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The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpress... See more...
Aliases for WNT6 Gene
Aliases for WNT6 Gene
External Ids for WNT6 Gene
- HGNC: 12785
- Entrez Gene: 7475
- Ensembl: ENSG00000115596
- OMIM: 604663
- UniProtKB: Q9Y6F9
Previous GeneCards Identifiers for WNT6 Gene
- GC02P217740
- GC02P218445
- GC02P219688
- GC02P219927
- GC02P219548
- GC02P219432
- GC02P219724
- GC02P211579
Summaries for WNT6 Gene
-
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT6 Gene
WNT6 (Wnt Family Member 6) is a Protein Coding gene. Diseases associated with WNT6 include Mullerian Aplasia And Hyperandrogenism and Gastric Cancer. Among its related pathways are Signaling by GPCR and Gastric cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT10B.
UniProtKB/Swiss-Prot Summary for WNT6 Gene
-
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.
Additional gene information for WNT6 Gene
- HGNC(12785)
- Entrez Gene(7475)
- Ensembl(ENSG00000115596)
- OMIM(604663)
- UniProtKB(Q9Y6F9)
- Open Targets Platform(ENSG00000115596)
- Search for WNT6 at DataMed
- Search for WNT6 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WNT6 Gene
Genomics for WNT6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for WNT6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around WNT6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WNT6
- Top Transcription factor binding sites by QIAGEN in the WNT6 gene promoter:
-
- MyoD
- PPAR-gamma2
Genomic Locations for WNT6 Gene
Genomic Locations for WNT6 Gene
- chr2:218,859,805-218,874,233
- (GRCh38/hg38)
- Size:
- 14,429 bases
- Orientation:
- Plus strand
- chr2:219,724,544-219,738,955
- (GRCh37/hg19)
- Size:
- 14,412 bases
- Orientation:
- Plus strand
Genomic View for WNT6 Gene
Genes around WNT6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q35 by HGNC
- 2q35 by Entrez Gene
- 2q35 by Ensembl
WNT6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WNT6 Gene
Proteins for WNT6 Gene
-
Protein details for WNT6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6F9-WNT6_HUMAN
- Recommended name:
- Protein Wnt-6
- Protein Accession:
- Q9Y6F9
- Q9H1J6
- Q9H238
Protein attributes for WNT6 Gene
- Size:
- 365 amino acids
- Molecular mass:
- 39721 Da
- Quaternary structure:
-
- Interacts with PORCN.
Protein Expression for WNT6 Gene
Post-translational modifications for WNT6 Gene
- Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
-
Glycosylation at Asn86 and Asn311
- NX_Q9Y6F9 (NX_Q9Y6F9-1)
- Modification sites at PhosphoSitePlus
Other Protein References for WNT6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences WNT6 Antibody (LS-A9111) and WNT6 Antibody (LS-A9110)
- G Biosciences Immunotag™ WNT6 Antibody
- Novus Biologicals Antibodies for WNT6
-
Abcam antibodies for WNT6
- Invitrogen Antibodies for WNT6 (AFLGC-WNT6)
- antibodies-online: Show 21 available WNT6 Antibodies ranked by validation data
- Compare Top WNT6 Antibodies
-
Recommended
- 48 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IHC (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 12 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 20 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
-
Boster Bio Antibodies for WNT6
Protein Products
-
OriGene Purified Proteins for WNT6
- Search Origene for MassSpec and Protein Over-expression Lysates for WNT6
- Origene Custom Protein Services for WNT6
-
Signalway Proteins for WNT6
-
Abcam proteins for WNT6
Assay Products
- G Biosciences Immunotag™ Protein Wnt-6 ELISA Kit
- antibodies-online: Show 9 available WNT6 Elisa Kits ranked by validation data
- Compare Top WNT6 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for WNT6 Gene
Domains & Families for WNT6 Gene
Gene Families for WNT6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for WNT6 Gene
Suggested Antigen Peptide Sequences for WNT6 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein Wnt (Q53S45_HUMAN)
- Protein Wnt-6 (WNT6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y6F9- Family:
-
- Belongs to the Wnt family.
