This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal tran... See more...

Aliases for WRAP73 Gene

Aliases for WRAP73 Gene

  • WD Repeat Containing, Antisense To TP73 2 3 5
  • WD Repeat-Containing Protein WRAP73 3 4
  • WD Repeat Domain 8 2 3
  • WDR8 3 4
  • WD Repeat-Containing Protein Antisense To TP73 Gene 4
  • Epididymis Secretory Sperm Binding Protein 3
  • WD Repeat-Containing Protein 8 4
  • WRAP73 5

External Ids for WRAP73 Gene

Previous HGNC Symbols for WRAP73 Gene

  • WDR8

Previous GeneCards Identifiers for WRAP73 Gene

  • GC01M003547

Summaries for WRAP73 Gene

Entrez Gene Summary for WRAP73 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification. [provided by RefSeq, Mar 2009]

GeneCards Summary for WRAP73 Gene

WRAP73 (WD Repeat Containing, Antisense To TP73) is a Protein Coding gene. Diseases associated with WRAP73 include Inflammatory Bowel Disease 19.

UniProtKB/Swiss-Prot Summary for WRAP73 Gene

  • The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238).

Gene Wiki entry for WRAP73 Gene

Additional gene information for WRAP73 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WRAP73 Gene

Genomics for WRAP73 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WRAP73 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WRAP73 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WRAP73

Genomic Locations for WRAP73 Gene

Genomic Locations for WRAP73 Gene
chr1:3,630,767-3,652,761
(GRCh38/hg38)
Size:
21,995 bases
Orientation:
Minus strand
chr1:3,547,331-3,569,325
(GRCh37/hg19)
Size:
21,995 bases
Orientation:
Minus strand

Genomic View for WRAP73 Gene

Genes around WRAP73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WRAP73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WRAP73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WRAP73 Gene

Proteins for WRAP73 Gene

  • Protein details for WRAP73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2S5-WRP73_HUMAN
    Recommended name:
    WD repeat-containing protein WRAP73
    Protein Accession:
    Q9P2S5
    Secondary Accessions:
    • Q5T0D6
    • Q9BUH7
    • Q9NTK7
    • Q9NX56

    Protein attributes for WRAP73 Gene

    Size:
    460 amino acids
    Molecular mass:
    51588 Da
    Quaternary structure:
    • Interacts with SSX2IP.

neXtProt entry for WRAP73 Gene

Post-translational modifications for WRAP73 Gene

  • Ubiquitination at Lys307, Lys321, and Lys330
  • Modification sites at PhosphoSitePlus

Other Protein References for WRAP73 Gene

No data available for DME Specific Peptides for WRAP73 Gene

Domains & Families for WRAP73 Gene

Gene Families for WRAP73 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WRAP73 Gene

Suggested Antigen Peptide Sequences for WRAP73 Gene

GenScript: Design optimal peptide antigens:
  • WD repeat domain 8 (Q5T0D5_HUMAN)
  • WD repeat domain 8 (Q5TBW1_HUMAN)
  • WD repeat-containing protein antisense to TP73 gene (WRP73_HUMAN)
genes like me logo Genes that share domains with WRAP73: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for WRAP73 Gene

Function for WRAP73 Gene

Molecular function for WRAP73 Gene

UniProtKB/Swiss-Prot Function:
The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238).

Phenotypes From GWAS Catalog for WRAP73 Gene

Gene Ontology (GO) - Molecular Function for WRAP73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 26545777
genes like me logo Genes that share ontologies with WRAP73: view
genes like me logo Genes that share phenotypes with WRAP73: view

Animal Model Products

CRISPR Products

miRNA for WRAP73 Gene

miRTarBase miRNAs that target WRAP73

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WRAP73

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WRAP73 Gene

Localization for WRAP73 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WRAP73 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Enriched in the proximal end of the mother centriole (PubMed:26545777). During ciliogenesis also associated with the basal body of the adjacent centriole (PubMed:26675238). {ECO:0000269 PubMed:26545777, ECO:0000269 PubMed:26675238}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WRAP73 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
plasma membrane 1
mitochondrion 1
cytosol 1
extracellular 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for WRAP73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IEA,IBA 21873635
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with WRAP73: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WRAP73 Gene

