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Aliases for WWC2 Gene

Aliases for WWC2 Gene

  • WW And C2 Domain Containing 2 2 3 5
  • WW, C2 And Coiled-Coil Domain Containing 2 2 3
  • BOMB 3 4
  • WW Domain-Containing Protein 2 4
  • BH3-Only Member B Protein 3
  • BH-3-Only Member B 4
  • Protein WWC2 3

External Ids for WWC2 Gene

Previous GeneCards Identifiers for WWC2 Gene

  • GC04P184351
  • GC04P184020
  • GC04P179780

Summaries for WWC2 Gene

Entrez Gene Summary for WWC2 Gene

  • This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling. [provided by RefSeq, Sep 2016]

GeneCards Summary for WWC2 Gene

WWC2 (WW And C2 Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include kinase binding and protein complex scaffold activity. An important paralog of this gene is WWC1.

Additional gene information for WWC2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WWC2 Gene

Genomics for WWC2 Gene

GeneHancer (GH) Regulatory Elements for WWC2 Gene

Promoters and enhancers for WWC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I183096 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 398 4.7 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B WWC2-AS2 GC04P183097 WWC2
GH04I183073 Enhancer 0.9 Ensembl ENCODE 11.8 -24.2 -24164 1.9 ELF3 MEIS2 CTCF MAX CEBPG ZNF2 RAD21 TEAD3 CC2D1A ARID2 WWC2 WWC2-AS2 LOC105377578 FAM92A1P2
GH04I183064 Enhancer 0.8 ENCODE 11.5 -33.9 -33910 0.6 ELF3 FOXA2 ZNF48 RAD21 MIXL1 SP5 MIER2 KAT8 MEF2D NFIL3 WWC2 LOC105377578 FAM92A1P2
GH04I183200 Enhancer 0.6 Ensembl ENCODE 10.8 +102.6 102614 1.6 USF1 MAX MYC WWC2 WWC2-AS2 WWC2-AS1 GC04M183137
GH04I183256 Enhancer 0.5 ENCODE 11.1 +158.3 158348 0.2 CTCF VEZF1 ZNF143 SMC3 REST RAD21 WWC2 WWC2-AS2 WWC2-AS1 CLDN22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WWC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WWC2 gene promoter:

Genomic Locations for WWC2 Gene

Genomic Locations for WWC2 Gene
222,143 bases
Plus strand

Genomic View for WWC2 Gene

Genes around WWC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WWC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WWC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WWC2 Gene

Proteins for WWC2 Gene

  • Protein details for WWC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein WWC2
    Protein Accession:
    Secondary Accessions:
    • Q32Q84
    • Q69YQ1
    • Q6AWB8
    • Q6ZSY9
    • Q6ZU09
    • Q7Z620
    • Q8TEB8
    • Q9H6P0

    Protein attributes for WWC2 Gene

    1192 amino acids
    Molecular mass:
    133891 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH17957.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI07684.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15215.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85032.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97477.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WWC2 Gene

neXtProt entry for WWC2 Gene

Post-translational modifications for WWC2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for WWC2 Gene

Domains & Families for WWC2 Gene

Gene Families for WWC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WWC2 Gene


Suggested Antigen Peptide Sequences for WWC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WWC family.
  • Belongs to the WWC family.
genes like me logo Genes that share domains with WWC2: view

Function for WWC2 Gene

Phenotypes From GWAS Catalog for WWC2 Gene

Gene Ontology (GO) - Molecular Function for WWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019900 kinase binding IPI 24682284
GO:0032947 protein complex scaffold activity IDA 24682284
genes like me logo Genes that share ontologies with WWC2: view
genes like me logo Genes that share phenotypes with WWC2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WWC2 Gene

Localization for WWC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WWC2 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 24682284
genes like me logo Genes that share ontologies with WWC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WWC2 Gene

Pathways & Interactions for WWC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 24682284
GO:0035331 negative regulation of hippo signaling IDA 24682284
GO:0046621 negative regulation of organ growth IMP 24682284
genes like me logo Genes that share ontologies with WWC2: view

