Aliases for WWTR1 Gene
External Ids for WWTR1 Gene
Previous GeneCards Identifiers for WWTR1 Gene
GeneCards Summary for WWTR1 Gene
WWTR1 (WW Domain Containing Transcription Regulator 1) is a Protein Coding gene. Diseases associated with WWTR1 include Epithelioid Hemangioendothelioma and Histiocytoid Hemangioma. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription corepressor activity. An important paralog of this gene is YAP1.
UniProtKB/Swiss-Prot Summary for WWTR1 Gene
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.