Aliases for WSCD1 Gene

Aliases for WSCD1 Gene

  • WSC Domain Containing 1 2 3 5
  • WSC Domain-Containing Protein 1 3 4
  • KIAA0523 4

External Ids for WSCD1 Gene

Previous GeneCards Identifiers for WSCD1 Gene

  • GC17P005915
  • GC17P005676
  • GC17P005772

Summaries for WSCD1 Gene

GeneCards Summary for WSCD1 Gene

WSCD1 (WSC Domain Containing 1) is a Protein Coding gene. Diseases associated with WSCD1 include Granulomatosis With Polyangiitis. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity. An important paralog of this gene is WSCD2.

Additional gene information for WSCD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WSCD1 Gene

Genomics for WSCD1 Gene

GeneHancer (GH) Regulatory Elements for WSCD1 Gene

Promoters and enhancers for WSCD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J006070 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.4 +13.1 13081 3.4 CTCF ZIC2 ZBTB10 ZBTB26 KLF7 ZEB1 EZH2 ZNF148 OSR2 MYC WSCD1 ENSG00000261879 ZNF594 RPAIN ENSG00000263164 ENSG00000263220 ZNF232 MIR497HG DHX33 ENSG00000263272
GH17J006074 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 502 +19.8 19791 5.8 TEAD4 ZNF623 RBM25 OSR2 POLR2A EZH2 ZNF768 ZNF664 SMARCA4 ZSCAN4 WSCD1 AIPL1 RF01853-004 lnc-WSCD1-2 ENSG00000285471
GH17J006069 Promoter/Enhancer 1.1 EPDnew ENCODE 500.4 +11.3 11309 0.2 CTCF USF1 ZNF10 OSR2 MYC SMC3 ZNF263 MXI1 RAD21 POLR2A WSCD1 lnc-WSCD1-2 RF01853-004 ENSG00000285471
GH17J006080 Promoter 0.3 EPDnew 500.4 +22.9 22922 0.1 WSCD1 RF01853-004 lnc-WSCD1-2 ENSG00000285471
GH17J005831 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 8.8 -222.8 -222821 6 TCF12 POLR2A RFX1 CUX1 TEAD1 CTBP1 FOXA2 SIN3A ZBTB17 MAFF WSCD1 USP6 piR-46501-045 piR-48209-265 ENSG00000285471 LOC339166
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WSCD1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WSCD1

Top Transcription factor binding sites by QIAGEN in the WSCD1 gene promoter:
  • AML1a
  • Lmo2
  • NF-kappaB1
  • Pax-6
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for WSCD1 Gene

Genomic Locations for WSCD1 Gene
chr17:6,057,807-6,124,427
(GRCh38/hg38)
Size:
66,621 bases
Orientation:
Plus strand
chr17:5,675,554-6,027,747
(GRCh37/hg19)
Size:
352,194 bases
Orientation:
Plus strand

Genomic View for WSCD1 Gene

Genes around WSCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WSCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WSCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WSCD1 Gene

Proteins for WSCD1 Gene

  • Protein details for WSCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q658N2-WSCD1_HUMAN
    Recommended name:
    WSC domain-containing protein 1
    Protein Accession:
    Q658N2
    Secondary Accessions:
    • A8K0N8
    • D3DTM3
    • O60276
    • Q96G45

    Protein attributes for WSCD1 Gene

    Size:
    575 amino acids
    Molecular mass:
    65694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WSCD1 Gene

Post-translational modifications for WSCD1 Gene

  • Glycosylation at Asn257 and Asn348
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WSCD1 Gene

Domains & Families for WSCD1 Gene

Gene Families for WSCD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WSCD1 Gene

Blocks:
  • Carbohydrate-binding WSC
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WSCD1 Gene

GenScript: Design optimal peptide antigens:
  • WSC domain-containing protein 1 (WSCD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q658N2

UniProtKB/Swiss-Prot:

WSCD1_HUMAN :
  • Belongs to the WSCD family.
Family:
  • Belongs to the WSCD family.
genes like me logo Genes that share domains with WSCD1: view

Function for WSCD1 Gene

Phenotypes From GWAS Catalog for WSCD1 Gene

Gene Ontology (GO) - Molecular Function for WSCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with WSCD1: view
genes like me logo Genes that share phenotypes with WSCD1: view