Function for WNT6 Gene
Molecular function for WNT6 Gene
- UniProtKB/Swiss-Prot Function:
- Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.
- GENATLAS Biochemistry:
- wingless-type MMTV integration site 6,Drosophila wingless (wg) segment polarity gene homolog,expressed in ectoderm,somites,limb and mammary gland in mice,involved in short-range signaling during embryonic patterning
LifeMap Function Summary for WNT6 Gene
During embryonic development, WNT6 as signaling molecule is secreted from the following cells
- Surface Ectoderm
It affects the following cells:
- Brain
- Paraxial Mesoderm
Phenotypes From GWAS Catalog for WNT6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0005109 | frizzled binding | IBA | 21873635 |
| GO:0005125 | cytokine activity | IBA | 21873635 |
Phenotypes for WNT6 Gene
- MGI mutant phenotypes for WNT6:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for WNT6:
Animal Model Products
-
Taconic Biosciences Mouse Models for WNT6
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WNT6 - Select products 50% OFF >
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-
OriGene CRISPR knockouts for WNT6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WNT6
-
Santa Cruz Biotechnology (SCBT) CRISPR for WNT6
miRNA for WNT6 Gene
- miRTarBase miRNAs that target WNT6
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for WNT6 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for WNT6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WNT6
Cell Line Products
-
Horizon Cell Lines for WNT6
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT6 Gene
Localization for WNT6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for WNT6 Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 4 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 4 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for WNT6 Gene
Pathways & Interactions for WNT6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Translation Non-genomic (rapid) action of Androgen Receptor |
Transcription Androgen Receptor nuclear signaling
.49
Translation Non-genomic (rapid) action of Androgen Receptor
.49
|
|
| 2 | Gastric cancer |
.62
.62
|
|
| 3 | Aldosterone synthesis and secretion |
.41
|
.41
|
| 4 | mTOR signaling pathway (KEGG) |
.38
|
|
| 5 | Wnt signaling pathway | ||
Pathways by source for WNT6 Gene
2 Sino Biological pathways for WNT6 Gene
4 BioSystems pathways for WNT6 Gene
6 Reactome pathways for WNT6 Gene
14 KEGG pathways for WNT6 Gene
2 GeneGo (Thomson Reuters) pathways for WNT6 Gene
- Transcription Androgen Receptor nuclear signaling
- Translation Non-genomic (rapid) action of Androgen Receptor
2 R&D Systems pathways for WNT6 Gene
1 Tocris pathway for WNT6 Gene
7 Qiagen pathways for WNT6 Gene
- Colorectal Cancer Metastasis
- GSK3 Signaling
- Hedgehog Signaling in Mammals
- Human Embryonic Stem Cell Pluripotency
- Nanog in Mammalian ESC Pluripotency
2 GeneTex pathways for WNT6 Gene
Interacting Proteins for WNT6 Gene
GPS-Prot Interaction Network for WNT6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001658 | branching involved in ureteric bud morphogenesis | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009798 | axis specification | IEA | -- |
| GO:0010628 | positive regulation of gene expression | IEA,IMP | 20113781 |
| GO:0016055 | Wnt signaling pathway | TAS | -- |
Transcripts for WNT6 Gene
mRNA/cDNA for WNT6 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000233948 1719 nts (view in UCSC)
- ENST00000486233 408 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for WNT6 - Select products 50% OFF >
- * WNT6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for WNT6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for WNT6
-
Santa Cruz Biotechnology (SCBT) CRISPR for WNT6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WNT6
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Clone Products
- Applied Biological Materials (abm): Clones for WNT6 - Select products 50% OFF >
- * WNT6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for WNT6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for WNT6
Relevant External Links for WNT6 Gene
- GeneLoc Exon Structure for
- WNT6
Expression for WNT6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
- Primary Enamel Knot Cells Enamel Knot
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Dental Enamel
-
Epithelial Cells
- Dental Placode Cells Dental Placode
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Primary Hair Placode Cells Hair Follicle
- Intermediate Keratinocytes Embryonic Epidermis
-
Kidney (Urinary System)
- Ureteric Bud Tip Cells Ureteric Bud
- Ureteric Bud
-
Hair (Integumentary System)
- Primary Hair Placode Cells Hair Follicle
- Basal Keratinocytes Embryonic Epidermis
-
Epidermis (Integumentary System)
- Intermediate Keratinocytes Embryonic Epidermis
- Basal Keratinocytes Embryonic Epidermis
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Peripheral Nervous System (Nervous System)
- Immature Schwann Cells Peripheral Nerve Domain
-
Hypoblast (Extraembryonic Tissues)
- Hypoblast Cells Hypoblast
- Gut Tube (Gastrointestinal Tract)
- Dermis (Integumentary System)
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for WNT6 Gene
This gene is overexpressed in Nerve - Tibial (x8.4).
