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Aliases for WNT9A Gene

Aliases for WNT9A Gene

  • Wnt Family Member 9A 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 14 2 3
  • Wingless-Type MMTV Integration Site Family, Member 9A 2 3
  • WNT14 3 4
  • Protein Wnt-9a 3
  • Protein Wnt-14 4

External Ids for WNT9A Gene

Previous HGNC Symbols for WNT9A Gene

  • WNT14

Previous GeneCards Identifiers for WNT9A Gene

  • GC01M223847
  • GC01M224494
  • GC01M225083
  • GC01M224415
  • GC01M226172
  • GC01M228106
  • GC01M198625

Summaries for WNT9A Gene

Entrez Gene Summary for WNT9A Gene

  • The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT9A Gene

WNT9A (Wnt Family Member 9A) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and HTLV-I infection. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT9B.

UniProtKB/Swiss-Prot for WNT9A Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity.

Gene Wiki entry for WNT9A Gene

Additional gene information for WNT9A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT9A Gene

Genomics for WNT9A Gene

GeneHancer (GH) Regulatory Elements for WNT9A Gene

Promoters and enhancers for WNT9A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J227942 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.3 2258 6 ARNT SIN3A ZNF2 ZBTB7B ZNF48 YY1 ZNF121 GLIS2 ELK1 ARID2 WNT9A OBSCN-AS1 WNT3A OBSCN IBA57 ENSG00000269934 MRPL55 MIR5008
GH01J227792 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 14.1 +153.9 153929 2.6 INSM2 KLF17 MZF1 FEZF1 ZNF335 GLIS2 ZNF366 ZNF143 EGR2 REST ZNF678 JMJD4 WNT9A C1orf35 SNAP47 COQ8A CDC42BPA LOC105373289 PRSS38
GH01J227787 Enhancer 1.4 Ensembl ENCODE dbSUPER 5.3 +159.9 159871 3 ARID4B GLI4 ZNF2 GLIS2 ZNF143 KLF7 KLF13 SP3 MXD4 SMARCB1 LOC105373289 PRSS38 LOC100126822 LOC100421842 SNAP47 CDC42BPA LOC100418874 C1orf35 WNT9A
GH01J227893 Enhancer 0.4 FANTOM5 15.5 +55.6 55624 0.1 ZNF48 WNT9A ZNF678 MIR5008 PRSS38
GH01J227885 Enhancer 1.2 FANTOM5 Ensembl ENCODE 3.4 +60.6 60612 4.1 PKNOX1 YY1 TCF12 GATA2 SCRT2 FOS EGR2 REST ZNF592 MBD2 WNT9A MIR5008 PRSS38
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WNT9A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WNT9A gene promoter:

Genomic Locations for WNT9A Gene

Genomic Locations for WNT9A Gene
chr1:227,918,656-227,947,975
(GRCh38/hg38)
Size:
29,320 bases
Orientation:
Minus strand
chr1:228,106,357-228,135,676
(GRCh37/hg19)

Genomic View for WNT9A Gene

Genes around WNT9A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT9A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT9A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT9A Gene

Proteins for WNT9A Gene

  • Protein details for WNT9A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14904-WNT9A_HUMAN
    Recommended name:
    Protein Wnt-9a
    Protein Accession:
    O14904
    Secondary Accessions:
    • A6NLW2
    • Q2M2J3
    • Q5VWU0
    • Q96S50

    Protein attributes for WNT9A Gene

    Size:
    365 amino acids
    Molecular mass:
    40320 Da
    Quaternary structure:
    • Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).

neXtProt entry for WNT9A Gene

Post-translational modifications for WNT9A Gene

  • Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at isoforms=103
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT9A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT9A Gene

Domains & Families for WNT9A Gene

Gene Families for WNT9A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for WNT9A Gene

Suggested Antigen Peptide Sequences for WNT9A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14904

UniProtKB/Swiss-Prot:

WNT9A_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT9A: view

Function for WNT9A Gene

Molecular function for WNT9A Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity.

