Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pat... See more...
Aliases for WT1 Gene
Aliases for WT1 Gene
External Ids for WT1 Gene
- HGNC: 12796
- Entrez Gene: 7490
- Ensembl: ENSG00000184937
- OMIM: 607102
- UniProtKB: P19544
Previous HGNC Symbols for WT1 Gene
- GUD
Previous GeneCards Identifiers for WT1 Gene
- GC11M034005
- GC11U900002
- GC11M032448
- GC11M032373
- GC11M032104
Summaries for WT1 Gene
-
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
-
WT1 is a tumor suppressor gene associated with the development of Wilms' Tumor, from which it was named. Mutations in exon 7 and 9 of WT1 have been recurrently identified in acute myeloid leukemia and associated with poorer prognosis and chemotherapy resistance.
GeneCards Summary for WT1 Gene
WT1 (WT1 Transcription Factor) is a Protein Coding gene. Diseases associated with WT1 include Wilms Tumor 1 and Denys-Drash Syndrome. Among its related pathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is EGR2.
UniProtKB/Swiss-Prot Summary for WT1 Gene
-
Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).
Additional gene information for WT1 Gene
- HGNC(12796)
- Entrez Gene(7490)
- Ensembl(ENSG00000184937)
- OMIM(607102)
- UniProtKB(P19544)
- Open Targets Platform(ENSG00000184937)
- Monarch Initiative
- Search for WT1 at DataMed
- Search for WT1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WT1 Gene
Genomics for WT1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for WT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around WT1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WT1
- Top Transcription factor binding sites by QIAGEN in the WT1 gene promoter:
-
- GATA-1
- TBP
Genomic Locations for WT1 Gene
Genomic Locations for WT1 Gene
- chr11:32,387,775-32,435,564
- (GRCh38/hg38)
- Size:
- 47,790 bases
- Orientation:
- Minus strand
- chr11:32,409,321-32,457,176
- (GRCh37/hg19)
- Size:
- 47,856 bases
- Orientation:
- Minus strand
Genomic View for WT1 Gene
Genes around WT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p13 by HGNC
- 11p13 by Entrez Gene
- 11p13 by Ensembl
WT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WT1 Gene
Proteins for WT1 Gene
-
Protein details for WT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P19544-WT1_HUMAN
- Recommended name:
- Wilms tumor protein
- Protein Accession:
- P19544
- A8K6S1
- B3KSA5
- Q15881
- Q16256
- Q16575
- Q4VXV4
- Q4VXV5
- Q4VXV6
- Q8IYZ5
Protein attributes for WT1 Gene
- Size:
- 449 amino acids
- Molecular mass:
- 49188 Da
- Quaternary structure:
-
- Homodimer. Interacts with WTIP. Interacts with actively translating polysomes. Detected in nuclear ribonucleoprotein (mRNP) particles. Interacts with HNRNPU via the zinc-finger region. Interacts with U2AF2. Interacts with CITED2 (By similarity). Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP and SRY. Interacts with AMER1. Interacts with RBM4.
- SequenceCaution:
-
- Sequence=AAB33443.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=CAA35956.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA35956.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAC39220.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAI95758.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAI95759.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- Presence of the KTS motif hinders interactions between DNA and zinc-finger 4.
- [Isoform 1]: Detected in nucleus speckle, may bind mRNA.
- [Isoform 7]: Produced by alternative initiation of isoform 1. Extended N-terminus.
- [Isoform 8]: Produced by alternative initiation of isoform 1. Extended N-terminus.