This gene is overexpressed in Spinal cord (27.6), Testis (19.1), Placenta (9.8), and Ovary (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WNT6 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WNT6
SOURCE GeneReport for Unigene cluster for WNT6 Gene:
Hs.29764mRNA Expression by UniProt/SwissProt for WNT6 Gene:
Q9Y6F9-WNT6_HUMAN
Tissue specificity:
Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected in the apical gland region of the gastric foveolar epithelium (at protein level).
Evidence on tissue expression from TISSUES for WNT6 Gene
- Intestine(2.7)
- Nervous system(2.6)
- Kidney(2.6)
- Liver(2.5)
- Heart(2.4)
- Lung(2.3)
- Muscle(2.2)
- Bone(2.2)
- Skin(2.1)
- Blood(2.1)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for WNT6
-
OriGene qPCR primer pairs and template standards for WNT6
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT6 Gene
Orthologs for WNT6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | WNT6 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | WNT6 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | WNT6 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | WNT6 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | WNT6 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Wnt6 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Wnt6 30 |
|
||
| Chicken (Gallus gallus) |
Aves | WNT6 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | WNT6 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | wnt6b 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009733 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Wnt6 30 31 32 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | cwn-1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
- Species where no ortholog for WNT6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for WNT6 Gene
- ENSEMBL:
- Gene Tree for WNT6 (if available)
- TreeFam:
- Gene Tree for WNT6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for WNT6: view image
Paralogs for WNT6 Gene
Paralogs for WNT6 Gene
(18) SIMAP similar genes for WNT6 Gene using alignment to 2 proteins:
- WNT6_HUMAN
- Q53S45_HUMAN
Variants for WNT6 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WNT6 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs786205888 | Likely Benign: Exstrophy-epispadias complex | 218,871,753(+) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv7296n54 | CNV | loss | 21841781 |
| nsv1072496 | CNV | deletion | 25765185 |
| nsv834542 | CNV | gain | 17160897 |
| nsv954838 | CNV | deletion | 24416366 |
Gene Damage Index Score:
3.13;
51.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for WNT6 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT6 Gene
Disorders for WNT6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mullerian aplasia and hyperandrogenism |
|
|
| gastric cancer |
|
|
| colorectal cancer |
|
|
| ectodermal dysplasia |
|
|
| norrie disease |
|
|
Search WNT6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for WNT6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for WNT6 Gene
Publications for WNT6 Gene
- WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells. (PMID: 11350055) Kirikoshi H … Katoh M (Biochemical and biophysical research communications 2001) 2 3 4 23
- Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization. (PMID: 10343101) Rankin J … Lindsay S (Cytogenetics and cell genetics 1999) 2 3 4
- WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells. (PMID: 22370641) Yuan G … Burgermeister E (Oncogene 2013) 3 4
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41
- Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PMID: 16953426) Beaty TH … Scott AF (Human genetics 2006) 3 41
ExternalLinks
Products for WNT6 Gene
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- Browse Boster Bio ELISA Kits
- Signalway Proteins for WNT6
Sources for WNT6 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB