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The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
WNT6 (Wnt Family Member 6) is a Protein Coding gene. Diseases associated with WNT6 include Mullerian Aplasia And Hyperandrogenism and Gastric Cancer. Among its related pathways are Signaling by GPCR and Gastric cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT10B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IEA | -- |
GO:0005109 | frizzled binding | IBA | 21873635 |
GO:0005125 | cytokine activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0005796 | Golgi lumen | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Translation Non-genomic (rapid) action of Androgen Receptor |
Transcription Androgen Receptor nuclear signaling
.49
Translation Non-genomic (rapid) action of Androgen Receptor
.49
|
|
2 | Gastric cancer |
.62
.62
|
|
3 | Aldosterone synthesis and secretion |
.41
|
.41
|
4 | mTOR signaling pathway (KEGG) |
.38
|
|
5 | Wnt signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001658 | branching involved in ureteric bud morphogenesis | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0009798 | axis specification | IEA | -- |
GO:0010628 | positive regulation of gene expression | IEA,IMP | 20113781 |
GO:0016055 | Wnt signaling pathway | TAS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | WNT6 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | WNT6 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | WNT6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | WNT6 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | WNT6 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Wnt6 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Wnt6 30 |
|
||
Chicken (Gallus gallus) |
Aves | WNT6 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | WNT6 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | wnt6b 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009733 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Wnt6 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | cwn-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs786205888 | Likely Benign: Exstrophy-epispadias complex | 218,871,753(+) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv7296n54 | CNV | loss | 21841781 |
nsv1072496 | CNV | deletion | 25765185 |
nsv834542 | CNV | gain | 17160897 |
nsv954838 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mullerian aplasia and hyperandrogenism |
|
|
gastric cancer |
|
|
colorectal cancer |
|
|
ectodermal dysplasia |
|
|
norrie disease |
|
|