Three dimensional structures from OCA and Proteopedia for WT1 Gene
Protein Expression for WT1 Gene
Post-translational modifications for WT1 Gene
Other Protein References for WT1 Gene
Antibody Products
- LifeSpan BioSciences WT1 / Wilms Tumor 1 Antibody and WT1 / Wilms Tumor 1 Monoclonal Antibody
- G Biosciences Immunotag™ WT1 Antibody
- NSJ Bioreagents WT1 Antibody (Mouse Monoclonal)
- Creative Diagnostics Anti-WT1 monoclonal antibody, clone 2F0
-
Creative Biolabs
- Recombinant Anti-Human WT1 Antibody Fab Fragment
- Recombinant Anti-Human WT1 Antibody
- Anti-WT1 immunotoxin 6F-H2 (IgG)-RTA
- Mouse Anti-WT1 Recombinant Antibody (WT1/857 + 6F-H2)
- Mouse Anti-WT1 Recombinant Antibody (5G236)
- Human Anti-WT1 Antibody (Aali)
- Mouse Anti-WT1 Recombinant Antibody (1A12)
- Rabbit Anti-WT1 Recombinant Antibody (D8I7F)
-
Custom Antibody ServicesOriGene Antibodies for WT1
- Novus Biologicals Antibodies for WT1
-
Abcam antibodies for WT1
- Invitrogen Antibodies for WT1 (AFLGC-WT1)
- antibodies-online: Show 104 available WT1 Antibodies ranked by validation data
- Compare Top WT1 Antibodies
-
Recommended
- 114 WB Antibodies (anti-human)
- 104 IHC (p) Antibodies (anti-human)
- 61 IHC Antibodies (anti-human)
- 42 IHC (f) Antibodies (anti-human)
- 26 FACS Antibodies (anti-human)
- 23 IF Antibodies (anti-human)
- 2 ICC Antibodies (anti-human)
- 46 IHC (p) Antibodies (anti-rat)
- 42 IHC (f) Antibodies (anti-rat)
- 22 WB Antibodies (anti-rat)
- 21 IF Antibodies (anti-rat)
- 5 FACS Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 49 IHC (p) Antibodies (anti-mouse)
- 42 IHC (f) Antibodies (anti-mouse)
- 40 WB Antibodies (anti-mouse)
- 21 IF Antibodies (anti-mouse)
- 5 FACS Antibodies (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for WT1
Protein Products
- RayBiotech Recombinant Human Wilms Tumor 1
- Creative Biomart Recombinant Human Wilms Tumor 1
- Search Origene for MassSpec and Protein Over-expression Lysates for WT1
- Origene Custom Protein Services for WT1
- antibodies-online: Show 16 available WT1 Proteins ranked by validation data
- Compare Top WT1 Proteins
-
Abcam proteins for WT1
Assay Products
-
Signalway ELISA kits for WT1
No data available for DME Specific Peptides for WT1 Gene
Domains & Families for WT1 Gene
Gene Families for WT1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for WT1 Gene
- InterPro:
- Blocks:
-
- C2H2-type zinc finger signature
- Wilm's tumour protein signature
- ProtoNet:
Suggested Antigen Peptide Sequences for WT1 Gene
- GenScript: Design optimal peptide antigens:
-
- Wilms tumor 1 (A0FJ57_HUMAN)
- Wilms tumor 1 (A0FJ58_HUMAN)
- WT1 protein (A8MN20_HUMAN)
- cDNA FLJ35849 fis, clone TESTI2006940, highly similar to Wilms' tumor protein (WT33) (B3KSA5_HUMAN)
- WT1 protein (Q6LBI3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P19544UniProtKB/Swiss-Prot:
WT1_HUMAN :- Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. Starting from the N-terminus, the second zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine, 5-formylcytosine or 5-carboxylcytosine.
- Belongs to the EGR C2H2-type zinc-finger protein family.
- Domain:
-
- Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. Starting from the N-terminus, the second zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine, 5-formylcytosine or 5-carboxylcytosine.
- The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
- Family:
-
- Belongs to the EGR C2H2-type zinc-finger protein family.
Function for WT1 Gene
Molecular function for WT1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).
- GENATLAS Biochemistry:
- Wilms tumor protein including WIT1 overlapping 5' - WT1 and divergently (antisense) transcribed sequences,transcriptional regulator binding to both GC-rich and TC repeat elements that are present in multiple promoters,first considered as a repressor but appearing now as a transcriptional activator of specific genes i.e AMH,DAX1 implicated in gonadal differentiation,highly expressed in the developing kidney located in the condensing mesenchyme,renal vesicle,developing podocytes and also expressed in urogenital tract,sometimes paternally imprinted in placenta and fetal brain but maternally imprinted in fibroblasts and lymphocytes,overexpressed in myelodysplastic syndrome in progression and in acute leukemia
