Aliases for WNT9A Gene
External Ids for WNT9A Gene
Previous HGNC Symbols for WNT9A Gene
Previous GeneCards Identifiers for WNT9A Gene
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT9A Gene
WNT9A (Wnt Family Member 9A) is a Protein Coding gene. Diseases associated with WNT9A include Brachydactyly, Type B1. Among its related pathways are Gastric cancer and Presenilin-Mediated Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT9B.
UniProtKB/Swiss-Prot for WNT9A Gene
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity.