Aliases for WSB1 Gene
External Ids for WSB1 Gene
Previous GeneCards Identifiers for WSB1 Gene
This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for WSB1 Gene
WSB1 (WD Repeat And SOCS Box Containing 1) is a Protein Coding gene. Diseases associated with WSB1 include Deafness, Autosomal Recessive 62. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is WSB2.
UniProtKB/Swiss-Prot Summary for WSB1 Gene
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.