Animal Models for WSCD1 Gene

MGI Knock Outs for WSCD1:
  • Wscd1 Wscd1<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for WSCD1

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WSCD1 Gene

Localization for WSCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WSCD1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WSCD1 gene
Compartment Confidence
extracellular 2
golgi apparatus 2
nucleus 1
endoplasmic reticulum 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WSCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WSCD1: view

Pathways & Interactions for WSCD1 Gene

PathCards logo

SuperPathways for WSCD1 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for WSCD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WSCD1 Gene

Drugs & Compounds for WSCD1 Gene

No Compound Related Data Available

Transcripts for WSCD1 Gene

mRNA/cDNA for WSCD1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WSCD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: -
SP3: -
SP4:
SP5: - -

Relevant External Links for WSCD1 Gene

GeneLoc Exon Structure for
WSCD1

Expression for WSCD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WSCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WSCD1 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3) and Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for WSCD1 Gene

This gene is overexpressed in Synovial fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WSCD1 Gene



Protein tissue co-expression partners for WSCD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WSCD1

SOURCE GeneReport for Unigene cluster for WSCD1 Gene:

Hs.370166

Evidence on tissue expression from TISSUES for WSCD1 Gene

  • Nervous system(4.7)
  • Muscle(4.1)
  • Stomach(4.1)
genes like me logo Genes that share expression patterns with WSCD1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WSCD1 Gene

Orthologs for WSCD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WSCD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WSCD1 31 30
  • 98.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia WSCD1 31 30
  • 88.93 (n)
OneToOne
dog
(Canis familiaris)
Mammalia WSCD1 31 30
  • 85.68 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wscd1 30
  • 82.98 (n)
mouse
(Mus musculus)
Mammalia Wscd1 17 31 30
  • 82.4 (n)
oppossum
(Monodelphis domestica)
Mammalia WSCD1 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WSCD1 31
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves WSCD1 31 30
  • 70.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 68 (a)
OneToMany
-- 31
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia wscd1 30
  • 62.56 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01007222.1 31
  • 65 (a)
OneToMany
si:ch211-55a7.1 30
  • 55.83 (n)
WSCD1 (2 of 3) 31
  • 49 (a)
OneToMany
WSCD1 (1 of 3) 31
  • 38 (a)
OneToMany
Dr.12914 30
fruit fly
(Drosophila melanogaster)
Insecta CG9164 31
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLG1 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 26 (a)
OneToMany
Species where no ortholog for WSCD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WSCD1 Gene

ENSEMBL:
Gene Tree for WSCD1 (if available)
TreeFam:
Gene Tree for WSCD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WSCD1: view image

Paralogs for WSCD1 Gene

Paralogs for WSCD1 Gene

(1) SIMAP similar genes for WSCD1 Gene using alignment to 7 proteins:

  • WSCD1_HUMAN
  • I3L0U0_HUMAN
  • I3L127_HUMAN
  • I3L2Y9_HUMAN
  • I3L3E6_HUMAN
  • I3L3G4_HUMAN
  • I3NI40_HUMAN
genes like me logo Genes that share paralogs with WSCD1: view

Variants for WSCD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WSCD1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs17855415 - p.His212Tyr

Additional dbSNP identifiers (rs#s) for WSCD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for WSCD1 Gene

Variant ID Type Subtype PubMed ID
esv26217 CNV loss 19812545
nsv1959 CNV deletion 18451855
nsv574278 CNV gain 21841781
nsv574310 CNV gain 21841781
nsv574311 CNV loss 21841781

Variation tolerance for WSCD1 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WSCD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WSCD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WSCD1 Gene

Disorders for WSCD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WSCD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
granulomatosis with polyangiitis
  • gpa
- elite association - COSMIC cancer census association via MalaCards
Search WSCD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WSCD1

genes like me logo Genes that share disorders with WSCD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WSCD1 Gene

Publications for WSCD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 54
  2. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry JR … Ong KK (Nature 2014) 3 54
  3. Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis. (PMID: 23740775) Xie G … Siminovitch KA (Arthritis and rheumatism 2013) 3 54
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung ML … Jeang KT (The Journal of biological chemistry 2009) 3 54
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 54

Products for WSCD1 Gene

Sources for WSCD1 Gene