Aliases for WNT9B Gene
External Ids for WNT9B Gene
Previous HGNC Symbols for WNT9B Gene
Previous GeneCards Identifiers for WNT9B Gene
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for WNT9B Gene
WNT9B (Wnt Family Member 9B) is a Protein Coding gene. Diseases associated with WNT9B include Cleft Lip and Mayer-Rokitansky-Kuster-Hauser Syndrome. Among its related pathways are Signaling by Wnt and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT9A.
UniProtKB/Swiss-Prot Summary for WNT9B Gene
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity).