This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this... See more...

Aliases for WNT2 Gene

Aliases for WNT2 Gene

  • Wnt Family Member 2 2 3 5
  • IRP 2 3 4
  • Wingless-Type MMTV Integration Site Family Member 2 2 3
  • Secreted Growth Factor 2 3
  • Int-1-Related Protein 3 4
  • Int-1-Like Protein 1 3 4
  • Protein Wnt-2 3 4
  • INT1L1 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • WNT2 5

External Ids for WNT2 Gene

Previous HGNC Symbols for WNT2 Gene

  • INT1L1

Previous GeneCards Identifiers for WNT2 Gene

  • GC07M115395
  • GC07M116457
  • GC07M116471
  • GC07M116511
  • GC07M116704
  • GC07M116916
  • GC07M111282

Summaries for WNT2 Gene

Entrez Gene Summary for WNT2 Gene

  • This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT2 Gene

WNT2 (Wnt Family Member 2) is a Protein Coding gene. Diseases associated with WNT2 include Peyronie's Disease and Septicemic Plague. Among its related pathways are Signaling by GPCR and Gastric cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT2B.

UniProtKB/Swiss-Prot Summary for WNT2 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).

Gene Wiki entry for WNT2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for WNT2 Gene

Genomics for WNT2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for WNT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J117322 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -0.5 -538 3 TEAD4 PRDM10 LARP7 PATZ1 POLR2A EZH2 ZNF341 ZNF561 SCRT2 ZSCAN29 WNT2 ENSG00000286390 lnc-ST7-1 LOC105375467 CFTR ASZ1
GH07J117228 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.6 +92.9 92897 3 POLR2A BACH1 RELA IKZF2 YBX1 PAX8 RELB CEBPB RUNX3 GATAD2B WNT2 LOC105375466 ENSG00000278482 CFTR ST7 ST7-OT3 RF00017-6575
GH07J117248 Enhancer 1.1 FANTOM5 Ensembl ENCODE 10.7 +72.7 72734 4.3 RELA IKZF2 GTF2F1 YY1 PKNOX1 TOE1 EED DPF2 RELB CEBPB WNT2 piR-43107-280 MTND2P37 CFTR ST7 RF00017-6575
GH07J117282 Enhancer 0.8 Ensembl ENCODE 11.4 +39.7 39651 2.2 ZNF512 PRDM1 ZNF24 CEBPB FOS TRIM25 MAFK ZNF513 JUND ZNF366 WNT2 CFTR LOC100421782 ST7 RF00017-6575
GH07J117385 Enhancer 0.6 ENCODE 10.7 -62.7 -62659 0.5 CTCF PRDM10 PRDM1 REST RAD21 TRIM22 SCRT2 ZNF316 ZNF592 SMC3 ASZ1 WNT2 CFTR ENSG00000286390
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WNT2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for WNT2

Top Transcription factor binding sites by QIAGEN in the WNT2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2

Genomic Locations for WNT2 Gene

Genomic Locations for WNT2 Gene
chr7:117,275,451-117,323,152
(GRCh38/hg38)
Size:
47,702 bases
Orientation:
Minus strand
chr7:116,916,685-116,963,343
(GRCh37/hg19)
Size:
46,659 bases
Orientation:
Minus strand

Genomic View for WNT2 Gene

Genes around WNT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT2 Gene

Proteins for WNT2 Gene

  • Protein details for WNT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09544-WNT2_HUMAN
    Recommended name:
    Protein Wnt-2
    Protein Accession:
    P09544
    Secondary Accessions:
    • A4D0V1
    • Q75N05
    • Q9UDP9

    Protein attributes for WNT2 Gene

    Size:
    360 amino acids
    Molecular mass:
    40418 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WNT2 Gene

Post-translational modifications for WNT2 Gene

  • Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn295
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT2 Gene

No data available for DME Specific Peptides for WNT2 Gene

Domains & Families for WNT2 Gene

Gene Families for WNT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for WNT2 Gene

