Aliases for WNT3A Gene
External Ids for WNT3A Gene
Previous GeneCards Identifiers for WNT3A Gene
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT3A Gene
WNT3A (Wnt Family Member 3A) is a Protein Coding gene. Diseases associated with WNT3A include Osteoporosis, Juvenile and Hypotrichosis Simplex. Among its related pathways are Gene regulatory network modelling somitogenesis and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein domain specific binding. An important paralog of this gene is WNT3.
UniProtKB/Swiss-Prot Summary for WNT3A Gene
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720).