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Aliases for WNT2 Gene

Aliases for WNT2 Gene

  • Wnt Family Member 2 2 3 5
  • Wingless-Type MMTV Integration Site Family Member 2 2 3
  • Secreted Growth Factor 2 3
  • Int-1-Related Protein 3 4
  • Int-1-Like Protein 1 3 4
  • INT1L1 3 4
  • IRP 3 4
  • Protein Wnt-2 3

External Ids for WNT2 Gene

Previous HGNC Symbols for WNT2 Gene

  • INT1L1

Previous GeneCards Identifiers for WNT2 Gene

  • GC07M115395
  • GC07M116457
  • GC07M116471
  • GC07M116511
  • GC07M116704
  • GC07M116916
  • GC07M111282

Summaries for WNT2 Gene

Entrez Gene Summary for WNT2 Gene

  • This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT2 Gene

WNT2 (Wnt Family Member 2) is a Protein Coding gene. Diseases associated with WNT2 include Autism and Colorectal Cancer. Among its related pathways are DNA Damage Response (only ATM dependent) and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT2B.

UniProtKB/Swiss-Prot for WNT2 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Gene Wiki entry for WNT2 Gene

Additional gene information for WNT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT2 Gene

Genomics for WNT2 Gene

GeneHancer (GH) Regulatory Elements for WNT2 Gene

Promoters and enhancers for WNT2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I117322 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.8 -0.6 -559 2.7 ZNF777 SUZ12 EBF1 ZNF335 ZFHX2 POLR2A PATZ1 SCRT2 ZSCAN29 PRDM10 WNT2 LOC105375467 ASZ1
GH07I117248 Enhancer 0.9 FANTOM5 ENCODE 10.7 +72.9 72871 4.3 PKNOX1 EBF1 BATF RELA ZNF121 NFATC1 CBFA2T2 ATF7 FOS IKZF2 LOC105375467 WNT2 MTND4P6 LOC105375466
GH07I117228 Enhancer 0.9 ENCODE dbSUPER 10.6 +93.0 93034 3 SMAD1 RB1 BACH1 PAX8 EBF1 YBX1 BATF RELA POLR2A NFATC1 WNT2 LOC105375466 ENSG00000278482 ST7 ST7-OT3
GH07I117385 Enhancer 0.7 ENCODE 10.7 -62.5 -62522 0.5 SCRT1 CTCF STAT1 ZNF687 ZNF654 TRIM22 REST RAD21 ZNF592 SREBF1 ASZ1 WNT2 CFTR
GH07I117350 Enhancer 0.5 FANTOM5 11.6 -26.9 -26874 0.2 ZNF687 NR2F1 EBF1 MLLT1 WNT2 ASZ1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WNT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WNT2 gene promoter:

Genomic Locations for WNT2 Gene

Genomic Locations for WNT2 Gene
46,659 bases
Minus strand

Genomic View for WNT2 Gene

Genes around WNT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT2 Gene

Proteins for WNT2 Gene

  • Protein details for WNT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Wnt-2
    Protein Accession:
    Secondary Accessions:
    • A4D0V1
    • Q75N05
    • Q9UDP9

    Protein attributes for WNT2 Gene

    360 amino acids
    Molecular mass:
    40418 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WNT2 Gene

Post-translational modifications for WNT2 Gene

  • Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at posLast=295295

Other Protein References for WNT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT2 Gene

Domains & Families for WNT2 Gene

Gene Families for WNT2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for WNT2 Gene

Suggested Antigen Peptide Sequences for WNT2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Wnt family.
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT2: view

Function for WNT2 Gene

Molecular function for WNT2 Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 2,Drosophila wingless (wg),segment polarity gene homolog,expressed in developing allantois,pericardium,ventral lateral mesoderm and in adult lung brain,heart,modulating cell fate and cell behavior during vertebrate development
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

LifeMap Function Summary for WNT2 Gene

During embryonic development, WNT2 as signaling molecule is secreted from the following cells
It affects the following cells:

Phenotypes From GWAS Catalog for WNT2 Gene

Gene Ontology (GO) - Molecular Function for WNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005109 frizzled binding IPI 10557084
GO:0005125 cytokine activity IDA 10557084
GO:0005515 protein binding IPI 10347172
GO:0048018 receptor ligand activity IDA 10557084
genes like me logo Genes that share ontologies with WNT2: view
genes like me logo Genes that share phenotypes with WNT2: view

Animal Models for WNT2 Gene

MGI Knock Outs for WNT2:

miRNA for WNT2 Gene

miRTarBase miRNAs that target WNT2

Clone Products

  • Addgene plasmids for WNT2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT2 Gene

Localization for WNT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT2 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
peroxisome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IEA,IDA 19038973
GO:0005886 colocalizes_with plasma membrane IDA 19038973
genes like me logo Genes that share ontologies with WNT2: view

Pathways & Interactions for WNT2 Gene

genes like me logo Genes that share pathways with WNT2: view

SIGNOR curated interactions for WNT2 Gene


Gene Ontology (GO) - Biological Process for WNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0002088 lens development in camera-type eye ISS 16258938
GO:0007267 cell-cell signaling IDA 10557084
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with WNT2: view

Drugs & Compounds for WNT2 Gene

(6) Drugs for WNT2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for WNT2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WNT2: view

Transcripts for WNT2 Gene

Unigene Clusters for WNT2 Gene

Wingless-type MMTV integration site family member 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for WNT2

Alternative Splicing Database (ASD) splice patterns (SP) for WNT2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: - -

Relevant External Links for WNT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WNT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT2 Gene

mRNA differential expression in normal tissues according to GTEx for WNT2 Gene

This gene is overexpressed in Lung (x12.3), Uterus (x6.5), and Prostate (x5.9).

