This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs)... See more...

Aliases for WRAP53 Gene

Aliases for WRAP53 Gene

  • WD Repeat Containing Antisense To TP53 2 3 5
  • Telomerase Cajal Body Protein 1 2 3 4
  • WD Repeat-Containing Protein 79 3 4
  • WRAP53beta 3 4
  • WDR79 3 4
  • TCAB1 3 4
  • WD40 Repeat-Containing Protein Encoding RNA Antisense To P53 3
  • WD40 Repeat-Containing Protein Antisense To TP53 Gene 4
  • WD40 Repeat-Containing Protein Antisense To TP53 3
  • WD Repeat Containing, Antisense To TP53 2
  • WD Repeat-Containing Protein WRAP53 3
  • WD-Encoding RNA Antisense To P53 2
  • WD40 Protein Wrap53 3
  • WD Repeat Domain 79 2
  • DKCB3 3

External Ids for WRAP53 Gene

Previous HGNC Symbols for WRAP53 Gene

  • WDR79

Previous GeneCards Identifiers for WRAP53 Gene

  • GC17P007534
  • GC17P007589
  • GC17P007483
  • GC17P007688
  • GC17P007814
  • GC17P007847
  • GC17P007877
  • GC17P007690
  • GC17P007728
  • GC17P007762
  • GC17P007790

Summaries for WRAP53 Gene

Entrez Gene Summary for WRAP53 Gene

  • This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for WRAP53 Gene

WRAP53 (WD Repeat Containing Antisense To TP53) is a Protein Coding gene. Diseases associated with WRAP53 include Dyskeratosis Congenita, Autosomal Recessive 3 and Dyskeratosis Congenita. Among its related pathways are Chaperonin-mediated protein folding and Chromosome Maintenance. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot Summary for WRAP53 Gene

  • RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29804836, PubMed:29695869). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29804836, PubMed:29695869). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493).

Additional gene information for WRAP53 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WRAP53 Gene

Genomics for WRAP53 Gene

GeneHancer (GH) Regulatory Elements for WRAP53 Gene

Promoters and enhancers for WRAP53 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WRAP53 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WRAP53

Top Transcription factor binding sites by QIAGEN in the WRAP53 gene promoter:
  • C/EBPbeta
  • deltaCREB
  • Sp1

Genomic Locations for WRAP53 Gene

Genomic Locations for WRAP53 Gene
chr17:7,686,071-7,703,502
(GRCh38/hg38)
Size:
17,432 bases
Orientation:
Plus strand
chr17:7,589,389-7,606,820
(GRCh37/hg19)
Size:
17,432 bases
Orientation:
Plus strand

Genomic View for WRAP53 Gene

Genes around WRAP53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WRAP53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WRAP53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WRAP53 Gene

Proteins for WRAP53 Gene

  • Protein details for WRAP53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUR4-TCAB1_HUMAN
    Recommended name:
    Telomerase Cajal body protein 1
    Protein Accession:
    Q9BUR4
    Secondary Accessions:
    • B3KPR9
    • D3DTQ4
    • Q08ET9
    • Q9NW09

    Protein attributes for WRAP53 Gene

    Size:
    548 amino acids
    Molecular mass:
    59309 Da
    Quaternary structure:
    • Component of the telomerase holoenzyme complex composed of one molecule of TERT, one molecule of WRAP53/TCAB1, two molecules of H/ACA ribonucleoprotein complex subunits DKC1, NOP10, NHP2 and GAR1, and a telomerase RNA template component (TERC) (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). The telomerase holoenzyme complex is associated with TEP1, SMG6/EST1A and POT1 (PubMed:19179534). Interacts with the chaperonin-containing T-complex (TRiC) complex; which mediates the folding of WRAP53/TCAB1 (PubMed:25467444). Interacts with COIL (PubMed:21072240). Interacts with SMN1 (PubMed:21072240). Interacts with RNF8 (PubMed:25512560). Interacts with histone H2AX/H2AFX (PubMed:26734725, PubMed:27715493).
    Miscellaneous:
    • The mRNA encoding this protein plays a critical role in the regulation of p53/TP53 expression at the post-transcriptional level; it is involved both in maintaining basal p53/TP53 mRNA levels and in p53/TP53 induction upon DNA damage.

neXtProt entry for WRAP53 Gene

Post-translational modifications for WRAP53 Gene

  • Phosphorylated at Ser-64 by ATM in response to DNA damage, promoting its interaction with histone H2AX/H2AFX and localization to sites of DNA double-strand breaks.
  • Ubiquitination at Lys173 and Lys176
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WRAP53 Gene

Domains & Families for WRAP53 Gene

Gene Families for WRAP53 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for WRAP53 Gene

Suggested Antigen Peptide Sequences for WRAP53 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54772, moderately similar to WD repeat protein 79 (B4E068_HUMAN)
  • WDR79 (C6ZGQ9_HUMAN)
  • WDR79 (C6ZGR0_HUMAN)
  • WDR79 (C6ZGX2_HUMAN)
  • WD40 repeat-containing protein encoding RNA antisense to p53 (WAP53_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BUR4

UniProtKB/Swiss-Prot:

TCAB1_HUMAN :
  • Belongs to the TCAB1 family.
Family:
  • Belongs to the TCAB1 family.
genes like me logo Genes that share domains with WRAP53: view

Function for WRAP53 Gene

Molecular function for WRAP53 Gene

UniProtKB/Swiss-Prot Function:
RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29804836, PubMed:29695869). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29804836, PubMed:29695869). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493).
UniProtKB/Swiss-Prot Induction:
(Microbial infection) Over-expressed following infection by Epstein-Barr virus.

