Aliases for WWTR1 Gene

Aliases for WWTR1 Gene

  • WW Domain Containing Transcription Regulator 1 2 3 5
  • WW Domain-Containing Transcription Regulator Protein 1 3 4
  • TAZ 3 4
  • Transcriptional Co-Activator With PDZ-Binding Motif 3
  • Transcriptional Coactivator With PDZ-Binding Motif 4

External Ids for WWTR1 Gene

Previous GeneCards Identifiers for WWTR1 Gene

  • GC03M150721
  • GC03M149235
  • GC03M146607

Summaries for WWTR1 Gene

CIViC Summary for WWTR1 Gene

GeneCards Summary for WWTR1 Gene

WWTR1 (WW Domain Containing Transcription Regulator 1) is a Protein Coding gene. Diseases associated with WWTR1 include Epithelioid Hemangioendothelioma and Histiocytoid Hemangioma. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Hippo signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription corepressor activity. An important paralog of this gene is YAP1.

UniProtKB/Swiss-Prot Summary for WWTR1 Gene

  • Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Gene Wiki entry for WWTR1 Gene

Additional gene information for WWTR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WWTR1 Gene

Genomics for WWTR1 Gene

GeneHancer (GH) Regulatory Elements for WWTR1 Gene

Promoters and enhancers for WWTR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J149652 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 509.6 +79.9 79919 7.8 ZSCAN5C POLR2G NCOR1 PHF8 TEAD4 ZFX CTCF ZIC2 KDM6A POLR2A WWTR1-AS1 WWTR1 COMMD2 WWTR1-IT1
GH03J149751 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.4 -15.6 -15587 2.2 EP300 RXRA ZBTB40 ZNF217 CTCF TCF12 MYC NRF1 POLR2G SP1 COMMD2 lnc-ANKUB1-3 WWTR1 EIF2A
GH03J149736 Enhancer 0.6 Ensembl ENCODE 500.7 +0.3 313 1.2 JUND GATA3 THRB MAFF TEAD3 FOXA1 WWTR1 lnc-WWTR1-1 piR-44940-002
GH03J149571 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 17.7 +152.2 152230 26.4 ZSCAN5C TCF12 SP1 JUND FOS ZNF639 ZNF10 EP300 ZIC2 REST WWTR1 WWTR1-AS1 RNU6-1098P lnc-TM4SF4-3 WWTR1-IT1
GH03J150406 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 -674.7 -674655 9.7 HNRNPK ZNF217 EP300 CTCF SIN3A NRF1 POLR2G USF1 NCOR1 GTF2E2 TSC22D2 lnc-SERP1-4 WWTR1-IT1 COMMD2 EIF2A WWTR1 NPM1P29 lnc-TSC22D2-3 HSALNG0029785
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WWTR1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WWTR1

Top Transcription factor binding sites by QIAGEN in the WWTR1 gene promoter:
  • AhR
  • AML1a
  • LCR-F1
  • MZF-1
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • USF-1
  • USF1

Genomic Locations for WWTR1 Gene

Genomic Locations for WWTR1 Gene
chr3:149,517,235-149,736,714
(GRCh38/hg38)
Size:
219,480 bases
Orientation:
Minus strand
chr3:149,235,022-149,454,501
(GRCh37/hg19)
Size:
219,480 bases
Orientation:
Minus strand

Genomic View for WWTR1 Gene

Genes around WWTR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WWTR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WWTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WWTR1 Gene

Proteins for WWTR1 Gene

  • Protein details for WWTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZV5-WWTR1_HUMAN
    Recommended name:
    WW domain-containing transcription regulator protein 1
    Protein Accession:
    Q9GZV5
    Secondary Accessions:
    • D3DNH7
    • Q8N3P2
    • Q9Y3W6

    Protein attributes for WWTR1 Gene

    Size:
    400 amino acids
    Molecular mass:
    44101 Da
    Quaternary structure:
    • Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP (By similarity). Interacts (via coiled-coil domain) with SMAD2 (via MH1 domain), SMAD3 and SMAD4. Interacts with MED15, PAX8 and NKX2-1. Interacts with TEAD1, TEAD2, TEAD3 and TEAD4.

