WNT2B Gene (Protein Coding)

Wnt Family Member 2B

GC01P112466
GIFtS:
44
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Altern... See more...

Aliases for WNT2B Gene

Aliases for WNT2B Gene

  • Wnt Family Member 2B 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 13 2 3
  • Wingless-Type MMTV Integration Site Family, Member 2B 2 3
  • XWNT2, Xenopus, Homolog Of 2 3
  • Protein Wnt-2b 3 4
  • WNT13 3 4
  • Protein Wnt-13 4
  • WNT2B 5
  • XWNT2 2

External Ids for WNT2B Gene

Previous HGNC Symbols for WNT2B Gene

  • WNT13

Previous GeneCards Identifiers for WNT2B Gene

  • GC01P113426
  • GC01P111881
  • GC01P112112
  • GC01P112308
  • GC01P112722
  • GC01P112810
  • GC01P113009
  • GC01P110867

Summaries for WNT2B Gene

Entrez Gene Summary for WNT2B Gene

  • This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for WNT2B Gene

WNT2B (Wnt Family Member 2B) is a Protein Coding gene. Diseases associated with WNT2B include Diarrhea 9 and Diarrhea. Among its related pathways are Signaling by GPCR and Gastric cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT2.

UniProtKB/Swiss-Prot Summary for WNT2B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.

Gene Wiki entry for WNT2B Gene

Additional gene information for WNT2B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WNT2B Gene

Genomics for WNT2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for WNT2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WNT2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WNT2B

Top Transcription factor binding sites by QIAGEN in the WNT2B gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4

Genomic Locations for WNT2B Gene

Genomic Locations for WNT2B Gene
chr1:112,466,541-112,530,165
(GRCh38/hg38)
Size:
63,625 bases
Orientation:
Plus strand
chr1:113,009,163-113,072,787
(GRCh37/hg19)
Size:
63,625 bases
Orientation:
Plus strand

Genomic View for WNT2B Gene

Genes around WNT2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT2B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for WNT2B Gene

Proteins for WNT2B Gene

Products:

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  • Protein details for WNT2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93097-WNT2B_HUMAN
    Recommended name:
    Protein Wnt-2b
    Protein Accession:
    Q93097
    Secondary Accessions:
    • O14903
    • Q5TEH9
    • Q5TEI2
    • Q9HDC1
    • Q9HDC2

    Protein attributes for WNT2B Gene

    Size:
    391 amino acids
    Molecular mass:
    43770 Da
    Quaternary structure:
    • Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Interacts with FZD4 and FZD5 (By similarity).

    Alternative splice isoforms for WNT2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT2B Gene

Protein Expression for WNT2B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for WNT2B Gene

  • Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn117 and Asn283
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT2B Gene

Domains & Families for WNT2B Gene

Gene Families for WNT2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for WNT2B Gene

InterPro:
Blocks:
  • Secreted growth factor Wnt protein
ProtoNet:

Suggested Antigen Peptide Sequences for WNT2B Gene

GenScript: Design optimal peptide antigens:
  • Protein Wnt (Q5TEH8_HUMAN)
  • Protein Wnt (Q5TEH9_HUMAN)
  • Protein Wnt-13 (WNT2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q93097

UniProtKB/Swiss-Prot:

WNT2B_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT2B: view

Function for WNT2B Gene

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  2. CRISPR
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  6. Cell Line

Molecular function for WNT2B Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.
GENATLAS Biochemistry:
wingless type 2B,Drosophila wingless (wg),segment polarity gene homolog,expressed in breast,gastric cancer,modulating cell fate and cell behavior during vertebrate development

Phenotypes From GWAS Catalog for WNT2B Gene

Gene Ontology (GO) - Molecular Function for WNT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
GO:0005109 frizzled binding IBA 21873635
GO:0005125 cytokine activity IBA 21873635
genes like me logo Genes that share ontologies with WNT2B: view
genes like me logo Genes that share phenotypes with WNT2B: view

Human Phenotype Ontology for WNT2B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WNT2B Gene

MGI Knock Outs for WNT2B:
  • Wnt2b Wnt2b<tm1b(EUCOMM)Wtsi>
  • Wnt2b Wnt2b<tm1.1Eem>

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT2B

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNT2B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WNT2B Gene

Localization for WNT2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT2B Gene

Secreted, extracellular space, extracellular matrix. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT2B gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WNT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,NAS 15135146
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0062023 collagen-containing extracellular matrix HDA 25037231
genes like me logo Genes that share ontologies with WNT2B: view

Pathways & Interactions for WNT2B Gene

PathCards logo

SuperPathways for WNT2B Gene

genes like me logo Genes that share pathways with WNT2B: view

Pathways by source for WNT2B Gene

2 GeneGo (Thomson Reuters) pathways for WNT2B Gene
  • Transcription Androgen Receptor nuclear signaling
  • Translation Non-genomic (rapid) action of Androgen Receptor
1 Tocris pathway for WNT2B Gene
7 Qiagen pathways for WNT2B Gene
  • Colorectal Cancer Metastasis
  • GSK3 Signaling
  • Hedgehog Signaling in Mammals
  • Human Embryonic Stem Cell Pluripotency
  • Nanog in Mammalian ESC Pluripotency
2 GeneTex pathways for WNT2B Gene

SIGNOR curated interactions for WNT2B Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for WNT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002062 chondrocyte differentiation IEP 15135146
GO:0002088 lens development in camera-type eye ISS 16258938
GO:0007275 multicellular organism development IEA --
GO:0008584 male gonad development IEP 17848411
GO:0009267 cellular response to starvation IEA --
genes like me logo Genes that share ontologies with WNT2B: view

Drugs & Compounds for WNT2B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for WNT2B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for WNT2B Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNT2B

Alternative Splicing Database (ASD) splice patterns (SP) for WNT2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3:

Relevant External Links for WNT2B Gene

GeneLoc Exon Structure for
WNT2B

Expression for WNT2B Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WNT2B Gene

mRNA expression in normal human tissues for WNT2B Gene
mRNA expression by BioGPS for WNT2B GenemRNA expression by GTEx for WNT2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WNT2B Gene

This gene is overexpressed in Testis (46.9) and Prostate (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WNT2B Gene



Protein tissue co-expression partners for WNT2B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WNT2B

SOURCE GeneReport for Unigene cluster for WNT2B Gene:

Hs.258575

mRNA Expression by UniProt/SwissProt for WNT2B Gene:

Q93097-WNT2B_HUMAN
Tissue specificity: Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines.

