Aliases for WNT4 Gene
External Ids for WNT4 Gene
Previous GeneCards Identifiers for WNT4 Gene
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT4 Gene
WNT4 (Wnt Family Member 4) is a Protein Coding gene. Diseases associated with WNT4 include 46,Xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs and Mullerian Aplasia And Hyperandrogenism. Among its related pathways are DNA Damage Response (only ATM dependent) and Thyroid hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT5A.
UniProtKB/Swiss-Prot for WNT4 Gene
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.