InterPro:
Blocks:
  • Secreted growth factor Wnt protein
ProtoNet:

Suggested Antigen Peptide Sequences for WNT2 Gene

GenScript: Design optimal peptide antigens:
  • Protein Wnt (A4D0V1_HUMAN)
  • Protein Wnt (C9JUI2_HUMAN)
  • Int-1-related protein (WNT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P09544

UniProtKB/Swiss-Prot:

WNT2_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT2: view

Function for WNT2 Gene

Molecular function for WNT2 Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
GENATLAS Biochemistry:
wingless-type MMTV integration site 2,Drosophila wingless (wg),segment polarity gene homolog,expressed in developing allantois,pericardium,ventral lateral mesoderm and in adult lung brain,heart,modulating cell fate and cell behavior during vertebrate development

LifeMap Function Summary for WNT2 Gene

During embryonic development, WNT2 as signaling molecule is secreted from the following cells
It affects the following cells:

Phenotypes From GWAS Catalog for WNT2 Gene

Gene Ontology (GO) - Molecular Function for WNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
GO:0005109 frizzled binding IPI 10557084
GO:0005125 cytokine activity IDA 10557084
GO:0005515 protein binding IPI 10347172
GO:0048018 receptor ligand activity IDA,IMP 17948129
genes like me logo Genes that share ontologies with WNT2: view
genes like me logo Genes that share phenotypes with WNT2: view

Animal Models for WNT2 Gene

MGI Knock Outs for WNT2:

Animal Model Products

CRISPR Products

miRNA for WNT2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNT2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT2 Gene

Localization for WNT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT2 Gene

Secreted, extracellular space, extracellular matrix. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT2 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IEA,IDA 19038973
GO:0031232 extrinsic component of external side of plasma membrane IDA 19038973
GO:0062023 collagen-containing extracellular matrix IDA 15507471
genes like me logo Genes that share ontologies with WNT2: view

Pathways & Interactions for WNT2 Gene

PathCards logo

SuperPathways for WNT2 Gene

genes like me logo Genes that share pathways with WNT2: view

Pathways by source for WNT2 Gene

2 Sino Biological pathways for WNT2 Gene
2 GeneGo (Thomson Reuters) pathways for WNT2 Gene
  • Transcription Androgen Receptor nuclear signaling
  • Translation Non-genomic (rapid) action of Androgen Receptor
1 Tocris pathway for WNT2 Gene
9 Qiagen pathways for WNT2 Gene
  • Colorectal Cancer Metastasis
  • G12-G13 in Cellular Signaling
  • GSK3 Signaling
  • Hedgehog Signaling in Mammals
  • Human Embryonic Stem Cell Pluripotency
2 GeneTex pathways for WNT2 Gene

SIGNOR curated interactions for WNT2 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for WNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0002088 lens development in camera-type eye ISS 16258938
GO:0007267 cell-cell signaling IDA 10557084
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with WNT2: view

Drugs & Compounds for WNT2 Gene

(6) Drugs for WNT2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for WNT2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WNT2: view

Transcripts for WNT2 Gene

mRNA/cDNA for WNT2 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for WNT2

Alternative Splicing Database (ASD) splice patterns (SP) for WNT2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for WNT2 Gene

GeneLoc Exon Structure for
WNT2

Expression for WNT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WNT2 Gene

mRNA differential expression in normal tissues according to GTEx for WNT2 Gene

This gene is overexpressed in Lung (x12.3), Uterus (x6.5), and Prostate (x5.9).

Protein differential expression in normal tissues from HIPED for WNT2 Gene

This gene is overexpressed in Placenta (56.2) and Prostate (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WNT2 Gene



Protein tissue co-expression partners for WNT2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for WNT2

SOURCE GeneReport for Unigene cluster for WNT2 Gene:

Hs.567356

mRNA Expression by UniProt/SwissProt for WNT2 Gene:

P09544-WNT2_HUMAN
Tissue specificity: Expressed in brain in the thalamus, in fetal and adult lung and in placenta.