Evidence on tissue expression from TISSUES for WNT2B Gene

  • Kidney(2.6)
  • Nervous system(2.5)
  • Skin(2.5)
  • Intestine(2.5)
  • Muscle(2.2)
  • Heart(2.1)
  • Bone(2.1)
  • Blood(2.1)
  • Eye(2)
genes like me logo Genes that share expression patterns with WNT2B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT2B Gene

Orthologs for WNT2B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia WNT2B 30 31
  • 99.6 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia WNT2B 31
  • 99 (a)
 OneToOne
LOC483220 30
  • 92.63 (n)
Cow
(Bos Taurus)
 Mammalia WNT2B 30 31
  • 92.5 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia WNT2B 31
  • 91 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Wnt2b 30
  • 88.32 (n)
Mouse
(Mus musculus)
 Mammalia Wnt2b 30 17 31
  • 87.49 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia WNT2B 31
  • 87 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves WNT2B 30 31
  • 75.27 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia WNT2B 31
  • 82 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC100491761 30
  • 70.62 (n)
African clawed frog
(Xenopus laevis)
 Amphibia wnt2b-A 30
Zebrafish
(Danio rerio)
 Actinopterygii wnt2bb 30 31
  • 70.62 (n)
 OneToMany
wnt2ba 31
  • 70 (a)
 OneToMany
wnt2b 30
Fruit Fly
(Drosophila melanogaster)
 Insecta Wnt5 32
  • 50 (a)
Wnt6 32
  • 45 (a)
Wnt2 32
  • 42 (a)
Wnt4 32
  • 31 (a)
Worm
(Caenorhabditis elegans)
 Secernentea cwn-2 32
  • 43 (a)
egl-20 32
  • 39 (a)
mom-2 32
  • 34 (a)
lin-44 32
  • 29 (a)
Species where no ortholog for WNT2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for WNT2B Gene

ENSEMBL:
Gene Tree for WNT2B (if available)
TreeFam:
Gene Tree for WNT2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WNT2B: view image

Paralogs for WNT2B Gene

Paralogs for WNT2B Gene

(18) SIMAP similar genes for WNT2B Gene using alignment to 3 proteins:

  • WNT2B_HUMAN
  • Q5TEH8_HUMAN
  • Q5TEH9_HUMAN
genes like me logo Genes that share paralogs with WNT2B: view

Variants for WNT2B Gene

Products:

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WNT2B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
718973 Benign: not provided 112,514,993(+) G/A MISSENSE_VARIANT
744351 Likely Benign: not provided 112,517,348(+) C/T SYNONYMOUS_VARIANT
767688 Benign: not provided 112,526,029(+) C/T MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
780255 Benign: not provided 112,517,171(+) T/C SYNONYMOUS_VARIANT
780256 Benign: not provided 112,520,473(+) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for WNT2B Gene

Structural Variations from Database of Genomic Variants (DGV) for WNT2B Gene

Variant ID Type Subtype PubMed ID
esv1009068 CNV deletion 20482838
esv2659003 CNV deletion 23128226
esv27061 CNV gain+loss 19812545
esv3587213 CNV loss 21293372
nsv1008375 CNV loss 25217958
nsv831081 CNV loss 17160897
nsv951397 CNV deletion 24416366

Variation tolerance for WNT2B Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNT2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT2B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT2B Gene

Disorders for WNT2B Gene

MalaCards: The human disease database

(9) MalaCards diseases for WNT2B Gene - From: OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diarrhea 9
  • diar9
diarrhea
  • diarrhea of presumed infectious origin
osmotic diarrhea
gastric cancer
  • gastric cancer, somatic
neural tube defects
  • neural tube defects, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search WNT2B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WNT2B_HUMAN
  • Diarrhea 9 (DIAR9) [MIM:618168]: An autosomal recessive form of chronic diarrhea characterized by neonatal-onset of osmotic diarrhea that is not substrate specific, abnormal crypt and villus architecture, and significant fat malabsorption evidenced by high levels of fecal fat. {ECO:0000269 PubMed:29909964}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for WNT2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with WNT2B: view

No data available for Genatlas for WNT2B Gene

Publications for WNT2B Gene

  1. Alternative splicing of the WNT-2B/WNT-13 gene. (PMID: 10944466) Katoh M … Koike J (Biochemical and biophysical research communications 2000) 2 3 4 23
  2. CLC- a novel susceptibility gene for allergic rhinitis? (PMID: 19650845) Bryborn M … Cardell LO (Allergy 2010) 3 23 41
  3. Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family. (PMID: 8761309) Katoh M … Terada M (Oncogene 1996) 2 3 4
  4. Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. (PMID: 29909964) O'Connell AE … Agrawal PB (American journal of human genetics 2018) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41

ExternalLinks

View latest publications for WNT2B gene in Mastermind

Products for WNT2B Gene

  • Addgene plasmids for WNT2B

Sources for WNT2B Gene