Aliases for WNT3 Gene
External Ids for WNT3 Gene
Previous HGNC Symbols for WNT3 Gene
Previous GeneCards Identifiers for WNT3 Gene
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT3 Gene
WNT3 (Wnt Family Member 3) is a Protein Coding gene. Diseases associated with WNT3 include Tetraamelia Syndrome 1 and Tetra-Amelia Syndrome. Among its related pathways are Signaling by Wnt and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT3A.
UniProtKB/Swiss-Prot Summary for WNT3 Gene
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406).