This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq,... See more...

Aliases for WSB2 Gene

Aliases for WSB2 Gene

  • WD Repeat And SOCS Box Containing 2 2 3 5
  • WD Repeat And SOCS Box-Containing Protein 2 3 4
  • CS Box-Containing WD Protein 3 4
  • WSB-2 3 4
  • SBA2 2 3
  • WD Repeat And SOCS Box-Containing 2 2
  • MGC10210 2
  • WSB2 5

External Ids for WSB2 Gene

Previous GeneCards Identifiers for WSB2 Gene

  • GC12M117997
  • GC12M118253
  • GC12M116882
  • GC12M116933
  • GC12M118470
  • GC12M115480

Summaries for WSB2 Gene

Entrez Gene Summary for WSB2 Gene

  • This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for WSB2 Gene

WSB2 (WD Repeat And SOCS Box Containing 2) is a Protein Coding gene. An important paralog of this gene is WSB1.

UniProtKB/Swiss-Prot Summary for WSB2 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Additional gene information for WSB2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WSB2 Gene

Genomics for WSB2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WSB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J118058 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 608.8 +0.2 181 7.5 CEBPG CTCF ATF7 PRDM10 ZNF512 IKZF1 ZNF692 RCOR2 POLR2A FOXA1 WSB2 lnc-RFC5-5 lnc-WSB2-1 VSIG10 RFC5 SUDS3 RPS2P5 lnc-WSB2-3
GH12J118051 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 608.5 +9.4 9406 3.9 CEBPG HNRNPL CREB1 GATAD2A ATF7 REST ZNF629 TFE3 SOX13 NFKBIZ WSB2 RFC5 lnc-WSB2-1 lnc-RFC5-5 piR-61945-110 lnc-WSB2-3
GH12J118015 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 18.5 +45.3 45335 2.2 ZNF221 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 ZNF629 TFE3 RFX1 ZNF692 RFC5 WSB2 SUDS3 FBXO21 ENSG00000277873 lnc-WSB2-3
GH12J118134 Promoter/Enhancer 1.7 EPDnew ENCODE CraniofacialAtlas 11.2 -75.0 -75016 5.3 BRCA1 SP1 HNRNPL CREB1 GATAD2A TFE3 SOX13 KDM1A ZNF692 POLR2A VSIG10 PEBP1 LOC101928274 lnc-TAOK3-1-002 piR-43107-077 RFC5 WSB2 SUDS3 lnc-TAOK3-9 TAOK3
GH12J118033 Enhancer 1 Ensembl ENCODE 17.3 +27.6 27646 2.4 CTCF TEAD4 BACH1 FOXA1 STAT3 JUND REST TCF12 IKZF2 GTF2F1 WSB2 RFC5 ENSG00000276292 MN297195 lnc-WSB2-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WSB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WSB2

Top Transcription factor binding sites by QIAGEN in the WSB2 gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B

Genomic Locations for WSB2 Gene

Genomic Locations for WSB2 Gene
chr12:118,032,687-118,062,430
(GRCh38/hg38)
Size:
29,744 bases
Orientation:
Minus strand
chr12:118,470,492-118,500,235
(GRCh37/hg19)
Size:
29,744 bases
Orientation:
Minus strand

Genomic View for WSB2 Gene

Genes around WSB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WSB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WSB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WSB2 Gene

Proteins for WSB2 Gene

  • Protein details for WSB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYS7-WSB2_HUMAN
    Recommended name:
    WD repeat and SOCS box-containing protein 2
    Protein Accession:
    Q9NYS7
    Secondary Accessions:
    • B4DIE6
    • B4DPV6
    • Q9NRX9

    Protein attributes for WSB2 Gene

    Size:
    404 amino acids
    Molecular mass:
    45286 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WSB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WSB2 Gene

Post-translational modifications for WSB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WSB2 Gene

Domains & Families for WSB2 Gene

Gene Families for WSB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WSB2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60240, highly similar to WD repeat and SOCS box-containing protein 2 (B4DFS1_HUMAN)
  • cDNA FLJ59692, highly similar to WD repeat and SOCS box-containing protein 2 (B4DIE6_HUMAN)
  • cDNA FLJ60778, highly similar to WD repeat and SOCS box-containing protein 2 (B4DPV6_HUMAN)
  • CS box-containing WD protein (WSB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NYS7