No data available for Pathways by source and SIGNOR curated interactions for WWC2 Gene

Drugs & Compounds for WWC2 Gene

No Compound Related Data Available

Transcripts for WWC2 Gene

Unigene Clusters for WWC2 Gene

WW and C2 domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WWC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP3: - - -

Relevant External Links for WWC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WWC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WWC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WWC2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (25.7) and Testis (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WWC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of WWC2 Gene:


SOURCE GeneReport for Unigene cluster for WWC2 Gene:


Evidence on tissue expression from TISSUES for WWC2 Gene

  • Nervous system(4.4)
  • Lung(4.3)
  • Kidney(4.2)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with WWC2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WWC2 Gene

Orthologs for WWC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for WWC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WWC2 33 34
  • 99.08 (n)
(Canis familiaris)
Mammalia WWC2 33 34
  • 87.08 (n)
(Rattus norvegicus)
Mammalia Wwc2 33
  • 83.67 (n)
(Mus musculus)
Mammalia Wwc2 33 16 34
  • 83.32 (n)
(Bos Taurus)
Mammalia WWC2 33 34
  • 82.6 (n)
(Monodelphis domestica)
Mammalia WWC2 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
(Gallus gallus)
Aves WWC2 33 34
  • 76.11 (n)
(Anolis carolinensis)
Reptilia WWC2 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC79698 33
  • 69.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta kibra 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5313 34
  • 62 (a)
CSA.8937 34
  • 22 (a)
Species where no ortholog for WWC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WWC2 Gene

Gene Tree for WWC2 (if available)
Gene Tree for WWC2 (if available)

Paralogs for WWC2 Gene

Paralogs for WWC2 Gene

(8) SIMAP similar genes for WWC2 Gene using alignment to 3 proteins: Pseudogenes for WWC2 Gene

genes like me logo Genes that share paralogs with WWC2: view

Variants for WWC2 Gene

Sequence variations from dbSNP and Humsavar for WWC2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs796052193 likely-benign, Long QT syndrome 183,289,511(+) T/C coding_sequence_variant, missense_variant
rs1000015379 -- 183,121,949(+) C/G intron_variant
rs1000029665 -- 183,230,502(+) C/A/T intron_variant
rs1000040175 -- 183,317,850(+) G/C 3_prime_UTR_variant
rs1000044530 -- 183,237,186(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WWC2 Gene

Variant ID Type Subtype PubMed ID
nsv956900 CNV deletion 24416366
nsv822872 CNV gain 20364138
nsv596342 CNV gain 21841781
nsv596340 CNV gain+loss 21841781
nsv528100 CNV gain 19592680
nsv507223 OTHER sequence alteration 20534489
nsv4629 CNV deletion 18451855
nsv292991 CNV deletion 16902084
nsv290254 CNV deletion 16902084
nsv1149378 CNV insertion 26484159
nsv1114613 CNV deletion 24896259
nsv1030766 CNV gain 25217958
nsv1029647 CNV gain 25217958
nsv1016376 CNV gain 25217958
esv8514 CNV gain 19470904
esv6918 CNV gain 19470904
esv3603435 CNV loss 21293372
esv3603434 CNV gain 21293372
esv2763420 CNV loss 21179565
esv2728859 CNV deletion 23290073
esv2728858 CNV deletion 23290073
esv2671317 CNV deletion 23128226
esv2661293 CNV deletion 23128226
esv26194 CNV loss 19812545
esv21553 CNV loss 19812545
esv1447400 CNV deletion 17803354
dgv9416n54 CNV loss 21841781

Variation tolerance for WWC2 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.70; 89.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WWC2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WWC2 Gene

Disorders for WWC2 Gene

Additional Disease Information for WWC2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WWC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WWC2 Gene

Publications for WWC2 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58

Products for WWC2 Gene

Sources for WWC2 Gene

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