The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 ... See more...

Aliases for WNT3 Gene

Aliases for WNT3 Gene

  • Wnt Family Member 3 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 3 2 3
  • WNT-3 Proto-Oncogene Protein 2 3
  • Proto-Oncogene Int-4 Homolog 3 4
  • Proto-Oncogene Wnt-3 3 4
  • INT4 3 4
  • MGC131950 2
  • MGC138321 2
  • MGC138323 2
  • TETAMS 3
  • WNT3 5

External Ids for WNT3 Gene

Previous HGNC Symbols for WNT3 Gene

  • INT4

Previous GeneCards Identifiers for WNT3 Gene

  • GC17M044339
  • GC17M047240
  • GC17M045183
  • GC17M045316
  • GC17M042196
  • GC17M044839
  • GC17M040220

Summaries for WNT3 Gene

Entrez Gene Summary for WNT3 Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT3 Gene

WNT3 (Wnt Family Member 3) is a Protein Coding gene. Diseases associated with WNT3 include Tetraamelia Syndrome 1 and Tetra-Amelia Syndrome. Among its related pathways are Signaling by GPCR and Gastric cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT3A.

UniProtKB/Swiss-Prot Summary for WNT3 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406).

Gene Wiki entry for WNT3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WNT3 Gene

Genomics for WNT3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WNT3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WNT3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WNT3

Top Transcription factor binding sites by QIAGEN in the WNT3 gene promoter:
  • E47
  • GATA-2
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx2-5
  • p53
  • Pax-3
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for WNT3 Gene

Genomic Locations for WNT3 Gene
chr17:46,762,506-46,833,154
(GRCh38/hg38)
Size:
70,649 bases
Orientation:
Minus strand
chr17:44,839,872-44,910,520
(GRCh37/hg19)
Size:
70,649 bases
Orientation:
Minus strand

Genomic View for WNT3 Gene

Genes around WNT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT3 Gene

Proteins for WNT3 Gene

  • Protein details for WNT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56703-WNT3_HUMAN
    Recommended name:
    Proto-oncogene Wnt-3
    Protein Accession:
    P56703
    Secondary Accessions:
    • Q2M237
    • Q9H1J9

    Protein attributes for WNT3 Gene

    Size:
    355 amino acids
    Molecular mass:
    39645 Da
    Quaternary structure:
    • Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).Interacts with PORCN. Interacts with WLS (By similarity).

    Three dimensional structures from OCA and Proteopedia for WNT3 Gene

neXtProt entry for WNT3 Gene

Post-translational modifications for WNT3 Gene

  • Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn90 and Asn301
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT3 Gene

Domains & Families for WNT3 Gene

Gene Families for WNT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted secreted proteins

Protein Domains for WNT3 Gene

InterPro:
Blocks:
  • Secreted growth factor Wnt protein
ProtoNet:

Suggested Antigen Peptide Sequences for WNT3 Gene

GenScript: Design optimal peptide antigens:
  • Proto-oncogene Int-4 homolog (WNT3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P56703

UniProtKB/Swiss-Prot:

WNT3_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT3: view

Function for WNT3 Gene

Molecular function for WNT3 Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406).
GENATLAS Biochemistry:
wingless-type MMTV integration site 3,Drosophila wingless (wg) segment polarity gene homolog,expressed in developing nervous system and in adult thalamus,cerebellum,pons,modulating cell fate and cell behavior during vertebrate development,required for the primary axis formation

LifeMap Function Summary for WNT3 Gene

During embryonic development, WNT3 as signaling molecule is secreted from the following cells
It affects the following cells:

Phenotypes From GWAS Catalog for WNT3 Gene

Gene Ontology (GO) - Molecular Function for WNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
GO:0005109 frizzled binding IBA,IPI 10557084
GO:0005125 cytokine activity IBA 21873635
GO:0005515 protein binding IPI 18313787
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with WNT3: view
genes like me logo Genes that share phenotypes with WNT3: view

Human Phenotype Ontology for WNT3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WNT3 Gene

MGI Knock Outs for WNT3:
  • Wnt3 Wnt3<tm1Brd>
  • Wnt3 Wnt3<tm1Amc>
  • Wnt3 Wnt3<tm2a(EUCOMM)Wtsi>
  • Wnt3 Wnt3<tm2Brd>
  • Wnt3 Wnt3<tm1Bhr>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNT3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WNT3 Gene

Localization for WNT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT3 Gene

Secreted, extracellular space, extracellular matrix. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT3 gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 4
golgi apparatus 4
nucleus 3
cytoskeleton 2
mitochondrion 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,TAS 18313787
GO:0005737 cytoplasm IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with WNT3: view

