This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A prot... See more...

Aliases for WNT7B Gene

Aliases for WNT7B Gene

  • Wnt Family Member 7B 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 7B 2 3
  • Protein Wnt-7b 3 4
  • WNT7B 5

External Ids for WNT7B Gene

Previous GeneCards Identifiers for WNT7B Gene

  • GC22U990050
  • GC03M013836
  • GC00M9P0021
  • GC22M044638
  • GC22M046316
  • GC22M029261

Summaries for WNT7B Gene

Entrez Gene Summary for WNT7B Gene

  • This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]

GeneCards Summary for WNT7B Gene

WNT7B (Wnt Family Member 7B) is a Protein Coding gene. Diseases associated with WNT7B include Microphthalmia, Syndromic 9 and Exudative Vitreoretinopathy 1. Among its related pathways are Signaling by GPCR and Gastric cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT7A.

UniProtKB/Swiss-Prot Summary for WNT7B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:30026314). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314).

Gene Wiki entry for WNT7B Gene

Additional gene information for WNT7B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WNT7B Gene

Genomics for WNT7B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WNT7B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J045978 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 600.7 -1.7 -1673 1.3 HNRNPL CTCF ZNF692 LARP7 PRDM1 ZNF143 ZIC2 ZNF776 ZSCAN4 PATZ1 WNT7B TRMU CDPF1 FBLN1 ENSG00000273243 LINC00899 ENSG00000235159 KIAA0930 NUP50 ENSG00000273145
GH22J045977 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 600.7 +0.9 861 3 TEAD4 PRDM10 ZIC2 PATZ1 REST EZH2 KLF9 ZBTB20 SP2 ZBTB10 WNT7B RF00017-3878 LOC107985535
GH22J045980 Enhancer 0.4 ENCODE 600.7 -1.0 -976 0 EZH2 ZNF600 ZBTB17 CTCF WNT7B piR-32214-460 PPARA
GH22J045611 Enhancer 1.1 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 11.8 +364.3 364263 1.9 RFX1 POLR2A MAFK TRIM28 SMARCA4 MAFF MYC WNT7B ATXN10 LINC01589 RNU6-1161P piR-38847 FBLN1
GH22J045608 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 11.8 +368.3 368274 1.5 JUND PRDM4 POLR2A WNT7B ATXN10 PRR34 RNU6-1161P LINC01589 piR-38847 FBLN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WNT7B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WNT7B

Top Transcription factor binding sites by QIAGEN in the WNT7B gene promoter:
  • AREB6
  • Egr-1
  • GATA-1
  • HEN1
  • LCR-F1
  • MyoD
  • Pax-4a
  • Pax-5
  • RFX1

Genomic Locations for WNT7B Gene

Genomic Locations for WNT7B Gene
chr22:45,920,362-45,977,162
(GRCh38/hg38)
Size:
56,801 bases
Orientation:
Minus strand
chr22:46,316,242-46,373,009
(GRCh37/hg19)
Size:
56,768 bases
Orientation:
Minus strand

Genomic View for WNT7B Gene

Genes around WNT7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT7B Gene

Proteins for WNT7B Gene

  • Protein details for WNT7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56706-WNT7B_HUMAN
    Recommended name:
    Protein Wnt-7b
    Protein Accession:
    P56706
    Secondary Accessions:
    • B8A596
    • Q96Q12

    Protein attributes for WNT7B Gene

    Size:
    349 amino acids
    Molecular mass:
    39327 Da
    Quaternary structure:
    • Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:16227623). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Interacts with FZD1 and FZD10. Interacts with FZD4 (in vitro). Interacts with PORCN (By similarity). Interacts with glypican GPC3 (PubMed:16227623). Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (PubMed:30026314).

neXtProt entry for WNT7B Gene

Post-translational modifications for WNT7B Gene

  • Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn83, Asn127, and Asn295
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT7B Gene

No data available for DME Specific Peptides for WNT7B Gene

Domains & Families for WNT7B Gene

Gene Families for WNT7B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for WNT7B Gene

InterPro:
Blocks:
  • Secreted growth factor Wnt protein
ProtoNet:

Suggested Antigen Peptide Sequences for WNT7B Gene

GenScript: Design optimal peptide antigens:
  • Protein Wnt (A8K0G1_HUMAN)
  • Protein Wnt (B8A595_HUMAN)
  • Protein Wnt (B8A597_HUMAN)
  • Protein Wnt (B8A598_HUMAN)
  • Protein Wnt-7b (WNT7B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P56706

UniProtKB/Swiss-Prot:

WNT7B_HUMAN :
  • The intrinsically disordered linker region is required for recognition by RECK in brain endothelial cells.
  • Belongs to the Wnt family.
Domain:
  • The intrinsically disordered linker region is required for recognition by RECK in brain endothelial cells.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT7B: view

