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Aliases for XACT Gene

Subcategory (RNA class) for XACT Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for XACT Gene

  • X Active Specific Transcript (Non-Protein Coding) 2 3 5
  • X Active Coating Transcript 2

External Ids for XACT Gene

Previous GeneCards Identifiers for XACT Gene

  • GC00U934172
  • GC0XU902142

Summaries for XACT Gene

Entrez Gene Summary for XACT Gene

  • This gene produces a spliced long non-coding RNA that is thought to play a role in the control of X-chromosome inactivation (XCI). This transcript has been shown to specifically coat the active X chromosome in human pluripotent cells. [provided by RefSeq, Mar 2015]

GeneCards Summary for XACT Gene

XACT (X Active Specific Transcript (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for XACT Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XACT Gene

Genomics for XACT Gene

GeneHancer (GH) Regulatory Elements for XACT Gene

Promoters and enhancers for XACT Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI113929 Enhancer 0.6 ENCODE 0.4 +9.0 9030 0.2 CTCF ZNF654 TEAD1 ZNF143 SMC3 REST RAD21 TEAD3 XACT GC0XP113892
GH0XI113868 Enhancer 0.6 ENCODE 0.2 +69.9 69885 0.2 HDAC1 LEF1 TEAD4 BHLHE40 TAL1 CBFA2T3 EP300 TCF12 NFIC NCOR1 QTRT1P1 XACT PIR54705
GH0XI113906 Enhancer 0.2 ENCODE 0.3 +31.9 31939 0.2 GC0XP113892 XACT
GH0XI113802 Enhancer 0.4 ENCODE 0.1 +135.2 135164 0.1 CEBPB EP300 TCF7L2 QTRT1P1 PIR54705 XACT
GH0XI113804 Enhancer 0.3 ENCODE 0.1 +133.5 133503 0.8 NFE2L2 QTRT1P1 PIR54705 XACT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around XACT on UCSC Golden Path with GeneCards custom track

Genomic Locations for XACT Gene

Genomic Locations for XACT Gene
321,919 bases
Minus strand

Genomic View for XACT Gene

Genes around XACT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XACT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XACT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XACT Gene

Proteins for XACT Gene

Post-translational modifications for XACT Gene

No Post-translational modifications

No data available for DME Specific Peptides for XACT Gene

Domains & Families for XACT Gene

Gene Families for XACT Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with XACT: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for XACT Gene

Function for XACT Gene

Phenotypes From GWAS Catalog for XACT Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XACT Gene

Localization for XACT Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for XACT Gene

Pathways & Interactions for XACT Gene

No Data Available

Interacting Proteins for XACT Gene

Gene Ontology (GO) - Biological Process for XACT Gene


No data available for Pathways by source and SIGNOR curated interactions for XACT Gene

Drugs & Compounds for XACT Gene

No Compound Related Data Available

Transcripts for XACT Gene

mRNA/cDNA for XACT Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for XACT Gene

No ASD Table

Relevant External Links for XACT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XACT Gene

NURSA nuclear receptor signaling pathways regulating expression of XACT Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XACT Gene

Orthologs for XACT Gene

Evolution for XACT Gene

Gene Tree for XACT (if available)
Gene Tree for XACT (if available)

No data available for Orthologs for XACT Gene

Paralogs for XACT Gene

No data available for Paralogs for XACT Gene

Variants for XACT Gene

Sequence variations from dbSNP and Humsavar for XACT Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000908788 -- 113,616,189(-) T/C downstream_transcript_variant
rs1001401757 -- 113,616,381(-) T/A non_coding_transcript_variant
rs1003818558 -- 113,618,851(-) A/C upstream_transcript_variant
rs1005036602 -- 113,619,690(-) T/C upstream_transcript_variant
rs1005395606 -- 113,619,323(-) G/T upstream_transcript_variant

Additional Variant Information for XACT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for XACT Gene

Disorders for XACT Gene

Additional Disease Information for XACT

No disorders were found for XACT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XACT Gene

Publications for XACT Gene

  1. Erosion of X Chromosome Inactivation in Human Pluripotent Cells Initiates with XACT Coating and Depends on a Specific Heterochromatin Landscape. (PMID: 25921272) Vallot C … Rougeulle C (Cell stem cell 2015) 2 3 58
  2. XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells. (PMID: 23334669) Vallot C … Rougeulle C (Nature genetics 2013) 2 3 58
  3. XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development. (PMID: 27989768) Vallot C … Rougeulle C (Cell stem cell 2017) 3 58
  4. Long non-coding RNAs and human X-chromosome regulation: a coat for the active X chromosome. (PMID: 23948700) Vallot C … Rougeulle C (RNA biology 2013) 3 58

Products for XACT Gene

Sources for XACT Gene

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