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This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
WNT2B (Wnt Family Member 2B) is a Protein Coding gene. Diseases associated with WNT2B include Diarrhea 9 and Diarrhea. Among its related pathways are Signaling by GPCR and Gastric cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IEA | -- |
GO:0005109 | frizzled binding | IBA | 21873635 |
GO:0005125 | cytokine activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA,NAS | 15135146 |
GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
GO:0062023 | collagen-containing extracellular matrix | HDA | 25037231 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Translation Non-genomic (rapid) action of Androgen Receptor |
Transcription Androgen Receptor nuclear signaling
.49
Translation Non-genomic (rapid) action of Androgen Receptor
.49
|
|
2 | Gastric cancer |
.62
.62
|
|
3 | Aldosterone synthesis and secretion |
.41
|
.41
|
4 | mTOR signaling pathway (KEGG) |
.38
|
|
5 | Wnt signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002062 | chondrocyte differentiation | IEP | 15135146 |
GO:0002088 | lens development in camera-type eye | ISS | 16258938 |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0008584 | male gonad development | IEP | 17848411 |
GO:0009267 | cellular response to starvation | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||
SP2: | - | - | |||||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | WNT2B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | WNT2B 31 |
|
OneToOne | |
LOC483220 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | WNT2B 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | WNT2B 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Wnt2b 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Wnt2b 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | WNT2B 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | WNT2B 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | WNT2B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100491761 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | wnt2b-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | wnt2bb 30 31 |
|
OneToMany | |
wnt2ba 31 |
|
OneToMany | |||
wnt2b 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Wnt5 32 |
|
|
|
Wnt6 32 |
|
|
|||
Wnt2 32 |
|
|
|||
Wnt4 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | cwn-2 32 |
|
|
|
egl-20 32 |
|
|
|||
mom-2 32 |
|
|
|||
lin-44 32 |
|
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
718973 | Benign: not provided | 112,514,993(+) | G/A | MISSENSE_VARIANT | |
744351 | Likely Benign: not provided | 112,517,348(+) | C/T | SYNONYMOUS_VARIANT | |
767688 | Benign: not provided | 112,526,029(+) | C/T | MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT | |
780255 | Benign: not provided | 112,517,171(+) | T/C | SYNONYMOUS_VARIANT | |
780256 | Benign: not provided | 112,520,473(+) | A/G | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1009068 | CNV | deletion | 20482838 |
esv2659003 | CNV | deletion | 23128226 |
esv27061 | CNV | gain+loss | 19812545 |
esv3587213 | CNV | loss | 21293372 |
nsv1008375 | CNV | loss | 25217958 |
nsv831081 | CNV | loss | 17160897 |
nsv951397 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
diarrhea 9 |
|
|
diarrhea |
|
|
osmotic diarrhea |
|
|
gastric cancer |
|
|
neural tube defects |
|
|