Protein differential expression in normal tissues from HIPED for WNT2 Gene

This gene is overexpressed in Placenta (56.2) and Prostate (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT2 Gene

Protein tissue co-expression partners for WNT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of WNT2 Gene:


SOURCE GeneReport for Unigene cluster for WNT2 Gene:


mRNA Expression by UniProt/SwissProt for WNT2 Gene:

Tissue specificity: Expressed in brain in the thalamus, in fetal and adult lung and in placenta.

Evidence on tissue expression from TISSUES for WNT2 Gene

  • Nervous system(4.8)
  • Lung(4.7)
  • Intestine(3.3)
  • Skin(3.1)
genes like me logo Genes that share expression patterns with WNT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT2 Gene

Orthologs for WNT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WNT2 33 34
  • 99.63 (n)
(Rattus norvegicus)
Mammalia Wnt2 33
  • 91.85 (n)
(Mus musculus)
Mammalia Wnt2 33 16 34
  • 91.76 (n)
(Bos Taurus)
Mammalia WNT2 33 34
  • 91.02 (n)
(Canis familiaris)
Mammalia WNT2 33 34
  • 90.74 (n)
(Ornithorhynchus anatinus)
Mammalia WNT2 34
  • 90 (a)
(Monodelphis domestica)
Mammalia WNT2 34
  • 89 (a)
(Gallus gallus)
Aves WNT2 33
  • 79.23 (n)
(Danio rerio)
Actinopterygii wnt2ba 33
  • 70.24 (n)
wnt2 34
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 35
  • 50 (a)
Wnt6 35
  • 44 (a)
Wnt2 35
  • 42 (a)
Wnt4 35
  • 33 (a)
(Caenorhabditis elegans)
Secernentea cwn-2 35
  • 42 (a)
cwn-1 35
  • 39 (a)
egl-20 35
  • 37 (a)
mom-2 35
  • 35 (a)
lin-44 35
  • 32 (a)
Species where no ortholog for WNT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WNT2 Gene

Gene Tree for WNT2 (if available)
Gene Tree for WNT2 (if available)

Paralogs for WNT2 Gene

Paralogs for WNT2 Gene

(18) SIMAP similar genes for WNT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WNT2: view

Variants for WNT2 Gene

Sequence variations from dbSNP and Humsavar for WNT2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000007052 -- 117,291,338(-) T/C intron_variant
rs1000106174 -- 117,318,063(-) A/G intron_variant
rs1000244555 -- 117,276,225(-) G/T downstream_transcript_variant
rs1000265588 -- 117,321,855(-) C/G intron_variant
rs1000323884 -- 117,321,564(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WNT2 Gene

Variant ID Type Subtype PubMed ID
nsv608256 CNV gain 21841781
nsv7405 OTHER inversion 18451855
nsv831108 CNV gain 17160897

Variation tolerance for WNT2 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT2 Gene

Disorders for WNT2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for WNT2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • autistic disorder
colorectal cancer
  • crc
frontotemporal dementia
  • ftd
proximal symphalangism
  • symphalangism, proximal, 1a
multiple synostoses syndrome
  • symphalangism-brachydactyly syndrome
- elite association - COSMIC cancer census association via MalaCards
Search WNT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WNT2

Genetic Association Database
Human Genome Epidemiology Navigator
Tumor Gene Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WNT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNT2 Gene

Publications for WNT2 Gene

  1. No association between the WNT2 gene and autistic disorder. (PMID: 11840514) McCoy PA … Pericak-Vance MA (American journal of medical genetics 2002) 3 4 22 44 58
  2. Association between autism and variants in the wingless-type MMTV integration site family member 2 ( WNT2) gene. (PMID: 19895723) Marui T … Kato N (The international journal of neuropsychopharmacology 2010) 3 22 44 58
  3. Evidence supporting WNT2 as an autism susceptibility gene. (PMID: 11449391) Wassink TH … Sheffield VC (American journal of medical genetics 2001) 3 4 22 58
  4. Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. (PMID: 2971536) Wainwright BJ … Pedersen PS (The EMBO journal 1988) 2 3 4 58
  5. Wnt signaling and Dupuytren's disease. (PMID: 21732829) Dolmans GH … BSSH-GODD Consortium (The New England journal of medicine 2011) 3 44 58

Products for WNT2 Gene

Sources for WNT2 Gene

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