Phenotypes From GWAS Catalog for WRAP53 Gene

Gene Ontology (GO) - Molecular Function for WRAP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IPI 20351177
GO:0005515 protein binding IEA,IPI 19179534
GO:0031625 ubiquitin protein ligase binding IPI 25512560
GO:0042393 histone binding IPI 26734725
GO:0042802 identical protein binding IPI 21072240
genes like me logo Genes that share ontologies with WRAP53: view
genes like me logo Genes that share phenotypes with WRAP53: view

Human Phenotype Ontology for WRAP53 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WRAP53 Gene

MGI Knock Outs for WRAP53:
  • Wrap53 Wrap53<tm1b(EUCOMM)Wtsi>

Animal Model Products

miRNA for WRAP53 Gene

miRTarBase miRNAs that target WRAP53

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WRAP53 Gene

Localization for WRAP53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WRAP53 Gene

Nucleus, Cajal body. Chromosome, telomere. Chromosome. Note=Released from telomerase RNA template component (TERC) in mitotic cells coincident with delocalization from Cajal bodies (PubMed:26170453). In response to DNA damage, localizes to sites of DNA double-strand breaks following phosphorylation by ATM (PubMed:26734725, PubMed:27715493). {ECO:0000269 PubMed:26170453, ECO:0000269 PubMed:26734725, ECO:0000269 PubMed:27715493}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WRAP53 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nuclear bodies (4)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WRAP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005697 telomerase holoenzyme complex IDA 19179534
genes like me logo Genes that share ontologies with WRAP53: view

Pathways & Interactions for WRAP53 Gene

genes like me logo Genes that share pathways with WRAP53: view

Gene Ontology (GO) - Biological Process for WRAP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007004 telomere maintenance via telomerase TAS 25467444
GO:0030576 Cajal body organization IMP 21072240
GO:0032203 telomere formation via telomerase IMP 19179534
genes like me logo Genes that share ontologies with WRAP53: view

No data available for SIGNOR curated interactions for WRAP53 Gene

Drugs & Compounds for WRAP53 Gene

No Compound Related Data Available

Transcripts for WRAP53 Gene

mRNA/cDNA for WRAP53 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WRAP53 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3: -

Relevant External Links for WRAP53 Gene

GeneLoc Exon Structure for
WRAP53

Expression for WRAP53 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WRAP53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WRAP53 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.0), Testis (13.7), Placenta (11.4), Fetal testis (9.2), and Pancreas (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WRAP53 Gene



Protein tissue co-expression partners for WRAP53 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WRAP53

SOURCE GeneReport for Unigene cluster for WRAP53 Gene:

Hs.408312

mRNA Expression by UniProt/SwissProt for WRAP53 Gene:

Q9BUR4-TCAB1_HUMAN
Tissue specificity: Expressed in all tissues and cell lines examined.

Evidence on tissue expression from TISSUES for WRAP53 Gene

  • Nervous system(4.8)
  • Kidney(4.2)
  • Liver(4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for WRAP53 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lacrimal apparatus
  • mandible
  • maxilla
  • mouth
  • neck
  • pharynx
  • salivary gland
  • scalp
  • skull
  • tooth
Thorax:
  • breast
  • chest wall
  • clavicle
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • trachea
Abdomen:
  • intestine
  • kidney
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
Pelvis:
  • anus
  • ovary
  • pelvis
  • penis
  • rectum
  • testicle
  • urethra
  • urinary bladder
  • uterus
  • vagina
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with WRAP53: view

No data available for mRNA differential expression in normal tissues for WRAP53 Gene

Orthologs for WRAP53 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WRAP53 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WRAP53 31 30
  • 99.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia WRAP53 31 30
  • 87.94 (n)
OneToOne
dog
(Canis familiaris)
Mammalia WRAP53 31 30
  • 84.72 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wrap53 30
  • 82.98 (n)
mouse
(Mus musculus)
Mammalia Wrap53 17 31 30
  • 82.53 (n)
oppossum
(Monodelphis domestica)
Mammalia WRAP53 31
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WRAP53 31
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WRAP53 31
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32703 30
zebrafish
(Danio rerio)
Actinopterygii wrap53 31 30
  • 60.5 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10050 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001885 30
  • 50.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta WDR79 31 30
  • 49.92 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y105E8A.8 31
  • 22 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G21520 30
  • 52.19 (n)
rice
(Oryza sativa)
Liliopsida Os03g0738000 30
  • 51.01 (n)
Species where no ortholog for WRAP53 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WRAP53 Gene

ENSEMBL:
Gene Tree for WRAP53 (if available)
TreeFam:
Gene Tree for WRAP53 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WRAP53: view image

Paralogs for WRAP53 Gene

(1) SIMAP similar genes for WRAP53 Gene using alignment to 4 proteins:

  • WAP53_HUMAN
  • E9PMG4_HUMAN
  • E9PMR3_HUMAN
  • K7EJ50_HUMAN
genes like me logo Genes that share paralogs with WRAP53: view

No data available for Paralogs for WRAP53 Gene

Variants for WRAP53 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WRAP53 Gene