Pathways & Interactions for WRAP73 Gene

PathCards logo

SuperPathways for WRAP73 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WRAP73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IBA 21873635
GO:0030030 cell projection organization IEA --
GO:0090307 mitotic spindle assembly IMP 26545777
GO:1902440 protein localization to mitotic spindle pole body IBA 21873635
GO:1902857 positive regulation of non-motile cilium assembly IMP 26545777
genes like me logo Genes that share ontologies with WRAP73: view

No data available for Pathways by source and SIGNOR curated interactions for WRAP73 Gene

Drugs & Compounds for WRAP73 Gene

No Compound Related Data Available

Transcripts for WRAP73 Gene

mRNA/cDNA for WRAP73 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WRAP73

Alternative Splicing Database (ASD) splice patterns (SP) for WRAP73 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3:

Relevant External Links for WRAP73 Gene

GeneLoc Exon Structure for
WRAP73

Expression for WRAP73 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WRAP73 Gene

Protein differential expression in normal tissues from HIPED for WRAP73 Gene

This gene is overexpressed in Bone (31.8) and Testis (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WRAP73 Gene



Protein tissue co-expression partners for WRAP73 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WRAP73

SOURCE GeneReport for Unigene cluster for WRAP73 Gene:

Hs.31714

mRNA Expression by UniProt/SwissProt for WRAP73 Gene:

Q9P2S5-WRP73_HUMAN
Tissue specificity: Ubiquitous. Predominant expression in heart, brain, liver, thymus, prostate, and testis, and barely detectable expression in lung.

Evidence on tissue expression from TISSUES for WRAP73 Gene

  • Blood(4.3)
  • Lung(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with WRAP73: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WRAP73 Gene

Orthologs for WRAP73 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WRAP73 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WRAP73 30 31
  • 99.06 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WRAP73 30 31
  • 86.3 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WRAP73 30 31
  • 84.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Wrap73 30 17 31
  • 84.57 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wrap73 30
  • 84.46 (n)
Oppossum
(Monodelphis domestica)
Mammalia WRAP73 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WRAP73 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WRAP73 30 31
  • 73.17 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WRAP73 31
  • 87 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wrap73 30
  • 70.93 (n)
MGC75994 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7927 30
Zebrafish
(Danio rerio)
Actinopterygii wrap73 30 31
  • 69.68 (n)
OneToOne
wufi45a07 30
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G07590 30
  • 52.83 (n)
Rice
(Oryza sativa)
Liliopsida Os10g0563300 30
  • 55.07 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6483 31
  • 51 (a)
OneToOne
Species where no ortholog for WRAP73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for WRAP73 Gene

ENSEMBL:
Gene Tree for WRAP73 (if available)
TreeFam:
Gene Tree for WRAP73 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WRAP73: view image

Paralogs for WRAP73 Gene

No data available for Paralogs for WRAP73 Gene

Variants for WRAP73 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WRAP73 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs16823940 - p.Val358Ile
rs2760320 - p.Ile331Met

Additional dbSNP identifiers (rs#s) for WRAP73 Gene

Structural Variations from Database of Genomic Variants (DGV) for WRAP73 Gene

Variant ID Type Subtype PubMed ID
esv1007908 CNV deletion 20482838
esv2247294 CNV deletion 18987734
esv2489412 CNV deletion 19546169
esv2758915 CNV gain 17122850
esv2853680 CNV deletion 24192839
esv29463 CNV loss 19812545
esv3585042 CNV gain 21293372
esv3585044 CNV gain 21293372
esv3585045 CNV gain 21293372
nsv1001715 CNV loss 25217958
nsv1012423 CNV gain 25217958
nsv410 CNV insertion 18451855
nsv470687 CNV loss 18288195
nsv545128 CNV loss 21841781
nsv951959 CNV deletion 24416366

Variation tolerance for WRAP73 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WRAP73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WRAP73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WRAP73 Gene

Disorders for WRAP73 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WRAP73 Gene - From: DISEASES

Disorder Aliases PubMed IDs
inflammatory bowel disease 19
  • ibd19
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with WRAP73: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WRAP73 Gene

Publications for WRAP73 Gene

  1. WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis. (PMID: 26675238) Kurtulmus B … Pereira G (Journal of cell science 2016) 3 4
  2. The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation. (PMID: 26545777) Hori A … Toda T (Biochemical and biophysical research communications 2015) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for WRAP73 Gene

  • Signalway ELISA kits for WRAP73
  • Signalway Proteins for WRAP73

Sources for WRAP73 Gene