Pathways & Interactions for WNT3 Gene

PathCards logo

SuperPathways for WNT3 Gene

SuperPathway Contained pathways
1 Translation Non-genomic (rapid) action of Androgen Receptor
.49
.49
2 Gastric cancer
3 Aldosterone synthesis and secretion
4 WNT ligand biogenesis and trafficking
5 Nanog in Mammalian ESC Pluripotency
.62
.62
genes like me logo Genes that share pathways with WNT3: view

Pathways by source for WNT3 Gene

2 GeneGo (Thomson Reuters) pathways for WNT3 Gene
  • Transcription Androgen Receptor nuclear signaling
  • Translation Non-genomic (rapid) action of Androgen Receptor
1 Tocris pathway for WNT3 Gene
9 Qiagen pathways for WNT3 Gene
  • Colorectal Cancer Metastasis
  • G12-G13 in Cellular Signaling
  • GSK3 Signaling
  • Hedgehog Signaling in Mammals
  • Human Embryonic Stem Cell Pluripotency
2 GeneTex pathways for WNT3 Gene

SIGNOR curated interactions for WNT3 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for WNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IMP 15588944
GO:0001707 mesoderm formation IEA --
GO:0007275 multicellular organism development IEA --
GO:0007276 gamete generation IEA --
GO:0007411 axon guidance IEA --
genes like me logo Genes that share ontologies with WNT3: view

Drugs & Compounds for WNT3 Gene

(9) Drugs for WNT3 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FH535 Pharma Wnt/B-catenin inhibitor, Inhibitor of Wnt/beta-catenin signaling 0
ICG 001 Pharma Wnt/β-catenin pathway inhibitor 0
IWP 2 Pharma Wnt production inhibitor,PORCN inhibitor, PORCN inhibitor; inhibits Wnt processing and secretion 0
IWR-1-endo Pharma Potent Wnt signaling inhibitor 0
Kartogenin Pharma 0

(1) Additional Compounds for WNT3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(9) ApexBio Compounds for WNT3 Gene

Compound Action Cas Number
FH535 Wnt/B-catenin inhibitor 108409-83-2
ICG 001 Wnt/β-catenin pathway inhibitor 847591-62-2
IWP-2 Wnt production inhibitor,PORCN inhibitor 686770-61-6
IWR-1-endo Potent Wnt signaling inhibitor 1127442-82-3
Kartogenin 4727-31-5
KY 02111 WNT signaling inhibitor 1118807-13-8
LGK-974 PORCN inhibitor,potent and specific 1243244-14-5
Salinomycin Polyether ionophore antibiotic;anti-cancer 53003-10-4
Wnt-C59 PORCN inhibitor,highly potent and selective 1243243-89-1
genes like me logo Genes that share compounds with WNT3: view

Drug Products

Transcripts for WNT3 Gene

mRNA/cDNA for WNT3 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNT3

Alternative Splicing Database (ASD) splice patterns (SP) for WNT3 Gene

No ASD Table

Relevant External Links for WNT3 Gene

GeneLoc Exon Structure for
WNT3

Expression for WNT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WNT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x9.3), Skin - Sun Exposed (Lower leg) (x6.9), and Liver (x5.3).

Protein differential expression in normal tissues from HIPED for WNT3 Gene

This gene is overexpressed in Liver, secretome (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WNT3 Gene



Protein tissue co-expression partners for WNT3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WNT3

SOURCE GeneReport for Unigene cluster for WNT3 Gene:

Hs.445884

Evidence on tissue expression from TISSUES for WNT3 Gene

  • Skin(3)
  • Nervous system(2.8)
  • Intestine(2.4)
  • Blood(2.2)
  • Bone(2.2)
  • Muscle(2.1)
  • Heart(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • chin
  • cranial nerve
  • ear
  • eye
  • face
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • nose
  • olfactory bulb
  • outer ear
  • pharynx
  • skull
Thorax:
  • breast
  • bronchus
  • chest wall
  • diaphragm
  • heart
  • lung
  • rib
  • rib cage
  • trachea
Abdomen:
  • abdominal wall
  • adrenal gland
  • duodenum
  • intestine
  • kidney
  • large intestine
  • small intestine
  • spleen
  • stomach
Pelvis:
  • anus
  • fallopian tube
  • pelvis
  • penis
  • placenta
  • rectum
  • testicle
  • ureter
  • urethra
  • urinary bladder
  • uterus
  • vagina
  • vulva
Limb:
  • lower limb
  • upper limb
General:
  • blood
  • blood vessel
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with WNT3: view