Phenotypes From GWAS Catalog for WNT9A Gene

Gene Ontology (GO) - Molecular Function for WNT9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005109 frizzled binding IBA --
GO:0048018 receptor ligand activity IDA 28733458
genes like me logo Genes that share ontologies with WNT9A: view
genes like me logo Genes that share phenotypes with WNT9A: view

Animal Models for WNT9A Gene

MGI Knock Outs for WNT9A:

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT9A

Clone Products

  • Addgene plasmids for WNT9A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT9A Gene

Localization for WNT9A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT9A Gene

Secreted, extracellular space, extracellular matrix. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT9A gene
Compartment Confidence
extracellular 5
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for WNT9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with WNT9A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WNT9A Gene

Pathways & Interactions for WNT9A Gene

genes like me logo Genes that share pathways with WNT9A: view

SIGNOR curated interactions for WNT9A Gene

Activates:

Gene Ontology (GO) - Biological Process for WNT9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007093 mitotic cell cycle checkpoint IMP 17351820
GO:0007267 cell-cell signaling NAS 9441749
GO:0007275 multicellular organism development NAS 9441749
GO:0008285 negative regulation of cell proliferation IMP 17351820
GO:0010469 regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with WNT9A: view

Drugs & Compounds for WNT9A Gene

No Compound Related Data Available

Transcripts for WNT9A Gene

mRNA/cDNA for WNT9A Gene

(18) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT9A Gene

Wingless-type MMTV integration site family, member 9A:
Representative Sequences:

Clone Products

  • Addgene plasmids for WNT9A

Alternative Splicing Database (ASD) splice patterns (SP) for WNT9A Gene

No ASD Table

Relevant External Links for WNT9A Gene

GeneLoc Exon Structure for
WNT9A
ECgene alternative splicing isoforms for
WNT9A

Expression for WNT9A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT9A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT9A Gene

This gene is overexpressed in Muscle - Skeletal (x7.8) and Colon - Sigmoid (x6.7).

Protein differential expression in normal tissues from HIPED for WNT9A Gene

This gene is overexpressed in Heart (61.2) and Platelet (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WNT9A Gene



Protein tissue co-expression partners for WNT9A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WNT9A Gene:

WNT9A

SOURCE GeneReport for Unigene cluster for WNT9A Gene:

Hs.149504
genes like me logo Genes that share expression patterns with WNT9A: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT9A Gene

Orthologs for WNT9A Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT9A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT9A 34 33
  • 99.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia WNT9A 34 33
  • 89.97 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt9a 33
  • 89.42 (n)
dog
(Canis familiaris)
Mammalia WNT9A 34 33
  • 89.15 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt9a 16 34 33
  • 89.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WNT9A 34
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT9A 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves WNT9A 34 33
  • 77.87 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT9A 34
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wnt9a 34 33
  • 73.21 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6377 33
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 34
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea egl-20 34
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToMany
Species where no ortholog for WNT9A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WNT9A Gene

ENSEMBL:
Gene Tree for WNT9A (if available)
TreeFam:
Gene Tree for WNT9A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WNT9A: view image

Paralogs for WNT9A Gene

Paralogs for WNT9A Gene

(15) SIMAP similar genes for WNT9A Gene using alignment to 2 proteins:

  • WNT9A_HUMAN
  • D9ZGG3_HUMAN
genes like me logo Genes that share paralogs with WNT9A: view

Variants for WNT9A Gene

Sequence variations from dbSNP and Humsavar for WNT9A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000032877 -- 227,948,754(-) G/A upstream_transcript_variant
rs1000083639 -- 227,944,302(-) C/T 5_prime_UTR_variant, intron_variant
rs1000165428 -- 227,923,388(-) G/A intron_variant
rs1000282343 -- 227,928,667(-) G/A intron_variant
rs1000339230 -- 227,923,782(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WNT9A Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV gain 17666407
nsv1068935 CNV deletion 25765185
nsv516409 CNV loss 19592680
nsv523935 CNV loss 19592680
nsv826908 CNV gain 20364138
nsv826920 CNV gain 20364138
nsv826931 CNV loss 20364138
nsv826942 CNV gain 20364138
nsv952132 CNV deletion 24416366

Variation tolerance for WNT9A Gene

Residual Variation Intolerance Score: 34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNT9A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT9A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT9A Gene

Disorders for WNT9A Gene

Additional Disease Information for WNT9A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WNT9A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WNT9A Gene

Publications for WNT9A Gene

  1. Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region. (PMID: 11414706) Saitoh T … Katoh M (Biochemical and biophysical research communications 2001) 3 4 22 58
  2. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PMID: 9441749) Bergstein I … Brown AM (Genomics 1997) 2 3 4 58
  3. Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women. (PMID: 20613673) Lee DY … Kim JG (Menopause (New York, N.Y.) 2010) 3 44 58
  4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 44 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58

Products for WNT9A Gene

Sources for WNT9A Gene

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