Phenotypes From GWAS Catalog for WT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA, IBA | 1332065 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA,ISS | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for WT1 Gene
- MGI mutant phenotypes for WT1:
-
inferred from 17 alleles
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- hematopoietic system phenotype
- embryo phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for WT1:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- shRNA abundance <= 50%
- Increased shRNA abundance (Z-score > 2)
- shRNA abundance <= 25%
- Decreased viability
- Increased viability
- Inconclusive
- Decreased viability (cell death)
- Decreased shRNA abundance (Z-score < -2)
- Decreased sensitivity to paclitaxel
Animal Models for WT1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WT1 - Select products 50% OFF >
- * WT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for WT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for WT1
miRNA for WT1 Gene
- miRTarBase miRNAs that target WT1
-
- hsa-miR-16-5p (MIRT000816)
- hsa-miR-15a-5p (MIRT000817)
- hsa-miR-212-3p (MIRT003966)
- mmu-miR-124-3p (MIRT015954)
- hsa-miR-5096 (MIRT528033)
- hsa-miR-192-5p (MIRT528034)
- hsa-miR-215-5p (MIRT528035)
- hsa-miR-3156-3p (MIRT528036)
- hsa-miR-532-3p (MIRT528037)
- hsa-miR-4301 (MIRT528038)
- hsa-miR-181a-2-3p (MIRT528039)
- hsa-miR-500b-3p (MIRT528040)
- hsa-miR-4637 (MIRT528041)
- hsa-miR-5003-5p (MIRT610237)
- hsa-miR-8485 (MIRT610238)
- hsa-miR-302d-5p (MIRT621593)
- hsa-miR-302b-5p (MIRT621594)
- hsa-miR-3685 (MIRT651486)
- hsa-miR-7152-5p (MIRT651487)
- hsa-miR-498 (MIRT651488)
- hsa-miR-155-3p (MIRT651489)
- hsa-miR-1236-3p (MIRT651490)
- hsa-miR-1266-3p (MIRT651491)
- hsa-miR-6777-3p (MIRT651492)
- hsa-miR-7159-3p (MIRT651493)
- hsa-miR-5006-5p (MIRT651494)
- hsa-miR-642a-5p (MIRT651495)
- hsa-miR-4755-3p (MIRT651496)
- hsa-miR-891b (MIRT651497)
- hsa-miR-877-3p (MIRT651498)
- hsa-miR-2276-5p (MIRT651499)
- hsa-miR-6892-3p (MIRT651500)
- hsa-miR-548al (MIRT651501)
- hsa-miR-4445-3p (MIRT651502)
- hsa-miR-193a-5p (MIRT733534)
- hsa-miR-1273e (MIRT761883)
- hsa-miR-1273g-3p (MIRT762007)
- hsa-miR-1285-3p (MIRT762229)
- hsa-miR-1827 (MIRT763150)
- hsa-miR-196a-3p (MIRT763520)
- hsa-miR-3187-5p (MIRT765332)
- hsa-miR-340-3p (MIRT765740)
- hsa-miR-3613-3p (MIRT766011)
- hsa-miR-371a-5p (MIRT767192)
- hsa-miR-371b-5p (MIRT767230)
- hsa-miR-372-5p (MIRT767274)
- hsa-miR-373-5p (MIRT767321)
- hsa-miR-3929 (MIRT767823)
- hsa-miR-4252 (MIRT768069)
- hsa-miR-4419b (MIRT768819)
- hsa-miR-4478 (MIRT769570)
- hsa-miR-4649-3p (MIRT770693)
- hsa-miR-4722-5p (MIRT771606)
- hsa-miR-4793-3p (MIRT772449)
- hsa-miR-485-5p (MIRT772663)
- hsa-miR-508-5p (MIRT773212)
- hsa-miR-5189-5p (MIRT773582)
- hsa-miR-612 (MIRT775873)
- hsa-miR-616-5p (MIRT776032)
- hsa-miR-6512-3p (MIRT776967)
- hsa-miR-661 (MIRT777482)
- hsa-miR-665 (MIRT777646)
- hsa-miR-6720-5p (MIRT777813)
- hsa-miR-6808-5p (MIRT779736)
- hsa-miR-6827-3p (MIRT779938)
- hsa-miR-6849-3p (MIRT780368)
- hsa-miR-6860 (MIRT780581)
- hsa-miR-6884-5p (MIRT781051)
- hsa-miR-6893-5p (MIRT781268)
- hsa-miR-7160-5p (MIRT781656)
- hsa-miR-766-3p (MIRT781920)
- hsa-miR-7703 (MIRT782079)
- hsa-miR-939-3p (MIRT782850)
- hsa-miR-940 (MIRT782961)
- hsa-miR-1292-3p (MIRT783432)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WT1
- Browse OriGene Inhibitory RNA Products For WT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WT1
Clone Products
- Applied Biological Materials (abm): Clones for WT1 - Select products 50% OFF >
- * WT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG225851
- MR225851
- MR225851L3
- MR225851L4
- RC220079
- RC220079L1
- RC220079L2
- RC220079L3
- RC220079L4
- RC220142
- RC220142L1
- RC220142L2
- RC220142L3
- RC220142L4
- RC221271
- RC221271L1
- RC221271L2
- RC221271L3
- RC221271L4
- RC221847
- RC221847L3
- RC221847L4
- RC230799
- RC230799L3
- RC230799L4
- RC231130
- RC231130L3
- RC231130L4
- RG220079
- RG220142
- RG221271
- RG221847
- RG230799
- RG231130
- RR203084
- RR203084L1
- RR203084L2
- RR203084L3
- RR203084L4
