Aliases for WNT2 Gene
External Ids for WNT2 Gene
Previous HGNC Symbols for WNT2 Gene
Previous GeneCards Identifiers for WNT2 Gene
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT2 Gene
WNT2 (Wnt Family Member 2) is a Protein Coding gene. Diseases associated with WNT2 include Peyronie's Disease and Septicemic Plague. Among its related pathways are Signaling by GPCR and Gastric cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT2B.
UniProtKB/Swiss-Prot Summary for WNT2 Gene
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).