Aliases for WWTR1 Gene
External Ids for WWTR1 Gene
Previous GeneCards Identifiers for WWTR1 Gene
GeneCards Summary for WWTR1 Gene
WWTR1 (WW Domain Containing Transcription Regulator 1) is a Protein Coding gene. Diseases associated with WWTR1 include Epithelioid Hemangioendothelioma and Histiocytoid Hemangioma. Among its related pathways are Cardiac conduction and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription corepressor activity. An important paralog of this gene is YAP1.
UniProtKB/Swiss-Prot Summary for WWTR1 Gene
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018).