- MR225851L3V
- MR225851L4V
- RC220079L1V
- RC220079L2V
- RC220079L3V
- RC220079L4V
- RC220142L1V
- RC220142L2V
- RC220142L3V
- RC220142L4V
- RC221271L1V
- RC221271L2V
- RC221271L3V
- RC221271L4V
- RC221847L3V
- RC221847L4V
- RC230799L3V
- RC230799L4V
- RC231130L3V
- RC231130L4V
- RR203084L1V
- RR203084L2V
- RR203084L3V
- RR203084L4V
- RC403435
- RC403436
- RC403437
- RC403438
- RC403439
- RC403440
- RC403441
- RC403442
- RC403443
- RC403444
- RC403445
- RC403446
- RC403447
- RC403448
- RC403449
- RC403450
- RC403451
- RC403452
- RC403453
- RC403454
- RC403455
- RC403456
- RC403457
- RC403458
- RC403459
- RC403460
- RC403461
- RC403462
- RC403463
- RC403464
- RC403465
- RC403466
- RC403467
- RC403468
- RC403469
- RC403470
- RC403471
- RC403472
- RC403473
- RC403474
- RC403475
- RC403476
- RC403477
- RC403478
- RC403479
- RC403480
- RC403481
- RC403482
- RC403483
- RC403484
- RC403485
- RC403486
- RC403487
- RC403488
- RC403489
- RC403490
- RC403491
- RC403492
- RC403493
- RC403494
- RC403495
- RC403496
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for WT1
- Addgene plasmids for WT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WT1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WT1 Gene
Localization for WT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for WT1 Gene
- Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Isoforms lacking the KTS motif have a diffuse nuclear location (PubMed:15520190). Shuttles between nucleus and cytoplasm. {ECO:0000250, ECO:0000269 PubMed:15520190}.
- [Isoform 1]: Nucleus speckle.
- [Isoform 4]: Nucleus, nucleoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 3 |
| cytoskeleton | 3 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| endosome | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 1662794 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IEA | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for WT1 Gene
Pathways by source for WT1 Gene
2 BioSystems pathways for WT1 Gene
1 KEGG pathway for WT1 Gene
1 R&D Systems pathway for WT1 Gene
Interacting Proteins for WT1 Gene
Selected Interacting proteins:
P19544-WT1_HUMAN
ENSP00000331327
for WT1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for WT1
SIGNOR curated interactions for WT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA,IMP | 23042785 |
| GO:0001570 | vasculogenesis | ISS | -- |
| GO:0001657 | ureteric bud development | ISS | -- |
| GO:0001658 | branching involved in ureteric bud morphogenesis | IGI | 10101119 |
| GO:0001822 | kidney development | IGI | 11912180 |
Drugs & Compounds for WT1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Doxorubicin | Approved, Investigational | Pharma | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 2029 | ||
| Carboplatin | Approved | Pharma | Antitumor agent that forms platinum-DNA adducts., Platinum | 2588 | ||
| Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3670 | ||
| Docetaxel | Approved, Investigational | Pharma | Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes | 2330 | ||
| Epirubicin | Approved | Pharma | 483 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- RayBiotech Recombinant Human Wilms Tumor 1
- Creative Biomart Recombinant Human Wilms Tumor 1
Transcripts for WT1 Gene
mRNA/cDNA for WT1 Gene
- 7 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000332351 2987 nts (view in UCSC)
- ENST00000379077 3186 nts (view in UCSC)
- ENST00000379079 2466 nts (view in UCSC)
- ENST00000448076 2114 nts (view in UCSC)
- ENST00000452863 3031 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WT1 - Select products 50% OFF >
- * WT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for WT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for WT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WT1
- Browse OriGene Inhibitory RNA Products For WT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WT1
Clone Products
- Applied Biological Materials (abm): Clones for WT1 - Select products 50% OFF >
- * WT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG225851
- MR225851
- MR225851L3
- MR225851L4
- RC220079
- RC220079L1
- RC220079L2
- RC220079L3
- RC220079L4
- RC220142
- RC220142L1
- RC220142L2
- RC220142L3
- RC220142L4