    Three dimensional structures from OCA and Proteopedia for WWTR1 Gene

neXtProt entry for WWTR1 Gene

Post-translational modifications for WWTR1 Gene

  • Phosphorylated by LATS2 and STK3/MST2. Phosphorylation by LATS2 results in creation of 14-3-3 binding sites, retention in the cytoplasm, and functional inactivation. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WWTR1 Gene

Domains & Families for WWTR1 Gene

Gene Families for WWTR1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for WWTR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WWTR1 Gene

GenScript: Design optimal peptide antigens:
  • Transcriptional coactivator with PDZ-binding motif (WWTR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZV5

UniProtKB/Swiss-Prot:

WWTR1_HUMAN :
  • The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes (By similarity).
Domain:
  • The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes (By similarity).
  • Binds to transcription factors via its WW domain.
genes like me logo Genes that share domains with WWTR1: view

Function for WWTR1 Gene

Molecular function for WWTR1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Phenotypes From GWAS Catalog for WWTR1 Gene

Gene Ontology (GO) - Molecular Function for WWTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS,IBA 11118213
GO:0003714 transcription corepressor activity IBA 21873635
GO:0005515 protein binding IEA,IPI 16099986
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with WWTR1: view
genes like me logo Genes that share phenotypes with WWTR1: view

Animal Models for WWTR1 Gene

MGI Knock Outs for WWTR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WWTR1

Clone Products

  • Addgene plasmids for WWTR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WWTR1 Gene

Localization for WWTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WWTR1 Gene

Nucleus. Cytoplasm. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained in the nucleus by MED15.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WWTR1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WWTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,IBA 11118213
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA,IBA 20412773
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with WWTR1: view

Pathways & Interactions for WWTR1 Gene

genes like me logo Genes that share pathways with WWTR1: view

Pathways by source for WWTR1 Gene

SIGNOR curated interactions for WWTR1 Gene

Gene Ontology (GO) - Biological Process for WWTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0001894 tissue homeostasis IEA --
GO:0001933 negative regulation of protein phosphorylation IMP 20412773
GO:0003015 heart process IEA --
genes like me logo Genes that share ontologies with WWTR1: view

Drugs & Compounds for WWTR1 Gene

No Compound Related Data Available

Transcripts for WWTR1 Gene

mRNA/cDNA for WWTR1 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WWTR1

Clone Products

  • Addgene plasmids for WWTR1

Alternative Splicing Database (ASD) splice patterns (SP) for WWTR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - -
SP2: -
SP3:
SP4: - - -
SP5:
SP6: - - - - - -
SP7: - - - - -
SP8:
SP9: - - -
SP10: -

Relevant External Links for WWTR1 Gene

GeneLoc Exon Structure for
WWTR1

Expression for WWTR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WWTR1 Gene

Protein differential expression in normal tissues from HIPED for WWTR1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WWTR1 Gene



Protein tissue co-expression partners for WWTR1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WWTR1

SOURCE GeneReport for Unigene cluster for WWTR1 Gene:

Hs.477921

mRNA Expression by UniProt/SwissProt for WWTR1 Gene:

Q9GZV5-WWTR1_HUMAN
Tissue specificity: Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue.

Evidence on tissue expression from TISSUES for WWTR1 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Pancreas(3.6)
  • Skin(3.2)
  • Lung(3.1)
  • Kidney(2.5)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with WWTR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WWTR1 Gene