No data available for mRNA Expression by UniProt/SwissProt for WNT3 Gene

Orthologs for WNT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WNT3 30 31
  • 99.62 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WNT3 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia WNT3 30 31
  • 93.8 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WNT3 30 31
  • 92.58 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Wnt3 30 17 31
  • 92.49 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wnt3 30
  • 91.92 (n)
Chicken
(Gallus gallus)
Aves WNT3 30 31
  • 83.76 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia WNT3 31
  • 96 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia wnt3 30
  • 78.73 (n)
African clawed frog
(Xenopus laevis)
Amphibia wnt3a-A 30
Zebrafish
(Danio rerio)
Actinopterygii wnt3 30 31
  • 78.66 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Wnt2 32
  • 46 (a)
Wnt6 32
  • 45 (a)
Wnt5 32
  • 41 (a)
Worm
(Caenorhabditis elegans)
Secernentea cwn-1 31 32
  • 38 (a)
OneToMany
egl-20 32
  • 35 (a)
lin-44 32
  • 31 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
OneToMany
Species where no ortholog for WNT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for WNT3 Gene

ENSEMBL:
Gene Tree for WNT3 (if available)
TreeFam:
Gene Tree for WNT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WNT3: view image

Paralogs for WNT3 Gene

(18) SIMAP similar genes for WNT3 Gene using alignment to 1 proteins:

  • WNT3_HUMAN
genes like me logo Genes that share paralogs with WNT3: view

Variants for WNT3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WNT3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs104894653 Pathogenic: Tetraamelia, autosomal recessive 46,773,743(-) G/A NONSENSE
rs114693722 Uncertain Significance: Tetraamelia, autosomal recessive 46,764,601(-) A/G THREE_PRIME_UTR_VARIANT
rs148902716 Likely Benign: not specified 46,769,942(-) C/T SYNONYMOUS_VARIANT
rs199742069 Uncertain Significance: Tetraamelia, autosomal recessive 46,818,626(-) C/T FIVE_PRIME_UTR_VARIANT
rs749737942 Uncertain Significance: not provided 46,773,681(-) G/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for WNT3 Gene

Structural Variations from Database of Genomic Variants (DGV) for WNT3 Gene

Variant ID Type Subtype PubMed ID
dgv1475n106 CNV deletion 24896259
dgv5668n54 CNV gain+loss 21841781
dgv5669n54 CNV gain+loss 21841781
dgv5670n54 CNV gain 21841781
dgv5671n54 CNV gain+loss 21841781
dgv5672n54 CNV gain 21841781
dgv5673n54 CNV loss 21841781
esv1005788 CNV deletion 20482838
esv1008863 CNV insertion 20482838
esv2656635 CNV deletion 23128226
esv2659354 CNV deletion 23128226
esv2758692 CNV gain+loss 17122850
esv28523 CNV loss 19812545
esv3435685 CNV insertion 20981092
esv3554487 CNV deletion 23714750
nsv1070832 CNV deletion 25765185
nsv1072742 CNV deletion 25765185
nsv1121937 CNV deletion 24896259
nsv1126465 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv428343 CNV gain+loss 18775914
nsv483083 CNV gain 15286789
nsv575460 CNV gain+loss 21841781
nsv575461 CNV loss 21841781
nsv833465 CNV loss 17160897

Variation tolerance for WNT3 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNT3 Gene

Human Gene Mutation Database (HGMD)
WNT3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT3 Gene

Disorders for WNT3 Gene

MalaCards: The human disease database

(21) MalaCards diseases for WNT3 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tetraamelia syndrome 1
  • tetams1
tetra-amelia syndrome
  • tetra-amelia
tetraamelia-multiple malformations syndrome
  • zimmer phocomelia
nodular basal cell carcinoma
  • basal cell carcinoma, nodular
cleft lip
  • cheiloschisis
- elite association - COSMIC cancer census association via MalaCards
Search WNT3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WNT3_HUMAN
  • Tetraamelia syndrome 1 (TETAMS1) [MIM:273395]: A form of tetraamelia, a rare disease characterized by rudimentary appendages or complete absence of all four limbs, and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. TETAMS1 patients manifest complete limb agenesis without defects of scapulae or clavicles. Other features include bilateral cleft lip/palate, diaphragmatic defect with bilobar right lung, renal and adrenal agenesis, pelvic hypoplasia, and urogenital defects. TETAMS1 transmission pattern is consistent with autosomal recessive inheritance. {ECO:0000269 PubMed:14872406}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for WNT3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with WNT3: view

No data available for Genatlas for WNT3 Gene

Publications for WNT3 Gene

  1. Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene. (PMID: 8244403) Roelink H … Nusse R (Genomics 1993) 2 3 4 23
  2. Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. (PMID: 14872406) Niemann S … Müller U (American journal of human genetics 2004) 3 4 23
  3. Molecular cloning and characterization of human WNT3. (PMID: 11604997) Katoh M (International journal of oncology 2001) 3 4 23
  4. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N … PD GWAS Consortium (Annals of neurology 2012) 3 41
  5. Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population. (PMID: 21812969) Liu X … Lee JH (BMC medical genetics 2011) 3 41

Products for WNT3 Gene

Sources for WNT3 Gene