- RC221271
- RC221271L1
- RC221271L2
- RC221271L3
- RC221271L4
- RC221847
- RC221847L3
- RC221847L4
- RC230799
- RC230799L3
- RC230799L4
- RC231130
- RC231130L3
- RC231130L4
- RG220079
- RG220142
- RG221271
- RG221847
- RG230799
- RG231130
- RR203084
- RR203084L1
- RR203084L2
- RR203084L3
- RR203084L4
- MR225851L3V
- MR225851L4V
- RC220079L1V
- RC220079L2V
- RC220079L3V
- RC220079L4V
- RC220142L1V
- RC220142L2V
- RC220142L3V
- RC220142L4V
- RC221271L1V
- RC221271L2V
- RC221271L3V
- RC221271L4V
- RC221847L3V
- RC221847L4V
- RC230799L3V
- RC230799L4V
- RC231130L3V
- RC231130L4V
- RR203084L1V
- RR203084L2V
- RR203084L3V
- RR203084L4V
- RC403435
- RC403436
- RC403437
- RC403438
- RC403439
- RC403440
- RC403441
- RC403442
- RC403443
- RC403444
- RC403445
- RC403446
- RC403447
- RC403448
- RC403449
- RC403450
- RC403451
- RC403452
- RC403453
- RC403454
- RC403455
- RC403456
- RC403457
- RC403458
- RC403459
- RC403460
- RC403461
- RC403462
- RC403463
- RC403464
- RC403465
- RC403466
- RC403467
- RC403468
- RC403469
- RC403470
- RC403471
- RC403472
- RC403473
- RC403474
- RC403475
- RC403476
- RC403477
- RC403478
- RC403479
- RC403480
- RC403481
- RC403482
- RC403483
- RC403484
- RC403485
- RC403486
- RC403487
- RC403488
- RC403489
- RC403490
- RC403491
- RC403492
- RC403493
- RC403494
- RC403495
- RC403496
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for WT1
- Addgene plasmids for WT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WT1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for WT1 Gene
- GeneLoc Exon Structure for
- WT1
Expression for WT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Cap Mesenchyme Cells Cap Mesenchyme
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Cortical Stroma Cells Interstitial Stroma
- Presumptive Podocytes Podocyte Layer
- S-shaped Body Proximal Cells S-shaped Body Proximal Segment
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Granulosa Cells Primary Follicle
- Gonad Somatic Cells Primitive Gonad
- Secondary follicles
-
Heart (Cardiovascular System)
- Mesenchymal Cells Epicardium
- Epicardial Progenitors Cells Epicardium
- Proepicardial Progenitor cells Proepicardium
- Vascular Smooth Muscle Cells Coronary Capillary Plexus
- Vascular Smooth Muscle Cells Coronary Vessels
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
- Sertoli cells Seminiferous Tubules
- Gonad Somatic Cells Primitive Gonad
- XY Germ Cells Testis Cord
-
Liver (Hepatobiliary System)
- Fetal Hepatic Stellate Cells Sinusoids
- Submesothelial Cells Mesoblastic Supporting Stroma
- Mesothelial Cells Hepatic Mesenchyme
- Hepatic Stellate Cells Sinusoids
- Intermediate Mesoderm (Gastrulation Derivatives)
-
Mesoderm (Gastrulation Derivatives)
- Intermediate Mesoderm Cells Intermediate Mesoderm
- Mesothelial Cells Hepatic Mesenchyme
- Septum Transversum Mesenchyme Cells Septum Transversum
-
Epithelial Cells
- Presumptive Podocytes Podocyte Layer
- Podocytes Podocyte Layer
- Coelomic Epithelial Cells Intraembryonic Coelom
-
Gonad (Reproductive System)
- Gonad Somatic Cells Primitive Gonad
- Coelomic Epithelial Cells Intraembryonic Coelom
- XY Germ Cells Testis Cord
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Proepicardial Progenitor cells Proepicardium
- Coelomic Epithelial Cells Intraembryonic Coelom
-
Smooth Muscle (Muscoskeletal System)
- Vascular Smooth Muscle Cells Coronary Capillary Plexus
- Vascular Smooth Muscle Cells Coronary Vessels
- Gut Tube (Gastrointestinal Tract)
- Mesenchymal Stem Cells (Uncategorized)
- Placenta (Extraembryonic Tissues)
- NULL (Uncategorized)
- Adipose (Muscoskeletal System)
-
Uterus (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for WT1 Gene
This gene is overexpressed in Uterus (x11.7), Fallopian Tube (x8.7), Ovary (x7.7), and Testis (x4.4).
This gene is overexpressed in Fetal ovary (29.4), Fetal testis (27.2), and Ovary (12.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WT1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WT1
SOURCE GeneReport for Unigene cluster for WT1 Gene:
Hs.591980mRNA Expression by UniProt/SwissProt for WT1 Gene:
P19544-WT1_HUMAN
Tissue specificity:
Expressed in the kidney and a subset of hematopoietic cells.
