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Aliases for WWC3 Gene

Aliases for WWC3 Gene

  • WWC Family Member 3 2 3 5
  • Protein WWC3 3
  • KIAA1280 4
  • BM042 3

External Ids for WWC3 Gene

Previous GeneCards Identifiers for WWC3 Gene

  • GC0XP009943
  • GC0XP007861

Summaries for WWC3 Gene

Entrez Gene Summary for WWC3 Gene

  • This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]

GeneCards Summary for WWC3 Gene

WWC3 (WWC Family Member 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include kinase binding and protein complex scaffold activity. An important paralog of this gene is WWC2.

Additional gene information for WWC3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WWC3 Gene

Genomics for WWC3 Gene

GeneHancer (GH) Regulatory Elements for WWC3 Gene

Promoters and enhancers for WWC3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI010014 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.0 969 4.9 HDGF RB1 ARID4B SIN3A NFXL1 KLF5 RAD21 BRCA1 ZNF48 RFX5 WWC3 WWC3-AS1
GH0XI010097 Enhancer 1.3 Ensembl ENCODE dbSUPER 13.4 +85.3 85316 6.2 PKNOX1 FOXA2 MLX ARID4B ETS1 ATF7 FOS RUNX3 RXRA NFYC WWC3 ENSG00000202469 CLCN4
GH0XI010082 Enhancer 1.2 Ensembl ENCODE dbSUPER 13.1 +67.9 67924 2.6 PKNOX1 FOXA2 SIN3A BATF RAD21 ATF7 ETV6 IKZF2 RUNX3 SMARCA5 WWC3 ENSG00000202469 CLCN4
GH0XI009980 Enhancer 1.1 FANTOM5 Ensembl ENCODE 12.6 -34.1 -34106 2.2 HDGF SOX5 SOX13 PKNOX1 ZNF687 TFE3 NR2F1 ELF1 ZNF217 IKZF1 WWC3 CLDN34
GH0XI010046 Enhancer 0.9 Ensembl ENCODE dbSUPER 12.6 +33.3 33340 4.3 TCF12 GATA3 TAL1 CBFA2T3 REST RUNX3 WWC3 GC0XP010062 WWC3-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WWC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WWC3 gene promoter:

Genomic Locations for WWC3 Gene

Genomic Locations for WWC3 Gene
128,917 bases
Plus strand

Genomic View for WWC3 Gene

Genes around WWC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WWC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WWC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WWC3 Gene

Proteins for WWC3 Gene

  • Protein details for WWC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein WWC3
    Protein Accession:
    Secondary Accessions:
    • A8KA96
    • Q659C1
    • Q9BTQ1

    Protein attributes for WWC3 Gene

    1092 amino acids
    Molecular mass:
    122676 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WWC3 Gene


neXtProt entry for WWC3 Gene

Post-translational modifications for WWC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WWC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WWC3 Gene

Domains & Families for WWC3 Gene

Gene Families for WWC3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WWC3 Gene


Suggested Antigen Peptide Sequences for WWC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WWC family.
  • Belongs to the WWC family.
genes like me logo Genes that share domains with WWC3: view

Function for WWC3 Gene

Phenotypes From GWAS Catalog for WWC3 Gene

Gene Ontology (GO) - Molecular Function for WWC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019900 kinase binding IPI 24682284
GO:0032947 protein complex scaffold activity IDA 24682284
genes like me logo Genes that share ontologies with WWC3: view
genes like me logo Genes that share phenotypes with WWC3: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WWC3 Gene

Localization for WWC3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WWC3 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WWC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 24682284
genes like me logo Genes that share ontologies with WWC3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WWC3 Gene

Pathways & Interactions for WWC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WWC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 24682284
GO:0035331 negative regulation of hippo signaling IDA 24682284
GO:0046621 negative regulation of organ growth IMP 24682284
genes like me logo Genes that share ontologies with WWC3: view

No data available for Pathways by source and SIGNOR curated interactions for WWC3 Gene

Drugs & Compounds for WWC3 Gene

No Compound Related Data Available

Transcripts for WWC3 Gene

mRNA/cDNA for WWC3 Gene

Unigene Clusters for WWC3 Gene

WWC family member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WWC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ·
SP1: - - - - -
SP2: - -
SP3: -
SP4: - -
SP6: - -

ExUns: 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25

Relevant External Links for WWC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WWC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WWC3 Gene

Protein differential expression in normal tissues from HIPED for WWC3 Gene

This gene is overexpressed in Liver (23.5), Plasma (23.3), and Placenta (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WWC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of WWC3 Gene:


SOURCE GeneReport for Unigene cluster for WWC3 Gene:


Evidence on tissue expression from TISSUES for WWC3 Gene

  • Nervous system(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with WWC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WWC3 Gene

Orthologs for WWC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for WWC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WWC3 33 34
  • 97.43 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
-- 34
  • 82 (a)
-- 34
  • 76 (a)
-- 34
  • 76 (a)
(Canis familiaris)
Mammalia WWC3 33 34
  • 84.88 (n)
(Bos Taurus)
Mammalia WWC3 33 34
  • 82.89 (n)
(Rattus norvegicus)
Mammalia Wwc3 33
  • 81.76 (n)
(Monodelphis domestica)
Mammalia WWC3 34
  • 74 (a)
(Gallus gallus)
Aves WWC3 33 34
  • 73.74 (n)
(Anolis carolinensis)
Reptilia WWC3 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wwc3 33
  • 68.61 (n)
(Danio rerio)
Actinopterygii wwc3 33 34
  • 61.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta kibra 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8937 34
  • 19 (a)
CSA.5313 34
  • 13 (a)
Species where no ortholog for WWC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WWC3 Gene

Gene Tree for WWC3 (if available)
Gene Tree for WWC3 (if available)

Paralogs for WWC3 Gene

Paralogs for WWC3 Gene

(2) SIMAP similar genes for WWC3 Gene using alignment to 3 proteins: Pseudogenes for WWC3 Gene

genes like me logo Genes that share paralogs with WWC3: view

Variants for WWC3 Gene

Sequence variations from dbSNP and Humsavar for WWC3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs193921110 uncertain-significance, Malignant tumor of prostate 10,126,289(+) C/A coding_sequence_variant, missense_variant
rs1000024781 -- 10,054,869(+) C/A intron_variant
rs1000025550 -- 10,125,329(+) C/T intron_variant
rs1000054512 -- 10,062,070(+) G/A intron_variant
rs1000130050 -- 10,053,473(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WWC3 Gene

Variant ID Type Subtype PubMed ID
esv25793 CNV loss 19812545
esv2758861 CNV loss 17122850
nsv1075718 CNV deletion 25765185
nsv1133761 CNV deletion 24896259
nsv425073 CNV insertion 16902084
nsv425191 CNV deletion 16902084
nsv524562 CNV gain 19592680

Variation tolerance for WWC3 Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WWC3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WWC3 Gene

Disorders for WWC3 Gene

Additional Disease Information for WWC3

No disorders were found for WWC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WWC3 Gene

Publications for WWC3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  5. Evolutionary and molecular facts link the WWC protein family to Hippo signaling. (PMID: 24682284) Wennmann DO … Kremerskothen J (Molecular biology and evolution 2014) 3 58

Products for WWC3 Gene

Sources for WWC3 Gene

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