Evidence on tissue expression from TISSUES for WNT2 Gene

  • Nervous system(4.8)
  • Lung(4.7)
  • Intestine(3.8)
  • Skin(3.7)
  • Blood(2.8)
  • Muscle(2.7)
  • Heart(2.6)
  • Liver(2.6)
  • Pancreas(2.5)
  • Eye(2.5)
  • Kidney(2.4)
  • Bone marrow(2.4)
  • Stomach(2.3)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with WNT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT2 Gene

Orthologs for WNT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia WNT2 30 31
  • 99.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Wnt2 30
  • 91.85 (n)
Mouse
(Mus musculus)
Mammalia Wnt2 30 17 31
  • 91.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia WNT2 30 31
  • 91.02 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia WNT2 30 31
  • 90.74 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia WNT2 31
  • 90 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia WNT2 31
  • 89 (a)
OneToOne
Chicken
(Gallus gallus)
Aves WNT2 30
  • 79.23 (n)
Zebrafish
(Danio rerio)
Actinopterygii wnt2ba 30
  • 70.24 (n)
wnt2 31
  • 70 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Wnt5 32
  • 50 (a)
Wnt6 32
  • 44 (a)
Wnt2 32
  • 42 (a)
Wnt4 32
  • 33 (a)
Worm
(Caenorhabditis elegans)
Secernentea cwn-2 32
  • 42 (a)
cwn-1 32
  • 39 (a)
egl-20 32
  • 37 (a)
mom-2 32
  • 35 (a)
lin-44 32
  • 32 (a)
Species where no ortholog for WNT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for WNT2 Gene

ENSEMBL:
Gene Tree for WNT2 (if available)
TreeFam:
Gene Tree for WNT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WNT2: view image

Paralogs for WNT2 Gene

(18) SIMAP similar genes for WNT2 Gene using alignment to 4 proteins:

  • WNT2_HUMAN
  • C9JUI2_HUMAN
  • F8WDR1_HUMAN
  • L8EA39_HUMAN
genes like me logo Genes that share paralogs with WNT2: view

Variants for WNT2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for WNT2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
719651 Benign: not provided 117,278,181(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
774454 Benign: not provided 117,297,673(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs1051751 - p.Cys294Phe
rs145839592 - p.Leu5Arg
rs148046128 - p.Arg299Trp

Additional dbSNP identifiers (rs#s) for WNT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for WNT2 Gene

Variant ID Type Subtype PubMed ID
nsv608256 CNV gain 21841781
nsv7405 OTHER inversion 18451855
nsv831108 CNV gain 17160897

Variation tolerance for WNT2 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT2 Gene

Disorders for WNT2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for WNT2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
peyronie's disease
  • peyronie disease
septicemic plague
  • plague, septicemic
colorectal cancer
  • crc
gastric cancer
  • gastric cancer, somatic
autism
  • autistic disorder
- elite association - COSMIC cancer census association via MalaCards
Search WNT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WNT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with WNT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNT2 Gene

Publications for WNT2 Gene

  1. No association between the WNT2 gene and autistic disorder. (PMID: 11840514) McCoy PA … Pericak-Vance MA (American journal of medical genetics 2002) 3 4 23 41
  2. Association between autism and variants in the wingless-type MMTV integration site family member 2 ( WNT2) gene. (PMID: 19895723) Marui T … Kato N (The international journal of neuropsychopharmacology 2010) 3 23 41
  3. Evidence supporting WNT2 as an autism susceptibility gene. (PMID: 11449391) Wassink TH … Sheffield VC (American journal of medical genetics 2001) 3 4 23
  4. Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. (PMID: 2971536) Wainwright BJ … Pedersen PS (The EMBO journal 1988) 2 3 4
  5. Wnt signaling and Dupuytren's disease. (PMID: 21732829) Dolmans GH … BSSH-GODD Consortium (The New England journal of medicine 2011) 3 41

Products for WNT2 Gene

Sources for WNT2 Gene