Evidence on tissue expression from TISSUES for WT1 Gene
- Kidney(3.5)
- Blood(3.1)
- Spleen(2.9)
- Heart(2.8)
- Nervous system(2.7)
- Muscle(2.7)
- Bone marrow(2.7)
- Skin(2.5)
- Lymph node(2.5)
- Lung(2.4)
- Intestine(2.4)
- Liver(2.4)
- Urine(2.3)
- Adrenal gland(2.1)
- Pancreas(2.1)
- Thyroid gland(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for WT1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- pituitary gland
- skull
Thorax:
- breast
- clavicle
- diaphragm
- esophagus
- heart
- heart valve
- lung
Abdomen:
- abdominal wall
- intestine
- kidney
- large intestine
- liver
- small intestine
- spleen
- stomach
Pelvis:
- fallopian tube
- ovary
- pelvis
- penis
- prostate
- testicle
- ureter
- urethra
- urinary bladder
- uterus
- vagina
- vas deferens
- vulva
Limb:
- arm
- digit
- femur
- fibula
- finger
- foot
- forearm
- hand
- humerus
- lower limb
- radius
- shin
- thigh
- tibia
- toe
- ulna
- upper limb
General:
- blood
- blood vessel
- coagulation system
- hair
- lymph node
- peripheral nervous system
- red blood cell
- skin
Primer Products
-
OriGene qPCR primer pairs for WT1
Gene Expression Assay Products
Orthologs for WT1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | WT1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | WT1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | WT1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Wt1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | WT1 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Wt1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | WT1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | WT1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | WT1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | wt1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | wt1-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | wt1a 30 31 |
|
OneToMany | |
| wt1b 31 |
|
OneToMany | |||
| wt1 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG3065 31 |
|
ManyToMany | |
| klu 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | egrh-2 31 |
|
OneToMany | |
| egrh-1 31 |
|
OneToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MIG2 31 |
|
ManyToMany | |
| MIG3 31 |
|
ManyToMany | |||
| -- 33 |
|
|
|||
| -- 33 |
|
|
|||
| -- 33 |
|
|
- Species where no ortholog for WT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for WT1 Gene
- ENSEMBL:
- Gene Tree for WT1 (if available)
- TreeFam:
- Gene Tree for WT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for WT1: view image
Paralogs for WT1 Gene
(96) SIMAP similar genes for WT1 Gene using alignment to 16 proteins:
- WT1_HUMAN
- A0FJ57_HUMAN
- A0FJ58_HUMAN
- A8MN20_HUMAN
- E9PKS2_HUMAN
- E9PPW3_HUMAN
- H0Y3F0_HUMAN
- H0Y7K5_HUMAN
- H0YED9_HUMAN
- J3KNN9_HUMAN
- Q6LBI3_HUMAN
- Q6LD16_HUMAN
- Q6PI38_HUMAN
- Q93046_HUMAN
- U5LSU3_HUMAN
- V9GZX5_HUMAN
- ZNF235
- ZNF224
- EGR4
- ZNF653
- ZNF180
- Sp1
- KLF6
- SP3
- SP1
- DKFZp686N0199
- A-328A3.4
- KLF13
- KLF4
- KLF7
- ZNF778
- ZNF234
- KLF16
- KLF1
- ZNF10
- ZNF78L1
- smap-7
- ZNFN1A2
- ZNF525
- ZNF468
- ZSCAN5A
- ZSCAN10
- ZNF79
- ZNF565
- ZNF112
- ZFP1
- DKFZp686M04222
- ZNF22
- ZNF56
- ZNF540
- ZNF324
- DKFZp686O1631
- KLF9
- kr-znf3
- ZNF692
- ZNF664
- ZFP41
- ZNF66
- ZNF473
- ZNF418
- ZNF384
- MYNN
- ZFS-5
- ZNF
- ZNF410
- ZNF600
- ZFS-6
- ZNF700
- HZF40
- ZNF697
- GZF1
- DKFZp313M0722
- ZNF323
- DKFZp434J0650
- ZSCAN21
- ZNF740
- ZNF589
- ZNF138
- ZNF562
- ZNF544
- ZNF133
- HKR1
- ZNF833P
- DKFZp666C237
- ZNF564
- GLIS3
- ZNF72
- zf30
- ZNF876P
- ZNF55
- ZNF219
- ZFS-2
- ZNF768
- ZNF19
- REST
- HZF36
- ZNF702P
- ZNF236
- ZNF808
- GTF3A
- ZFP64
- PRDM9
- ZNF491
- ZNF137P
- ZNF720
- ZNF283
- ZNF136
- ZNF770
- HZF16
- ZNF844
- ZNF791
- ZNF710
