The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpress... See more...

Aliases for WNT6 Gene

Aliases for WNT6 Gene

  • Wnt Family Member 6 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 6 2 3
  • Protein Wnt-6 3 4
  • WNT6 5

External Ids for WNT6 Gene

Previous GeneCards Identifiers for WNT6 Gene

  • GC02P217740
  • GC02P218445
  • GC02P219688
  • GC02P219927
  • GC02P219548
  • GC02P219432
  • GC02P219724
  • GC02P211579

Summaries for WNT6 Gene

Entrez Gene Summary for WNT6 Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT6 Gene

WNT6 (Wnt Family Member 6) is a Protein Coding gene. Diseases associated with WNT6 include Mullerian Aplasia And Hyperandrogenism and Gastric Cancer. Among its related pathways are Signaling by GPCR and Gastric cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT10B.

UniProtKB/Swiss-Prot Summary for WNT6 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WNT6 Gene

Genomics for WNT6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WNT6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J218859 Promoter 1.1 EPDnew Ensembl 600.7 0.0 -4 0.8 PRDM10 EZH2 ZBTB20 ZBTB26 KLF8 ZNF777 ZNF335 ZFP69B SUZ12 GLIS1 WNT6 ANKZF1 L13705-008 PRKAG3
GH02J218860 Promoter/Enhancer 1 Ensembl ENCODE 600.7 +1.1 1096 0.6 EZH2 ZNF600 ZNF341 ZBTB20 SP2 ZBTB26 USF1 ZBTB17 ZNF335 ZNF366 WNT6 WNT10A
GH02J218858 Enhancer 0.4 Ensembl 600.7 -1.5 -1504 0.2 PATZ1 EZH2 ZNF398 WNT6 L13705-008 PRKAG3
GH02J218829 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18 -27.3 -27291 5.8 KDM1A ZIC2 ZNF600 ESR1 CEBPB RCOR1 ZFHX2 BCOR ZNF768 ZNF513 PRKAG3 WNT6 PLCD4 RNF25 STK36 LOC100129175 MIR375 SLC11A1 RPL23AP31
GH02J218885 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +26.6 26596 2.8 SP1 BACH1 LARP7 STAT3 ZNF143 RELA TCF12 IKZF2 POLR2A TRIM22 WNT6 RNU6-642P PRKAG3 LINC00608 FEV CRYBA2 WNT10A CNOT9 LOC107984111 LOC105373882
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WNT6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WNT6

Top Transcription factor binding sites by QIAGEN in the WNT6 gene promoter:
  • MyoD
  • PPAR-gamma2

Genomic Locations for WNT6 Gene

Genomic Locations for WNT6 Gene
chr2:218,859,805-218,874,233
(GRCh38/hg38)
Size:
14,429 bases
Orientation:
Plus strand
chr2:219,724,544-219,738,955
(GRCh37/hg19)
Size:
14,412 bases
Orientation:
Plus strand

Genomic View for WNT6 Gene

Genes around WNT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT6 Gene

Proteins for WNT6 Gene

  • Protein details for WNT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6F9-WNT6_HUMAN
    Recommended name:
    Protein Wnt-6
    Protein Accession:
    Q9Y6F9
    Secondary Accessions:
    • Q9H1J6
    • Q9H238

    Protein attributes for WNT6 Gene

    Size:
    365 amino acids
    Molecular mass:
    39721 Da
    Quaternary structure:
    • Interacts with PORCN.

neXtProt entry for WNT6 Gene

Post-translational modifications for WNT6 Gene

  • Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn86 and Asn311
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT6 Gene

Domains & Families for WNT6 Gene

Gene Families for WNT6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for WNT6 Gene

InterPro:
Blocks:
  • Secreted growth factor Wnt protein
ProtoNet:

Suggested Antigen Peptide Sequences for WNT6 Gene

GenScript: Design optimal peptide antigens:
  • Protein Wnt (Q53S45_HUMAN)
  • Protein Wnt-6 (WNT6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6F9

UniProtKB/Swiss-Prot:

WNT6_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT6: view

Function for WNT6 Gene

Molecular function for WNT6 Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.
GENATLAS Biochemistry:
wingless-type MMTV integration site 6,Drosophila wingless (wg) segment polarity gene homolog,expressed in ectoderm,somites,limb and mammary gland in mice,involved in short-range signaling during embryonic patterning

LifeMap Function Summary for WNT6 Gene

During embryonic development, WNT6 as signaling molecule is secreted from the following cells

Phenotypes From GWAS Catalog for WNT6 Gene

Gene Ontology (GO) - Molecular Function for WNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
GO:0005109 frizzled binding IBA 21873635
GO:0005125 cytokine activity IBA 21873635
genes like me logo Genes that share ontologies with WNT6: view
genes like me logo Genes that share phenotypes with WNT6: view

Animal Models for WNT6 Gene

MGI Knock Outs for WNT6:
  • Wnt6 Wnt6<tm1Akis>
  • Wnt6 Wnt6<tm1b(NCOM)Mfgc>

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT6

CRISPR Products

miRNA for WNT6 Gene

miRTarBase miRNAs that target WNT6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNT6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT6 Gene

Localization for WNT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT6 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT6 gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 4
golgi apparatus 4
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for WNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with WNT6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WNT6 Gene