Function for WNT7B Gene

Molecular function for WNT7B Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:30026314). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314).
GENATLAS Biochemistry:
wingless-type MMTV integration site 7B,Drosophila wingless (wg) segment polarity gene homolog,expressed in specific region of the forebrain,the kidney and the limb ectoderm,modulating cell fate and cell behavior during vertebrate development

LifeMap Function Summary for WNT7B Gene

During embryonic development, WNT7B as signaling molecule is secreted from the following cells

Phenotypes From GWAS Catalog for WNT7B Gene

Gene Ontology (GO) - Molecular Function for WNT7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
GO:0005109 frizzled binding IBA 21873635
GO:0005125 cytokine activity IBA 21873635
GO:0005515 protein binding IPI 30026314
GO:0048018 receptor ligand activity IDA 28733458
genes like me logo Genes that share ontologies with WNT7B: view
genes like me logo Genes that share phenotypes with WNT7B: view

Animal Models for WNT7B Gene

MGI Knock Outs for WNT7B:

Animal Model Products

CRISPR Products

miRNA for WNT7B Gene

miRTarBase miRNAs that target WNT7B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNT7B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT7B Gene

Localization for WNT7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT7B Gene

Secreted, extracellular space, extracellular matrix. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT7B gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 4
golgi apparatus 4
nucleus 3
cytoskeleton 2
mitochondrion 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for WNT7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with WNT7B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WNT7B Gene

Pathways & Interactions for WNT7B Gene

PathCards logo

SuperPathways for WNT7B Gene

genes like me logo Genes that share pathways with WNT7B: view

Pathways by source for WNT7B Gene

2 Sino Biological pathways for WNT7B Gene
2 GeneGo (Thomson Reuters) pathways for WNT7B Gene
  • Transcription Androgen Receptor nuclear signaling
  • Translation Non-genomic (rapid) action of Androgen Receptor
1 Tocris pathway for WNT7B Gene
7 Qiagen pathways for WNT7B Gene
  • Colorectal Cancer Metastasis
  • GSK3 Signaling
  • Hedgehog Signaling in Mammals
  • Human Embryonic Stem Cell Pluripotency
  • Nanog in Mammalian ESC Pluripotency
2 GeneTex pathways for WNT7B Gene

SIGNOR curated interactions for WNT7B Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for WNT7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development ISS --
GO:0003338 metanephros morphogenesis ISS --
GO:0007257 activation of JUN kinase activity IEA --
GO:0007275 multicellular organism development IEA --
GO:0016055 Wnt signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with WNT7B: view

Drugs & Compounds for WNT7B Gene

No Compound Related Data Available

Transcripts for WNT7B Gene

mRNA/cDNA for WNT7B Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNT7B

Alternative Splicing Database (ASD) splice patterns (SP) for WNT7B Gene

No ASD Table

Relevant External Links for WNT7B Gene

GeneLoc Exon Structure for
WNT7B

Expression for WNT7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WNT7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT7B Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.5), Skin - Not Sun Exposed (Suprapubic) (x6.5), and Esophagus - Mucosa (x5.4).

Protein differential expression in normal tissues from HIPED for WNT7B Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WNT7B Gene



Protein tissue co-expression partners for WNT7B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WNT7B

SOURCE GeneReport for Unigene cluster for WNT7B Gene:

Hs.512714

mRNA Expression by UniProt/SwissProt for WNT7B Gene:

P56706-WNT7B_HUMAN
Tissue specificity: Moderately expressed in fetal brain, weakly expressed in fetal lung and kidney, and faintly expressed in adult brain, lung and prostate.

Evidence on tissue expression from TISSUES for WNT7B Gene

  • Nervous system(3)
  • Skin(2.7)
  • Intestine(2.7)
  • Lung(2.6)
  • Bone marrow(2.6)
  • Eye(2.5)
  • Kidney(2.5)
  • Pancreas(2.3)
  • Muscle(2.3)
  • Lymph node(2.3)
  • Heart(2.3)
  • Stomach(2.2)
  • Bone(2.2)
  • Liver(2.2)
  • Spleen(2.2)
  • Blood(2.2)
  • Thyroid gland(2.2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with WNT7B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT7B Gene

