tree for XACT (if available)

No data available for Orthologs for XACT Gene

Paralogs for XACT Gene

No data available for Paralogs for XACT Gene

Variants for XACT Gene

Additional dbSNP identifiers (rs#s) for XACT Gene

Additional Variant Information for XACT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
XACT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for XACT Gene

Disorders for XACT Gene

Additional Disease Information for XACT

No disorders were found for XACT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XACT Gene

Publications for XACT Gene

  1. Erosion of X Chromosome Inactivation in Human Pluripotent Cells Initiates with XACT Coating and Depends on a Specific Heterochromatin Landscape. (PMID: 25921272) Vallot C … Rougeulle C (Cell stem cell 2015) 2 3 54
  2. XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells. (PMID: 23334669) Vallot C … Rougeulle C (Nature genetics 2013) 2 3 54
  3. XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development. (PMID: 27989768) Vallot C … Rougeulle C (Cell stem cell 2017) 3 54
  4. Long non-coding RNAs and human X-chromosome regulation: a coat for the active X chromosome. (PMID: 23948700) Vallot C … Rougeulle C (RNA biology 2013) 3 54

Products for XACT Gene

Sources for XACT Gene