Pathways & Interactions for WNT6 Gene

PathCards logo

SuperPathways for WNT6 Gene

genes like me logo Genes that share pathways with WNT6: view

Pathways by source for WNT6 Gene

2 Sino Biological pathways for WNT6 Gene
2 GeneGo (Thomson Reuters) pathways for WNT6 Gene
  • Transcription Androgen Receptor nuclear signaling
  • Translation Non-genomic (rapid) action of Androgen Receptor
2 R&D Systems pathways for WNT6 Gene
1 Tocris pathway for WNT6 Gene
7 Qiagen pathways for WNT6 Gene
  • Colorectal Cancer Metastasis
  • GSK3 Signaling
  • Hedgehog Signaling in Mammals
  • Human Embryonic Stem Cell Pluripotency
  • Nanog in Mammalian ESC Pluripotency
2 GeneTex pathways for WNT6 Gene

SIGNOR curated interactions for WNT6 Gene

Activates:

Gene Ontology (GO) - Biological Process for WNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0007275 multicellular organism development IEA --
GO:0009798 axis specification IEA --
GO:0010628 positive regulation of gene expression IEA,IMP 20113781
GO:0016055 Wnt signaling pathway TAS --
genes like me logo Genes that share ontologies with WNT6: view

Drugs & Compounds for WNT6 Gene

No Compound Related Data Available

Transcripts for WNT6 Gene

mRNA/cDNA for WNT6 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNT6

Alternative Splicing Database (ASD) splice patterns (SP) for WNT6 Gene

No ASD Table

Relevant External Links for WNT6 Gene

GeneLoc Exon Structure for
WNT6

Expression for WNT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WNT6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT6 Gene

This gene is overexpressed in Nerve - Tibial (x8.4).

Protein differential expression in normal tissues from HIPED for WNT6 Gene

This gene is overexpressed in Spinal cord (27.6), Testis (19.1), Placenta (9.8), and Ovary (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WNT6 Gene



Protein tissue co-expression partners for WNT6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WNT6

SOURCE GeneReport for Unigene cluster for WNT6 Gene:

Hs.29764

mRNA Expression by UniProt/SwissProt for WNT6 Gene:

Q9Y6F9-WNT6_HUMAN
Tissue specificity: Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected in the apical gland region of the gastric foveolar epithelium (at protein level).

Evidence on tissue expression from TISSUES for WNT6 Gene

  • Intestine(2.7)
  • Nervous system(2.6)
  • Kidney(2.6)
  • Liver(2.5)
  • Heart(2.4)
  • Lung(2.3)
  • Muscle(2.2)
  • Bone(2.2)
  • Skin(2.1)
  • Blood(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with WNT6: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT6 Gene

Orthologs for WNT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WNT6 30
  • 99.56 (n)
Oppossum
(Monodelphis domestica)
Mammalia WNT6 31
  • 93 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia WNT6 30 31
  • 92.15 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WNT6 30 31
  • 90.96 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WNT6 31
  • 88 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Wnt6 30 17 31
  • 87.57 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wnt6 30
  • 86.9 (n)
Chicken
(Gallus gallus)
Aves WNT6 30 31
  • 74.9 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WNT6 31
  • 75 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii wnt6b 30 31
  • 68.06 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009733 30
  • 63.22 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Wnt6 30 31 32
  • 58.39 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea cwn-1 31
  • 33 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 26 (a)
ManyToMany
Species where no ortholog for WNT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for WNT6 Gene

ENSEMBL:
Gene Tree for WNT6 (if available)
TreeFam:
Gene Tree for WNT6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WNT6: view image

Paralogs for WNT6 Gene

(18) SIMAP similar genes for WNT6 Gene using alignment to 2 proteins:

  • WNT6_HUMAN
  • Q53S45_HUMAN
genes like me logo Genes that share paralogs with WNT6: view

Variants for WNT6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WNT6 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs786205888 Likely Benign: Exstrophy-epispadias complex 218,871,753(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for WNT6 Gene

Structural Variations from Database of Genomic Variants (DGV) for WNT6 Gene

Variant ID Type Subtype PubMed ID
dgv7296n54 CNV loss 21841781
nsv1072496 CNV deletion 25765185
nsv834542 CNV gain 17160897
nsv954838 CNV deletion 24416366

Variation tolerance for WNT6 Gene

Gene Damage Index Score: 3.13; 51.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNT6 Gene

Human Gene Mutation Database (HGMD)
WNT6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT6 Gene

Disorders for WNT6 Gene

MalaCards: The human disease database

(8) MalaCards diseases for WNT6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mullerian aplasia and hyperandrogenism
  • mullerian duct failure and hyperandrogenism
gastric cancer
  • gastric cancer, somatic
colorectal cancer
  • crc
ectodermal dysplasia
  • congenital ectodermal defect
norrie disease
  • nd
- elite association - COSMIC cancer census association via MalaCards
Search WNT6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WNT6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with WNT6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNT6 Gene

Publications for WNT6 Gene

  1. WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells. (PMID: 11350055) Kirikoshi H … Katoh M (Biochemical and biophysical research communications 2001) 2 3 4 23
  2. Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization. (PMID: 10343101) Rankin J … Lindsay S (Cytogenetics and cell genetics 1999) 2 3 4
  3. WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells. (PMID: 22370641) Yuan G … Burgermeister E (Oncogene 2013) 3 4
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41
  5. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PMID: 16953426) Beaty TH … Scott AF (Human genetics 2006) 3 41

Products for WNT6 Gene

  • Signalway Proteins for WNT6

Sources for WNT6 Gene