Orthologs for WNT7B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT7B Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia WNT7B 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia WNT7B 30 31
  • 94.27 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Wnt7b 30 17 31
  • 91.4 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WNT7B 31
  • 91 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wnt7b 30
  • 90.74 (n)
Chimpanzee
(Pan troglodytes)
Mammalia WNT7B 30 31
  • 90.13 (n)
OneToOne
Chicken
(Gallus gallus)
Aves WNT7B 30 31
  • 80.13 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WNT7B 31
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.229 30
Zebrafish
(Danio rerio)
Actinopterygii wnt7ba 31
  • 79 (a)
OneToMany
wnt7bb 30 31
  • 78.07 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Wnt2 30 31 32
  • 59.02 (n)
OneToMany
Wnt5 32
  • 47 (a)
Wnt6 32
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010283 30
  • 48.17 (n)
Worm
(Caenorhabditis elegans)
Secernentea cwn-2 32
  • 44 (a)
egl-20 32
  • 40 (a)
mom-2 32
  • 35 (a)
lin-44 32
  • 32 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
OneToMany
Species where no ortholog for WNT7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for WNT7B Gene

ENSEMBL:
Gene Tree for WNT7B (if available)
TreeFam:
Gene Tree for WNT7B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WNT7B: view image

Paralogs for WNT7B Gene

(18) SIMAP similar genes for WNT7B Gene using alignment to 5 proteins:

  • WNT7B_HUMAN
  • A8K0G1_HUMAN
  • B8A595_HUMAN
  • B8A597_HUMAN
  • B8A598_HUMAN
genes like me logo Genes that share paralogs with WNT7B: view

Variants for WNT7B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WNT7B Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
728040 Benign: not provided 45,923,003(-) C/T SYNONYMOUS_VARIANT
756527 Likely Benign: not provided 45,950,131(-) C/A SYNONYMOUS_VARIANT
786386 Benign: not provided 45,923,156(-) G/T SYNONYMOUS_VARIANT
rs1475762618 Likely Pathogenic: Anophthalmia-microphthalmia syndrome 45,923,167(-) G/A MISSENSE_VARIANT
rs1569119395 Pathogenic: Microphthalmia syndromic 9 45,949,926(-) G/A NONSENSE

Additional dbSNP identifiers (rs#s) for WNT7B Gene

Structural Variations from Database of Genomic Variants (DGV) for WNT7B Gene

Variant ID Type Subtype PubMed ID
dgv2469n106 OTHER inversion 24896259
esv2008251 CNV deletion 18987734
esv2043867 CNV deletion 18987734
esv2671287 CNV deletion 23128226
esv2724416 CNV deletion 23290073
esv2724418 CNV deletion 23290073
esv2724419 CNV deletion 23290073
esv2724420 CNV deletion 23290073
esv2724421 CNV deletion 23290073
esv3558254 CNV deletion 23714750
esv3558256 CNV deletion 23714750
esv5358 CNV loss 18987735
esv996787 CNV deletion 20482838
nsv1072646 CNV deletion 25765185
nsv1111606 CNV deletion 24896259
nsv1121248 CNV deletion 24896259
nsv1144031 CNV deletion 24896259
nsv1146350 CNV deletion 26484159
nsv1151174 CNV deletion 26484159
nsv1152661 OTHER inversion 26484159
nsv1153512 CNV deletion 26484159
nsv191273 CNV deletion 16902084
nsv474098 CNV novel sequence insertion 20440878
nsv476960 CNV novel sequence insertion 20440878
nsv477240 CNV novel sequence insertion 20440878
nsv829281 CNV gain 20364138
nsv829282 CNV loss 20364138
nsv829283 CNV gain 20364138
nsv955176 CNV deletion 24416366

Variation tolerance for WNT7B Gene

Residual Variation Intolerance Score: 9.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNT7B Gene

Human Gene Mutation Database (HGMD)
WNT7B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT7B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT7B Gene

Disorders for WNT7B Gene

MalaCards: The human disease database

(10) MalaCards diseases for WNT7B Gene - From: ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
microphthalmia, syndromic 9
  • pmd
exudative vitreoretinopathy 1
  • evr1
persistent hyperplastic primary vitreous
  • congenital retinal detachment
neural tube defects
  • neural tube defects, susceptibility to
norrie disease
  • nd
- elite association - COSMIC cancer census association via MalaCards
Search WNT7B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WNT7B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with WNT7B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNT7B Gene

Publications for WNT7B Gene

  1. Molecular cloning and characterization of human WNT7B. (PMID: 11562755) Kirikoshi H … Katoh M (International journal of oncology 2001) 2 3 4 23
  2. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. (PMID: 8168088) Huguet EL … Harris AL (Cancer research 1994) 2 3 4 23
  3. A molecular mechanism for Wnt ligand-specific signaling. (PMID: 30026314) Eubelen M … Vanhollebeke B (Science (New York, N.Y.) 2018) 3 4
  4. Wnt signaling and Dupuytren's disease. (PMID: 21732829) Dolmans GH … BSSH-GODD Consortium (The New England journal of medicine 2011) 3 41
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41

Products for WNT7B Gene

Sources for WNT7B Gene