Variants for WT1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WT1 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 635489 | Uncertain Significance: Nephrotic syndrome, type 4 | 32,396,305(-) | T/C | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 639084 | Uncertain Significance: Frasier syndrome; Wilms tumor 1; Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome; Drash syndrome | 32,434,975(-) | G/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 639136 | Uncertain Significance: Frasier syndrome; Wilms tumor 1; Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome; Drash syndrome | 32,399,957(-) | T/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 640025 | Uncertain Significance: Frasier syndrome; Wilms tumor 1; Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome; Drash syndrome | 32,428,571(-) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 641525 | Uncertain Significance: Frasier syndrome; Wilms tumor 1; Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome; Drash syndrome | 32,396,391(-) | G/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3387730 | CNV | insertion | 20981092 |
| esv3397537 | CNV | insertion | 20981092 |
| esv3421146 | CNV | insertion | 20981092 |
| esv3579463 | CNV | loss | 25503493 |
| nsv1038188 | CNV | gain | 25217958 |
| nsv1044547 | CNV | gain | 25217958 |
| nsv1051559 | CNV | gain | 25217958 |
| nsv472951 | CNV | novel sequence insertion | 20440878 |
| nsv832108 | CNV | loss | 17160897 |
| nsv951598 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.94;
19.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for WT1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WT1 Gene
Disorders for WT1 Gene
(190) MalaCards diseases for WT1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wilms tumor 1 |
|
|
| denys-drash syndrome |
|
|
| frasier syndrome |
|
|
| meacham syndrome |
|
|
| nephrotic syndrome, type 4 |
|
Search WT1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
WT1_HUMAN- Frasier syndrome (FS) [MIM:136680]: Characterized by a slowly progressing nephropathy leading to renal failure in adolescence or early adulthood, male pseudohermaphroditism, and no Wilms tumor. As for histological findings of the kidneys, focal glomerular sclerosis is often observed. There is phenotypic overlap with Denys-Drash syndrome. Inheritance is autosomal dominant. {ECO:0000269 PubMed:10571943}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Wilms tumor 1 (WT1) [MIM:194070]: Embryonal malignancy of the kidney that affects approximately 1 in 10'000 infants and young children. It occurs both in sporadic and hereditary forms. {ECO:0000269 PubMed:1317572, ECO:0000269 PubMed:15150775, ECO:0000269 PubMed:9108089, ECO:0000269 PubMed:9529364}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Denys-Drash syndrome (DDS) [MIM:194080]: Typical nephropathy characterized by diffuse mesangial sclerosis, genital abnormalities, and/or Wilms tumor. There is phenotypic overlap with WAGR syndrome and Frasier syndrome. Inheritance is autosomal dominant, but most cases are sporadic. {ECO:0000269 PubMed:10738002, ECO:0000269 PubMed:10799199, ECO:0000269 PubMed:11182928, ECO:0000269 PubMed:11519891, ECO:0000269 PubMed:1302008, ECO:0000269 PubMed:1338906, ECO:0000269 PubMed:15349765, ECO:0000269 PubMed:1655284, ECO:0000269 PubMed:8111391, ECO:0000269 PubMed:8112732, ECO:0000269 PubMed:8295405, ECO:0000269 PubMed:8388765, ECO:0000269 PubMed:8411073, ECO:0000269 PubMed:8741319, ECO:0000269 PubMed:8956030, ECO:0000269 PubMed:9475094, ECO:0000269 PubMed:9529364}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Nephrotic syndrome 4 (NPHS4) [MIM:256370]: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. Most patients with NPHS4 show diffuse mesangial sclerosis on renal biopsy, which is a pathologic entity characterized by mesangial matrix expansion with no mesangial hypercellularity, hypertrophy of the podocytes, vacuolized podocytes, thickened basement membranes, and diminished patency of the capillary lumen. {ECO:0000269 PubMed:11182928, ECO:0000269 PubMed:15253707, ECO:0000269 PubMed:20798252, ECO:0000269 PubMed:9529364, ECO:0000269 PubMed:9607189}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Meacham syndrome (MEACHS) [MIM:608978]: Rare sporadically occurring multiple malformation syndrome characterized by male pseudohermaphroditism with abnormal internal female genitalia comprising a uterus and double or septate vagina, complex congenital heart defect and diaphragmatic abnormalities. {ECO:0000269 PubMed:17853480}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=A chromosomal aberration involving WT1 may be a cause of desmoplastic small round cell tumor (DSRCT). Translocation t(11;22)(p13;q12) with EWSR1.
- Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. {ECO:0000269 PubMed:8401592}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
Additional Disease Information for WT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for WT1 Gene
Publications for WT1 Gene
- Mutation analysis of five candidate genes in Chinese patients with hypospadias. (PMID: 15266301) Wang Y … Shen Y (European journal of human genetics : EJHG 2004) 3 4 23 41
- Prevalence of WT1 mutations in a large cohort of patients with steroid-resistant and steroid-sensitive nephrotic syndrome. (PMID: 15253707) Ruf RG … APN Study Group (Kidney international 2004) 3 4 23 41
- Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. (PMID: 1655284) Pelletier J … Fouser L (Cell 1991) 3 4 23 41
- The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity. (PMID: 19416806) Rivera MN … Haber DA (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 23
- Eye involvement in children with primary focal segmental glomerulosclerosis. (PMID: 18058136) Ozaltin F … Bakkaloglu A (Pediatric nephrology (Berlin, Germany) 2008) 3 23 41
ExternalLinks
Products for WT1 Gene
- Custom Antibody ServicesOriGene Antibodies for WT1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for WT1
- Origene Custom Protein Services for WT1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WT1
- Browse OriGene Inhibitory RNA Products For WT1
- OriGene qPCR primer pairs for WT1
- OriGene CRISPR knockouts for WT1
- MG225851
- MR225851
- MR225851L3
- MR225851L4
- RC220079
- RC220079L1
- RC220079L2
- RC220079L3
- RC220079L4
- RC220142
- RC220142L1
- RC220142L2
- RC220142L3
- RC220142L4
- RC221271
- RC221271L1
- RC221271L2
- RC221271L3
- RC221271L4
- RC221847
- RC221847L3
- RC221847L4
- RC230799
- RC230799L3
- RC230799L4
- RC231130
- RC231130L3
- RC231130L4
- RG220079
- RG220142
- RG221271
- RG221847
- RG230799
- RG231130
- RR203084
- RR203084L1
- RR203084L2
- RR203084L3
- RR203084L4
- MR225851L3V
- MR225851L4V
- RC220079L1V
- RC220079L2V
- RC220079L3V
- RC220079L4V
- RC220142L1V
- RC220142L2V
- RC220142L3V
- RC220142L4V
- RC221271L1V
- RC221271L2V
- RC221271L3V
- RC221271L4V
- RC221847L3V
- RC221847L4V
- RC230799L3V
- RC230799L4V
- RC231130L3V
- RC231130L4V
- RR203084L1V
- RR203084L2V
- RR203084L3V
- RR203084L4V
- RC403435
- RC403436
- RC403437
- RC403438
- RC403439
- RC403440
- RC403441
- RC403442
- RC403443
- RC403444
- RC403445
- RC403446
- RC403447
- RC403448
- RC403449
- RC403450
- RC403451
- RC403452
- RC403453
- RC403454
- RC403455
- RC403456
- RC403457
- RC403458
- RC403459
- RC403460
- RC403461
- RC403462
- RC403463
- RC403464
- RC403465
- RC403466
- RC403467
- RC403468
- RC403469
- RC403470
- RC403471
- RC403472
- RC403473
- RC403474
- RC403475
- RC403476
- RC403477
- RC403478
- RC403479
- RC403480
- RC403481
- RC403482
- RC403483
- RC403484
- RC403485
- RC403486
- RC403487
- RC403488
- RC403489
- RC403490
- RC403491
- RC403492
- RC403493
- RC403494
- RC403495
- RC403496
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For WT1
- Sino Biological Human cDNA Clone for WT1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for WT1
- Novus Biologicals proteins and lysates for WT1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for WT1
- Abcam proteins for WT1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for WT1 (AFLGC-WT1)
- VectorBuilder Custom and pre-made DNA vectors for WT1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for WT1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for WT1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for WT1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for WT1
- Addgene plasmids for WT1
- antibodies-online: Show 104 available WT1 Antibodies ranked by validation data
- Compare Top WT1 Antibodies
- Recommended
- 114 WB Antibodies (anti-human)
- 104 IHC (p) Antibodies (anti-human)
- 61 IHC Antibodies (anti-human)
- 42 IHC (f) Antibodies (anti-human)
- 26 FACS Antibodies (anti-human)
- 23 IF Antibodies (anti-human)
- 2 ICC Antibodies (anti-human)
- 46 IHC (p) Antibodies (anti-rat)
- 42 IHC (f) Antibodies (anti-rat)
- 22 WB Antibodies (anti-rat)
- 21 IF Antibodies (anti-rat)
- 5 FACS Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 49 IHC (p) Antibodies (anti-mouse)
- 42 IHC (f) Antibodies (anti-mouse)
- 40 WB Antibodies (anti-mouse)
- 21 IF Antibodies (anti-mouse)
- 5 FACS Antibodies (anti-mouse)
- antibodies-online: Show 19 available WT1 Elisa Kits ranked by validation data
- Compare Top WT1 Elisa Kits
- antibodies-online: Show 16 available WT1 Proteins ranked by validation data
- Compare Top WT1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for WT1
- Search Santa Cruz Biotechnology (SCBT) for WT1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for WT1
- Horizon Cell Lines for WT1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WT1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for WT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WT1
- Signalway ELISA kits for WT1