UniProtKB/Swiss-Prot:

WSB2_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
genes like me logo Genes that share domains with WSB2: view

Function for WSB2 Gene

Molecular function for WSB2 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Phenotypes From GWAS Catalog for WSB2 Gene

Gene Ontology (GO) - Molecular Function for WSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with WSB2: view
genes like me logo Genes that share phenotypes with WSB2: view

Animal Models for WSB2 Gene

MGI Knock Outs for WSB2:
  • Wsb2 Wsb2<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WSB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WSB2 Gene

Localization for WSB2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WSB2 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for WSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with WSB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for WSB2 Gene

Pathways & Interactions for WSB2 Gene

PathCards logo

SuperPathways for WSB2 Gene

No Data Available

UniProtKB/Swiss-Prot Q9NYS7-WSB2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for WSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with WSB2: view

No data available for Pathways by source and SIGNOR curated interactions for WSB2 Gene

Drugs & Compounds for WSB2 Gene

No Compound Related Data Available

Transcripts for WSB2 Gene

mRNA/cDNA for WSB2 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WSB2

Alternative Splicing Database (ASD) splice patterns (SP) for WSB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8:

Relevant External Links for WSB2 Gene

GeneLoc Exon Structure for
WSB2

Expression for WSB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WSB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WSB2 Gene

This gene is overexpressed in Spinal cord (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WSB2 Gene



Protein tissue co-expression partners for WSB2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WSB2

SOURCE GeneReport for Unigene cluster for WSB2 Gene:

Hs.506985

Evidence on tissue expression from TISSUES for WSB2 Gene

  • Nervous system(4.9)
  • Lung(3.3)
  • Heart(2.3)
  • Skin(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with WSB2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WSB2 Gene

Orthologs for WSB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WSB2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WSB2 30 31
  • 99.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WSB2 30 31
  • 92.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WSB2 30 31
  • 92.29 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WSB2 31
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Wsb2 30 17 31
  • 88.61 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wsb2 30
  • 87.21 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia WSB2 31
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WSB2 30 31
  • 74.37 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WSB2 31
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wsb2 30
  • 69.01 (n)
Str.11444 30
Zebrafish
(Danio rerio)
Actinopterygii wsb2 31
  • 45 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta can 31
  • 7 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea taf-5 31
  • 11 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF5 31
  • 10 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToMany
Species where no ortholog for WSB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for WSB2 Gene

ENSEMBL:
Gene Tree for WSB2 (if available)
TreeFam:
Gene Tree for WSB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WSB2: view image

Paralogs for WSB2 Gene

Paralogs for WSB2 Gene

(6) SIMAP similar genes for WSB2 Gene using alignment to 8 proteins:

  • WSB2_HUMAN
  • B4DFS1_HUMAN
  • B4DIE6_HUMAN
  • B4DPV6_HUMAN
  • F5GXB6_HUMAN
  • F5H024_HUMAN
  • F5H280_HUMAN
  • F5H2L7_HUMAN

Pseudogenes.org Pseudogenes for WSB2 Gene

genes like me logo Genes that share paralogs with WSB2: view

Variants for WSB2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WSB2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
768591 Benign: not provided 118,062,151(-) G/A SYNONYMOUS_VARIANT
776754 Benign: not provided 118,042,916(-) T/C MISSENSE_VARIANT,INTRON_VARIANT
783674 Benign: not provided 118,036,433(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for WSB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for WSB2 Gene

Variant ID Type Subtype PubMed ID
esv25263 CNV gain 19812545
esv3581916 CNV gain 25503493
esv3630882 CNV loss 21293372
nsv1071058 CNV deletion 25765185
nsv1126323 CNV deletion 24896259
nsv560388 CNV loss 21841781

Variation tolerance for WSB2 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WSB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WSB2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WSB2 Gene

Disorders for WSB2 Gene

Additional Disease Information for WSB2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for WSB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WSB2 Gene

Publications for WSB2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile BT … Hilton DJ (Trends in biochemical sciences 2002) 2 3
  4. WD repeat and SOCS box containing protein 2 in the proliferation, cycle progression, and migration of melanoma cells. (PMID: 31103822) Zhang Y … Song X (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for WSB2 Gene

  • Signalway Proteins for WSB2

Sources for WSB2 Gene