Aliases for WWC1 Gene
External Ids for WWC1 Gene
Previous GeneCards Identifiers for WWC1 Gene
The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
GeneCards Summary for WWC1 Gene
WWC1 (WW And C2 Domain Containing 1) is a Protein Coding gene. Diseases associated with WWC1 include Memory Quantitative Trait Locus and Wilson-Turner X-Linked Mental Retardation Syndrome. Among its related pathways are Signaling by GPCR and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and protein binding, bridging. An important paralog of this gene is WWC2.
UniProtKB/Swiss-Prot Summary for WWC1 Gene
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.