Orthologs for WWTR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for WWTR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WWTR1 31 30
  • 99.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia WWTR1 31 30
  • 91.99 (n)
OneToOne
dog
(Canis familiaris)
Mammalia WWTR1 31 30
  • 91.75 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Wwtr1 17 31 30
  • 89.09 (n)
rat
(Rattus norvegicus)
Mammalia Wwtr1 30
  • 88.48 (n)
oppossum
(Monodelphis domestica)
Mammalia WWTR1 31
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WWTR1 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves WWTR1 31 30
  • 77.22 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WWTR1 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wwtr1 30
  • 73.07 (n)
Str.8743 30
zebrafish
(Danio rerio)
Actinopterygii wwtr1 31 30
  • 69.06 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta yki 31
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7043 31
  • 17 (a)
OneToMany
Species where no ortholog for WWTR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WWTR1 Gene

ENSEMBL:
Gene Tree for WWTR1 (if available)
TreeFam:
Gene Tree for WWTR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WWTR1: view image

Paralogs for WWTR1 Gene

Paralogs for WWTR1 Gene

(2) SIMAP similar genes for WWTR1 Gene using alignment to 8 proteins:

  • WWTR1_HUMAN
  • C9J038_HUMAN
  • C9J337_HUMAN
  • C9J588_HUMAN
  • C9JQS8_HUMAN
  • C9JR84_HUMAN
  • H7C4Q0_HUMAN
  • H7C4Z7_HUMAN
genes like me logo Genes that share paralogs with WWTR1: view

Variants for WWTR1 Gene

Additional dbSNP identifiers (rs#s) for WWTR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for WWTR1 Gene

Variant ID Type Subtype PubMed ID
dgv831n67 CNV loss 20364138
dgv8644n54 CNV loss 21841781
dgv8645n54 CNV loss 21841781
dgv8646n54 CNV loss 21841781
dgv8647n54 CNV loss 21841781
dgv8648n54 CNV loss 21841781
esv2311493 CNV deletion 18987734
esv2483367 CNV deletion 19546169
esv25506 CNV loss 19812545
esv2670574 CNV deletion 23128226
esv2674585 CNV deletion 23128226
esv2726042 CNV deletion 23290073
esv2726043 CNV deletion 23290073
esv2833014 CNV deletion 24192839
esv3307369 CNV mobile element insertion 20981092
esv34142 CNV loss 18971310
esv3417310 CNV insertion 20981092
esv3562709 CNV deletion 23714750
esv3569053 CNV loss 25503493
esv3598147 CNV loss 21293372
esv3893785 CNV gain 25118596
esv996267 CNV deletion 20482838
nsv1071510 CNV deletion 25765185
nsv1131737 CNV deletion 24896259
nsv237898 CNV deletion 16902084
nsv4057 CNV insertion 18451855
nsv518493 CNV loss 19592680
nsv522752 CNV loss 19592680
nsv525253 CNV loss 19592680
nsv592008 CNV loss 21841781
nsv819268 CNV loss 19587683
nsv829754 CNV gain 17160897

Variation tolerance for WWTR1 Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.57; 82.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WWTR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WWTR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WWTR1 Gene

Disorders for WWTR1 Gene

MalaCards: The human disease database

(12) MalaCards diseases for WWTR1 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
epithelioid hemangioendothelioma
  • hemangioendothelioma epithelioid
histiocytoid hemangioma
  • angiolymphoid hyperplasia with eosinophilia
malignant epithelioid hemangioendothelioma
  • epithelioid hemangioendothelioma, malignant
malignant hemangioma
diabetes mellitus, neonatal, with congenital hypothyroidism
  • ndh
- elite association - COSMIC cancer census association via MalaCards
Search WWTR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WWTR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WWTR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WWTR1 Gene

Publications for WWTR1 Gene

  1. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. (PMID: 11118213) Kanai F … Yaffe MB (The EMBO journal 2000) 2 3 4 23 54
  2. Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M … Ramoni MF (Circulation 2009) 3 41 54
  3. TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. (PMID: 19010321) Di Palma T … Zannini M (Experimental cell research 2009) 3 4 54
  4. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. (PMID: 19324877) Zhang H … Guan KL (The Journal of biological chemistry 2009) 3 4 54
  5. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. (PMID: 18568018) Varelas X … Wrana JL (Nature cell biology 2008) 3 4 54

Products for WWTR1 Gene

Sources for WWTR1 Gene